Clinical trials: Long-term Outcomes
Critical Illness, Sepsis
Measuring Outcomes of Activity in Intensive Care
Millions of older adults are hospitalized for a critical illness each year and although they are more likely than ever to survive this illness, they commonly face significant morbidity in the form of disabilities in basic…
- Conditions
- Critical Illness, Sepsis, Mechanical Ventilation, Physical Activity
- Trial name
- MOSAIC (NCT03115840)
- Where
- 2 sites in United States
- Volunteers
- 312 people
- Sponsor
- Vanderbilt University Medical Center
Osteoarthritis of Hip, Traumatic Arthritis of Hip
Long-Term Multi-center Evaluation of E-Poly and Regenerex
There are two distinct aims of this study: 1. This prospective study is designed to document the long-term (10-year) radiographic and clinical outcomes of a new type of highly cross-linked polyethylene liner which contains…
- Trial name
- NCT00545285
- Testing
- Total Hip Arthroplasty
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Massachusetts General Hospital
Polysomnography, Sleep Apnea Syndromes
Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep Database
The primary purpose of the proposed study is to validate our previously developed predictive model for adults with obstructive sleep apnea using (i) clinical data from multiple large academic centers, (ii) a longer follow-up…
- Conditions
- Polysomnography, Sleep Apnea Syndromes, Risk Factors, Prognosis
- Trial name
- NCT03834792
- Testing
- No intervention but exposure
- Where
- Canada
- Volunteers
- 5,155 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Obstructive Pulmonary Disease COPD
Long-term Real-world Study of Dupilumab in COPD : Patient Characteristics, Safety and Patient-reported Outcomes
The OBS19236 is a retrospective and prospective, non-interventional observational study in COPD patients treated with dupilumab as part of routine clinical care.
- Trial name
- AURORA (NCT07380711)
- Where
- 28 sites in France
- Volunteers
- 500 people
- Sponsor
- Sanofi
Cataract, Astigmatism
Observational Prospective Clinical Investigation on Monofocal Toric Intraocular Lens
Evaluation, at least one-year long-term, of the clinical performance and safety of Mini Toric Ready Intraocular Lens (IOL), a monofocal toric intraocular lens.
- Trial name
- NCT06250855
- Testing
- Mini Toric IOL
- Where
- 2 sites in Romania
- Volunteers
- 105 people
- Sponsor
- SIFI SpA
COPD
Portable Oxygen Concentrator to Improve Quality of Life in Chronic Obstructive Pulmonary Disease
Evaluate subjects in an prospective observational study Subjects will be administered scientifically validated questionnaires Determine the affect of the Portable Oxygen Concentrator (POC) on improvements in: 1.
- Trial name
- NCT01948544
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- StratiHealth
Diabetes Mellitus, Hemodialysis
Effects of Tinzaparin on Cardio-vascular Outcomes and on Blood Lipids in Diabetic Patients on Chronic Hemodialysis
Low molecular weight heparin (LMWH) provides a safe and effective alternative to UFH for hemodialysis anticoagulation. While unfractionated (UF) heparin has been implicated in hyper-lipidemia, the effect of LMWHs on the lipid…
- Trial name
- NCT00407641
- Testing
- Tinzaparin administration, Heparin administration
- Where
- 13 sites in Romania
- Sponsor
- Anemia Working Group Romania
Scar, Surgical Wound
Correlation of Early Postoperative Scar Appearance With Long-term Scar Outcomes
A retrospective cohort study of early and late period postoperative scars using previously validated survey measures and clinical photographs.
- Conditions
- Scar, Surgical Wound, Quality of Life, Mohs Micrographic Surgery
- Trial name
- NCT04015453
- Testing
- Mohs micrographic surgery
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Pulmonary Embolism, Chronic Thromboembolic Pulmonary Hypertension
Validation of SEARCH, a Novel Hierarchical Algorithm to Define Long-term Outcomes After Pulmonary Embolism
Potential outcomes after PE occur on a spectrum: complete recovery, exercise intolerance from deconditioning/anxiety, dyspnea from concomitant cardiopulmonary conditions, dyspnea from residual pulmonary vascular occlusion…
- Trial name
- ValidSEARCH (NCT05568927)
- Testing
- SEARCH algorithm
- Where
- 8 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Diego
Smoking, Smoking Cessation
A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco
This nationwide telephone and mail- based research study will recruit 1,400 cigarette smokers who are not motivated to quit to test the effects of a marketed oral, non-combustible smokeless tobacco product on cigarette smoking…
- Trial name
- NCT01509586
- Testing
- Potentially Reduced Exposure Product (PREP): a smokeless, spit-free tobacco product
- Where
- United States
- Volunteers
- 1,236 people
- Sponsor
- Medical University of South Carolina
Von Hippel-Lindau Disease, Central Nervous System Hemangioblastoma
Pediatric Von Hippel-Lindau Disease: Natural History, Predictive Factors, and Long-Term Functional Outcomes of Central Nervous System Hemangioblastomas
Von Hippel-Lindau (VHL) disease is a rare hereditary cancer predisposition syndrome associated with the development of central nervous system hemangioblastomas from childhood.
- Trial name
- VHL-PED-CHB (NCT07705529)
- Where
- 3 sites in France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoxic-Ischemic Encephalopathy, Birth Asphyxia
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries
The investigators will conduct a study on non-vigorous infants at birth to determine if umbilical cord milking (UCM) results in lower rate of moderate to severe hypoxic ischemic encephalopathy (HIE) or death than early clamping…
- Trial name
- CORDMILK (NCT03657394)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 3,442 people
- Sponsor
- Nemours Children's Clinic
Hyperplasia, Stenosis
Stent vs. Angioplasty for Treatment of Thrombosed AV Grafts: Long-Term Outcomes
Arteriovenous grafts are used as the vascular access in 40-50% of hemodialysis patients. Grafts are prone to recurrent stenosis (narrowing) and thrombosis (clotting).
- Trial name
- NCT00496639
- Testing
- angioplasty, stent placement
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Kidney Foundation, United States
Breast Cancer
Oncoplastic Surgery Outcomes Database
This is a retrospective and prospective chart review of surgical outcomes and collecting patient satisfaction outcomes using validated surveys for oncoplastic breast surgery and Goldilocks mastectomy.
- Trial name
- NCT07597837
- Testing
- Oncoplastic Breast Surgery
- Where
- 2 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Tufts Medical Center
Obesity
Short- and Long-Term Effects of Antibiotics on Childhood Growth
The objectives of the proposed study are to assess the effects of different types, timing, and amount of antibiotic use in the first two years of life with (Specific Aim 1) body mass index (BMI) and obesity at ages 5 and 10 years…
- Trial name
- ABX (NCT02744846)
- Testing
- Antibiotics exposure
- Volunteers
- 681,739 people
- Sponsor
- Harvard Pilgrim Health Care
Periodontal Diseases, Periodontal Pocket
Periodontal Maintenance and the COVID-19 Pandemic
Periodontal disease is a chronic condition affecting the teeth and surrounding support structures, characterized by tooth loss and alveolar bone loss.
- Trial name
- NCT05125835
- Where
- Canada
- Volunteers
- 428 people
- Sponsor
- Brock University
Colorectal Cancer
FOcUs on Colorectal CAncer oUtcomes: Long-Term Study
Colorectal cancer (CRC) affects men and women of all racial and ethnic groups and accounts for more than 600,000 deaths per year, globally.
- Trial name
- Foucault (NCT03965325)
- Testing
- Use of a standardized set to collect clinical and patient-centered data, to assess the trend of the Global Health Status overtime in colorectal cancer patients
- Where
- France
- Volunteers
- 133 people
- Sponsor
- IHU Strasbourg
COVID-19 Patients
Investigating Long-term Health Effects and Complications in COVID-19 Recoveries
Clarify the incidence of functional impairments in cured COVID-19 patients and identify influencing factors. Build a multi-omics database for COVID-19 patients in the recovery period to elucidate the biological biomarkers and…
- Trial name
- NCT06349720
- Testing
- respiratory rehabilitation
- Where
- China
- Volunteers
- 17,000 people, healthy volunteers welcome
- Sponsor
- Zhaohui Tong
Peri-Implantitis
Long-term Surgical Treatment Outcome of Peri-implantitis Lesions
The surgical treatment outcome of patients that have been or are consecutively treated at the University of Malmö, at Blekinge hospital, and at the Dental Clinic of the Sigmund Freud University Vienna will be evaluated on an a…
- Trial name
- NCT05339789
- Where
- 3 sites in Austria, Sweden
- Volunteers
- 650 people
- Sponsor
- Malmö University
Long-term Effects Secondary to Cancer Therapy in Children, Lymphoma
Long-Term Effects of Treatment in Patients Previously Treated for Childhood Hodgkin's Lymphoma
RATIONALE: Assessing the long-term effects of cancer treatment in cancer survivors may help improve the ability to plan effective treatment and follow-up care.
- Trial name
- NCT00091091
- Testing
- medical chart review, questionnaire administration, management of therapy complications
- Where
- 15 sites in United States
- Volunteers
- 530 people
- Sponsor
- Children's Oncology Group