Clinical trials: Long Term
Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program
CAR-T Long Term Follow Up (LTFU) Study
Per Health Authorities guidelines for gene therapy medicinal products that utilize integrating vectors (e.g. lentiviral vectors), long term safety and efficacy follow up of treated patients is required.
- Trial name
- PAVO (NCT02445222)
- Testing
- Previously treated CAR-T patients
- Where
- 120 sites in United States, Australia and 21 more
- Volunteers
- 1,105 people
- Sponsor
- Novartis Pharmaceuticals
Generally Healthy Adults Who Are Long-term Supplement Users
An Evaluation of Long-Term Supplement Use on Biological Age and Metabolic Health Markers - The BioAge Trial
This study will evaluate whether dietary supplement use (> 1 year) is associated with differences in biological age relative to chronological age, as well as differences in metabolic health and functional fitness tests.
- Trial name
- NCT07755943
- Testing
- No Intervention: Observational Cohort
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shaklee Corporation
Long Term Safety Following GM T Cell Therapy
A Safety and Efficacy Long-Term Follow-up Study of Adult Participants Treated With Gene Modified T Cells
This is a prospective study for the Long-Term Follow-Up (LTFU) of safety and efficacy of all participants exposed to gene modified (GM) T cell therapy in accordance with Health Authorities' guidance for participants treated with…
- Trial name
- NCT06798298
- Testing
- Non-interventional
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Regeneron Pharmaceuticals
Long Term Efficacy and Safety
A Long-term Follow-up Trial of Patients Previously Treated With Imlifidase Prior to Kidney Transplantation and a Non-comparative Transplanted Patient Group
A prospective, post-authorisation long-term follow-up trial of patients previously treated with imlifidase prior to kidney transplantation, including a non-comparative concurrent reference cohort.
- Trial name
- PAES-LTFU (NCT05937750)
- Testing
- Imlifidase administered in the 20-HMedIdeS-19 (PAES) study, Best available treatment administered in the 20-HMedIdeS-19 (PAES) study
- Where
- 14 sites in Austria, Czechia and 5 more
- Volunteers
- 150 people
- Sponsor
- Hansa Biopharma AB
Long-Term Organ Damage in Adult Patients With Active Systemic Lupus Erythematosus
Long-Term Organ Damage: Anifrolumab Versus Real-World Standard of Care in Adult Patients With Active Systemic Lupus Erythematosus
This is an External control arm study to generate evidence on the comparative effect of anifrolumab plus Standard of Care in TULIP versus Real World Standard of Care on organ damage in adult patients with moderately to severely…
- Trial name
- LASER (NCT06485674)
- Where
- Canada
- Volunteers
- 561 people
- Sponsor
- AstraZeneca
Dry Eye Syndrome, Glaucoma and Concomitant Dry Eye Syndrome
Evaluation of Performance and Safety of Carbopol 980 NF 0.2%- Based Medical Device in the Management of Patients With Glaucomar or Ocular Hypertension and Concomitant Dry Eye Syndrome on Multiple Long-term Topical Hypotensive Therapy
The main aim of this investigation is to evaluate the effect of the preservative-free ophthalmic solution IRIDIUM® A gel on the ocular surface of patients with glaucoma or OHT and concomitant DES under multiple long-term topical…
- Conditions
- Dry Eye Syndrome, Glaucoma and Concomitant Dry Eye Syndrome, Ocular Hypertension and Concomitant Dry Eye Syndrome, Multiple Long-term Topical Hypotensive Therapy
- Trial name
- NCT06190028
- Testing
- Iridium A Gel
- Where
- 3 sites in Italy
- Volunteers
- 65 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Multiple Chronic Conditions, Chronic Disease
Virta Health Registry
The purpose of this registry is to establish a research data repository, comprised of data generated in the course of providing clinical services to patients treated by Virta Health, to conduct secondary research on clinical…
- Conditions
- Multiple Chronic Conditions, Chronic Disease, Disease Progression, Long-Term Care
- Trial name
- NCT03474692
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Virta Health
Long Term Follow-up
Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729)
This is a long term follow-up study for chronic hepatitis B (CHB) subjects who have received imdusiran treatment in a prior clinical trial, stopped NA therapy during that trial, and remain off therapy.
- Trial name
- NCT06277037
- Testing
- Non-interventional
- Where
- 18 sites in United States, Australia and 5 more
- Volunteers
- 50 people
- Sponsor
- Arbutus Biopharma Corporation
Patients With Uncomplicated Long-term Central Venous Catheter-related Biofilm-related Infection
Conservative Treatment of Catheter - Related Injections With Gentamicine/EDTA
Catheter-related infections are frequent. Treatment without catheter removal is difficult because of the presence of biofilm. The association of gentamicin and EDTA is active in vitro and in vivo against biofilms formed by Gram…
- Trial name
- CATH-GE (NCT04789928)
- Testing
- Gentamicins-EDTA
- Where
- 6 sites in France
- Volunteers
- 8 people
- Sponsor
- Institut Pasteur
Long Term Follow up Dry Eye Disease
Evaluation of the Long Term Follow up of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease
The objective of this safety long-term follow-up study was to evaluate the safety of OC-01 Nasal Spray at 6 months and 12 months post treatment in the OPP-002 study (NCT03636061).
- Trial name
- NCT03920215
- Testing
- OC-01 Low Dose, 0.12 mg/mL, OC-01 Mid Dose, 0.6 mg/mL, OC-01 High Dose, 1.2 mg/mL
- Where
- 3 sites in United States
- Volunteers
- 101 people
- Sponsor
- Oyster Point Pharma, Inc.
Long-term Follow-up
Long-Term Follow-Up of Patients Who Received Gene-Modified Cell Therapy
Observational long-term follow-up study of patients who have been exposed to a gene-modified cell therapy produced by ex vivo transduction of immune cells expressing viral or non-viral vectors in studies sponsored by Sorrento…
- Trial name
- NCT05472649
- Testing
- Gene-Modified Cell Therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Sorrento Therapeutics, Inc.
Focus: Long-term Retention of Gadolinium-based Contrast Agent
Long-Term Retention of Gadolinium in Bone
The main objective was to prospectively explore the potential for long-term retention of Gadolinium (Gd) in bones in patients who have received a single dose of Gadolinium-based contrast agents (GBCA) or multiple doses of the…
- Trial name
- NCT01853163
- Testing
- Gadolinium analysis in bone and tissue samples
- Where
- 16 sites in United States, Germany and 4 more
- Volunteers
- 92 people
- Sponsor
- Navitas Life Sciences GmbH
Survivorship and Long-term Safety and Effectiveness of the Stelkast Surpass Acetabular System
Active Surveillance Post-Approval Atudy of the Stelkast Surpass Acetabular System
The active surveillance post-approval study of the Stelkast Surpass Acetabular System is a retrospective, multi-center, single-arm study intended to collect data on the survivorship and long-term safety and effectiveness of the…
- Trial name
- NCT01672086
- Testing
- Stelkast Surpass Acetabular System implant
- Where
- 4 sites in United States
- Volunteers
- 347 people
- Sponsor
- StelKast, Inc.
Long-term Safety of TIP
Ext. Long-term Safety Study in CF Patients: Single Arm TIP
The purpose of this extension study is to collect additional 48 weeks of safety data from patients taking TIP who have completed the core study CTBM100C2401.
- Trial name
- NCT01775137
- Testing
- TBM100
- Where
- 21 sites in United States, Argentina and 7 more
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Long Term Safety of the AMS 1.0
PROGRESS-AMS 1.0 Clinical Long Term Follow-Up
The primary objective of this study is to collect long term clinical follow-up data on all patients enrolled in the PROGRESS AMS-1.0 study to assess long term safety of the AMS-1.0
- Trial name
- NCT01610102
- Where
- 6 sites in Australia, Belgium and 3 more
- Volunteers
- 55 people
- Sponsor
- Biotronik AG
Change in Cognitive Function and Fatigue During Extended Performance of the Cognitive Demand Battery (CDB) at 1, 3 and 6 Hours Post Consumption, Change in Long Term Declarative Memory at 1, 3 and 6 Hours Post-intervention.
Plant Based Extracts and Cognition
Acute, randomized, placebo controlled, double blind, 4 arm crossover study to determine the effect of different combinations of plant based extracts on cognitive function and cerebral blood flow.
- Trial name
- CEOPTB (NCT02202629)
- Testing
- Beverage containing plant based extracts
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D