Clinical trials: Locomotor Activity
Postural Balance
Evaluation of Foot Mechanical Information on Static Task and Locomotion
Sensory foot integration is evaluated by foam under feet both in research and clinical contexts. However, there is no norm defined regarding foam characteristics and this evaluation is mostly performed using a static task.
- Trial name
- NCT05170750
- Testing
- Foams, Foam / Orthopedic insole
- Where
- 2 sites in France
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Rennes 2
Spinal Cord Injury
Restoring Walking With a Powered Exoskeleton After Spinal Cord Injury
Powered exoskeletons have emerged recently, promising to offer walking to individuals with severe spinal cord injury who are unable to walk.
- Trial name
- NCT02322125
- Testing
- ReWalk
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Incomplete Spinal Cord Injury
Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility.
- Trial name
- AGILE SCI (NCT04340063)
- Testing
- Gait training performed on a treadmill, Gait training performed in a Movement Amplification Environment
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Obesity and Overweight
Effect of Simulated Weight Loss on the Energy Cost of Locomotion in Overweight or Obese Adolescents
Current literature suggests that part of the energy response to weight loss is not due to changes in fat mass and lean mass, but rather to a homeostatic adaptation aimed at limiting or even preventing weight loss and preserving…
- Trial name
- DELOAD (NCT07155746)
- Testing
- Incremental walking exercise on an AlterG treadmill (anti-gravity)
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Emile Roux
Vojta Therapy, Reflex Locomotion
Vojta Therapy in Early Stroke Rehabilitation
Stroke is the major cause for permanent disability in adults. It is still unclear, which physiotherapeutic approaches are most effective.
- Trial name
- NCT03035968
- Testing
- Vojta therapy, conventional physiotherapy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Corina Epple
Rectal Cancer, Defect of Floor of Lesser Pelvis
Collagen Implant (Biological Mesh) Versus GM Flap for Reconstruction of Pelvic Floor After ELAPE in Rectal Cancer
The trial compares two different techniques for reconstruction of the lesser pelvic floor after an extended abdominoperineal excision for locally advanced rectal cancer.
- Trial name
- NEAPE (NCT01347697)
- Testing
- Reconstruction with an acellular porcine dermal collagen implant (biological mesh), Reconstruction with a gluteus maximus myocutaneous flap
- Where
- 8 sites in Finland, Sweden
- Volunteers
- 91 people
- Sponsor
- Umeå University
Young Children With Motor Disabilities
Using Head-mounted, Eye-tracking to Compare Looking, Manual Exploration and Social Interaction During Active Locomotion
The three purposes of this study are: 1) to determine the feasibility of using a head-mounted eye-tracker and examine the effects of the optimal mobility training on increasing visual and manual exploration in toddlers with…
- Trial name
- NCT05441137
- Testing
- Ride-On Cars Training with Different Postures, Conventional Therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
Cerebral Palsy (CP)
Activities-based Locomotor Training in Children With Cerebral Palsy
This project aims to improve the quality of life and functional outcomes for young non-ambulatory children with Cerebral Palsy (CP) by investigating the efficacy of an Activities-Based Locomotor Training (AB-LT) program compared…
- Trial name
- ENGAGE-CP (NCT07184411)
- Testing
- Activities-based locomotor training, physical therapy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor University
Spinal Cord Injury
Robotic-assisted Locomotor Training on Mobility and Cardiopulmonary Function in Patients Suffering From Spinal Cord Injury
Evidences showed that patients suffering from spinal cord injury (SCI) have poor mobility and higher chance to develop cardiopulmonary diseases, which leads to poor quality of life and shorter life expectancy.
- Trial name
- NCT01989806
- Testing
- Robotic-assisted body weight supported treadmill training (Lokomat V6, Hocoma AG, Switzerland), Passive lower limbs mobilization training (Motomed Vivo 2, RECK, Germany)
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Kowloon Hospital, Hong Kong
COMPARISON BETWEEN GROUP TREATED WITH BOTULINUM TOXIN AND PLACEBO
Study of the Effect of Botulinum Toxin Injection in Rectus Femoris and Triceps on the Length and the Strength During Locomotion in Chronic Hemiparetic Patients
The aim of this randomized controlled study is to quantify the modification during locomotion of chronic hemiparetic patients of the strength and the length of Rectus Femoris and Triceps Surae induced by botulinum toxin injection…
- Trial name
- FOLOTOX (NCT01821573)
- Testing
- botulinum toxin type A, injection of NaCl 0.9%
- Where
- 3 sites in France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spinal Cord Injuries
Effects of Robotic Versus Manually-Assisted Locomotor Training for Individuals With Incomplete Spinal Cord Injury
The purpose of this study is to collect data comparing two means of providing locomotor training: manual and robotic and the possible differential effects it may have on walking ability for persons with spinal cord injury (SCI).
- Trial name
- DE (NCT00127439)
- Testing
- Manually Assisted Locomotor Training, Robotic Assisted Locomotor Training
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Transformation of Paralysis to Stepping
The main goal of the project is to develop multiple noninvasive neuromodulatory strategies to facilitate full weight bearing stepping overground in people with paralysis.
- Trial name
- NCT04105114
- Testing
- Buspirone, Non-invasive Spinal Cord Stimulation, Overground stepping
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Gait Disorders
Impact of tDCS on Locomotion and Equilibrium in Hemiplegic Patients
The aim of this trial is to quantify the improvement of locomotion and equilibrium induced par tDCS in anode polarity position in post stroke hemiplegic patients.
- Trial name
- HEMILOCOSTICOR (NCT02134158)
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Child Development
Dual Tasking in Children With Cerebral Palsy and Healthy Children: an EEG Study
Simultaneous execution of motor and cognitive tasks is embedded in the daily life of children. An EEG study will be conducted on healthy children and children with cerebral palsy to study the neural correlates during dual tasking…
- Trial name
- PRALOC (NCT04634292)
- Testing
- EEG
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Traumatic Amputation of Lower Extremity
Characterizing Ankle Function During Sloped Locomotion for Prosthesis Development
The proposed study aims to characterize biological ankle joint function during walking and running on slopes in order to further develop advanced powered ankle-foot prostheses.
- Trial name
- NCT01784003
- Testing
- Powered ankle-foot prosthesis
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Cybersickness
Investigation of the Effects of Two Types of Locomotion in the Virtual Environment
Virtual Reality (VR) is a technology that enables individuals to engage in a computer-generated, three-dimensional (3D) environment by utilizing specialized electronic equipment.
- Trial name
- NCT06206213
- Testing
- Assessment of two different locomotion types.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Patients With Chronic Stroke
Enhanced Motor Recovery Using Serotonergic Agents in Stroke
The information derived from this study will be critical to establishing appropriate rehabilitative interventions post-stroke. In particular, traditional use of pharmacological agents to alter motor function post-stroke is…
- Trial name
- NCT01751854
- Testing
- SSRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Improving Walking After Spinal Cord Injury
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to…
- Trial name
- NCT07223710
- Testing
- Paired Associative Stimulation, Locomotor Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Mobility Impairment, Community Dwelling Older Adults
Motor Imagery and Turning Practice to Improve Mobility: Pilot Trial
The goal of this clinical trial is to evaluate whether combining in-person turning practice with home-based Motor Imagery Therapy (MIT) is feasible and may improve mobility in community-dwelling older adults aged 65 years and…
- Trial name
- MI-TURN (NCT07705360)
- Testing
- Motor Imagery Therapy, Stress Management Education, Locomotor Turning Practice
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boise State University
Lower Limb Amputation
Exploratory Functional Assessment After Lower Limb Amputation: Locomotion, Balance, Energy Performance and Strategies for Adapting to Orthopaedic Devices
The general aim of this exploratory study is therefore to investigate and quantify the functional capacities of patients with lower limb amputations (transtibial and transfemoral), with no change in their management, and to…
- Trial name
- AMILOCO (NCT07094074)
- Testing
- Walk tests, Functional testing, Balance analysis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon