Clinical trials: Lock Solution
Catheter Blockage, Catheter-Related Infections
Comparison of Effectiveness and Complications of Catheter Lock Solutions in Non-tunneled Hemodialysis Catheters
In our study, investigators will investigate the effectiveness and complications of two catheter lock solutions one of which is the standard heparin routinely used in comparison to Sodium bicarbonate.
- Conditions
- Catheter Blockage, Catheter-Related Infections, Dialysis Catheter; Thrombosis, Catheter Infection
- Trial name
- NCT04772209
- Testing
- Sodium bicarbonate, Heparin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 441 people
- Sponsor
- Zonguldak Ataturk State Hospital
Chronic Renal Failure, Haemodialysis, Haemodiafiltration, Haemofiltration
Catheter Dysfunction Rate in Patients Undergoing Kidney Replacement Therapy. Evaluation of the Safety and Efficacy of Anti-reflux Valves Without Heparin Lock Solution
Catheter dysfunction and infections are the most common complications observed among patients with dialysis catheters for long-term dialysis ( CDLD ) .
- Conditions
- Chronic Renal Failure, Haemodialysis, Haemodiafiltration, Haemofiltration, Kidney Replacement Therapy, Catheter Infection, Catheter Dysfunction, Catheter Related Bloodstream Infections
- Trial name
- DUKE (NCT06259266)
- Testing
- Anti-reflux valve for dialysis catheter
- Where
- France
- Sponsor
- University Hospital, Clermont-Ferrand
Catheter-Related Infections
ATAPAC Study (TauroLock Activity in Adult Cancer Patients)
The purpose of this study is to compare the efficacy of a lock taurolidine-citrate solution vs standard saline solution for primary prevention of central venous catheter-associated bloodstream infection in adult patients treated…
- Trial name
- ATAPAC (NCT02279121)
- Testing
- Taurolock, saline solution
- Where
- France
- Volunteers
- 162 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
End Stage Renal Disease, Hemodialysis
Addition of Heparin to Taurolock-TM CLS in HD Patients With TCC Dose it Improve Catheter Patency Problems ?
Addition of Heparin to the Catheter Lock Solution (CLS): Taurolock-TM will improve the vascular patency compared to Taurolock-TM alone , in hemodialysis patients with Tunneled Cuffed Catheter(TCC) as vascular access.
- Trial name
- NCT00749619
- Testing
- Catheter Lock Solution Taurolidine and Citrate, Catheter Lock Solution :Taurolidine and Citrate and Heparin, Catheter Lock Solution : Heparin
- Where
- Israel
- Sponsor
- Western Galilee Hospital-Nahariya
Catheter Related Blood Stream Infection, Hemodialysis
Antimicrobial Locks for Hemodialysis Catheter Infections
Tunneled hemodialysis catheters are susceptible to infection with high incidence of complication to the hemodialysis patients .The study aimed to prevent catheter infection through comparing use of antimicrobial solution…
- Conditions
- Catheter Related Blood Stream Infection, Hemodialysis, Vascular Access
- Trial name
- NCT07074821
- Testing
- Taurolidine citrate 4% and heparin 500
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Ministry of Health
Bacteremia
Central Venous Catheter Lock Solution
The purpose of this study is to determine whether the application of 47% citrate lock solution decreases the incidence of infection and thrombosis of central venous catheter in hemodialysis population.
- Trial name
- CVCLS (NCT00862966)
- Testing
- citrate, heparin
- Where
- Bosnia and Herzegovina
- Volunteers
- 40 people
- Sponsor
- University Medical Center, Tuzla
Chronic Myeloproliferative Disorders, Infection
Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies
RATIONALE: Antimicrobial solution comprising trimethoprim-sulfamethoxazole, edetate calcium disodium, and ethanol may help prevent blockages and infections from forming in patients with central venous access catheters or…
- Conditions
- Chronic Myeloproliferative Disorders, Infection, Leukemia, Lymphoma
- Trial name
- NCT01101412
- Testing
- Edetate Calcium Disodium, Ethanol, Trimethoprim-sulfamethoxazole
- Sponsor
- M.D. Anderson Cancer Center
Tunnelled Hemodialysis Catheter Infection
Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN to Prevent Tunnelled Catheter Infections in Chronic Hemodialysis Patients
The purpose of this study is to assessed the efficacy of a combined solution of ethanol (4%) and low molecular weight heparins LMWH in preventing tunnelled dialysis catheter infection in chronic hemodialysis patients
- Trial name
- ETERNITY (NCT03083184)
- Testing
- Ethanol, enoxaparin
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
ESRD
Antibiotic Lock Solutions in the Prevention of Catheter Related Bacteremia
To study the efficacy of an antibacterial/anticoagulant solution instilled into the hemodialysis (HD) catheters after each treatment ("antibiotic lock solution - ALS") to prevent catheter related bacteremia (CRB) and to salvage…
- Trial name
- NCT00294502
- Testing
- Gentamycin/citrate, Minocycline/EDTA
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Catheter-Related Infections, Citrate Adverse Reaction
DuraLock-C Catheter Lock Solution
To evaluate the safety and performance of DuraLock-C 4.0%, 30.0%, and 46.7% for the maintenance of central venous catheter (CVC) patency in adult hemodialysis (HD) patients
- Trial name
- NCT04787926
- Testing
- Locking Solution
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Medical Components, Inc dba MedComp
Pediatric Intestinal Failure
KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure
A multi-site, randomized, 2-arm open-label trial to determine if 4% Tetrasodium (EDTA) catheter lock solution is more effective than heparin lock (standard of care) in preventing central venous catheter occlusions in children…
- Trial name
- NCT05879835
- Testing
- KiteLock 4% Sterile Catheter Lock Solution, Heparin Lock Solution
- Where
- 8 sites in United States
- Volunteers
- 124 people
- Sponsor
- SterileCare Inc.
Catheter Complications
Use of Tetrasodium EDTA Catheter Lock Solution for Patients on HTPN
Parenteral nutrition (PN) is a lifesaving therapy in patients with chronic intestinal failure. PN is administered via a central venous catheter (CVC), and patients are dependent on this line for ongoing nutrition.
- Trial name
- NCT04067245
- Testing
- Tetrasodium EDTA catheter lock solution
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Catheter Related Infection
Comparative Effectiveness of 30%TSC and Heparin Lock Solution in Hemodialysis Catheters
BACKGROUND: Central venous catheters (CVC) are the only option when hemodialysis is needed for patients without definitive vascular access.
- Trial name
- CITRIM (NCT02563041)
- Testing
- 30% TSC, Heparin
- Volunteers
- 179 people
- Sponsor
- Catholic University of Pelotas
End Stage Renal Failure, Hemodialysis
Catheters Dysfunction Rate After Instillation of Ethanol 60% Lock Solution in Tunneled Silicone Catheter of Chronic Hemodialysis Patients
The primary objective of the study is to examine the risk of catheter dysfunction during the dialysis session that follows the instillation of ethanol 60% as lock solution in tunneled silicone catheters of end stage renal failure…
- Trial name
- Ethanol (NCT00563342)
- Testing
- Ethanol
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infection
Antimicrobial Catheter Lock Solution for the Treatment of Central Line Associated Bloodstream Infection (CLABSI)
A CVC is a sterile flexible tube that allows a drug to flow from a bottle or bag directly into a patient's bloodstream. CVCs may cause infections when bacteria gets into the catheter and enters the bloodstream.
- Trial name
- NCT01539343
- Testing
- Antimicrobial Solution
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center