Clinical trials: Locally Advanced Cervical Cancer
Locally Advanced Cervical Carcinoma
A Clinical Study of QL1706 Combined With Chemotherapy as Neoadjuvant Therapy for High-Risk Locally Advanced Cervical Cancer
This study aims to compare the efficacy and safety of "neoadjuvant immunotherapy combined with chemotherapy followed by immunotherapy combined with radiotherapy during the radiotherapy period" versus "standard concurrent…
- Trial name
- NCT07613567
- Testing
- standard EBRT+Brachytherapy, Cisplatin, Neoadjuvant chemoimmunotherapy
- Where
- China
- Volunteers
- 486 people
- Sponsor
- Fujian Cancer Hospital
Neoadjuvant Immunotherapy, Locally Advanced Cervical Cancer
QL1706 Plus Neoadjuvant Chemotherapy Followed by Type I Hysterectomy for Locally Advanced Cervical Cancer
The goal of this clinical trial is to determine the effectiveness of the combination therapy of Eparbrutinib (QL1706) with neoadjuvant chemotherapy followed by Type I hysterectomy in treating locally advanced cervical cancer.
- Trial name
- QNACTH (NCT07205497)
- Testing
- QL1706+TC
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Locally Advanced Cervical Carcinoma
A Clinical Study on the Treatment of LACC With Cadonilimab Combined With Chemotherapy Followed by CCRT
This study mainly evaluated the efficacy and safety of Cadonilimab combined with chemotherapy followed by concurrent chemoradiotherapy versus standard concurrent chemoradiotherapy in the treatment of locally advanced cervical…
- Trial name
- NCT07400536
- Testing
- standard EBRT+Brachytherapy, Concurrent chemotherapy, Immune induction therapy
- Where
- China
- Volunteers
- 378 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Locally Advanced Cervical Cancer, Cachexia
A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer
Cervical cancer, ranking as the fourth most prevalent malignancy in women globally, presents significant challenges in nutritional management.
- Trial name
- NCT07338487
- Testing
- Nanocrystalline Megestrol Acetate Oral Suspension
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Second Xiangya Hospital of Central South University
Locally Advanced Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Stage IB3 Cervical Cancer FIGO 2018
A Vaccine (PDS0101) and Chemoradiation for the Treatment of Stage IB3-IVA Cervical Cancer, the IMMUNOCERV Trial
This phase IIA trial studies the effect of a vaccine (PDS0101) when given together with chemotherapy and radiation therapy (chemoradiation) in treating patients with stage IB3-IVA cervical cancer.
- Conditions
- Locally Advanced Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Stage IB3 Cervical Cancer FIGO 2018, Stage II Cervical Cancer FIGO 2018, Stage IIA Cervical Cancer FIGO 2018
- Trial name
- NCT04580771
- Testing
- Cisplatin, Liposomal HPV-16 E6/E7 Multipeptide Vaccine PDS0101, Radiation Therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Locally Advanced Cervical Cancer
Trial Assessing the Inhibitor of Programmed Cell Death Ligand 1 (PD-L1) Immune Checkpoint Atezolizumab
The primary objective of this randomized phase II trial is to evaluate the clinical benefits of the addition of atezolizumab to standard chemoradiotherapy (CRT) (first given concurrently with CRT, then continued as adjuvant…
- Trial name
- ATEZOLACC (NCT03612791)
- Testing
- Atezolizumab, Radiotherapy, Cisplatin
- Where
- France
- Volunteers
- 189 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Locally Advanced Cancer, Cervical Cancer
Carboplatin-Paclitaxel Adjuvant Chemotherapy in the Treatment of Locally Advanced Cervical Cancer
This is a mutlicentric, open-label non-randomized, national, 2-stage phase II trial to assess efficacy and safety of a weekly Carboplatin-Paclitaxel adjuvant chemotherapy after intensity modulated extended-field chemoradiation in…
- Trial name
- ACCRAPAN (NCT04016142)
- Testing
- Carboplatin-Paclitaxel adjuvant chemotherapy
- Where
- 6 sites in France
- Volunteers
- 21 people
- Sponsor
- Centre Oscar Lambret
Locally Advanced Cervical Cancer
Cadonilimab Combined With RT in LACC Patients Ineligible for CCRT
Concurrent chemoradiotherapy (CRT) is the standard of care for locally advanced cervical cancer (LACC). However, a substantial proportion of patients have contraindications to cisplatin based chemotherapy due to advanced age…
- Trial name
- NCT07450963
- Testing
- Cadonilimab, RT
- Volunteers
- 45 people
- Sponsor
- Ruijin Hospital
Locally Advanced or Metastatic Solid Tumors, PTEN Loss or Low Expression
A Single-arm, Open-label, Multicenter, Phase Ib/II Clinical Trial of CVL237 Tablets in Combination With Serplulimab Injection for the Treatment of Advanced Solid Tumors With PTEN Loss or Low Expression
This is a single-arm, open-label, multicenter, Phase Ib/II clinical trial of CVL237 tablets in combination with serplulimab injection for the treatment of advanced solid tumors with PTEN loss or low expression
- Trial name
- NCT07446049
- Testing
- CVL237 tablets
- Volunteers
- 180 people
- Sponsor
- Convalife (Shanghai) Co., Ltd.
Cancer, Neoplasms
A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
This study will investigate OC-001 as monotherapy, and in combination with, Avelumab, in various cancer types
- Conditions
- Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer
- Trial name
- NCT04260802
- Testing
- OC-001, Drug: OC-001 in Combination with Avelumab
- Where
- 5 sites in Canada
- Volunteers
- 73 people
- Sponsor
- Ocellaris Pharma, Inc.
Locally Advanced Cervical Carcinoma, Locally Advanced Colorectal Carcinoma
STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma
This phase I trial tests the safety and side effects of STIL101 for injection and how well it works in treating patients with pancreatic cancer, colorectal cancer (CRC), renal cell cancer (RCC), cervical cancer (CC) and melanoma…
- Conditions
- Locally Advanced Cervical Carcinoma, Locally Advanced Colorectal Carcinoma, Locally Advanced Malignant Solid Neoplasm, Locally Advanced Melanoma
- Trial name
- NCT06626256
- Testing
- Aldesleukin, Biopsy, Biospecimen Collection
- Sponsor
- City of Hope Medical Center
Neoadjuvant Treatment for Locally Advanced Cervical Cancer
QL1706 Plus Chemotherapy as Neoadjuvant Therapy for Locally Advanced Cervical Cancer: A Phase II Trial
Cervical cancer ranks as the second most common malignancy of the female genital tract. According to the World Health Organization, there are 530,000 new cases and approximately 250,000 cervical-cancer-related deaths worldwide…
- Trial name
- NCT07286253
- Testing
- Drug: Drug: QL1706 5mg/kg, iv drip,d1,Q3W;Albumin-Bound Paclitaxel 260mg/m2, iv drip, d1, Q3W;Cisplatin50mg/m2, iv drip, d1, Q3W;Carboplatin AUC 5 ivdrip, d1, Q3W
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
LOCALLY ADVANCED CERVICAL CANCERS
Iparomlimab/Tuvonralimab Injection Plus CCRT in LACC
This study is a clinical study to evaluate the safety and efficacy of Iparomlimab/Tuvonralimab Injection (QL1706, a Bifunctional Mabpair Product of Anti-PD-1 and Anti-CTLA-4 Antibodies) in Combination With Concurrent…
- Trial name
- NCT07232654
- Testing
- Iparomlimab/Tuvonralimab, Cisplatin, Brachytherapy and External Beam Radiotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Locally Advanced Cervical Cancer, Brachytherapy
This is a Multicentre International Study Evaluating CT-based IGABT With / Without Either TRUS During BT/Pre BT MR as Per IBS-GECESTRO-ABS Recommendations for Target contouring-as an Alternative to MRIGABT for Cervical Cancer From Implementation Perspectives Under EMBRACE-III:TRIPLET IMPACT Study.
Title: Integration of Multi-modality Imaging Protocols with Emphasis on CT in Image-Guided Adaptive Brachytherapy (IGABT) for Cervical Cancer - EMBRACE III-TRIPLET : IMPACT Study Locally advanced cervical cancer (LACC) remains a…
- Conditions
- Locally Advanced Cervical Cancer, Brachytherapy, CT, Transrectal Ultrasound
- Trial name
- IMPACT (NCT07249021)
- Testing
- CT IGABT
- Where
- India
- Volunteers
- 1,200 people
- Sponsor
- Homi Bhabha Cancer Hospital & Research Centre
LOCALLY ADVANCED CERVICAL CANCERS
Neoadjuvant Ivonescimab Plus Chemotherapy Followed by Concurrent Chemoradiotherapy in High-Risk Locally Advanced Cervical Cancer
This is a single-arm, phase II clinical trial evaluating the efficacy and safety of neoadjuvant Ivonescimab combined with paclitaxel and cisplatin (TP regimen), followed by concurrent chemoradiotherapy, in patients with…
- Trial name
- NCT07244965
- Testing
- Ivonescimab Combined With Chemotherapy, CONCURRENT CHEMORADIATION (CISPLATIN)
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
LOCALLY ADVANCED CERVICAL CANCERS
Outcomes of Image-guided High-dose-rate Uterovaginal Brachytherapy With Single Implantation
Background and Rationale: Locally advanced cervical cancer remains a major public health concern worldwide and in France. Standard-of-care management involves concurrent chemoradiotherapy followed by brachytherapy, which is…
- Trial name
- UNICURE-HD (NCT07213427)
- Testing
- data collection
- Volunteers
- 363 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cervical Cancer, Locally Advanced Cervical Cancer
Nivolumab in Association With Radiotherapy and Cisplatin in Locally Advanced Cervical Cancers Followed by Adjuvant Nivolumab for up to 6 Months (NiCOL)
To date, the majority of clinical trials on checkpoint inhibitors have tested these agents as monotherapy, and the next logical step is to evaluate rational therapeutic associations.
- Trial name
- NiCOL (NCT03298893)
- Testing
- Nivolumab Injection, Cisplatin, radiotherapy
- Where
- 3 sites in France
- Volunteers
- 21 people
- Sponsor
- Institut Curie
Locally Advanced Cervical Cancer
Neoadjuvant Iparomlimab and Tuvonralimab Plus Chemotherapy-eclipse for Locally Advanced Cervical Cancer (NICE-CC)
Locally advanced cervical cancer (LACC) remains a significant global health concern with limited treatment options. Recent advancements suggest that using neoadjuvant anti-PD-1 inhibitors in combination with chemotherapy…
- Trial name
- NICE-CC (NCT07055399)
- Testing
- neoadjuvant chemo-immunotherapy: Iparomlimab and tuvonralimab plus cisplatin,nab-paclitaxel for 1 cycle and Iparomlimab and tuvonralimab for 2 cycles
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Fujian Cancer Hospital
Locally Advanced Cervical Carcinoma, Premature Ovarian Failure
Autologous Heterotopic Fresh Ovarian Graft in Woman With LACC Eligible for Pelvic Radiotherapy Treatment.
Pelvic chemoradiotherapy (CRT) is an effective treatment for Locally Advanced Cervical Cancer (LACC). However, CRT induces premature ovarian failure ceasing the production of ovarian hormones.
- Trial name
- NCT05462379
- Testing
- Ovarian graft
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- MARILIA ALBANEZI BERTOLAZZI
Locally Advanced Cervical Carcinoma
Evaluation of Ultraaccelerated High Dose Rate Intrauterine Interventional Radiotherapy
To evaluate the degree of acute and long-term intestinal, urinary and vaginal toxicity, and the impact on sexual activity of an accelerated fractionation of high dose rate interventional radiotherapy (IRT-HDR) in patients with…
- Trial name
- EROS3 (NCT06398938)
- Testing
- Interventional Radiotherapy
- Where
- Italy
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS