Clinical trials: Localized Prostate Carcinoma
Prostate Cancer
Focal Salvage Brachytherapy Study (FocaSaBra)
The aim of this prospective phase II study is to evaluate the toxicity of salvage partial (focal) prostate brachytherapy in patients after prior radiotherapy (standard teleradiotherapy with / without brachytherapy…
- Trial name
- FocaSaBra (NCT05715502)
- Testing
- brachytherapy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- The Greater Poland Cancer Centre
Prostate Cancer
Prospective Evaluation of Focal Brachytherapy Using Cesium-131 For Patients With Low Risk Prostate Cancer
The standard options for men with very low risk prostate cancer include active surveillance and the standard treatment options for low risk disease, i.e.
- Trial name
- NCT02290366
- Testing
- Focal prostate brachytherapy with Cesium-131
- Where
- United States
- Sponsor
- Ronald M. Benoit, MD
Prostate Cancer
Image-guided, Tumor-focused Radiotherapy Treatment in Intermediate and High-risk Prostate Cancer
This is a phase II non-blinded randomized controlled trial of image-guided, tumor-focused radiotherapy in patients with intermediate- or high-risk prostate cancer planning to undergo definitive radiotherapy with or without…
- Trial name
- RadTARGET (NCT06990542)
- Testing
- Image-guided tumor-focused radiation therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Diego
Prostate Cancer
Intervention Trial Evaluating Focal Therapy Using High Intensity Focused Ultrasound for the Treatment of Prostate Cancer
The investigators aim to evaluate cancer control, genitourinary, rectal and overall health-related quality of life outcomes and effectiveness of focal therapy for localised prostate cancer using High Intensity Focused Ultrasound…
- Trial name
- NCT02265159
- Testing
- Focal Therapy Using High Intensity Focused Ultrasound
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Intermediate Risk Prostate Cancer (Diagnosis), Prostate Cancer
Dose-dEscalated MR-Guided Radiotherapy for Localized Prostate Cancer
DESTINATION 2 is a multi-centre randomised trial treating intermediate risk localised prostate cancer with 2 fraction Stereotactic Body Radiotherapy (SBRT).
- Trial name
- DESTINATION 2 (NCT07674225)
- Testing
- Prostate radical radiotherapy
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Prostate Cancer IRE Study (PRIS)
The aim of this study is to evaluate the feasibility to treat localized prostate cancer diagnosed with MRI and targeted/systematic biopsies, with IRE in comparison with conventional radical treatments with the primary objective…
- Trial name
- PRIS (NCT05513443)
- Testing
- Irreversible electroporation, IRE, Radical prostatectomy, Radiation therapy
- Where
- Sweden
- Volunteers
- 184 people
- Sponsor
- Karolinska Institutet
Prostate Cancer
Stereotactic Body Radiotherapy (SBRT) Post Prostatectomy
This phase I study will assess the toxicity profile and efficacy of SBRT (Stereotactic body radiotherapy) in patients with localized prostate cancer who are considered candidates for post-prostatectomy radiation.
- Trial name
- PLUTO-MPC (NCT04848909)
- Testing
- stereotactic body radiotherapy (SBRT)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Resectable Localized Prostate Cancer
HCQ in Resectable Localized Prostate Cancer
This is randomized, double blind, placebo controlled proof of principle (window of opportunity) study of oral hydroxychloroquine in patients with resectable localized prostate cancer.
- Trial name
- NCT06408298
- Testing
- Hydroxychloroquine Sulfate 400Mg Tab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Lionel.D.Lewis, MD
Prostate Cancer, Localized Prostate Carcinoma
Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CT
The purpose of this research study is to test the efficacy of ADT on prostate-specific membrane antigen (PSMA), a marker of prostate cancer, before and after scheduled ADT.
- Trial name
- NCT07455903
- Testing
- Leuprolide, Degarelix, Relugolix
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baptist Health South Florida
Localized Prostate Adenocarcinoma
Feasibility of MR-Informed Adaptive Marker-less SBRT in Patients With Bilateral Hip Prostheses Undergoing SBRT for Localized Prostate Cancer
Hip replacements and prostate cancer are independently and both together increasing prevalent in the aging population. In the United States, the prevalence of hip prostheses among men was 1.1 million in 20101, with approximately…
- Trial name
- HIP-PRO (NCT07042256)
- Testing
- Low-field MR-informed adaptive marker-less SBRT for definitive treatment of localized prostate cancer in patients with bilateral hip prostheses
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- University of Zurich
Prostate Cancer
A Phase 2 Trial of Darolutamide as a Prostate-Specific Membrane Antigen (PSMA) Expression Enhancer in Patients With Localized Prostate Cancer
Prostate cancer is the second leading cause of cancer death in men. According to estimates by the American Cancer Society Prostate for 2022, about 268,490 men would be diagnosed with prostate cancer and 34,500 would die from the…
- Trial name
- NCT05900973
- Testing
- Darolutamide Oral Tablet [Nubeqa]
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- D'Or Institute for Research and Education
Prostate Cancer
Focal Therapy for Prostate Cancer - A Pilot Study of Focal Low Dose Rate Brachytherapy
This project will develop and evaluate a treatment plan for prostate focal therapy based on low dose rate brachytherapy. The participants entering this study are those suitable for active surveillance.
- Trial name
- FTPC (NCT01830166)
- Testing
- Low Dose Radiation Focal Brachytherapy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- British Columbia Cancer Agency
Prostate Cancer
Assessment of HIFU-induced Prostate Necrosis With Shear-wave Ultrasound Elastography
Transrectal High-intensity Focused Ultrasound (HIFU) is a minimally-invasive therapy for prostate cancer that is currently assessed in two indications: as a first-line treatment (either total or focal) for patients who are not…
- Trial name
- IDITOP-1 (NCT01729442)
- Testing
- Shear-wave ultrasound elastography (SWUE)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Cancer
Impact of Group Psychological Interventions on Extracellular Vesicles in People Who Had Cancer
Background: There is some evidence demonstrating the effect of psychological interventions in improvements in health biological parameters.
- Trial name
- MindGAP-P (NCT04298398)
- Testing
- Mindfulness Based-Cognitive Therapy (MBCT), Emotion Focused Therapy Group for Cancer Recovery (EFT-CR), Treatment as usual (no intervention)
- Volunteers
- 108 people
- Sponsor
- Instituto Portugues de Oncologia, Francisco Gentil, Porto
Prostate Cancer (Adenocarcinoma), Vitamin D on Tumor Response and Inflammatory Markers
Comparative Analysis of Immunological Responses to Vitamin D Replacement Therapy in Black and West African Men Diagnosed With Prostate Cancer: Elucidating Differential Effects on Immune Function Between Patients With Localized Disease and Those With Metastatic Progression
This study is testing whether fixing vitamin D deficiency in Black/West African men with prostate cancer can strengthen their immune system, improve quality of life, and even slow cancer progression compared to those who remain…
- Trial name
- iCCaRE (NCT07598032)
- Testing
- vitamin D 25(OH)D
- Where
- Nigeria
- Volunteers
- 200 people
- Sponsor
- University of Ilorin Teaching Hospital
Prostate Cancer
Focal Therapy for Localized Prostate Cancer
This prospective registry and longitudinal study that is designed to carefully measure details of prostate cancer patients' outcomes with focal therapy. The goal of which is to improve patient care.
- Trial name
- NCT06270043
- Testing
- Focal Therapy
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Prostate Cancer (Adenocarcinoma), Prostate Cancer (Diagnosis)
PSMA PET for Surveillance After Focal Therapy
This study is about adding PSMA PET (Prostate Specific Membrane Antigen- Positron Emission Tomography) to routine magnetic resonance imaging (MRI) scans to help detect prostate cancer recurrence in men who have undergone focal…
- Conditions
- Prostate Cancer (Adenocarcinoma), Prostate Cancer (Diagnosis), Prostate Cancer Metastatic Disease
- Trial name
- NCT07115914
- Testing
- PSMA PET/CT scan
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Chicago
Prostate Cancer
Ablatherm Integrated Imaging High Intensity Focused Ultrasound for the Indication of Low Risk, Localized Prostate Cancer
The purpose of this study is to determine the substantial equivalence of the Ablatherm high intensity focused ultrasound (HIFU) as compared to cryotherapy for the treatment of low risk, localized prostate cancer.
- Trial name
- NCT00295802
- Testing
- Integrated Imaging High Intensity Focused Ultrasound, Endocare CRYOcare Cryosurgical and Galil Medical CRYO-HIT Systems (cryotherapy)
- Where
- 15 sites in United States, Canada
- Volunteers
- 141 people
- Sponsor
- EDAP TMS S.A.
Prostate Cancer
Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer
The primary objectives of this study are to evaluate the safety and tolerability of xaluritamig administered as monotherapy or in combination with an oral Gonadotropin-releasing Hormone (GnRH) antagonist in the neoadjuvant…
- Trial name
- NCT06613100
- Testing
- Xaluritamig, GnRH Antagonist
- Where
- 9 sites in United States, Germany
- Volunteers
- 40 people
- Sponsor
- Amgen
Prostate Cancer, Localized Carcinoma
Validation of the Stockholm3 Test for Detection of Prostate Cancer in the Swiss Population
The purpose of this study is to collect blood samples to investigate the prognostic performance of the STHLM3 test in a population of Swiss and German men suspected of harbouring prostate cancer based on a combination of elevated…
- Trial name
- NCT05294627
- Testing
- Stockholm3
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University Hospital, Basel, Switzerland