Clinical trials: Local Anesthetic
Anesthesia, Local
A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population
A Phase 3, randomized, active-controlled, study in pediatric subjects. It is designed to evaluate the safety and anesthetic efficacy of one dose of AG-920 ophthalmic solution compared to Proparacaine Hydrochloride Ophthalmic…
- Trial name
- NCT05325853
- Testing
- AG-920, Proparacaine Ophthalmic
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Stroke, Anesthesia
"GOLIATH" - General Or Local Anaestesia in Intra Arterial THerapy
Patients suffering a stroke with a large vessel occlusion is often treated intra veneous thrombolyse and on top of that also intra arterial therapy. It is unknown what form of anaestesia is best during intra arterial therapy.
- Conditions
- Stroke, Anesthesia, Cerebral Revascularization
- Trial name
- GOLIATH (NCT02317237)
- Testing
- Local anesthesia
- Where
- Denmark
- Volunteers
- 128 people
- Sponsor
- University of Aarhus
Pain, Needle Phobia
The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children
This study compares the efficacy of the Synera patch with Eutectic Mixture of Local Anesthetics (EMLA) as a topical anesthetic for venipuncture in pediatric patients.
- Trial name
- NCT00530803
- Testing
- EMLA Cream, Synera Patch
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Montefiore Medical Center
Abdominal Muscles/Ultrasonography, Adult
TAP Catheters Versus Intrathecal Morphine for Cesarean Section
Morphine, when given as part of spinal anesthesia, is associated high incidence of nausea and pruritus, which may affect quality of recovery.
- Conditions
- Abdominal Muscles/Ultrasonography, Adult, Anesthetics, Local/Administration & Dosage, Ropivacaine/Administration & Dosage
- Trial name
- NCT01593280
- Testing
- TAP catheter, intrathecal morphine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stamford Anesthesiology Services, PC
Pain Management, Outpatient Hysteroscopy
Hysteroscopy Anesthesia for Relief of Pain
This randomized clinical trial aims to evaluate the effect of local anesthesia on pain perception in patients undergoing outpatient diagnostic hysteroscopy.
- Conditions
- Pain Management, Outpatient Hysteroscopy, Local Anesthesia, Procedural Pain Relief
- Trial name
- HARP (NCT07178379)
- Testing
- Local paracervical Anesthesia
- Volunteers
- 70 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Trigger Thumb
Trigger Thumb Randomized Controlled Trial
We are conducting this study to determine if administration of local anesthetic to the thumb prior to surgery can reduce the amount of anesthetic gas given during the course of surgery.
- Trial name
- NCT03873480
- Testing
- Administration of Marcaine without Epinephrine prior to the start of surgery
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Children's Hospital of Philadelphia
Pain, Postoperative
Pre-incision Versus Post-incision Local Anesthetic During Robotic Sacrocolpopexy
Obtaining Likest-pain scale score on postoperative day one after injection of local anesthetic into incision sites of a laparoscopic/robotic-assisted sacrocolpopexy
- Trial name
- CLAPPS (NCT04996251)
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Chronic Subdural Hematoma
Outcome of Single Burr Hole Under Local Anaesthesia in the Management of Chronic Subdural Hematoma
Aim of the work: Is to evaluate the prognosis of single burr hole under local anesthesia in management of CSDH according to clinical picture, risk factors, and age.
- Trial name
- NCT03447327
- Testing
- single burr hole
- Volunteers
- 67 people
- Sponsor
- Zagazig University
Dental Anxiety
Modification of Blood Pressure Levels and Oxygen Saturation in Patients Undergoing Conscious Sedation
The objective is to compare the changes produced in cardiological and respiratory parameters in three groups of patients undergoing oral surgery.
- Trial name
- NCT03789942
- Testing
- Oral surgery
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Clinica Luis Ortiz
Mitral Regurgitation, Local Anaesthesia
Deep Sedation Instead of General Anaesthesia in Percutaneous Mitral Valve Repair Using the MitraClip® System
Percutaneous mitral valve repair (PMVR) with the MitraClip® system has emerged as a therapeutic alternative to surgical valve repair in patients who are at high risk and unsuitable for surgery.
- Conditions
- Mitral Regurgitation, Local Anaesthesia, Percutaneous Repair
- Trial name
- NCT02023762
- Volunteers
- 21 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Local Anesthesia of the Skin
Fractional Laser Assisted Delivery of Anesthetics III
The purpose of this study is to compare the effect of pretreatment with two different ablative laser modalities, a CO2 laser and an Er:YAG laser, and to assess the role of laser density in fractional laser assisted topical…
- Trial name
- NCT02938286
- Testing
- Fractional CO2 laser, 2.5 mJ, 5% density, Fractional CO2 laser, 2.5 mJ, 15% density, Fractional Er:YAG laser, 9 mJ, 5% density
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Dysphagia
Anesthetic to Reduce Dysphagia After Anterior Cervical Discectomy and Fusion Surgery
The main objective of this study is to analyze the effects of local anesthetic application into the retropharyngeal space and its ability to reduce dysphagia symptoms and/or occurrence rates in patients undergoing anterior…
- Trial name
- NCT02376205
- Testing
- bupivacaine hydrochloride 0.5% solution, 0.9% NaCl solution
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Justin Parker Neurological Institute
Pain
Clinical Trial Comparing Epidurals and Local Anaesthetic Wound Catheters in Patients Having Bowel Surgery
The purpose of this study is to find out whether the use of Painbuster® (a local anaesthetic wound catheter) can be used instead of epidurals for patients having bowel surgery in an enhanced recovery programme.
- Trial name
- NCT01279980
- Testing
- Epidural, Local anaesthetic wound catheter
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Scarborough General Hospital
Erector Spinae Plane Block
Effect of Erector Spinae Plane Block in Patients Scheduled for Kyphoplasty
Patients, older than 50 years, with vertebral fracture scheduled for percutaneous balloon kyphoplasty will be enrolled for the study. Some patients will be under local anesthesia with sedation and analgesia for the procedure.
- Trial name
- NCT05970380
- Testing
- Erector spinae plane block, Local anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Bozyaka Training and Research Hospital
Post-operative Pain, Post-operative Delirium
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
The goal of this clinical trial is to assess whether the use of intermittent superficial parasternal intercostal plane blocks reduces opioid usage in patients undergoing cardiac surgery with median sternotomy.
- Conditions
- Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery, Chronic Pain
- Trial name
- EPOCH (NCT06028126)
- Testing
- Intermittent Superficial Parasternal Intercostal Plane Block - Experimental
- Where
- 4 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Unity Health Toronto
Tibial Plateau Fractures
Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau
The investigators are conducting this research study to find better ways of treating pain following knee surgery. There is a standard (accepted) approach, which involves injection of numbing medication into the area around the…
- Trial name
- NCT06639503
- Testing
- Bupivacain
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Chicago
Injection Pain, Local Anesthesia Infiltration
Clinical Trial Comparing Pain Perception in Children Using Two Different Local Anesthesia Tools
The goal of this clinical study is to learn whether the Super Pen (SP) device can reduce pain during local anesthesia (LA) infiltration for primary teeth compared to the conventional syringe (CS) in children aged 6-12 years.
- Conditions
- Injection Pain, Local Anesthesia Infiltration, Pediatric Patient
- Trial name
- NCT07292194
- Testing
- super pen
- Where
- Jordan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Lamis D. Rajab
Acute Appendicitis
Laparoscopic-Assisted TAP Block VErsus Trocar-site Infiltration After Laparoscopic Appendectomy
This randomized controlled trial compared laparoscopic-assisted transversus abdominis plane (TAP) block with trocar-site local anesthetic infiltration for postoperative pain management in adult patients undergoing laparoscopic…
- Trial name
- NCT07849751
- Testing
- laparoscopic-assisted transversus abdominis plane block, trocar-site local anesthetic infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Anesthesia, Local, Analgesia
Analgesic Efficacy of Ultrasound Guided Bilateral Erector Spinae Plane Block in Pediatric.
This randomized, double-blinded, study aims to compare the efficacy of analgesia and any side effects of U/S guided bilateral Erector SpinaePlane block versus non-block t paediatric patients undergoing corrective cardiac…
- Trial name
- NCT04452656
- Testing
- bilateral erector spinae block
- Where
- Egypt
- Volunteers
- 98 people
- Sponsor
- Cairo University
Rescue Analgesia
Comparison of Rescue Analgesia Requirement in Patients Undergoing Laparoscopic Cholecystectomy After Transversus Abdominal Plane (tap) Block Vs Local Anesthetic Wound Infiltration At the End of Surgery
patients undergoing laparoscopic cholecystectomy will be diveided into 2 groups A \& B . Group A will receive local anesthetic wound infiltration and group B will receive Transversus abdominal plane block as a post operative…
- Trial name
- TAP (NCT06803966)
- Testing
- Post Operative Analgesia
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Fazaia Ruth Pfau Medical College