Clinical trials: Liver Transplant
Infection
Telaprevir Plus Standard of Care (SOC) in HCV Associated Hepatocellular Carcinoma (HCC)
The goal of this clinical research study is to learn if the antiviral combination of telaprevir, pegylated Interferon Alfa 2a (PegIFN alfa-2a) and ribavirin (RBV) can prevent the virus from coming back after the liver transplant.
- Trial name
- NCT01821963
- Testing
- Pegylated Interferon Alfa 2a, Ribavirin, Telaprevir
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
End Stage Liver Disease
Pilot Trial of Eculizumab Therapy to Reduce Preservation Injury in Human Macrosteatotic Liver Transplantation
The number of liver transplants that can be performed is limited by the availability of organs. Livers that are steatotic (i.e., infiltrated by triglycerides and other fatty substances) are usually not used for transplants, due…
- Trial name
- NCT03468140
- Testing
- Eculizumab, No intervention
- Where
- United States
- Sponsor
- Yale University
End Stage Liver DIsease
Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation.
Study groups: The study is a multicenter (Pisa and Milan), prospective, randomized study comparing D-HOPE (HMP) vs NMP in DCD and ECD-DBD (extended criteria brain-dead donors).
- Trial name
- DCDNet (NCT04744389)
- Testing
- Hypothermic Machine Perfusion, Normothermic Machine Perfusion
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Liver Transplantation (LT)
Mental Health Outcomes and Psychological Evaluation After Liver Transplantation
Receiving a liver transplant is a major life event that can be physically and emotionally challenging. During the first five years after transplantation, more than one in two liver transplant recipients experience a mental health…
- Trial name
- mHOPE (NCT07734142)
- Testing
- questionnaires, Individual semi-structured interview
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant; Complications, Renal Complication of Procedure
Renal Outcomes Among Post Liver Transplantation Patients
To evaluate Renal outcomes among patients, post liver transplantation at Assiut university.
- Trial name
- NCT06123260
- Testing
- renal function tests
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Hepatitis C, Renal Transplant
Peginterferon Alfa-2a Plus Ribavirin Combination Treatment in Chronic Hepatitis C Post-Renal Transplant Patients
There is a distinct lack of published literature on the effect of combination treatment of PEG-interferon and ribavirin on post-renal transplantation hepatitis C virus (HCV) patients.
- Trial name
- NCT00881582
- Testing
- Pegylated interferon alfa-2a plus ribavarin
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 32 people
- Sponsor
- King Abdulaziz Medical City
Chronic Hepatitis c, Liver Transplant Infection
Grazoprevir/Elbasvir for Genotype 1b Chronic Hepatitis C After Liver or Kidney Transplantation
Grazoprevir/elbasvir combination therapy is highly effective in the treatment of genotype 1b chronic hepatitis C, and the drug-drug interaction with central immunosuppressant, such as tacrolimus, should be manageable.
- Conditions
- Chronic Hepatitis c, Liver Transplant Infection, Kidney Transplant Infection
- Trial name
- NCT03723824
- Testing
- grazoprevir 100 mg/ elbasvir 50 mg, Zepatier®
- Where
- 2 sites in Taiwan
- Volunteers
- 14 people
- Sponsor
- Taichung Veterans General Hospital
Hepatitis C, Chronic; AUD
Hepatitis C Alcohol Reduction Treatment
Subjects are being asked to take part in a research study to test two levels of alcohol services for patients with hepatitis C virus (HCV) who drink alcohol.
- Trial name
- HepART-RCT (NCT02176980)
- Testing
- Brief alcohol counseling, Group and Individual Therapy Sessions
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- Duke University
Acute Pain
Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy
Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in…
- Trial name
- NCT02645903
- Testing
- Transversus Abdominis Plane Block, standard general anesthesia
- Volunteers
- 50 people
- Sponsor
- Inonu University
Cholangiocarcinoma
Liver Resection Versus Radio-chemotherapy-Transplantation for Hilar Cholangiocarcinoma
A prospective, open-label, randomised, multicentre, comparative study in two parallel groups comparing an interventional group with liver transplantation preceded by neoadjuvant radio-chemotherapy and a control group receiving…
- Trial name
- TRANSPHIL (NCT02232932)
- Testing
- CAPECITABINE-Radiotherapy -Liver Transplantation, RESECTION
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplantation, Liver Preservation for Transplant
OCS Liver PROTECT Trial: Preserving and Assessing Donor Livers for Transplantation
A prospective, phased-pivotal, international randomized trial to evaluate the effectiveness of the OCS™ Liver to preserve and assess donor livers intended for transplantation.
- Trial name
- PROTECT (NCT02522871)
- Testing
- OCS™ Liver System, Control
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- TransMedics
Intestinal Microbiota, Complication of Transplanted Liver
Human Microbiota and Liver Transplant
The microbiota represents the collections of microbial communities that colonize a host. In health, the microbiota protects against pathogens and maturation of the immune system.
- Conditions
- Intestinal Microbiota, Complication of Transplanted Liver, Acute Rejection of Liver Transplant, Infection
- Trial name
- NCT02223468
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Vall d'Hebron
Polycystic Liver Disease
Polycystic Liver Disease in Kidney Transplant
The purpose of this study is to see if one kind of immunosuppressive drug has better effects for the patient's polycystic liver disease than another type.
- Trial name
- NCT00934791
- Testing
- Tacrolimus, Sirolimus, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Evidence of Liver Transplantation
A Pilot Trial of Pediatric Liver Transplantation Without Steroids
Objective: The overall objective is to investigate whether a steroid free immunosuppressive regimen is as safe and effective as a steroid containing regimen following pediatric liver transplantation and whether it promotes…
- Trial name
- NCT00694408
- Testing
- methyl prednisolone, hydrocortisone, prednisolone, No steroids
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Diabetes Mellitus, Non-alcoholic Fatty Liver Disease
Transplantation of Microbes for Treatment of Metabolic Syndrome & NAFLD
Non-alcoholic fatty liver disease (NAFLD) occurs when excess fat is deposited in the liver. Almost all patients also have obesity and insulin resistance (the inability of the body to effectively use insulin).
- Trial name
- FMT (NCT02496390)
- Testing
- Autologous, Allogeneic
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Non-Alcoholic Steato-Hepatitis, Liver Cirrhosis
Genetic Studies of Non-Alcoholic Fatty Liver Disease
Background: Non-alcoholic fatty liver disease is the most common form of liver disease in the United States. It includes many conditions.
- Conditions
- Non-Alcoholic Steato-Hepatitis, Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT01629095
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Personalized Pharmaceutical Plan After Transpantation
Establishment of a Personalized Pharmaceutical Plan in Renal or Hepatic Transplant Patients
The main objective of the study is to evaluate the impact of the Personalized Pharmaceutical Plan on the therapeutic adherence to immunosuppressive treatments one year after liver or kidney transplantation.
- Trial name
- GREPH (NCT04295928)
- Testing
- PPP
- Where
- 12 sites in France
- Volunteers
- 1,716 people
- Sponsor
- University Hospital, Tours
Antibiotic Prophylaxis, Postoperative Infection
Comparison of 9 Doses vs 3 Doses of Post Operative Antibiotics in Live Liver Donors
Antibiotic resistance is a very serious and dangerous situation in modern world. Judicious use of antibiotics is therefore of extreme importance not just in preventing antibiotic resistance but also it decreases cost of the…
- Trial name
- NCT03765645
- Testing
- Piperacillin + Tazobactam
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
HIV
Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver)
This research is being done to better understand opportunistic infections and cancer in transplant recipients with HIV who receive livers from a donor with HIV compared to livers from donors without HIV.
- Trial name
- NCT07665372
- Testing
- HIV D+/R+, HIV D-/R+
- Where
- 19 sites in United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Hepatitis C Virus Infection, Liver Transplantation
Effect of Immunosuppression Drug Weaning on Hepatitis C Virus (HCV)-Induced Liver Damage After Liver Transplantation
Viral infections can profoundly influence alloimmune responses and hamper allograft tolerance induction. Persistent hepatitis C virus (HCV) infection occurs in 50% of liver and 20% of kidney transplant recipients, but the impact…
- Trial name
- NCT00668369
- Testing
- Gradual immunosuppression drug withdrawal.
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Hospital Clinic of Barcelona