Clinical trials: Liver Fibrosis
Hepatic Encephalopathy
Cerebrovascular Reactivity in Hepatic Encephalopathy
It has been observed that patients with cirrhosis present a generalized state of vasoconstriction as an homeostatic response to splanchnic arteriolar vasodilatation.
- Trial name
- NCT01099293
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Liver Cirrhosis
Compositional Shift of Gut Microbiome According to the Complications in Patients With Liver Cirrhosis
Change in gut microbiome is closely associated with liver cirrhosis diseases initiation, progression, establishment, and severity.
- Trial name
- NCT05786755
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Hepatitis C, Chronic
Noninvasive Evaluation of Hepatic Fibrosis in Chronic Hepatitis C
Chronic viral hepatitis C is a frequent liver disease. It is associated with variable degree of hepatic fibrosis. To date, liver histology is still regarded as the gold standard to detect, diagnose and quantify liver fibrosis.
- Trial name
- NCT00399815
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Alcoholic Liver Disease, Alcoholic Fibrosis of Liver
Early Detection of Alcoholic Liver Disease
This is an observational study to identify the prevalence of advanced liver fibrosis among patients with excessive alcohol intake using a non-invasive method (FibroScan®) and to characterize the main environmental, genetic and…
- Conditions
- Alcoholic Liver Disease, Alcoholic Fibrosis of Liver, Alcoholic Cirrhosis, Excessive Drinking
- Trial name
- NCT04070508
- Sponsor
- University of Pittsburgh
Chronic Liver Disease
BreathID 13C-Methacetin Breath Test for Detecting Cirrhosis
This trial is a pivotal trial to validate the use of a 13 C labeled substrate called methacetin and the BreathID automatic breath testing system, for determination of cirrhosis in patients with chronic liver disease.
- Trial name
- MBT (NCT00736840)
- Testing
- c13 methacetin solution with breath analyzer
- Where
- 11 sites in United States, Israel
- Volunteers
- 414 people
- Sponsor
- Meridian Bioscience, Inc.
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Primary Biliary Cirrhosis
Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis
The purpose of this study is to compare the efficacy of Ursofalk 500 mg tablets versus Ursofalk 500 mg capsules in the treatment of Primary Biliary Cirrhosis (PBC).
- Trial name
- NCT01510860
- Testing
- UDCA (Ursodeoxycholic acid)
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Dr. Falk Pharma GmbH
Cushing Syndrome, Metabolic Syndrome
Evaluation of the Severity of Hepatic Fibrosis by Magnetic Resonance Elastography in the Diagnosis of Endogenous Hypercorticism
The main hypothesis of the HEPACORT study is that upon diagnosis of endogenous Cushing's syndrome, significant liver fibrosis may be present, particularly in the most severe forms of Cushing's syndrome.
- Trial name
- HEPACORT (NCT05911620)
- Testing
- Magnetic resonance elastography (MRE)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Central Hospital, Nancy, France
Chronic Liver Disease, Fibrosis, Liver
Non Invasive Electrical Impedance Technology (EIT) for Diagnosing Liver Diseases Severity
The aims of this study are to assess the performance of the non-invasive Electrical Impedance Technology (EIT) in evaluating the liver fibrosis stage in patients with chronic liver diseases, in comparisons with a liver biopsy…
- Conditions
- Chronic Liver Disease, Fibrosis, Liver, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT03492879
- Testing
- EIT Technology
- Volunteers
- 210 people
- Sponsor
- Prof. Ziv Ben-Ari MD
Cirrhosis, Hepatic Encephalopathy
Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement
Hypothesis: Improvement in cognitive dysfunction with IV albumin in patients with cirrhosis with prior HE and MHE lasts for several weeks after albumin infusion has ended, and is due to persistent improvement in inflammatory…
- Trial name
- HEAL-LAST (NCT06052176)
- Testing
- Albumin Infusion
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Ascites Hepatic, Liver Failure
Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver Failure
The investigators aim to study the predictive value of presepsin in ascites in newly admitted patients with chronic liver failure.
- Conditions
- Ascites Hepatic, Liver Failure, Cirrhosis, Liver
- Trial name
- PASS (NCT06224023)
- Testing
- Determination of presepsin levels in ascites
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Primary Biliary Cirrhosis
Efficacy and Safety Study of Allogenic Mesenchymal Stem Cells for Patients With Refractory Primary Biliary Cirrhosis
The study is designed to evaluate the safety and efficacy of intravenous administration of bone marrow derived mesenchymal stem cells for patients with refractory primary biliary cirrhosis (PBC).
- Trial name
- MSCsTreatPBC (NCT01440309)
- Testing
- Biological: mesenchymal stem cell, ursodeoxycholic acid
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Robert Chunhua Zhao, MD, PhD
Liver Fibrosis
Study of Hydroxynidone Capsules in Patients With Hepatic Impairment and Matched Healthy Controls
This trial adopts a single-center, single-dose, open-label, non-randomized, parallel-controlled design. It will be conducted in participants with varying degrees of hepatic impairment, as well as in participants with normal…
- Trial name
- NCT07394309
- Testing
- Hydronidone capsules
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Bariatric Surgery Candidate, NAFLD
Effectiveness of Bariatric Surgery for NAFLD/NASH
This is a prospective, multicenter cohort study, which subjects were obese patients requiring bariatric surgery. This study aims to explore the the effectiveness of bariatric surgery for NAFLD/NASH with fribrosis, to explore the…
- Conditions
- Bariatric Surgery Candidate, NAFLD, NASH With Fibrosis
- Trial name
- NCT04366999
- Testing
- SG, RYGB, OAGB
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Beijing Friendship Hospital
Hepatitis C, Chronic, Disease Progression
Prospective Observational Study of Disease Progression in Chronic Hepatitis C
The purpose of this study is to determine the progression of chronic hepatitis C patients infected by paid plasma donation,and explore the possible pathogenic mechanisms of disease progression in chronic hepatitis C.
- Conditions
- Hepatitis C, Chronic, Disease Progression, Liver Cirrhosis
- Trial name
- NCT02011932
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Beijing YouAn Hospital
Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency
Liver Disease in Urea Cycle Disorders
This is a multi-center, cross-sectional study to assess risk for liver fibrosis and hepatic injury in individuals with urea cycle disorders (UCDs) using serum biomarkers, Fibroscan, and MRE.
- Conditions
- Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency, Citrullinemia 1, ARGI Deficiency
- Trial name
- NCT04612764
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Baylor College of Medicine
Alcoholic Liver Cirrhosis
Study to Evaluate Hepatic Artery Injection of Autologous Human Bone Marrow-Derived MSCs in Patients With Alcoholic LC
This study is to evaluate the safety and efficacy of a single dose of Cellgram™ delivered via hepatic artery in patients with decompensated alcoholic liver cirrhosis.
- Trial name
- NCT03838250
- Testing
- Cellgram™ (Bone marrow-derived MSCs)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Pharmicell Co., Ltd.
Cirrhosis, Liver
Longitudinal Monitoring of Stool Characteristics
In patients with cirrhosis and healthy controls to determine the utility of an App to classify BSS compared to assessment made by the patients themselves using the BSS and correlate these with other stool characteristics and gut…
- Trial name
- NCT05604274
- Testing
- App to monitor stool consistency and symptoms
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Liver Cirrhosis, Liver Insufficiency
Hepatocyte Matrix Implant Study Indonesia
This clinical investigation of the hepatocyte matrix implant is an evaluation blinded non-randomized and monocentric pilot study of Phase I, which is conducted as a therapeutic investigation.
- Conditions
- Liver Cirrhosis, Liver Insufficiency, Chronic Liver Disease
- Trial name
- HMIIndo (NCT01335568)
- Testing
- Hepatocyte Matrix Implant
- Where
- Indonesia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Baermed
Liver Fibroses, Liver Cirrhosis
Competitive Accuracy of Radiological Imaging Compared to Liver Biopsy in Patients With Liver Fibrosis
The study "Competitive Accuracy of Radiological Imaging Compared to Liver Biopsy in Patients With Liver Fibrosis" is designed to test the accuracy of non-interventional radiological imaging and compare its results with the "gold…
- Trial name
- NCT05008263
- Testing
- Liver elastography (2D-SWE), Liver scintigraphy with 99mTc-mebrofenin
- Where
- Lithuania
- Volunteers
- 72 people
- Sponsor
- Vilnius University