Clinical trials: Liver Failures, Chronic
Chronic Liver Disease, Acute Derangement of Liver Function
Clinical Features and Natural History of Acute-on-Chronic Liver Failure in Korean Patients With Chronic Liver Disease
Chronic liver disease including liver cirrhosis is still associated with high mortality, although advancement of medical management and transplantation.
- Trial name
- NCT02650011
- Testing
- Acute deterioration of liver function
- Where
- South Korea
- Volunteers
- 1,520 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Acute on Chronic Liver Failure
Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial)
SIRS in ACLF exacerbate adverse effects of ammonia - sarcopenia, infections, immune dysfunction, HE and organ dysfunction Persistent or incident hyperammonemia during first week of hospitalization in patients with ACLF is…
- Trial name
- NCT06808009
- Testing
- Lactulose, Rifaximin, Standard Medical treatment
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatitis C Infection, HIV Infection
A Safety and Tolerability Study of Nitazoxanide in HIV-HCV Treatment Failures
Background: Chronic hepatitis C (CHC) is a major health problem that particularly affects individuals with human immunodeficiency virus (HIV) infection, and can lead to cirrhosis and liver failure.
- Trial name
- NCT01185028
- Testing
- Nitazoxanide With Pegylated Interferon And Ribavirin
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Acute and Chronic Hepatic Failure With Developing Coma
Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure
The purpose of this study is to understand mechanisms associated with the development of coma during hepatic failure. As of today, those mechanisms are not understood and it is difficult to intervene and prevent coma development…
- Trial name
- NCT01582087
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Acute-On-Chronic Liver Failure
Granulocyte Colony Stimulating Factor (G-CSF) to Treat Acute-on-chronic Liver Failure
Multicentre, open, randomised, and controlled trial conducted in patients diagnosed with acute on chronic liver failure (ACLF) who meet inclusion/exclusion criteria.The objective of GRAFT-trial is to evaluate efficacy and safety…
- Trial name
- NCT02669680
- Testing
- G-CSF, Standard therapy
- Where
- 21 sites in Germany
- Volunteers
- 176 people
- Sponsor
- University of Leipzig
Liver Failure
UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure
Hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) is a severe disease with high mortality. Our previous study have demonstrated that peripheral infusion of bone marrow-derived mesenchymal stromal cells (MSCs)…
- Trial name
- NCT02812121
- Testing
- umbilical cord blood mesenchymal stem cells
- Volunteers
- 261 people
- Sponsor
- Sun Yat-sen University
Liver Failure
Prognosis Scoring System for Acute-on-Chronic Liver Failure
This research is to establish a simple and practical system to predict the prognosis of sever hepatitis B.Seven factors (level of serum total bilirubin, prothrombin time, severity of hepatic encephalopathy, hepatorenal…
- Trial name
- NCT01961440
- Volunteers
- 1,000 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute-On-Chronic Liver Failure
Effect of Goal Directed Ammonia Lowering Therapy in Acute on Chronic Liver Failure Patients With Hepatic Encephalopathy.
In this study, all patients with ACLF (Acute on Chronic Liver Failure) with grade III/IV HE (Hepatic Encephalopathy) getting admitted in our institute will be enrolled after the fulfilment of inclusion/exclusion criteria and…
- Trial name
- NCT02321371
- Testing
- Lactulose + Rifaximin, Lactulose
- Where
- India
- Volunteers
- 73 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
Plasma Exchange in Acute on Chronic Liver Failure
Acute on chronic liver failure (ACLF) is a distinct syndrome in patients with chronic liver disease with rapid clinical deterioration and has high short term mortality within one month.Despite aggressive clinical care, only half…
- Trial name
- PLEXAR (NCT04051437)
- Testing
- Plasma exchange, Standard medical treatment
- Volunteers
- 130 people
- Sponsor
- Asian Institute of Gastroenterology, India
End Stage Liver DIsease, Chronic Liver Failure
The Early Strength Training Program in Post-transplant Liver Cases
Liver transplantation (LT) is a current life-saving procedure performed as an open-abdominal surgery for patients with end-stage liver diseases (ESLD).
- Conditions
- End Stage Liver DIsease, Chronic Liver Failure, Liver Transplant Disorder, Muscle Loss
- Trial name
- NCT04546048
- Testing
- Strength Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Memorial Hospital Groups
Acute on Chronic Liver Failure, Hepatitis B
Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure
Background: Reactivation of hepatitis B is a well-characterized syndrome marked by the abrupt reappearance or rise of hepatitis B virus (HBV) DNA in the serum of a patient with previously inactive or resolved HBV infection.
- Trial name
- ACLF (NCT01074645)
- Testing
- Tenofovir disoproxil fumarate (TDF)
- Where
- India
- Volunteers
- 27 people
- Sponsor
- Govind Ballabh Pant Hospital
Acute on Chronic Hepatic Failure
Allogenic Bone Marrow Mesenchymal Stem Cell Therapy in Acute-on-chronic Liver Failure
Double-blind placebo randomized controlled trial evaluating the clinical efficacy of allogenic bone marrow derived mesenchymal stem cells in cirrhotic patients with acute-on-chronic liver failure
- Trial name
- Liveradvance (NCT02857010)
- Testing
- Allogenic mesenchymal stem cells
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Pere Gines
Thrombelastography,Acute on Chronic Liver Failure, Platelet
A Prospective Study of Application of Platelet Mapping in HBV-related Acute-on-chronic-liver Failure in China
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. Thrombelastography measures the dynamics of thrombin production and provides a global assessment of…
- Trial name
- NCT03281278
- Testing
- standard treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis
Evaluating Novel Scoring Systems to Predict Outcomes in Acute-on-Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is a serious condition where a patient with long-term liver disease suddenly experiences severe liver worsening and failure of other organ systems, such as the kidneys or lungs.
- Conditions
- Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis, End Stage Liver Disease
- Trial name
- NCT07734896
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute-On-Chronic Liver Failure, Chronic Liver Failure
Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults
This is a prospective single-center dose escalation study of the administration of the microencapsulated hepatocyte therapy in adult liver failure.
- Trial name
- NCT05727722
- Testing
- a single course of micro-encapsulated hepatocytes intraperitoneal transplantation therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Acute on Chronic Liver Failure
Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF)
This is an interventional, double blind, randomized (2:1), and placebo-controlled study of 2 infusions of a 1 dose regimen of HepaStem in patients recently diagnosed (≤1 week) with ACLF grade 1 or 2 on top of Standard of Care…
- Trial name
- DHELIVER (NCT04229901)
- Testing
- HepaStem
- Where
- 47 sites in Austria, Belgium and 12 more
- Volunteers
- 133 people
- Sponsor
- Cellaion SA
Acute-On-Chronic Liver Failure
Risk Factors Affecting MSC Efficacy in ACLF Patients
Mesenchymal stromal cells (MSCs) are potential therapy for many diseases, with the ability of tissue regeneration, repair and immunomodulation. Acute-on-chronic liver failure (ACLF) is a severe disease with high mortality.
- Trial name
- NCT07198854
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 446 people
- Sponsor
- Sun Yat-sen University
Chronic-on-acute Liver Failure
Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure.
This was a non-blinded, prospective clinical study. From June 2020 to October 2021, 254 patients with HBV-ACLF were treated at the Department of Infectious Diseases, Xiangya Hospital, Central South University (Changsha, China).
- Trial name
- NCT05392673
- Testing
- KM-8800 plasma exchange device (Kuraray, Tokyo, Japan)
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Xiangya Hospital of Central South University
Cirrhosis, Liver, Sepsis
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension
In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the…
- Conditions
- Cirrhosis, Liver, Sepsis, Acute on Chronic Liver Failure
- Trial name
- NCT05059795
- Testing
- Albumin + electrolyte solution, POCUS guided fluid resuscitation
- Where
- 2 sites in India
- Volunteers
- 350 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute-on-Chronic Liver Failure (ACLF)
PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure
The goal of this single-center, prospective, randomized controlled study is to evaluate the safety and efficacy of PT-MSCs Exosome Injection (code: PT-MSCs-EVS-2023-1) in treating patients with acute-on-chronic liver failure…
- Trial name
- NCT07409259
- Testing
- exosome injection, standard comprehensive internal medical treatment,
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University