Clinical trials: Limbal Stem-cell Deficiency
Limbal Stem Cell Deficiency
Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD
The aim of this clinical trial is to investigate the efficacy (by monitoring neovascularization and epithelial defects) of up to four doses of the investigational medicinal product (IMP) LSC2 topically administered on the target…
- Trial name
- NCT03549299
- Testing
- LSC2
- Where
- 5 sites in United States, Germany
- Volunteers
- 16 people
- Sponsor
- RHEACELL GmbH & Co. KG
Limbal Stem Cells Deficiency
Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency
The purpose of this trial is to confirm the efficacy of Holoclar at one year after the first treatment in patients suffering from moderate to severe LSCD (Limbal Stem Cell Deficiency) secondary to ocular burns.
- Trial name
- HOLOCORE (NCT02577861)
- Testing
- Biopsy from donor eye, Implant of Holoclar, Ophtalmologic examination
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Holostem s.r.l.
Limbal Stem Cell Deficiency
Cultivated Autologous Oral Mucosal Epithelial Transplantation
Earlier protocol for cultivated oral mucosal epithelial transplantation (COMET) requires trypsin/EDTA to isolate epithelial cells from tissue, and uses murine 3T3 cells as feeder cells, which results in biosafety concern.
- Trial name
- NCT03943797
- Testing
- Cultivated oral mucosal epithelial cell transplantation
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Limbal Stem Cell Deficiency
Corneal Epithelial Allograft From Living-related Donor for LSCD
The purpose of the study is to explore whether femtosecond laser-assisted corneal epithelial allograft from living-related donor is more effective than limbal conjunctival allograft from living-related donor for ocular surface…
- Trial name
- NCT03217435
- Testing
- Corneal epithelial allograft, Limbal conjunctival allograft, Femtosecond laser
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chunxiao Wang
Limbal Stem-cell Deficiency
Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency
The study purpose is to evaluate the efficacy and safety of cultivated oral mucosal epithelial sheet transplantation as a novel therapy for limbal stem cell deficiency, for which no effective approaches has thus far been…
- Trial name
- NCT02415218
- Testing
- Mucosal cell sheet transplantation
- Where
- Thailand
- Volunteers
- 6 people
- Sponsor
- Siriraj Hospital
Limbal Stem Cell Deficiency
Corneal Epithelial Autograft for LSCD
The purpose of the study is to explore whether femtosecond laser-assisted corneal epithelial autograft is more effective than limbal conjunctival autograft for ocular surface reconstruction in patients with limbal stem cell…
- Trial name
- NCT03217487
- Testing
- Corneal epithelial autograft, Limbal conjunctival autograft, Femtosecond laser
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chunxiao Wang
Limbal Stem-cell Deficiency
Multiple Noninvasive Examination Modality to Evaluate the Severity of Ocular Surface Disorders
Here the investigators proposed this study to collect cases of different etiologies of ocular surface diseases. With at least one of these four non-invasive examination modalities, the investigators aim to analyze and compare the…
- Trial name
- NCT03594370
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Limbal Stem-cell Deficiency
The Effects of Allogeneic SLET
To investigate the effect of allogeneic SLET and re-epithelialization after allogeneic SLET.
- Trial name
- NCT04021134
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Limbal Stem-cell Deficiency
The Effects of Autologous SLET
This study aims to prospectively evaluate the therapeutic effects of autologous simple limbal epithelial transplantation for patients with limbal stem cell deficiency.
- Trial name
- NCT04021875
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Limbal Stem Cell Deficiency
Biodegradable Synthetic Scaffold as a Substitute for hAM in Limbal Epithelial Cells Transplant in LSCD Patients
The purpose of this clinical study is to undertake a pilot safety and efficacy study of a synthetic biodegradable membrane as a substitute for using donor human amniotic membrane (hAM) for the treatment of limbal stem cell…
- Trial name
- NCT02568527
- Testing
- PLGA scaffold
- Where
- India
- Volunteers
- 5 people
- Sponsor
- Virender S Sangwan, MBBS, MS
Limbal Stem Cell Deficiency
ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation
In this study the prognostic value of ABCB5 in survival of the limbal stem cell transplantation expanded in vitro on amniotic membrane for corneal surface reconstruction in patients with limbal stem cell deficiency will be…
- Trial name
- NCT02579993
- Testing
- Pannus and conjunctival dissection, Human cultivated limbal stem cell transplantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Limbal Stem-cell Deficiency
Autologous Oral Mucosa Transplantation for Limbal Stem Cell Deficiency
PURPOSE: To report clinical and histochemical results of oral mucosa graft transplantation in eyes with limbal stem cell deficiency. DESIGN: Prospective observational study.
- Trial name
- NCT03226015
- Volunteers
- 27 people
- Sponsor
- Klinikum Chemnitz gGmbH
Aniridia
Correlation of Gene Abnormalities and Clinical Manifestations of Aniridia
This study will examine specific gene changes in patients with aniridia, a disease in which the iris (colored part of the eye) is absent or partially absent, and will correlate the changes with clinical manifestations of the…
- Trial name
- NCT00265590
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Eye Institute (NEI)
Limbal Stem Cell Deficiency
Transplantation of Autologous Oral Mucosal Epithelial Stem Cell Sheet for Treating Limbal Stem Cell Deficiency Disease
The aim of this trials investigates the therapeutic effects of application autologous oral mucosal epithelial cell sheets in the treatment of limbal stem cell deficiency disease.
- Trial name
- NCT03015779
- Testing
- cultured autologous oral mucosal epithelial cell sheet
- Volunteers
- 7 people
- Sponsor
- He Eye Hospital
Limbal Stem Cell Deficiency, Stevens-johnson Syndrome
Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
To investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.
- Conditions
- Limbal Stem Cell Deficiency, Stevens-johnson Syndrome, Ocular Cicatricial Pemphigoid, Chemical Burn
- Trial name
- NCT02149732
- Testing
- cultivated oral mucosal epithelial sheet transplantation
- Where
- 2 sites in South Korea
- Sponsor
- Seoul National University Hospital
Limbal Stem Cell Deficiency (LSCD)
The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED)
Corneal epithelial cells and limbal stem cells (LSC) are located in the limbus basal epithelium that are necessary for repair of corneal.
- Trial name
- NCT02649621
- Testing
- Amniotic Membrane Extract Eye Drop (AMEED)
- Volunteers
- 10 people
- Sponsor
- Royan Institute
Limbal Stem Cell Deficiency
Multicenter Study of CAOMECS Transplantation to Patients With Total Limbal Stem Cell Deficiency
This clinical study is a scientific study on patients who do not have any limbal stem cells. In this clinical study tissue is taken from the inside of the mouth, and cells from that tissue (epithelial cells) will be grown to form…
- Trial name
- NCT01489501
- Testing
- Surgical transplantation of CAOMECS to the ocular surface
- Where
- Germany
- Sponsor
- CellSeed France S.A.R.L.
Limbal Stem Cell Deficiency
Autologous Transplantation of Cultivated Limbal Stem Cells on Amniotic Membrane in Limbal Stem Cell Deficiency (LSD) Patients
The purpose of this study is to evaluate the efficacy, safety, and long term outcomes of ex vivo cultured limbal stem cell on amniotic membrane transplantation for corneal surface reconstruction in cases of partial and sever…
- Trial name
- NCT00736307
- Testing
- Cultured limbal stem cells Transplantation
- Where
- 2 sites in Iran
- Volunteers
- 10 people
- Sponsor
- Royan Institute