Clinical trials: Lichen Planus
Lichen Planus
Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen)
Lichen planus is a chronic cutaneous and mucosal disease characterized by the infiltration of cluster of differentiation (CD) CD8 T lymphocytes, localized under the basal membrane and associated with apoptosis of basal…
- Trial name
- HPVLichen (NCT02761122)
- Testing
- Human biological samples
- Where
- 3 sites in France
- Volunteers
- 21 people
- Sponsor
- Institut Pasteur
Atrophic Vaginitis, Vaginal Atrophy
VALOR: Vaginal Atrophy & Long-term Observation of Recovery
Vulvovaginal skin conditions, namely vaginal atrophy, lichen sclerosus, lichen simplex chronicus and lichen planus affecting the female adult population will be treated with a novel gel dressing to test the short- and long-term…
- Conditions
- Atrophic Vaginitis, Vaginal Atrophy, Genitourinary Syndrome of Menopause, Lichen Sclerosus of Vulva
- Trial name
- VALOR (NCT05953090)
- Testing
- 7-0940
- Where
- 14 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Stratpharma AG
Chronic Idiopathic Urticaria, Chronic Idiopathic Pruritus
A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases
Participants with diseases characterized by chronic pruritus experiencing moderate to severe pruritus will be enrolled in this pilot Phase 2 study.
- Conditions
- Chronic Idiopathic Urticaria, Chronic Idiopathic Pruritus, Lichen Planus, Lichen Simplex Chronicus
- Trial name
- NCT03858634
- Testing
- KPL-716
- Where
- 14 sites in United States
- Volunteers
- 58 people
- Sponsor
- Genentech, Inc.
Lichen Plano-Pilaris
Nemolizumab to Treat Lichen Planopilaris, a Noncontrolled, Prospective, Pilot Study.
Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia characterized by progressive, permanent hair loss and scalp symptoms such as pruritus and burning.
- Trial name
- NCT07396168
- Testing
- Nemolizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Skin Center Dermatology Group
Oral Lichen Planus
Intra-oral Treatment of OLP With Rivelin®-CLO Patches
Participants with symptomatic Oral Lichen Planus lesions will be treated with Rivelin® patches containing either 0, 1, 5, or 20 μg clobetasol per patch. Each participant will apply up to 6 patches twice daily for 4 weeks.
- Trial name
- NCT03592342
- Testing
- Clobetasol Propionate
- Where
- 27 sites in United States, Canada and 4 more
- Volunteers
- 140 people
- Sponsor
- Dermtreat
Sore Throat, Aphthous Ulcer
Observational Study of OROSEDAL in Sore Throat and Minor Oral Lesions
This prospective, multicenter, national, observational, non-interventional post-market clinical follow-up study will evaluate the performance and safety of OROSEDAL in children and adults with sore throat or minor oral lesions…
- Conditions
- Sore Throat, Aphthous Ulcer, Oral Lichen Planus, Minor Mouth Lesion
- Trial name
- NCT07620353
- Testing
- OROSEDAL
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Laboratoires Elerte
Vaginitis, Atrophic Vaginitis
a Flexible Wound Dressing for the Management of Genital Skin Conditions
The objective of the study is to determine the efficacy of 7-0940 in the management of genital skin conditions in female patients
- Conditions
- Vaginitis, Atrophic Vaginitis, Lichen Planus, Lichen Sclerosus
- Trial name
- NCT05396261
- Testing
- Film forming silicone gel (7-0940)
- Where
- Australia
- Volunteers
- 54 people
- Sponsor
- Stratpharma AG
Oral Lichen Planus, Dental Plaque
Dual-light Antibacterial Photodynamic Therapy as an Adjunctive Treatment to Corticosteroid Treatment in OLP
This study is designed to investigate the effectiveness of plaque control intervention by home-use dual-light aPDT Lumoral -device as an adjunctive or alternative treatment to triamcinolone acetonide (TCA) mouth rinse or other…
- Conditions
- Oral Lichen Planus, Dental Plaque, Oral Bacterial Infection
- Trial name
- RELIEF-OLP (NCT05401201)
- Testing
- Lumoral treatment, Standard oral hygiene self care
- Where
- 2 sites in Finland
- Volunteers
- 13 people
- Sponsor
- Koite Health Oy
Lichen Planopilaris
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with lichen planopilaris
- Trial name
- ALPINE (NCT07532603)
- Testing
- Oral Brepocitinib
- Where
- 61 sites in United States, Australia and 2 more
- Volunteers
- 342 people
- Sponsor
- Priovant Therapeutics, Inc.
Lichen Planus: Cutaneous Lichen Planus, Mucosal Lichen Planus and Lichen Planopilaris
PoC Study to Evaluate the Efficacy and Safety of Secukinumab 300 mg in Patients With Lichen Planus
The primary purpose of the proof of concept study is to elucidate the efficacy of secukinumab in the treatment of adult patients with biopsy-proven lichen planus not adequately controlled by topical therapies, and to assess the…
- Trial name
- PRELUDE (NCT04300296)
- Testing
- secukinumab 300 mg Q4W, secukinumab 300 mg Q2W
- Where
- 35 sites in United States, France and 1 more
- Volunteers
- 111 people
- Sponsor
- Novartis Pharmaceuticals
Cutaneous Lichen Planus
A Study to Assess the Efficacy and Safety of GIA632 Across a Range of Doses in Participants With Moderate to Severe Cutaneous Lichen Planus
This study will evaluate the safety and efficacy of GIA632 in participants with moderate to severe cutaneous lichen planus (cLP).
- Trial name
- ELIPSI (NCT07775924)
- Testing
- GIA632
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 259 people
- Sponsor
- Novartis Pharmaceuticals
Cutaneous Lichen Planus
A Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Cutaneous Lichen Planus
The purpose of this study will be to evaluate efficacy and safety of Ruxolitinib cream in participants With Cutaneous Lichen Planus.
- Trial name
- NCT05593432
- Testing
- Ruxolitinib cream, Vehicle cream
- Where
- 24 sites in United States, Canada
- Volunteers
- 64 people
- Sponsor
- Incyte Corporation
Oral Lichen Planus
Evaluating LP-10 in Subjects With OLP
This is a multicenter, dose-ranging study including adult male and female subjects (>= 18 years old) with symptomatic Oral Lichen Planus (OLP).
- Trial name
- NCT06233591
- Testing
- LP-10 (Liposomal Tacrolimus)
- Where
- 7 sites in United States
- Volunteers
- 24 people
- Sponsor
- Lipella Pharmaceuticals, Inc.
Lichen Planus
Cellular and Molecular Biomarkers in Patients With Lichen Planus
Lichen planus (LP) is a chronic inflammatory disease of unknown aetiology, affecting the skin and mucous membranes, characterised by a CD8+ cytotoxic T-cell infiltrate, associated with epithelial cell death and disruption of the…
- Trial name
- HELP (NCT06451744)
- Testing
- Blood samples collection, Skin or mucous membrane brushing, Skin or mucous membrane biopsy
- Where
- 6 sites in France
- Volunteers
- 70 people
- Sponsor
- Institut Pasteur