Clinical trials: Leukoplakia Oral
Oral Cancer, Oral Cavity Cancer
Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions
The primary goal of this study is to see if photodynamic therapy (PDT) is effective for treatment of lesions in the oral cavity which have high risk of becoming oral cancer.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Oral Leukoplakia, Oral Lichen Planus
- Trial name
- NCT06876038
- Testing
- 5-Amino Levulinic Acid
- Where
- 2 sites in India
- Volunteers
- 65 people
- Sponsor
- University of Massachusetts, Boston
Lichen Planus, Oral Leukoplakia
Biomarkers for Oral Cancer
The purpose is to determine the extent of genetic damage in oral mucosal lesions ascertained in the study, whether specific genotypes are associated with genetic damage observed in the oral mucosal lesions, whether the extent of…
- Conditions
- Lichen Planus, Oral Leukoplakia, Mouth Neoplasms
- Trial name
- NCT00341497
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Oral Leukoplakia, Oral Lichen Planus
Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy
Abstract Objective: To study the diagnostic efficiency of Rose Bengal with Toluidine blue in detecting the biopsy sites and thus establish an accurate diagnosis in oral premalignant lesions.
- Conditions
- Oral Leukoplakia, Oral Lichen Planus, Premalignant Lesion
- Trial name
- NCT03031899
- Testing
- Biopsy, Rose Bengal, toluidine blue
- Volunteers
- 27 people
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Leukoplakia, Periodontal Disease
Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR
In Phase II trials, treatment with ketorolac tromethamine oral rinse has been shown to block periodontal disease progression even in the absence of standard clinical intervention such as scaling and root planing which is…
- Trial name
- NCT00001698
- Testing
- Ketorolac Rinse
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Oral Leukoplakia
Pioglitazone for Oral Premalignant Lesions
The goal of this clinical research study is to learn how Actos (pioglitazone) may affect oral premalignant lesions (OPLs) and/or the risk of mouth cancer. The safety of this drug will also be studied.
- Trial name
- NCT00951379
- Testing
- Pioglitazone hydrochloride, laboratory biomarker analysis
- Where
- 13 sites in United States, Canada and 1 more
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography
This clinical trial aims to assess the efficacy of Optical Coherence Tomography (OCT) in the early diagnosis of oral cancer. It focuses on Oral Potentially Malignant Disorders (OPMDs) as precursors to Oral Squamous Cell Carcinoma…
- Conditions
- Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder, Oral Leukoplakia, Proliferative Verrucous Leukoplakia
- Trial name
- SYMILIS OCT (NCT06321003)
- Testing
- OCT (Optical Coherence Tomography)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Palermo
Oral Leukoplakia, Oral Cancer
Least Invasive Nonlinear Light Microscopy
Evaluate the ability to image oral mucosa in healthy volunteer by nonlinear microscopy
- Trial name
- NCT00767442
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Oral Leukoplakia
Rosiglitazone Maleate in Treating Patients With Oral Leukoplakia
This phase II trial is studying how well rosiglitazone works in preventing oral cancer in patients with oral leukoplakia. Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back.
- Trial name
- NCT00369174
- Testing
- rosiglitazone maleate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Leukoplakia, Oral
Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia
This research study is studying an immunotherapy drug, as a possible treatment for oral proliferative verrucous leukoplakia (OPVL).
- Trial name
- NCT03692325
- Testing
- Nivolumab
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Dana-Farber Cancer Institute
Erythroplakia, Fanconi Anemia
Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer
This clinical trial studies widefield fluorescence and reflectance imaging, fluorescence spectroscopy, and tissue samples in regularly examining (monitoring) participants at risk for developing oral cancer.
- Conditions
- Erythroplakia, Fanconi Anemia, Lichen Planus, Oral Cavity and Lip Precancerous Condition
- Trial name
- NCT00542373
- Testing
- Cytology Specimen Collection Procedure, Diagnostic Microscopy, Diagnostic Procedure
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- M.D. Anderson Cancer Center
Leukoplakia, Lichen
Photodynamic Therapy for Oral Precursor Lesions
Pre-malignant lesions are difficult to treat. Even after surgical removal they tend to re-appear. Often the lesions are to large and are apparent on many sites, therefore surgical removal is not always possible.
- Trial name
- PDT (NCT01497951)
- Testing
- Aminolaevulinic acid
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Medical University of Vienna
Head and Neck Cancer
Fenretinide in Treating Patients With Leukoplakia of the Mouth
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of or treat early cancer. Fenretinide may be an effective drug in treating leukoplakia.
- Trial name
- NCT00004161
- Testing
- fenretinide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Oral Leukoplakia
Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia
There is no consensus on treatment of leukoplakia but surgical excision is the preferred choice if suitable in size, which does not prevent clinical recurrence and malignant transformation.
- Trial name
- NCT07387900
- Testing
- Metformin Hydrochloride
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Pneumonia, Pneumocystis Carinii, HIV Infections
Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)
To determine which of 2 doses of dapsone is effective prophylaxis for Pneumocystis carinii pneumonia (PCP) in patients with oral thrush or hairy leukoplakia and less than 400 CD4 lymphocytes per mm3.
- Trial name
- NCT00002043
- Testing
- Dapsone
- Where
- United States
- Sponsor
- Jacobus Pharmaceutical
Oral Leukoplakia
Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study
Aims: To evaluate the qualitative and quantitative parameters of finger and palmar dermatoglyphic patterns in patients with oral premalignant and malignant lesions OBJECTIVES: 1.
- Trial name
- QQA-FPD-PMML (NCT06256809)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Head and Neck Cancer, Precancerous Condition
Celecoxib in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of celecoxib may prevent or treat head and neck cancer.
- Trial name
- NCT00101335
- Testing
- celecoxib
- Where
- United States
- Sponsor
- Fox Chase Cancer Center
Oral Leukoplakia
Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia
The goal of this clinical trial is to learn if calcipotriol and photodynamic therapy are equally effective in treatment of leukoplakia or not.
- Trial name
- NCT07658508
- Testing
- Calcipotriol 0.005% gel, ALA mediated PDT
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Oral Lichen Planus, Oral Leukoplakia
Intra and Extra Oral Inspection of Oral Mucosa
Dental health professionals have a responsibility to perform routine intra- and extraoral inspection on their patients for detecting abnormalities.
- Conditions
- Oral Lichen Planus, Oral Leukoplakia, Erythroplakia
- Trial name
- NCT04079491
- Testing
- questionnaire survey
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Dalarna County Council, Sweden
Erythroplakia, Oral Leukoplakia
Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia
This phase IIb trial tests whether metformin works in preventing oral cancer in patients with oral leukoplakia (white patches) or erythroplakia (red patches). Metformin is in a class of drugs called biguanides.
- Trial name
- NCT05237960
- Testing
- Biopsy, Biospecimen Collection, Extended Release Metformin Hydrochloride
- Where
- 10 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- University of Arizona
Erythroleukoplakia, Leukoplakia
Pembrolizumab in Treating Participants With Leukoplakia
This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.
- Conditions
- Erythroleukoplakia, Leukoplakia, Verrucous Oral Leukoplakia
- Trial name
- NCT03603223
- Testing
- Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Jonsson Comprehensive Cancer Center