Clinical trials: Leiomyoma, open to volunteers
Renal Tumor Histology, Cutaneous Leiomyoma
Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer
This study will investigate what causes hereditary leiomyomatosis renal (kidney) cell cancer, or HLRCC, and how the disease is related to the development of kidney tumors.
- Conditions
- Renal Tumor Histology, Cutaneous Leiomyoma, Kidney Cancer
- Trial name
- NCT00050752
- Where
- United States
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Uterine Polyps, Uterine Fibroids
Office Hysteroscopy Versus Operating-room Hysteroscopy for Uterine Lesions
HYPHOP is a multicenter, randomized clinical trial comparing two care pathways for women who need operative hysteroscopy to treat intrauterine lesions, such as uterine polyps, small submucosal fibroids, or retained pregnancy…
- Conditions
- Uterine Polyps, Uterine Fibroids, Retained Products of Conception
- Trial name
- HYPHOP (NCT07908615)
- Testing
- Operating-room hysteroscopy with resectoscope, Outpatient hysteroscopic morcellation/aspiration
- Where
- 9 sites in France
- Volunteers
- 474 people
- Sponsor
- Nantes University Hospital
Uterine Fibroids, Hysterectomy
Predictors of Success and Failure of v-NOTES Hysterectomy for Large and Very Large Uteri
Uterine fibroids are the most common benign tumors in women of reproductive age and are a major indication for hysterectomy. This retrospective, single-center observational study aims to identify factors associated with the…
- Conditions
- Uterine Fibroids, Hysterectomy, Vaginal Natural Orifice Transluminal Endoscopic Surgery (v-NOTES)
- Trial name
- PRE v-NOTES (NCT07895953)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Uterine Fibroid
Epidemiology and Risk Factors of Uterine Fibroids in China
Uterine fibroids are the most common form of benign uterine tumors in the uterine muscle layer, which had a certain rate of malignancy, but it is rare.
- Trial name
- NCT05840042
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang
Female Infertility, Uterine Fibroid
The Effects of Uterine Fibroids on Pregnancy in Women
Female fertility may be affected by uterine fibroids, although this association has not been elucidated. This retrospective cohort study aims to evaluate the impact of fibroids on women fertility.
- Trial name
- NCT06020924
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,658 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang
Uterine Fibroid, Uterine Sarcoma
Radiomics-Based Non-Invasive MRI Differentiation of Uterine Sarcomas and Fibroids
This retrospective case-control study aims to develop and validate a diagnostic model based on multimodal big data and artificial intelligence to differentiate uterine leiomyoma from uterine sarcoma.
- Conditions
- Uterine Fibroid, Uterine Sarcoma, Diagnose Disease, AI (Artificial Intelligence)
- Trial name
- NCT07129005
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Tongji Hospital
Uterine Fibroid, Uterine Sarcoma
A Prospective Validation Study of Radiomics in the Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma
In our previous study, based on the multi-center clinical big data collected from January 2012 to January 2025, we have completed the construction of a multimodal early warning model for the malignant transformation of uterine…
- Conditions
- Uterine Fibroid, Uterine Sarcoma, AI (Artificial Intelligence), Radiomic
- Trial name
- NCT07269535
- Testing
- No intervention (observational study)
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Uterine Fibroid
Bearing nsPVA Embolization for Uterine Artery Embolization (BETTER-UAE)
This is a prospective, multicenter, observational, post-market clinical follow-up study in subjects treated with Bearing nsPVA Embolization Particles for uterine fibroid embolization.
- Trial name
- BETTER-UAE (NCT06153667)
- Testing
- Bearing nsPVA
- Where
- 4 sites in United States, Australia and 1 more
- Volunteers
- 100 people
- Sponsor
- Merit Medical Systems, Inc.
Leiomyoma, Uterine, Leiomyoma
Prescription of Letrozole for Uterine Myoma
The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as…
- Conditions
- Leiomyoma, Uterine, Leiomyoma, Fibroid, Fibroid Uterus
- Trial name
- PLUM (NCT06143631)
- Testing
- Letrozole 2.5mg
- Where
- 5 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus
Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery
Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic…
- Conditions
- Uterine Fibroids (Leiomyoma), Adenomyosis of Uterus, Endometriosis, Endometrial Cancer
- Trial name
- NCT07860203
- Testing
- DEX 0.2 μg/kg/h., SGB
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Catherin Zhang
Surgery
LapBox® Manual Containment System
This study to evaluate the leak integrity of the LapBox Manual Containment System for laparoscopic hysterectomy and myomectomy. The goal is to determine the integrity of this containment system in order to increase surgical…
- Trial name
- NCT07767968
- Testing
- LapBox Manual Containment System, Standard of Care Specimen Bag
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Wisconsin, Madison
Dysmenorrhea, Menstrual Pain
Vaginal Sildenafil for Primary Dysmenorrhea
This open-label, non-randomized mechanistic study will evaluate whether a single 100 mg vaginal sildenafil citrate suppository reduces uterine hypercontractility during menstruation in adults with moderate-to-severe dysmenorrhea.
- Conditions
- Dysmenorrhea, Menstrual Pain, Endometriosis, Uterine Fibroid
- Trial name
- SILDYS (NCT07508358)
- Testing
- Sildenafil citrate vaginal suppository
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kevin Hellman
Endometriosis, Adenomyosis of Uterus
Artificial Intelligence Into Ultrasound Diagnostics in Reproductive Medicine
The goal of this observational study is to develop and validate artificial intelligence (AI)-based algorithms that support ultrasound diagnosis of endometriosis, adenomyosis, myometrial masses, uterine malformations, and impaired…
- Conditions
- Endometriosis, Adenomyosis of Uterus, Leiomyoma (Uterine Fibroids), Uterine Neoplasms
- Trial name
- AUDRIE (NCT07810920)
- Where
- Hungary
- Volunteers
- 1,600 people
- Sponsor
- Semmelweis University
Postoperative Pain, Fibroid Uterus
QL Block in Laparoscopic Myomectomy
This study aims to determine the efficacy of a quadratus lumborum (QL) block in decreasing postoperative pain in patients undergoing myomectomy for uterine fibroids.
- Trial name
- NCT05979493
- Testing
- Bupivacain, Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Joseph Findley MD
Benign Gynecological Disease, Uterine Fibroids
Prospective Perioperative Clinical Registry for Women Undergoing Benign Gynecological Surgery
This prospective observational registry aims to systematically collect preoperative, intraoperative, and postoperative clinical data from patients undergoing surgery for benign gynecological conditions.
- Conditions
- Benign Gynecological Disease, Uterine Fibroids, Endometriosis, Adenomyosis
- Trial name
- OPGYNBEN (NCT07772076)
- Testing
- Standard Surgical Procedures for Benign Gynecological Conditions
- Where
- Italy
- Volunteers
- 6,000 people
- Sponsor
- IRCCS San Raffaele
Uterine Fibroids (UF), Microwave Ablation
Safety and Efficacy of Microwave Ablation Alone Versus Microwave Ablation Combined With Chemical Ablation in the Treatment of Uterine Fibroids: A Prospective, Multicenter Study
Uterine fibroids are the most common benign tumors in women of reproductive age, with a prevalence of 20%-50%, often causing menorrhagia, anemia, pelvic pain, and pressure symptoms that markedly impair quality of life.
- Conditions
- Uterine Fibroids (UF), Microwave Ablation, Ultrasound
- Trial name
- NCT07754877
- Testing
- Microwave ablation combined with chemical ablation, Microwave ablation
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Peking University Aerospace Center Hospital
Advanced Kidney Carcinoma, Advanced Renal Cell Carcinoma
Mercaptopurine for the Treatment of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), Uterine/Cutaneous Leiomyomas, and Kidney Cancer
This phase I/II trial studies the side effects and best dose of mercaptopurine, and to see how well it works in treating patients with hereditary leiomyomatosis and renal cell carcinoma (HLRCC).
- Conditions
- Advanced Kidney Carcinoma, Advanced Renal Cell Carcinoma, Hereditary Leiomyomatosis and Renal Cell Carcinoma, Metastatic Kidney Carcinoma
- Trial name
- NCT07716735
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Uterine Fibroids (Leiomyoma), Uterine Myoma
Terlipressin vs Placebo to Reduce Bleeding in Fibroid Surgery
A myomectomy is a surgery to remove noncancerous growths (fibroids) from the uterus while keeping the uterus in place. This surgery can cause significant blood loss.
- Conditions
- Uterine Fibroids (Leiomyoma), Uterine Myoma, Leiomyoma
- Trial name
- NCT07746349
- Testing
- terlipressin (vasoconstrictor)
- Volunteers
- 80 people
- Sponsor
- Sevil Cankaya
Endometriosis, Fibroids
Impact of Educational Videos on Pre-operative Anxiety
The goal of this clinical trial is to learn if educational videos can reduce pre-operative anxiety in patients undergoing minimally invasive gynecologic surgery.
- Conditions
- Endometriosis, Fibroids, Adenomyosis, Pelvic Pain
- Trial name
- NCT07740759
- Testing
- educational video
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UConn Health
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital