Clinical trials: Left Ventricular Systolic Dysfunction
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Cardiac Structure and Function in Patients with Cystic Fibrosis
In a prospective observational cohort study (n = 100), the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and cystic fibrosis genotype and severity and determine whether these…
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis, Pulmonary, Cystic Fibrosis of Pancreas
- Trial name
- NCT06084468
- Where
- 2 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Herlev and Gentofte Hospital
Heart Failure, Left Ventricular (LV) Systolic Dysfunction
AI-based Prediction of Cardiac Function Using Echocardiography and Body Composition Data (ECHO-FIT Study)
This prospective observational study (ECHO-FIT Study) aims to develop and validate a predictive model for cardiac function, particularly left ventricular ejection fraction (LVEF), by integrating echocardiographic measurements…
- Conditions
- Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Body Composition Measurement, Artificial Intelligence (AI)
- Trial name
- ECHO-FIT (NCT06811519)
- Testing
- Body Composition Analyzer (ACCUNIQ BC720)
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Left Ventricular Systolic Dysfunction, Myocardial Infarction
Adherence to Cied Implantation Guidelines and Cardiac Rehabilitation
There are limited data on how the guideline indications for ICD implantation are applied in clinical practice across Europe. Moreover, the impact of "time-dependence" of some indications to implantation on the guidelines…
- Trial name
- ANGELICA (NCT05764109)
- Where
- Italy
- Volunteers
- 488 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction
Ertugliflozin for Functional Mitral Regurgitation
In patients with heart failure (HF) and left ventricular (LV) dilation, adverse LV remodeling causes tethering of mitral valve (MV) preventing sufficient coaptation of normal leaflets and resulting in functional MR.
- Trial name
- EFFORT (NCT04231331)
- Testing
- Ertugliflozin
- Where
- 3 sites in South Korea
- Volunteers
- 128 people
- Sponsor
- Asan Medical Center
Hyperkalaemia, Heart Failure with Reduced Ejection Fraction
Hyperkalaemia and Its Impact on Therapy with RAASi
Renin-angiotensin-aldosterone system inhibitors (RAASi) have transformed prognosis of patients with heart failure with reduced ejection fraction, diabetic nephropathy and chronic kidney disease.
- Conditions
- Hyperkalaemia, Heart Failure with Reduced Ejection Fraction, Left Ventricular Systolic Dysfunction
- Trial name
- REVIEW (NCT04249648)
- Where
- United Kingdom
- Volunteers
- 651 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Left Ventricular Systolic Dysfunction (Disorder)
Artificial Intelligence-assisted Diagnosis and Prognostication in Low Ejection Fraction Using Electrocardiograms
This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of left ventricular systolic dysfunction.
- Trial name
- NCT05117970
- Testing
- AI-enabled ECG-based Screening Tool
- Where
- Taiwan
- Volunteers
- 13,631 people
- Sponsor
- National Defense Medical Center, Taiwan
Left Ventricular Systolic Dysfunction
The SMART-LV Pilot Study
The goal of this pilot study is to evaluate the prospective performance of an image-based, smartphone-adaptable artificial intelligence electrocardiogram (AI-ECG) strategy to predict and detect left ventricular systolic…
- Trial name
- NCT05630170
- Testing
- AI-ECG
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Chronic Kidney Diseases, Left Ventricular Systolic Dysfunction
Early Evaluation of Left Ventricular Systolic Function Impairment in Patients With Chronic Kidney Disease by Multimodal Ultrasonography
The goal of this observational study is to learn about the value of multimodal ultrasound in early detection of left ventricular systolic dysfunction in patients with chronic kidney disease(CKD).
- Trial name
- NCT06221891
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Arrhythmias, Cardiac, Atrioventricular Block
ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing
The goal of this observational study is to evaluate the clinical characteristics of patients undergoing permanent cardiac pacing and to compare procedural efficacy and safety of different implantation approaches in the clinical…
- Conditions
- Arrhythmias, Cardiac, Atrioventricular Block, Reduced Systolic Function, Atrial Fibrillation
- Trial name
- TREEBEARD (NCT06324682)
- Testing
- Cardiac pacing - Conventional RV pacing, Cardiac pacing - Conduction System Pacing, Cardiac pacing - Cardiac resynchronization therapy (pacing - CRTP - or defibrillation - CRTD)
- Where
- 31 sites in Italy
- Volunteers
- 8,400 people
- Sponsor
- University Hospital of Ferrara
Inflammatory Arthritis, Rheumatoid Arthritis
The Relationship Between Inflammatory ARTritis and CArdiac DIseAse
The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to…
- Conditions
- Inflammatory Arthritis, Rheumatoid Arthritis, Spondylitis, Ankylosing, Axial Spondyloarthritis
- Trial name
- ARTCADIA (NCT05647577)
- Where
- Denmark
- Volunteers
- 1,285 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Left Ventricular Systolic Dysfunction
AI-ECG Screening for Left Ventricular Systolic Dysfunction
The purpose of the current study is to verify the effectiveness of the artificial intelligence algorithm applied to the electrocardiogram as a potential screening tool for left ventricular systolic dysfunction.
- Trial name
- NCT06231797
- Testing
- AI algorithm conducted on 12-lead ECG and transthoracic echocardiography
- Volunteers
- 1,530 people
- Sponsor
- Seoul National University Hospital
Left Ventricular Function Systolic Dysfunction
Global Strain and Mechanical Dispersion May Predict Death and Ventricular Arrhythmias Better Than Ejection Fraction
The aim of the study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than ejection fraction(EF) in patients with myocardial infarction and heart failure regardless…
- Trial name
- NCT02286908
- Where
- 8 sites in Czechia, Norway
- Volunteers
- 3,100 people
- Sponsor
- Oslo University Hospital
Left Ventricular Systolic Dysfunction
A Study to Evaluate Accuracy and Validity of the "Chang Gung" Ventricular Systolic Dysfunction Screening Software
The purpose of this research is to test a software tool called the "Chang Gung" Ventricular Systolic Dysfunction screening software, which uses a 12-lead electrocardiogram to determine if a patient has left ventricular systolic…
- Trial name
- NCT05861115
- Testing
- "Chang Gung" Ventricular Systolic Dysfunction Screening Software
- Where
- Taiwan
- Volunteers
- 1,172 people
- Sponsor
- Chang Gung Memorial Hospital
Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction
Operative Mitral Valve Reconstruction in Functional mv Insufficiency With Reduced Systolic Ventricle Function
Functional mitral insufficiency poses a challenge with regard to the optimal time of intervention, particularly because they are frequently associated with left ventricular (LV) dilation and reduced LV ejection fraction (EF).
- Conditions
- Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction, Mitral Valve Prolapse
- Trial name
- REFORM-MR (NCT03470155)
- Testing
- mitral valve repair
- Where
- 6 sites in Germany
- Volunteers
- 105 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Asymptomatic Left Ventricular Systolic Dysfunction (Disorder), Heart Failure
ECG AI-Guided Screening for Low Ejection Fraction
This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of left ventricular systolic dysfunction.
- Trial name
- EAGLE (NCT04000087)
- Testing
- AI-enabled ECG-based Screening Tool
- Where
- United States
- Volunteers
- 358 people
- Sponsor
- Mayo Clinic
Heart Failure, Left Ventricular Systolic Dysfunction
Mechanisms and Innovations in Cardiac Resynchronisation Therapy
The aim of this study is to compare the effectiveness of multiple modalities of cardiac resynchronisation therapy using high precision acute electrical and haemodynamic measurements.These modalities include biventricular pacing…
- Conditions
- Heart Failure, Left Ventricular Systolic Dysfunction, Left Bundle-Branch Block, Right Bundle-Branch Block
- Trial name
- MIC (NCT04221763)
- Testing
- His-bundle pacing.
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- Imperial College London
Aortic Stenosis, Left Ventricular Function Systolic Dysfunction
Transcatheter Aortic Valve Implantation Without Predilation
The purpose of this study is to demonstrate that the avoidance of balloon valvuloplasty for predilation of the native aortic valve is associated with a reduction of the composite primary endpoint in TAVI patients with severely…
- Conditions
- Aortic Stenosis, Left Ventricular Function Systolic Dysfunction, High-risk Patients, Transcatheter Aortic Valve Implantation
- Trial name
- SIMPLIFy TAVI (NCT01539746)
- Testing
- TAVI without BAV, TAVI standard procedure
- Where
- 6 sites in Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bonn
Chronic Heart Failure, Iron Deficiency
Intravenous Iron Treatment in Patients With Heart Failure and Iron Deficiency: IRONMAN
This study will address whether the additional use of Intravenous (IV) iron on top of standard care will improve the outlook for patients with heart failure and iron deficiency.
- Conditions
- Chronic Heart Failure, Iron Deficiency, Left Ventricular Systolic Dysfunction
- Trial name
- IRONMAN (NCT02642562)
- Testing
- Ferric Derisomaltose
- Where
- 72 sites in United Kingdom
- Volunteers
- 1,160 people
- Sponsor
- University of Glasgow
Left Ventricular Systolic Dysfunction, Sudden Cardiac Death
Heart Rate Response to Regadenoson and Sudden Cardiac Death
The purpose of this study is to determine whether a blunted heart rate response to regadenoson is an independent predictor of sudden cardiac death.
- Trial name
- NCT01842035
- Testing
- regadenoson
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Impairment, Cognitive Change
How is COGNItive Function Affected by Cardiac Resynchronisation Therapy?
The primary objective of COGNI-CRT is to assess whether Cardiac Resynchronisation Therapy (CRT) can improve cognitive function in patients with systolic HF (LVEF ≤35%), when compared to a control group of patients implanted with…
- Conditions
- Cognitive Impairment, Cognitive Change, Heart Failure, Systolic, Heart Failure
- Trial name
- COGNI-CRT (NCT03755570)
- Testing
- Repeatable Assessment of Neuropsychological Status, Hospital Anxiety and Depression Scale, Frontal Assessment Battery
- Where
- United Kingdom
- Volunteers
- 198 people
- Sponsor
- Royal Cornwall Hospitals Trust