Clinical trials: Leak, Anastomotic
Anastomotic Leak
Predictors of Intestinal Anastomosis Leakage, Application of New Predictors and New Scores
Aim of the work This study aims at; Early detection of disruption and leakage of intestinal anastomotic sites whether small or large intestine by using biochemical markers as predictors and indicators of leakage with application…
- Trial name
- NCT04422106
- Testing
- Predictors of intestinal anastomosis leakage, application of new predictors and new scores
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Mansoura University
Pancreatic Trauma, Pancreatic Duct Injury
A Retrospective Analysis of Pancreatic Injuries and Treatment Outcomes
The goal of this observational study is to compare the presentation, treatment, and outcomes in patients suffering traumatic pancreatic injuries from blunt or penetrating trauma. The questions this study aims to answer are: 1.
- Conditions
- Pancreatic Trauma, Pancreatic Duct Injury, Pancreas Necrosis, Pancreas Cyst
- Trial name
- NCT06227871
- Testing
- Exploratory laparotomy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kern Medical Center
Rectal Cancer Patients, Rectal Cancer Surgery
FLuorescent Angiography in REduction of Anastomotic Leak in Rectal Cancer Surgery
The goal of this clinical trial is to find out whether using a special green dye called indocyanine green (ICG) during minimally invasive rectal cancer surgery can help surgeons assess blood flow to the bowel and reduce leakage…
- Conditions
- Rectal Cancer Patients, Rectal Cancer Surgery, Colorectal Cancer, Anastomotic Leak Rectum
- Trial name
- FLARE (NCT07899125)
- Testing
- Indocyanine Green Fluorescence Angiography, Standard Surgical Perfusion Assessment
- Where
- India
- Volunteers
- 610 people
- Sponsor
- Basavatarakam Indo American Cancer Hospital & Research Institute
Anastomotic Leakage
SEAL Registry - European Registry for the Effectiveness of LifeSeal® Kit
This study will assess the effectiveness of commercially available LifeSeal® Kit as measured by the incidence of post-operative clinical anastomotic leak rates in subjects undergoing low and ultralow anterior resection with an…
- Trial name
- NCT02881359
- Testing
- LifeSeal® Kit
- Where
- 8 sites in Belgium, Netherlands
- Volunteers
- 200 people
- Sponsor
- LifeBond Ltd.
Anastomotic Leak Rectum, Rectal Cancer
Healing of Rectal Anastomosis Sealed With a Concentrate Derived From the Patient's Blood, After Rectal Cancer Surgery
Rectal cancer is one of the most frequent cancer diseases, with more than 1500 new cases per year in Denmark. Fortunately, if the tumor is discovered early, surgeons can remove the part of the intestine that is afflicted, and…
- Conditions
- Anastomotic Leak Rectum, Rectal Cancer, Anastomotic Leakage
- Trial name
- OBANORES (NCT05293054)
- Testing
- Application of autologous fibrin matrix (Obsidian)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Anastomotic Leak, Anastomotic Leak Large Intestine
Low Tie Versus High Tie of the Inferior Mesenteric Vein During Colorectal Cancer Surgery: A Randomized Clinical Trial
This study aim to determine if a different surgical technique could result in a lower anastomotic leak rate. The two techniques are equally used around the world and well described by the international literature but this is the…
- Conditions
- Anastomotic Leak, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum, Colon Cancer
- Trial name
- LOTHVEIN (NCT05411783)
- Testing
- Low tie of IMV
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- San Carlo di Nancy Hospital
Rectal Cancer
Anastomotic Leakage After Anterior Resection of Rectal Cancer
Anastomotic leakage (AL) is one of the most-feared postoperative complications after anterior resection of rectal cancer. This complication compromises both short term and long term outcome of patients.
- Trial name
- NCT03281070
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Total Colectomy, Subtotal Colectomy
RISK FACTORS FOR ANASTOMOTIC LEAKAGE FOLLOWING TOTAL OR SUBTOTAL COLECTOMY (RIALTCOT)
Higher anastomotic leakage (AL) rate is reported after ileosigmoid (ISA) or ileorectal anastomosis (IRA) in total or subtotal colectomy (TSC) compared to colonic or colorectal anastomosis.
- Trial name
- RIALTCOT (NCT04512326)
- Testing
- Total or Subtotal colectomy
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Anastomotic Leak, Anastomosis; Complications
ESCP Safe Anastomosis proGramme in coLorectal surgEry
EAGLE is an international service improvement study to investigate the value of an educational tool delivered to surgeons and their teams to reduce the risk of anastomotic leak (leak of a join in the bowel) after right…
- Trial name
- EAGLE (NCT04270721)
- Testing
- The EAGLE Safe Anastomosis Quality Improvement Intervention
- Where
- Russia
- Volunteers
- 4,400 people
- Sponsor
- University of Birmingham
Esophageal Cancer, Esophagus Cancer
Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer
A prospective, multi-centre, exploratory and observational one-arm study to evaluate preventive Endoluminal Vacuum Therapy(pEVT) to prevent anastomotic leakage after esophagectomy due to esophageal cancer.
- Conditions
- Esophageal Cancer, Esophagus Cancer, Anastomotic Leak
- Trial name
- ESPY (NCT06097078)
- Testing
- Eso-SPONGE®
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Aesculap AG
Adult Patients, Intestinal Continuity (Anastomosis)
Anastomotic Leakage After Colon Cancer Surgery
Anastomotic leak (AL) is one of the most feared complications after colon cancer (CC) surgery. The incidence varies according to the studies, the definition used and the location of the excised segment.
- Conditions
- Adult Patients, Intestinal Continuity (Anastomosis), Colon Cancer
- Trial name
- ANACO II (NCT05643105)
- Testing
- Any kind of colectomy
- Where
- Spain
- Volunteers
- 1,628 people
- Sponsor
- Hospital San Carlos, Madrid
Rectal Cancer
Transanal Reinforcement of Low Rectal Anastomosis in Rectal Cancer Surgery
Anastomotic leak after low rectal cancer surgery occurs between 3 and 24% of the cases and is a severe complication leading to sepsis, permanent colostomy, higher risk of local cancer recurrence and eventually death.
- Trial name
- LessStoReS (NCT02279771)
- Testing
- transanal anastomotic reinforcement, protective ileostomy group, a circular anal dilator (CAD)
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Donato F Altomare
Leakage After Esophagectomy, Leakage After Gastrectomy
Eso-Sponge Registry
This international, prospective and multicenter registry was designed to collect clinical evidence for the endoscopic vacuum treatment using Eso-SPONGE® for anastomotic leakage after esophageal resection or iatrogenic or…
- Conditions
- Leakage After Esophagectomy, Leakage After Gastrectomy, Perforation of the Esophagus
- Trial name
- NCT02662777
- Testing
- Eso-SPONGE® vacuum treatment
- Where
- 17 sites in Germany
- Volunteers
- 108 people
- Sponsor
- Aesculap AG
Anastomotic Leakage, Rectal Neoplasms
Use of the TDT for Prevention of Anastomotic Leakage After Laparoscopic Anterior Resection for Rectal Cancer
The rate of anastomotic leakage after laparoscopic anterior resection（LAR） for medium \& low rectal cancer is still high. the transanal drainage tube (TDT) was thought to be useful for deduce the rate.
- Trial name
- NCT02686567
- Testing
- with TDT, without TDT
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Third Military Medical University
Esophageal Neoplasms, Esophagectomy
Effect of Neck Flexion on Esophagogastric Anastomotic Leakage After MIE
Esophageal cancer (EC) is the eighth most common cancer and the sixth leading cause of cancer deaths worldwide. Minimally invasive esophagectomy (MIE) is regarded as a safe and effective management for resectable EC.
- Conditions
- Esophageal Neoplasms, Esophagectomy, Anastomotic Leak
- Trial name
- NCT02418052
- Testing
- neck flexion
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Rectal Neoplasms
Defunctioning Cannula Ileostomy After Lower Anterior Resection of Rectal Cancer
Most surgeons suggest the use of fecal diverting to address the high morbidity and mortality associated with anastomotic leakage (AL) in patients with high risk factors on AL who are undergoing anterior resections.
- Trial name
- NCT01980238
- Testing
- cannula ileostomy, loop ileostomy, LAR
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Gynecologic Cancer, Anastomotic Leak
ECO-LEAK Technique: Early Detection of Colorectal Anastomotic Leakage by Transvaginal Ultrasound
The main hypothesis is that anastomotic leakage can be predicted peri- and postoperatively.To this end, the aim is to establish the accuracy of transvaginal ultrasound with transrectal enema (Ecoenema-TV) for the diagnosis of…
- Conditions
- Gynecologic Cancer, Anastomotic Leak, Cytoreductive Surgery
- Trial name
- NCT05942209
- Testing
- ECO-LEAK transvaginal ultrasound, ECO-LEAK with CT-Scan or rectoscopy, CT-Scan or rectoscopy
- Where
- Spain
- Volunteers
- 766 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Rectal Carcinoma, Laparoscopy
Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer
The study evaluates the feasibility and advantage of modified laparoscopic double-staple anastomosis technique which to eliminate the 'dog ears' in laparoscopic rectal anterior resection.
- Conditions
- Rectal Carcinoma, Laparoscopy, Anastomotic Leak
- Trial name
- NCT02770911
- Testing
- without "Dog Ear" group, with "Dog Ear" group
- Volunteers
- 250 people
- Sponsor
- Fujian Medical University
Anastomotic Leak, Platelet-Rich Fibrin
Leukocyte and and Platelet-rich Fibrin Plasma for the Prevention of Anastomotic Leakage in Colorectal Anastomosis
Anastomotic leak rate in colorectal surgery is estimated between 4 and 20 percent. Leukocyte and and platelet-rich fibrin plasma (L-PRF) is second generation platelet concentrate whose application in colorectal anastomosis in…
- Conditions
- Anastomotic Leak, Platelet-Rich Fibrin, Colorectal Surgery
- Trial name
- NCT05264467
- Testing
- Platelet rich fibrin on colorectal anastomosis
- Where
- Chile
- Volunteers
- 106 people
- Sponsor
- Universidad de Concepcion
Anastomotic Leak
Risk Factors Associated With Anastomotic Leak and Perioperative Mortality in Elderly
This is a retrospective cohort study of all consecutive patients who underwent colon or rectal resection, between the years 2012-2017 at Rabin Medical Center, a tertiary referral center in Israel.
- Trial name
- NCT04518384
- Testing
- colon or rectum resection
- Where
- Israel
- Volunteers
- 536 people
- Sponsor
- Rabin Medical Center