Clinical trials: Laryngopharyngeal Reflux
Gastroesophageal Reflux Disease, Hiatal Hernia
Registry of Outcomes From AntiReflux Surgery
Prospective registry comparing outcomes after laparoscopic treatment of gastroesophageal reflux disease and hiatal hernia.
- Trial name
- ROARS (NCT02923362)
- Testing
- Laparoscopic Fundoplication, LINX Antireflux
- Where
- 19 sites in United States
- Volunteers
- 1,941 people
- Sponsor
- The Heartburn Foundation
Pulmonary Aspiration of Gastric Contents, Emergency Surgery
Gastric Ultrasound for Airway Management in Emergency Patients
This prospective observational cohort study evaluates the association between gastric residual content and volume, assessed by point-of-care gastric ultrasound (PoCUS), and the choice of airway management technique (Rapid…
- Conditions
- Pulmonary Aspiration of Gastric Contents, Emergency Surgery, Gastric Residual Volume, Airway Management
- Trial name
- NCT07640165
- Testing
- Preoperative Gastric Point-of-Care Ultrasound (PoCUS)
- Where
- Indonesia
- Volunteers
- 43 people
- Sponsor
- Universitas Indonesia
Gastroesophageal Reflux
Pharmacokinetic and Safety of Dexlansoprazole in Adolescents With Gastroesophageal Reflux Disease
The purpose of this study is to asses the pharmacokinetics and safety of dexlansoprazole modified release (MR), once daily (QD), in adolescent subjects (age 12-17 years old) with Symptomatic Gastroesophageal Reflux Disease.
- Trial name
- NCT00847210
- Testing
- Dexlansoprazole MR
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Takeda
Regurgitation, Gastric
Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant Formula
A randomised, controlled, double-blind trial to evaluate the tolerance and safety of a new partly fermented anti-regurgitation infant formula containing prebiotics and locust bean gum in infants with regurgitation.
- Trial name
- Leopard (NCT03371615)
- Testing
- Anti-regurgitation infant formula
- Where
- 2 sites in Poland
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Laryngopharyngeal Reflux, Laryngopharyngitis Chronic
Method of Early Diagnosis of Laryngopharyngeal Reflux
The investigator will issue a Patient Information Consent for the participant in the study. 1.Patients will be asked to complete the Reflux Symptom Index questionnaire. Clinical survey, medical history. 2.
- Conditions
- Laryngopharyngeal Reflux, Laryngopharyngitis Chronic, Gastro Esophageal Reflux, Laryngitis
- Trial name
- LPR (NCT04771221)
- Testing
- pH metry, Filling out the questionnaire, Endoscopic laryngoscopy
- Where
- 2 sites in Kazakhstan
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Kazakh Medical University of Continuing Education
Extraesophageal Reflux, Laryngopharyngeal Reflux
Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance
The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution…
- Conditions
- Extraesophageal Reflux, Laryngopharyngeal Reflux, Dysphagia, Chronic Cough
- Trial name
- NCT07365046
- Testing
- High resolution oesophageal manometry with impedance, 24-hour pH metry
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava
Laryngopharyngeal Reflux
The Effects of Dexlansoprazole for the Treatment of Throat-Related Reflux
Recent studies have demonstrated that patients with throat-related reflux often require twice daily proton pump inhibitor therapy to attain significant symptomatic improvement, with once daily therapy offering little relief.
- Trial name
- NCT01317472
- Testing
- dexlansoprazole
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pulmonary Aspiration of Gastric Contents
Comparison of Different Preoperative Fasting Times in Pediatric Patients Undergoing Elective General Anaesthesia
Rationale of this study is to provide an evidence on minimal safe clear fluid fasting duration without the risk of aspiration of gastric contents during elective pediatric procedures under general anesthesia.
- Trial name
- NCT05922072
- Testing
- Nasogastric aspiration for measurement of Residual Gastric Volume, Nasogastric Aspiration for Measurement of Gastric pH
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- King Edward Medical University
Laryngopharyngeal Reflux, Zenker's Diverticulum
Laryngopharyngeal Reflux Before and After Cricopharyngeal Myotomy
The purpose of this study is to see if people with reflux with a Zenker's diverticulum have increased reflux into the throat following a cricopharyngeal myotomy.
- Trial name
- NCT01880892
- Testing
- Cricopharyngeal myotomy, PH probe Testing
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Laryngopharyngeal Reflux
A New Nasopharyngeal pH Probe for Diagnosis of Laryngopharyngeal Reflux
The purpose of this study is to evaluate the utility of a minimally invasive nasopharyngeal pH probe for the diagnosis of laryngopharyngeal reflux (LPR) in children with airway compromise; to determine whether it is comparable to…
- Trial name
- NCT01308502
- Testing
- Dx-pH probe
- Where
- United States
- Sponsor
- Children's Hospital of Philadelphia
Pulmonary Aspiration of Gastric Contents, Adverse Effects in the Therapeutic Use of Other and Unspecified General Anaesthetics
Safety of Gastric Volume Emptying After the Intake of Maltodextrin and Glutamine
Carbohydrates (CHO)-based drinks 2h before the induction of anesthesia are recommended to decrease insulin resistance. The addition of glutamine (GLN) in these beverages may enhance the benefits of CHO alone.
- Conditions
- Pulmonary Aspiration of Gastric Contents, Adverse Effects in the Therapeutic Use of Other and Unspecified General Anaesthetics, Pulmonary Aspiration During Anaesthetic Induction
- Trial name
- NCT01798342
- Testing
- Maltodextrin, Glutamine
- Where
- Brazil
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
Extraesophageal Symptoms, Cough
Screening for Barrett's Esophagus in Otolaryngology Patients
The purpose of this project is to develop an accurate method to identify patients that suffer from acid reflux, but may not present with classic reflux symptoms (such as heart burn).
- Conditions
- Extraesophageal Symptoms, Cough, Throat Clearing, Hoarseness
- Trial name
- SCE (NCT00695227)
- Testing
- Screening for Barrett's Esophagus
- Where
- United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pulmonary Aspiration of Gastric Contents
A Multicentre Preoperative Fasting Audit
The new European Society of Anaesthesiology and Intensive Care (ESAIC) preoperative fasting guideline recommends a one hour minimum fasting time for clear fluids.
- Trial name
- EUROFAST (NCT05519969)
- Where
- Sweden
- Volunteers
- 307,162 people
- Sponsor
- Uppsala University
Laryngopharyngeal Reflux
Study of an Oropharyngeal Aerosolized pH Probe for Diagnosing Laryngopharyngeal Reflux (LPR)
This study is a test of how well a new FDA-approved device is for diagnosing a condition known as laryngopharyngeal reflux (LPR).
- Trial name
- NCT00321503
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Laryngopharyngeal Reflux
Clinical Study of Jinsang Liyan Capsules Combined With PPI in the Treatment of LPRD
The goal of this clinical trial is to compare the efficacy of Jinsang Liyan capsule in combination with PPI versus PPI alone for the treatment of Laryngopharyngeal Reflux Disease (LPRD).
- Trial name
- NCT05879029
- Testing
- Jinsang Liyan Capsule; Rabeprazole enteric-coated tablets.
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Tongji Hospital
Laryngopharyngeal Reflux
Efficacy and Safety of Alginos Oral Suspension to Treat Laryngopharyngeal Reflux
Laryngopharyngeal reflux (LPR), the backflow of gastric acid into the larynx and hypopharynx, is a contributing factor to hoarseness, throat clearing, throat pain, and globus sensation.
- Trial name
- NCT01450748
- Testing
- Sodium alginate
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- TTY Biopharm
Laryngopharyngeal Reflux
Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal Reflux
The purpose of this study is to determine whether Lansoprazole 30mg taken twice daily is effective in the treatment of laryngitis due to gastroesophageal reflux.
- Trial name
- NCT00369265
- Testing
- Lansoprazole, Sugar pill
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- American Institute for Voice and Ear Research
Pulmonary Aspiration of Gastric Contents
Body Position and Ultrasound Examination of the Gastric Antrum
Pulmonary aspiration of gastric contents is a complication causing significant morbidity and mortality related to anesthesia. Ultrasound examination of the gastric antrum allows the detection of preoperative gastric contents…
- Trial name
- POSIGAST (NCT04097236)
- Testing
- Qualitative and quantitative assessment of gastric content volume with bed elevation, Qualitative and quantitative assessment of gastric content volume without bed elevation
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Laryngopharyngeal Reflux
Reflux Band in Laryngopharyngeal Reflux
This 12 week biomarker targeted double blind randomized controlled trial (RCT) will enroll subjects with salivary pepsin positive laryngopharyngeal reflux (LPR) to assess efficacy of the external upper esophageal sphincter (UES)…
- Trial name
- NCT04827355
- Testing
- External Upper Esophageal Sphincter (UES) Compression Device
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Diego
Respiratory Aspiration of Gastric Contents
Gastric Ultrasound for Estimation of the Aspiration Risk Study
The purpose of this research study is to look at the effectiveness of current anesthesia guidelines regarding food and drink prior to surgery in patients who are likely to have food and drink remain in their stomach longer than…
- Trial name
- NCT03310528
- Testing
- Interview questionnaire, Gastric ultrasound exam
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida