Clinical trials: Laparotomy Surgery
Laparoscopy, Abdominal Surgery by Laparotomy
Deep Rectus Sheath (DRS) Block in Abdominal Surgery
The goal of this observational study is to learn about the effectiveness of the Deep Rectus Sheath (Preperitoneal) block in patients undergoing abdominal surgery.
- Trial name
- DRS block (NCT07586462)
- Testing
- Other blocks
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- San Giovanni di Dio Hospital
Perforated Viscus, Intestinal Obstruction
Acute High-risk Abdominal Surgery Study - an Optimized Perioperative Course
The objective of this study is to implement an optimized perioperative course for patients undergoing acute high-risk abdominal surgery in order to improve the outcome.
- Trial name
- AHA (NCT01899885)
- Testing
- AHA (Acute Highrisk Abdominalsurgery): Optimized Course
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- Hvidovre University Hospital
ERAS, Compliance
Pre-habilitation Within ERAS Protocol for Gynecologic Oncology Surgery: The Pre_ERAS Study
ERAS (Enhanced Recovery After Surgery) protocols are step-by-step care plans that help patients recover faster after surgery. They focus on keeping the body's normal functions, lowering stress from surgery, and supporting a…
- Conditions
- ERAS, Compliance, Quality of Life (QOL), Excercise
- Trial name
- Pre_ERAS (NCT07210164)
- Testing
- Ocoxin, Structured self-guided exercise
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Surgical Wound
Comparison of Interrupted Suturing Versus Continuous Suturing in Laparotomy Wound Closed.
Emergency laparotomy is associated with high morbidity, particularly due to wound dehiscence and infection. Choosing an optimal suturing technique can significantly impact patient outcomes, but data on the comparison of…
- Trial name
- NCT07601919
- Testing
- Interrupted Closure, Continuous Closure
- Where
- Pakistan
- Volunteers
- 184 people
- Sponsor
- Muhammad Aamir Latif
Pain, Postoperative
Study Comparing Two Methods of TransversusAbdominis Plane
Interventional, randomised, prospective, multicentric study
- Trial name
- CHIRTAP (NCT04108221)
- Testing
- laparoscopy or laparotomy withTransversusAbdominis Plane Block
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Institut Jean-Godinot
COVID-19, Emergency General Surgery
Outcomes in Emergency Laparotomies During COVID-19 Pandemic
NLR has previously been observed to correlate with complications in upper GI (1) and colorectal (2) surgery. The investigators sought to assess if a similar correlation can be identified in emergency general surgical patients and…
- Trial name
- NCT04419571
- Testing
- Emergency Laparotomy
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Barking, Havering and Redbridge University Hospitals NHS Trust
Laparotomy, Peritonitis
Standardized Perioperative Management of Patients Operated With Acute Abdominal Surgery in a High-risk Emergency Setting
The objective of the study is to handle patients with the need for an acute laparotomy according to a standardised perioperative protocol and to document the measurement as they are performed (i.e.
- Conditions
- Laparotomy, Peritonitis, Ileus, Perforated Bowel
- Trial name
- SMASH (NCT03549624)
- Testing
- Standardised protocol for the perioperative management in patients in need of an acute laparotomy
- Where
- Sweden
- Volunteers
- 1,435 people
- Sponsor
- Sahlgrenska University Hospital
Post Operative Pain, Regional Block
Dual Injection ESPB Versus Single Injection ESPB for Laparotomies
To evaluate and compare the efficacy of single level injection erector spinae plane block versus double level injection Erector spinae plane block in laparotomies
- Trial name
- NCT05633329
- Testing
- single level, dual level
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Incisional Hernia After Midline Laparotomy, Emergency Abdominal Surgery
Prophylactic Mesh Reinforcement Versus Primary Closure After Emergency Midline Laparotomy (PREEMPT)
The PREEMPT trial is a multicenter randomized controlled trial comparing prophylactic onlay biosynthetic mesh reinforcement with primary suture closure in adult patients undergoing emergency midline laparotomy.
- Trial name
- PREEMPT (NCT07753551)
- Testing
- Prophylactic Biosynthetic Mesh Placement, Direct suture
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- University of Rome Tor Vergata
Endometrial Carcinoma
Endometrial Carcinoma: Comparison of Surgical Approaches (Laparoscopy vs Laparotomy)
Since the publication of the LAP2 study, a prospective randomized trial, laparoscopy has been considered the gold standard for treating patients with early-stage endometrial cancer (EC).
- Trial name
- LPSvsLPT (NCT06790004)
- Testing
- Laparotomy, Laparoscopy
- Where
- 8 sites in Italy
- Volunteers
- 700 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Myoma
Safety and Efficacy Study of a Hydrogel, Applied Following Removal of Myomas During Gynecologic Surgery, Administered for the Prevention/Reduction of Postoperative Adhesion Formation
The purpose of this study was to determine whether the adhesion prevention gel was safe to use, and was effective for the prevention/reduction of adhesion formation that typically occurs following gynecological surgery to remove…
- Trial name
- NCT00562471
- Testing
- Adhibit Adhesion Prevention Gel, Standard of Care Comparator
- Where
- 6 sites in Canada, Germany and 1 more
- Volunteers
- 76 people
- Sponsor
- Angiotech Pharmaceuticals
Suture Techniques, Wound Closure Techniques
Small Bites Vs Large Bites Abdominal Midline Incisional Closure
The goal of this trial is to compare the effectiveness of small bite versus large bite abdominal incision closure in emergency settings. It will also evaluate the safety and outcomes of each technique.
- Conditions
- Suture Techniques, Wound Closure Techniques, Laparotomy/Standerds, Surgical Wound Dehiscence
- Trial name
- NCT07154277
- Testing
- Small bite closure, Large bite closure
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Dow University of Health Sciences
Peritonitis, Surgical Site Infection
NPWT vs Primary Closure in SSI Prevention for Emergency Laparotomies for Peritonitis
The study aims to evaluate the efficacy of negative pressure wound therapy (NPWT) compared with primary closure (PC) in surgical site infection (SSI) prevention for laparotomy for peritonitis.
- Conditions
- Peritonitis, Surgical Site Infection, Infections, Wound Infection
- Trial name
- PRISTINE (NCT05684198)
- Testing
- subcutaneous NPWT
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Gdansk
Abdomen, Acute, Surgery--Complications
Survival After Emergency Laparotomy in Octogenarians
In this single-center retrospective study we wanted to investigate mortality and postoperative complications after emergency laparotomy performed in patients aged 80 years or above.
- Conditions
- Abdomen, Acute, Surgery--Complications, Postoperative Complications, Frailty
- Trial name
- NCT04176432
- Testing
- No intervention
- Volunteers
- 106 people
- Sponsor
- Haukeland University Hospital
Incisional Hernia, Hernia
Comparison of Mesh Fixation Techniques in Elective Laparoscopic Repair of Incisional Hernia - ReliaTack™ v ProTack™
This study is designed to examine the effects on post operative pain after the use of a fixation device to secure a mesh in the abdomen to repair a hernia of the abdominal wall.
- Conditions
- Incisional Hernia, Hernia, Abdominal Hernia
- Trial name
- TACKoMesh (NCT03434301)
- Testing
- ReliaTack™, Protack™
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Manchester University NHS Foundation Trust
Emergency Laparotomy, Quality Improvement
Quality Improvement Audit of ERAS Protocol Adherence in Emergency Laparotomy
This study evaluates the implementation of Enhanced Recovery After Surgery (ERAS) protocols during emergency laparotomy procedures in a resource-limited hospital in Sudan.
- Conditions
- Emergency Laparotomy, Quality Improvement, Implementation Science, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- NCT06757127
- Testing
- ERAS Protocol Adaptation for Emergency Laparotomy
- Where
- Sudan
- Volunteers
- 40 people
- Sponsor
- Sudan Medical Specialization Board
Obesity, Gastric Cancer
Effect of Obesity on Surgical Outcomes and Survival for Gastric Cancer
As the number of obesity continues to increase, surgical oncologist pay more attention to the effect of obesity on surgical outcomes and survival of digestive systemin cancers.
- Trial name
- NCT02800005
- Testing
- AFA group (successive patients), BMI group (successive patients)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Jian-Kun Hu
Laparotomy Closure After Abdominal Surgery, Suture Materials
Comparison of Vicryl Versus Prolene for Midline Rectus Sheath Closure After Elective Laparotomy
This randomized controlled trial compared two commonly used suture materials, Prolene and Vicryl, for closing the midline rectus sheath after elective laparotomy.
- Conditions
- Laparotomy Closure After Abdominal Surgery, Suture Materials, Complications Wounds
- Trial name
- NCT07451990
- Testing
- Vicryl (Polyglactin 910) Suture, Prolene (Polypropylene) Suture
- Where
- Pakistan
- Volunteers
- 152 people
- Sponsor
- Hayatabad Medical Complex
Laparotomy, Thoracotomy
Peritoneal Cavity Conditioning During Open Surgery.
Given the observations in animal models and the available data in the human our hypothesis is that peritoneal cavity conditioning (carbon dioxide with 4% of oxygen and 10% of N2O, 100% humidification at 32°C,) during open…
- Trial name
- NCT01098175
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- KU Leuven
Surgical Site Infections, Gastric Cancer
Povidone-iodine and the Normal Saline Cleaning the Incision for the SSIs
Surgical site infections (SSIs) is one of the most common complications of upper abdominal surgery. Previous studies found that type of surgical incision, emergency operation or not, surgical duration, age of patient, body mass…
- Conditions
- Surgical Site Infections, Gastric Cancer, Dehiscence of Laparotomy Wound
- Trial name
- NCT02436395
- Testing
- Group A (povidone-iodine wash the surgical incision), Group B (normal saline wash the surgical incision)
- Where
- China
- Volunteers
- 340 people
- Sponsor
- West China Hospital