Clinical trials: Laparotomy
Frailty, Surgery
An Investigation of Frailty Markers and Outcomes in Patients Requiring Emergency Laparotomy
Over 30,000 emergency abdominal operations (laparotomy, EmLAP) are performed in the UK annually and they are usually performed in adults over the age of 65.
- Conditions
- Frailty, Surgery, Sarcopenia
- Trial name
- NCT05416047
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Necrotising Enterocolitis Neonatal
Neonatal Laparotomy - A Trial Investigating the Impact of Location of Surgery
This is a pilot randomised trial allocating neonates requiring emergency laparotomy to surgery either on the neonatal unit or in the operating theatre.
- Trial name
- NeoLap (NCT07754435)
- Testing
- IN theatre, ON unit
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Laparotomy
PDS vs Polyamide for Midline Abdominal Closure
Within the last decade the customary trend of using non absorbable sutures has changed, with numerous studies and meta-analyses advocating the use of slowly absorbable sutures, claiming comparable wound strength with…
- Trial name
- PPMAC (NCT00514566)
- Testing
- Suture for midline abdominal closure
- Where
- India
- Volunteers
- 64 people
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Ventilator Lung
Individualized Perioperative Open Lung Ventilatory Approach in Emergency Abdominal Laparotomy. A Prospective Multicenter Randomized Controlled Trial.
Prospective multicenter randomized controlled trial. Individualized perioperative open lung ventilatory approach in emergency abdominal laparotomy.
- Trial name
- NCT04229810
- Testing
- STD-02, iOLA-iHFNC
- Volunteers
- 732 people
- Sponsor
- Hospital Clinic of Barcelona
Ocular Hypertension
Intraocular Pressure During Robotic Assisted Laparoscopic Procedures Utilizing Steep Trendelenburg Positioning
The purpose of this study is to measure pressures within the eye (during surgery to remove the prostate or abdominopelvic masses) as the body position required for these laparoscopic procedures has been associated with increases…
- Trial name
- NCT01261871
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- United States Naval Medical Center, San Diego
Abdomen, Acute, Surgery--Complications
Survival After Emergency Laparotomy in Octogenarians
In this single-center retrospective study we wanted to investigate mortality and postoperative complications after emergency laparotomy performed in patients aged 80 years or above.
- Conditions
- Abdomen, Acute, Surgery--Complications, Postoperative Complications, Frailty
- Trial name
- NCT04176432
- Testing
- No intervention
- Volunteers
- 106 people
- Sponsor
- Haukeland University Hospital
Mortality Rate
Machine Learning Platforms to Predict 30-day Mortality After Emergency Laparotomy
This study seeks to utilise retrospective patient data to train machine learning algorithms to predict the short term mortality and morbidity after an emergency laparotomy.
- Trial name
- NCT05828914
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- The University of Hong Kong
Endometrial Cancer
Hysteroscopic Lymphatic Mapping for Endometrial Cancer
The goal of this clinical research study is to learn if a procedure called intraoperative (during surgery) lymphatic mapping can be used to find the sentinel lymph node in patients with endometrial cancer.
- Trial name
- NCT00671606
- Testing
- Intraoperative Lymphatic Mapping
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center
Surgical Wound Infection
Comparison of Surgical Site Infection Rate Between Primary, Delayed Primary and Vacuum Assisted Closures.
The objective of the study is to compare infection rates between primary, delayed primary and vacuum assisted closures in contaminated and dirty/infected laparotomy wounds.
- Trial name
- NCT02649543
- Testing
- Primary Closure, Vacuum Assisted Closure, Delayed Primary Closure
- Where
- Mexico
- Volunteers
- 81 people
- Sponsor
- Eduardo Flores Villalba
Uterine Cervical Neoplasm, Laparotomy
Different Surgical Approaches in Patients of Early-stage Cervical Cancer
This multi-center, randomized controlled study aims to compare the survival outcomes (including overall survival, progression-free survival and disease-free survival between Chinese uterine cervical patients receiving different…
- Conditions
- Uterine Cervical Neoplasm, Laparotomy, Laparoscopy, Survival
- Trial name
- NCT03739944
- Testing
- Laparotomic radical hysterectomy, Laparotomic radical trachelectomy, Laparoscopic radical hysterectomy
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Lei Li
Gangrenous Postoperative Ventral Hernia (Diagnosis), Dehiscence of Laparotomy Wound
Prevention of Postoperative Ventral Hernias
The research is aimed at identifying factors of herniation after median laparotomy and developing surgical methods for preventing postoperative ventral hernias and eventrations.
- Trial name
- NCT04562363
- Testing
- Suturing of a laparotomic wound with modified methods
- Where
- 2 sites in Russia
- Volunteers
- 700 people
- Sponsor
- Ryazan State Medical University
External Causes of Morbidity and Mortality
Comparative Analysis of APACHE II and P-POSSUM
To compare APACHE II and P-POSSUM scoring system in emergency laparotomy.
- Trial name
- NCT02471612
- Where
- India
- Volunteers
- 159 people
- Sponsor
- Tata Main Hospital
Emergencies, Frail Older Adult
Emergency Laparotomy and Frailty Study
Patients aged over 65 comprise more than half the emergency general surgical workload, however, available risk-prediction tools for such patients are extrapolated from younger cohorts.
- Conditions
- Emergencies, Frail Older Adult, Laparotomy
- Trial name
- ELF (NCT02952430)
- Testing
- Emergency laparotomy
- Volunteers
- 500 people
- Sponsor
- North Western Research Collaborative
Incisional Hernia
Intraperitoneal Mesh-Implementation After Laparotomy
Aim of the study is to evaluate the risk reduction of intraperitoneal mesh-implementation after laparotomy (Group 1) in a randomized control trial compared with patients with standard abdominal closure (Everett-suture).
- Trial name
- NCT01003067
- Testing
- Mesh implementation
- Where
- Switzerland
- Volunteers
- 267 people
- Sponsor
- Kantonsspital Liestal
Surgical Procedures, Operative
Determining Universal Processes Related to Best Outcome in Emergency Gastrointestinal Surgery: an International Evaluation
A multicentre, international evaluation of emergency abdominal surgery to establish surgical outcomes and identify common, modifiable best practice processes.
- Trial name
- GlobalSurg-1 (NCT02179112)
- Testing
- Emergency Abdominal Surgery
- Where
- United Kingdom
- Volunteers
- 10,745 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Surgery
Effect of Acute Normovolemic Haemodilution on Allogenic Transfusion Needs In Laparotomy
This study is aimed to determine if acute normovolemic hemodilution (ANH), an established blood conservation technique, reduces the requirement for allogeneic blood transfusion in operations with prediction of surgical bleeding…
- Trial name
- ANH (NCT02290964)
- Testing
- ANH
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Universitas Padjadjaran
Gastrointestinal Cancer
The Laparotomy Study
The depth of neuromuscular blockade (NMB) during surgery may cause a clinical dilemma between optimal surgical conditions and the risk of postoperative residual blockade.
- Trial name
- NCT02140593
- Where
- Denmark
- Volunteers
- 128 people
- Sponsor
- Herlev Hospital
Digestive System Disease, Surgery
Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia
The purpose of this study is to evaluate the superiority of IV lidocaine combined with morphine spinal anesthesia versus placebo combined with morphine spinal anesthesia, in reducing postoperative morphine consumption at 48…
- Trial name
- LIDORACHI (NCT07076641)
- Testing
- rachi morphine anesthesia, laparotomy, Lidocaine IV
- Where
- France
- Volunteers
- 76 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Laparotomy, Thoracotomy
Peritoneal Cavity Conditioning During Open Surgery.
Given the observations in animal models and the available data in the human our hypothesis is that peritoneal cavity conditioning (carbon dioxide with 4% of oxygen and 10% of N2O, 100% humidification at 32°C,) during open…
- Trial name
- NCT01098175
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- KU Leuven