Clinical trials: Language
Rehabilitation of Speech and Language Disorders, Speech Disorders
MyoVoice to Restore Natural, Hands-free Communication to Individuals With Vocal Impairments
This study will evaluate the ability of MyoVoice to replace natural speech. Referred to generally as an Augmentative and Alternative Communication (AAC) device, MyoVoice uses electrical signals recorded non-invasively from speech…
- Conditions
- Rehabilitation of Speech and Language Disorders, Speech Disorders, Speech, Alaryngeal, Communication Aids for Disabled
- Trial name
- NCT04762043
- Testing
- Experimental System: MyoVoice, Reference System: Electrolarynx
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Altec Inc.
Primary Tauopathies, Corticobasal Degeneration Syndrome
BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients with Four Different…
- Conditions
- Primary Tauopathies, Corticobasal Degeneration Syndrome, Frontotemporal Lobar Degeneration With Tau Inclusions, MAPT Mutation Carriers, Symptomatic
- Trial name
- TauBasket (NCT03658135)
- Testing
- BIIB092
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Aphasia, Stroke
Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine
The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions…
- Trial name
- PICTURE-IT (NCT05845047)
- Testing
- PICTURE-IT, CoDeLT
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Johns Hopkins University
Obsessive Compulsive Disorder
Neural Mechanisms of CBT Response in Hoarding Disorder
The purpose of this research is to measure changes in brain activity with functional magnetic resonance imaging (fMRI) before and after cognitive-behavioral therapy for compulsive hoarding.
- Trial name
- NCT01956344
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Dyslexia
Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia
This study aims to determine whether levodopa, in combination with a high frequency training of (grammatical) rules, is effective in boosting learning success in healthy subjects and whether this kind of training in combination…
- Trial name
- NCT00111371
- Testing
- Levodopa
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Aphasia, Stroke
Post-Stroke Aphasia and Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment Study
In this study the investigators will examine the efficacy of navigated excitatory repetitive transcranial magnetic stimulation (nerTMS) for the treatment of post stroke aphasia.
- Trial name
- PART (NCT01512264)
- Testing
- Magstim SuperRapid
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
Neck Pain
Translation of Neck Disability Index Into Local Pakistani Languages of Pakistan
The aim of the study is to translate the neck disability index (NDI) questionnaire into Pushto, Punjabi, Sindhi and Balochi versions and o test the validity \& reliability of translated versions of NDI among neck pain patients in…
- Trial name
- NCT04843241
- Where
- Pakistan
- Volunteers
- 500 people
- Sponsor
- Riphah International University
Bronchopulmonary Dysplasia
Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data
Early Prediction of Bronchopulmonary Dysplasia in Preterm Infants Using Clinical Data from the First Three Postnatal Weeks with Large Language Models: A Retrospective Study This retrospective, observational study aims to evaluate…
- Trial name
- NCT07525167
- Testing
- Artificial Intelligence-Based Risk Prediction
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Konya City Hospital
Aphasia, Acquired, Stroke
Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of…
- Conditions
- Aphasia, Acquired, Stroke, Healthy Aging
- Trial name
- sentence (NCT06405594)
- Testing
- Language Condition
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Peripheral Facial Paralysis, Quality of Life
Validation of a French-language Version of Quality of Life Questionnaires in Patients With Peripheral Facial Palsy
Facial palsy is a serious and disabling disease whose drudgery and sensation are probably underestimated. Psychological, social and economic issues have major impacts although vital prognosis is not engaged in this pathology.
- Trial name
- PFQDV (NCT03581253)
- Testing
- Facial disability Index" (FDi), "Facial Clinimetric Evaluation" (FaCE)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Stroke, Aphasia
Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia
A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted.
- Conditions
- Stroke, Aphasia, Apraxia of Speech
- Trial name
- START (NCT04816799)
- Testing
- Startle Adjuvant Rehabilitation Therapy (START)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Arizona State University
Sign Language Skills, Teacher Practice
Strategic and Interactive Signing Instruction Experiment
This RCT study involves teachers divided into an experimental group and a control group. Teachers in the experimental group will receive SISI training to support the sign language development of deaf children, while those in the…
- Trial name
- NCT06729164
- Testing
- Strategic and Interactive Signing Instruction, Business-As-Usual Instruction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Tennessee, Knoxville
Language Development, Language Development Disorders
Efficacy of an Early Rhythmic Intervention in Infancy
The present project develops from a wide research line aiming at identifying very early electrophysiological risk markers for neurodevelopmental disorders.
- Conditions
- Language Development, Language Development Disorders, Infant Development, Intervention
- Trial name
- NCT04755309
- Testing
- Rhythmic intervention, Passive auditory stimulation
- Where
- Italy
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Back Pain, Pain
Albanian Versions and Validations of Pain Assessment Tools, Back Pain and Autonomy Questionnaires
A total of 200 participants are predicted to be enrolled for completing questionnaires in relation of pain assessment tools, back pain disability and autonomy in Albania.
- Conditions
- Back Pain, Pain, Disability Physical
- Trial name
- Validation (NCT04131998)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Developmental Language Disorder and Language Impairment, Anxiety Disorders and Symptoms
Reducing Anxiety Problems Among Children Indicated to Have Developmental Language Disorder
This study aims to pilot a world-first intervention, a mental health intervention augmented for children indicated with developmental language disorder (DLD).
- Trial name
- RAP-iDLD (NCT05552365)
- Testing
- Adapted Cognitive Behavioural, Treatment as Usual
- Where
- Singapore
- Volunteers
- 9 people
- Sponsor
- Nanyang Technological University
Developmental Language Disorder
Language Outcomes, Mechanisms, and Trajectories in Adults With and Without Developmental Language Disorder
The investigators' overall objective is to characterize the long-term outcomes of Developmental Language Disorder (DLD) in adulthood and to identify specific cognitive mechanisms mediating these outcomes.
- Trial name
- NCT06898671
- Testing
- Eye-Tracking in Visual World Paradigm
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Dementia Caregiver
Dementia Family Caregiver Study
The proposed study will test a 3-month, community health worker (CHW) delivered home visit, culturally and language-appropriate intervention for ethnic and underserved dementia family caregivers of persons with dementia (PWD)…
- Trial name
- NCT04894006
- Testing
- Community Health Worker (CHW) Home Visit Intervention, Attention Control Group with WIoT Technology, Usual Care
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Aphasia, Acquired
Word Retrieval in the Wild in People With Post-Stroke Aphasia
People with post-stroke aphasia (PWA) suffer from anomia, a condition where they know what they want to say but cannot retrieve the words.
- Trial name
- NCT05338216
- Testing
- Traditional EMA, Micro-Interaction EMA
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northeastern University
Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant
Nabilone for Agitation in Frontotemporal Dementia
The primary goal of this study is to test the hypothesis that oral nabilone treatment will reduce agitation compared with placebo in patients with Frontotemporal Dementia (both behavioural variant frontotemporal dementia and…
- Conditions
- Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant, Primary Progressive Aphasia, bvFTD
- Trial name
- Nabilone-FTD (NCT05742698)
- Testing
- Nabilone
- Where
- 7 sites in Canada
- Volunteers
- 3 people
- Sponsor
- Simon Ducharme, MD
Autism Spectrum Disorder
More and Less Social Comprehension
The goal of this early Phase 1 clinical trial is to assess if the social content of a story impacts autistic children's listening comprehension of stories.
- Trial name
- MLSC (NCT06116552)
- Testing
- More Social Stories, Less Social Stories
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Kansas Medical Center