Clinical trials: Lacunar Strokes
Cerebrovascular Accident, Hypertension
Secondary Prevention of Small Subcortical Strokes Trial
The goal of this study is to learn if combination antiplatelet therapy (aspirin and clopidogrel) is more effective than aspirin alone for the prevention of recurrent stroke and cognitive decline, and if intensive blood pressure…
- Trial name
- SPS3 (NCT00059306)
- Testing
- aspirin, clopidogrel, Target of Blood Pressure
- Where
- 63 sites in United States, Canada and 5 more
- Volunteers
- 3,020 people
- Sponsor
- University of British Columbia
Lacunar Stroke, Small Vessel Cerebrovascular Disease
Telecoached Exercise Intervention for Connectivity Enhancement in Small Vessel Disease (TELECONNECT-SVD)
The TELECONNECT-SVD study is a prospective, randomized, multicenter trial aimed at testing the efficacy of a remotely delivered exercise protocol on brain functional connectivity in patients with small vessel disease…
- Trial name
- TELECONNECT (NCT06525987)
- Testing
- Physical activity
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of L'Aquila
Cerebral Small Vessel Diseases, Lacunar Stroke
Retinal Vessel Leakage in Cerebral Small Vessel Disease
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: Does retinal vessel leakage occur in cerebral small vessel disease?…
- Conditions
- Cerebral Small Vessel Diseases, Lacunar Stroke, Vascular Dementia
- Trial name
- NCT06416371
- Testing
- Fundus fluorescein angiography, with ultrawide field retinal imaging
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Lacunar Stroke
The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke
The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke.
- Trial name
- LACUNAR_CA (NCT06354881)
- Testing
- Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Leicester
Stroke, Lacunar, Stroke, Acute Ischemic
Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT)
The goal of this multicenter, double-blind, 2×2 factorial randomized controlled trial is to evaluate the efficacy and safety of isosorbide mononitrate, butylphthalide, and their combination in reducing disability in patients with…
- Conditions
- Stroke, Lacunar, Stroke, Acute Ischemic, Cerebral Small Vessel Diseases
- Trial name
- NCT07252544
- Testing
- Isosorbide Mononitrate, Butylphthalide
- Volunteers
- 3,156 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioN
Progressing stroke is associated poor functional outcome and neurological deficit. Currently, no treatment for progressing stroke is recommended on the guideline. Carbogen is a mixture of 5% CO2 with 95% O2.
- Trial name
- NCT06770426
- Testing
- carbogen with or without phenyleprhine, phenylephrine
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Neurologic Disorder, Paralysis
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT05041114
- Testing
- Motor Neuroprosthesis
- Where
- 3 sites in Australia
- Sponsor
- Synchron Medical, Inc.
Stroke, Acute, Stroke, Ischemic
Neuroimaging in Acute Stroke
The main aim of this study is to identify the predictive value of CT parameters (e-ASPECTS, CTP, collateral vessel status, volume, and location of ischemic lesion volume) at a 3-month functional outcome defined by the modified…
- Trial name
- e-Stroke (NCT05864495)
- Where
- Czechia
- Volunteers
- 500 people
- Sponsor
- University Hospital Ostrava
Ischemic Stroke, Cerebral Infarction
Detection of Silent Atrial Fibrillation aFter Ischemic StrOke
The primary objective of this study is to evaluate whether, in patients with first-ever atherothrombotic or lacunar stroke without any previous history of atrial fibrillation (AF)/atrial flutter (AFL)/atrial tachycardia (AT), the…
- Conditions
- Ischemic Stroke, Cerebral Infarction, Brain Ischemia, Brain Infarction
- Trial name
- SAFFO (NCT02684825)
- Testing
- Reveal LINQTM- LNQ11 Internal Loop Recorder plus standard cardiac monitoring
- Where
- Italy
- Volunteers
- 317 people
- Sponsor
- Danilo Toni