Clinical trials: Lacunar Stroke, open to volunteers
Lacunar Stroke
A Multicenter Randomized Clinical Trial Compared With Standard Clinical Practice to Evaluate the Efficacy of a Polyphenol-rich Salicornia Extract in the Progression of Cognitive Decline in a Cohort of Patients With Lacunar Infarcts (SALACUNAR)
SALACUNAR (LACI-2-polyphenols) is a multi-center randomized controlled trial (RCT) to evaluate the effect of a polyphenol-rich supplement on small vessel neurovascular disease.
- Trial name
- SALACUNAR (NCT07353424)
- Testing
- B-salicornia
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Cerebral Small Vessel Disease, Stroke
Cerebral Small Vessel Disease Progression Dependent on Stroke Type
The goal of this prospective, observational study is to understand if cerebral small vessel disease (CSVD) has different velocities and patterns of temporal development, dependent on a concurrent ischemic stroke.
- Conditions
- Cerebral Small Vessel Disease, Stroke, Stroke Recurrence, Biomarkers
- Trial name
- ZMA_BIO (NCT07611136)
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Johannes Dorst
Lacunar Stroke, Stroke
Lacunar Stroke hyperAcute Clinical Utilization of Novel Approach Regimens: Rt-PA vs. DAPT Randomised Clinical Trial
The goal of this clinical trial is to learn if a combination of antiplatelet drugs works better than intravenous tissue plasminogen activator to treat small ischemic stroke (lacunar stroke).
- Conditions
- Lacunar Stroke, Stroke, Ischemic Stroke
- Trial name
- LACUNAR-tPA (NCT07111559)
- Testing
- rt-PA, DAPT
- Where
- 29 sites in Japan
- Volunteers
- 500 people
- Sponsor
- Nippon Medical School
Stroke, Vascular Severe Brain Injury
Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury
The rehabilitation outcome and recovery, in people after stroke or with vascular severe brain injury(vSBI), are difficult to predict.
- Conditions
- Stroke, Vascular Severe Brain Injury, Rehabilitation
- Trial name
- PRISMA (NCT06871800)
- Testing
- blood withdrawal
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Lacunar Strokes
Constitution of a Clinico-radiological Database and a Biobank for Patients With Lacunar Infarcts
The aim of this study is to determine in patients with a recent lacunar strokes (<15 days), the natural history of cognitive disturbances and disability.
- Trial name
- DHU-LAC (NCT03552926)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lacunar Stroke, Small Vessel Cerebrovascular Disease
Telecoached Exercise Intervention for Connectivity Enhancement in Small Vessel Disease (TELECONNECT-SVD)
The TELECONNECT-SVD study is a prospective, randomized, multicenter trial aimed at testing the efficacy of a remotely delivered exercise protocol on brain functional connectivity in patients with small vessel disease…
- Trial name
- TELECONNECT (NCT06525987)
- Testing
- Physical activity
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of L'Aquila
Cerebral Small Vessel Diseases, Lacunar Stroke
Retinal Vessel Leakage in Cerebral Small Vessel Disease
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: Does retinal vessel leakage occur in cerebral small vessel disease?…
- Conditions
- Cerebral Small Vessel Diseases, Lacunar Stroke, Vascular Dementia
- Trial name
- NCT06416371
- Testing
- Fundus fluorescein angiography, with ultrawide field retinal imaging
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Lacunar Stroke
The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke
The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke.
- Trial name
- LACUNAR_CA (NCT06354881)
- Testing
- Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Leicester
Stroke, Lacunar, Stroke, Acute Ischemic
Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT)
The goal of this multicenter, double-blind, 2×2 factorial randomized controlled trial is to evaluate the efficacy and safety of isosorbide mononitrate, butylphthalide, and their combination in reducing disability in patients with…
- Conditions
- Stroke, Lacunar, Stroke, Acute Ischemic, Cerebral Small Vessel Diseases
- Trial name
- NCT07252544
- Testing
- Isosorbide Mononitrate, Butylphthalide
- Volunteers
- 3,156 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioN
Progressing stroke is associated poor functional outcome and neurological deficit. Currently, no treatment for progressing stroke is recommended on the guideline. Carbogen is a mixture of 5% CO2 with 95% O2.
- Trial name
- NCT06770426
- Testing
- carbogen with or without phenyleprhine, phenylephrine
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University