Clinical trials: Lactate
Coronary Heart Disease
Efficacy and Safety of Hypertonic Sodium Lactate Solution Compared With 6% HES Solution in CABG Patients
The choice of fluid therapy is controversial in cardiac surgery. Numerous studies have shown that colloid is better as compared to crystalloids.
- Trial name
- NCT01654653
- Testing
- Hypertonic sodium lactate, 6% Hydroxy Ethyl Starch
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Sepsis, Disease Progression
Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department
To investigate the role of initial venous lactate in predicting the severity progression to overt septic shock and 30-day mortality in non-elderly patients without hemodynamic shock who suspected to have acute infections.
- Conditions
- Sepsis, Disease Progression, Septic Shock, Fatal Outcome
- Trial name
- NCT01947127
- Where
- Thailand
- Volunteers
- 458 people
- Sponsor
- Chulalongkorn University
Sensitive Skin
TRPV Expression in Subjects With Sensitive Skin
Sensitive skin syndrome is defined as the presence of burning, itching or any other unpleasant sensation on the skin, due to physical, chemical or psychological factors.
- Trial name
- NCT01871883
- Testing
- Skin biopsy, Oral mucosa specimen
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Blood Glucose, High
Admission Blood Glucose as a Predictor of Morbidity and Mortality in Polytraumatized Patients
In polytrraumatized patients, Does hyperglycaemia on admission increase the risk of morbidity and mortality compared to polytraumatised patients with normal blood glucose level ?
- Trial name
- NCT04100369
- Testing
- laboratory
- Volunteers
- 100 people
- Sponsor
- Assiut University
Low Bone Density, Osteopenia
Safety and Pharmacokinetics of Orally Administered Strontium L-Lactate in Healthy Adults
No clinical trials have evaluated strontium L-lactate (SrLac), the strontium salt of the L-enantiomer of lactic acid. Therefore, this clinical study was conducted to obtain general safety and pharmacokinetic (PK) information…
- Conditions
- Low Bone Density, Osteopenia, Osteoporosis, Postmenopausal
- Trial name
- NCT03761979
- Testing
- Strontium L-lactate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- BioLink Life Sciences, Inc.
Pregnancy, Cesarean Section
Different Approaches to Maternal Hypotension During Cesarean Section
The aim of this study is to compare two different therapeutic approaches to blood pressure reduction: pharmacological vs. non-pharmacological.
- Conditions
- Pregnancy, Cesarean Section, Anesthesia,Spinal, Hypotension
- Trial name
- NCT00991627
- Testing
- Bupivacaine, Morphine, Lactated Ringer's solution
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Parma
Fluid Therapy
Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients
The aim of the FLUID Trial is to conduct a pragmatic, multi-centre, open label randomized cluster cross-over trial (RCT) to determine whether fluid administration with 0.9% saline as compared to Ringer's lactate decreases death…
- Trial name
- FLUID (NCT04512950)
- Testing
- Ringer's lactate, 0.9% saline
- Where
- 7 sites in Canada
- Volunteers
- 43,626 people
- Sponsor
- Ottawa Hospital Research Institute
Shock
Continuous Central Venous Lactate Monitoring by Intravascular Microdialysis : a Comparison to Sequential Arterial Lactate Measurement During Shock.
During shock, arterial hypotension, inadequate cardiac output and microcirculatory alterations lead to tissue hypoxia, multiple organ failure and death. Arterial lactate is considered as the best marker of tissue hypoxia.
- Trial name
- NCT03464747
- Testing
- EIRUS system (Maquet Critical Care AB, 17154, Solna, Sweden)
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sepsis, Obstructive Shock
Use of Renin Versus Lactic Acid as Tissue Perfusion Biomarkers for Mortality Prediction in Hypotensive Critically Ill Patients
Measurement of Whole Blood Lactate Concentrations Whole blood lactate concentrations will be measured at the time of study enrollment and at 24, 48, and 72 hours.
- Conditions
- Sepsis, Obstructive Shock, Critical Illness, Hypotensive
- Trial name
- NCT05810415
- Testing
- Renin levels and lactic acid levels
- Where
- 2 sites in Egypt
- Volunteers
- 84 people
- Sponsor
- Al-Azhar University
Athletic Performance, Aerobic Capacity
Individualized Training to Improve Aerobic Capacity and 2,000 m Rowing Performance in Youth Rowers
The goal of this randomized clinical trial is to learn whether an individualized rowing training program based on ventilatory thresholds can improve aerobic capacity and 2,000 m rowing performance in youth rowers from Valdivia…
- Conditions
- Athletic Performance, Aerobic Capacity, Rowing Performance
- Trial name
- NCT07602244
- Testing
- Individualized Rowing Training, Usual Rowing Training
- Where
- Chile
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad San Sebastián
Cardiac Surgery, Cardiopulmonary Bypass
Norepinephrine Infusion During Cardiopulmonary Bypass
The primary objective is to test the efficacy and safety of the accuracy of continuous intravenous infusion of norepinephrine during cardiopulmonary bypass (CPB) on the prevention of hyperlactatemia after cardiac surgery.
- Trial name
- Norcal (NCT04312971)
- Testing
- Norepinephrine, Increase infusion rate, Decrease infusion rate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Macular Degeneration
A Safety and Efficacy Study of MSI-1256F (Squalamine Lactate) To Treat "Wet" Age-Related Macular Degeneration
Age-Related Macular Degeneration (AMD) is a degenerative eye disease of the retina that causes a progressive loss of central vision. AMD is the leading cause of legal blindness among adults age 50 or older in the Western world.
- Trial name
- NCT00089830
- Testing
- MSI-1256F (Squalamine Lactate)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Genaera Corporation
Hyperlactatemia, Healthy
The Role of Lactate in Lipolysis and Catabolism in Humans
Lactate may have anti-lipolytic effects when plasma concentrations of lactate reach levels similar to those seen during high intensity exercise.
- Conditions
- Hyperlactatemia, Healthy, Lactate
- Trial name
- LILACH (NCT04710875)
- Testing
- Na-lactate, Sodium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Triage, Emergency Department Triage
Impact of Point-of-care Lactate Testing as Triage Supplement on Patient Management Using Manchester Triage System
Although the Manchester Triage System (MTS) is widely used and validated internationally, it has some limitations. Its accuracy is moderate, especially for children and the elderly.
- Conditions
- Triage, Emergency Department Triage, Emergency Department Overcrowding, Emergency Medicine
- Trial name
- NCT07123857
- Testing
- re-triage
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Maribor
Muscle Fatigue
Microcurrent Therapy and the Post-Exercise Physiological Response (MENS_PE)
The goal of this clinical trial is to find out whether microcurrent therapy changes blood levels of creatine kinase, a marker of muscle stress, during the first 48 hours after exercise in military personnel.
- Trial name
- MENS_PE (NCT07877337)
- Testing
- Microcurrents Therapy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Hygiene
Dermacyd Femina (Lactic Acid) Pocket BR - Photo Evaluation
To demonstrate the absence of photoirritation and photosensitization potential of the product Dermacyd Femina (Lactic Acid) Pocket BR.
- Trial name
- NCT00783640
- Testing
- Lactic Acid
- Where
- Brazil
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Sanofi
Coronary Artery Disease, Atrial Fibrillation
Postoperative Lactate and Atrial Fibrillation After CABG
Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG).
- Trial name
- NCT05448521
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Gastrointestinal Microbiome, Immunoglobulin A
The Effect of Maternal Dadiah Supplementation During Pregnancy on Child Growth and Gastrointestinal Health Outcomes
The aim of our study is to assess the effect of giving dadiah as a supplement to pregnant women on improving the growth and digestive health of children.
- Conditions
- Gastrointestinal Microbiome, Immunoglobulin A, Growth; Stunting, Nutritional
- Trial name
- NCT05140928
- Testing
- Dadiah Pudding, Pudding without Dadiah
- Where
- Indonesia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Andalas University
Tumor Lysis Syndrome
Rasburicase in Patients at Risk for Tumor Lysis Syndrome
Primary Objectives: To determine the efficacy of rasburicase administered as a single dose followed by as needed dosing (investigational arm) as compared to fixed dosing for 5 days (standard treatment arm) in the treatment of…
- Trial name
- NCT00628628
- Testing
- As Needed Rasburicase, Fixed Dose Rasburicase
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- M.D. Anderson Cancer Center
HIV Infections, Lipodystrophy
A Study of Increased Lactic Acid and Abnormal Fat Distribution in HIV-Positive Patients
The purpose of this study is to see if the findings of increased lactic acid and abnormal fat distribution get better when d4T is replaced with abacavir, abacavir plus lamivudine, or Combivir (a pill containing lamivudine plus…
- Trial name
- NCT00005764
- Testing
- Lamivudine/Zidovudine, Abacavir sulfate, Lamivudine
- Where
- 31 sites in United States
- Volunteers
- 100 people
- Sponsor
- Glaxo Wellcome