Clinical trials: Labor and Childbirth
Preterm Delivery, Short Cervix
PREGNANT Short Cervix Trial
The purpose of this research study is to evaluate the usefulness of progesterone vaginal gel in decreasing the preterm birth rate in a population of pregnant women with short cervical length and at high risk for preterm birth.
- Conditions
- Preterm Delivery, Short Cervix, Short Uterine Cervical Length
- Trial name
- NCT00615550
- Testing
- progesterone
- Where
- 49 sites in United States, Belarus and 8 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Juniper Pharmaceuticals, Inc.
Preterm Birth
Oxygen Assist Module in Preterm Infants on High Flow Nasal Cannula Support.
Oxygen treatment is common in babies born early (preterm) and requiring intensive care. Having too much or too little oxygen can increase the risk of damage to the eyes and lungs, and contribute to death or disability.
- Trial name
- ROAM (NCT04687618)
- Testing
- High Flow Nasal Cannula withAutomatic control of FiO2 using OAM, High Flow Nasal Cannula with manual control of FiO2
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Premature Infants
Targeted Protein Fortification in Extremely Low Birth Weight Preterm Infants
While new innovations in the care of extremely premature infants have led to decreased morbidity and mortality, poor postnatal growth remains as a major challenge.
- Trial name
- NCT02943746
- Testing
- Standard Protein Diet, High Protein Diet
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Respiratory Insufficiency Syndrome of Newborn
CPAP vs NIPPV: A COMPARATIVE EFFECTIVENESS RESEARCH
Aim: Investigators aim is to conduct two complementary and concurrent CER projects using a pragmatic clinical trial design and registry-based RWD to identify the optimal respiratory management practices for extremely preterm…
- Trial name
- NCT04075123
- Testing
- CPAP
- Where
- Canada
- Volunteers
- 1,829 people
- Sponsor
- Canadian Neonatal Network
Fetal Bradycardia Complicating Labor and Delivery, Fetal Bradycardia During Labor
Oxytocin and Fetal Heart Rate Changes
The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia.
- Conditions
- Fetal Bradycardia Complicating Labor and Delivery, Fetal Bradycardia During Labor, Fetal Heart Rate or Rhythm Abnormality Affecting Fetus
- Trial name
- NCT03232918
- Testing
- Half dose Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Unyime Ituk
Parental Stress, Parental Satisfaction
The Effect of Short Film and Video-Based Education on the Intensive Care Unit Introduction for Parents of Premature Infants on Stress, Care Participation, and Satisfaction Levels
The primary objective of this single-center, parallel-group, randomized controlled experimental study is to evaluate the effect of short film and video-based education on the intensive care unit orientation provided to parents of…
- Conditions
- Parental Stress, Parental Satisfaction, Care Participation
- Trial name
- NCT07410923
- Testing
- Short Film-Based Education, routine care, Video-based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mersin University
Apnea of Prematurity, Preterm Infant
Detection of Respiratory Events Using Acoustic Monitoring in Extremely Preterm Infants
Extremely preterm infants, born before 29 weeks of pregnancy, often face breathing difficulties, also known as respiratory events, due to their undeveloped lungs and respiratory systems.
- Conditions
- Apnea of Prematurity, Preterm Infant, Periodic Breathing, Hypopnea
- Trial name
- DREAM 2 (NCT07552025)
- Testing
- Wireless acoustic sensor, Semi-structured interview, Nox T3s portable sleep monitoring device
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Bronchopulmonary Dysplasia
Neonatal Intensive Care (NICU) Course and Hospital Outcome of Infants With BPD Treated Using Inhaled Nitric Oxide
This is a chart review study of neonates admitted to Primary Children's Medical Center or University of Utah NICU who had or developed a diagnosis of bronchopulmonary dysplasia (BPD) and were treated for this condition with…
- Trial name
- NCT00757146
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Utah
Pre-Term, Respiratory Disease
Closed-loop Oxygen Control in Ventilated Infants Born at or Near Term
Ventilated neonates frequently require supplementary oxygen to allow for adequate oxygen delivery to the tissues and normal cell metabolism.
- Trial name
- NCT05017727
- Testing
- Closed-loop automated oxygen control with Oxygenie Auto-O2 software (SLE6000)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- King's College Hospital NHS Trust
Preterm Birth
Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy With Prior Spontaneous Preterm Birth
Preterm birth (PTB) is the major cause of perinatal morbidity and mortality. Worldwide, about 15 million babies are born too soon every year, causing 1.1 million deaths, as well as short- and long-term disability in countless…
- Trial name
- NCT02923973
- Testing
- Transvaginal ultrasound cervical length screening
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Federico II University
Birth Asphyxia, Premature Birth
Oxygen Toxicity in the Resuscitation in Extremely Premature Infants
The investigators hypothesize that using low oxygen concentrations during resuscitation of extremely premature infants will avoid oxidative stress derived damage and improve outcome.
- Trial name
- OXTOX (NCT00494702)
- Testing
- Resuscitation
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Fundacion Para La Investigacion Hospital La Fe
Post-partum Hemorrhage
Mostafa Maged Maneuver in Comparison With Bimanual Uterine Compression to Control Post-partum Hemorrhage
The current study aimed to investigate the effectiveness of the Mostafa Maged maneuver compared to Bimanual uterine compression in controlling postpartum hemorrhage during vaginal delivery.
- Trial name
- NCT06002256
- Testing
- Mostafa Maged maneuver, Bimanual uterine compression
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ministry of Health and Population, Egypt
Postpartum Hemorrhage, Cesarean Section Complications
Tranexamic Acid in Patients for Caesarian Delivery.
This is a prospective, double-blinded, randomized placebo-controlled trial. The study will be approved by the DUHS institutional review board (IRB) and the trial will be registered at clinical trial registry.
- Conditions
- Postpartum Hemorrhage, Cesarean Section Complications, Obstetric Anesthesia Problems
- Trial name
- TXA; CD (NCT05759156)
- Testing
- Tranexamic acid injection
- Where
- Pakistan
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Cervical Insufficiency
Patient Attitudes Toward Ultrasound Measurement of Cervical Length
The investigators propose a prospective evaluation of methods to assess cervical length for uncomplicated singleton gestations between 18-28 weeks presenting to the MFM office for routine mid pregnancy ultrasound.
- Trial name
- TVUS (NCT01482039)
- Testing
- Sequential ultrasound, Transvaginal ultrasound
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Intermountain Women and Children's Research
Cesarean Section Complications
Topical Tranexamic Acid Plus Bilateral Uterine Artery Ligation During Cesarean Delivery
Placenta previa (PP) is an obstetric condition that is closely linked with massive obstetric hemorrhage with a varied incidence about once in every 200 live births.
- Trial name
- NCT03741075
- Testing
- BUA, topical tranexamic acid
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Sepsis, PROM, Preterm (Pregnancy)
Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates
Preterm infants are born at less than 37 weeks of pregnancy. Sometimes a break or tear in the fluid filled bag that surrounds and protects the infant during pregnancy leads to an untimely birth.
- Conditions
- Sepsis, PROM, Preterm (Pregnancy), Early-Onset Neonatal Sepsis, Preterm Premature Rupture of Membrane
- Trial name
- SAUNA (NCT06377397)
- Testing
- Antibiotics
- Where
- 9 sites in India
- Volunteers
- 1,500 people
- Sponsor
- Indian Council of Medical Research
Preterm Birth, Preterm Labor
Impact of the PREEMI Package on Neonatal Mortality
The purpose of this Quality Improvement initiative is to reduce severe morbidity and mortality among premature infants through proven and cost-effective clinical management during the antenatal, intrapartum, and postpartum…
- Conditions
- Preterm Birth, Preterm Labor, Neonatal Death
- Trial name
- PREEMI (NCT03923023)
- Where
- 2 sites in Zambia
- Volunteers
- 11,195 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Preterm Birth
AttachMent Preterm in the Loire Infant Follow-up Team
The purpose of this study is to describe the attachment representations of children born prematurely at age 3 and 5 with regard to their neurocognitive and behavioral development.
- Trial name
- AMPLIFy (NCT04304846)
- Testing
- Questionnaires and interviews
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Angers
Sepsis, Premature Birth
Predictors of Sepsis in Ex-Preterm Infants
The aims of this study are to: Assess whether ex-preterm infants have a persistently immature immune system, which may decrease their ability to respond to infections, when they reach term-corrected gestational age.
- Trial name
- NCT03433846
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Preterm
Automated Versus Manual Oxygen Control in Preterm Babies on Respiratory Support
Babies admitted in the NICU (neonatal intensive care unit) frequently need supplemental oxygen to keep their oxygen saturation (SpO2) in target range (TR).
- Trial name
- NCT06622161
- Testing
- automated oxygen vs manual oxygen
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Aga Khan University Hospital, Pakistan
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