Clinical trials: Labor Stage, Second
Persistent Occipital Posterior Presentation During Labor Delivery
Trial of Prophylactic Manual Rotation of Persistent Occiput Posterior Presentation During the Early Second Stage of Labor to Reduce Operative Delivery: a Prospective Multicenter Randomized Control Trial
Superiority multicenter prospective randomized study on operative delivery (instrumental delivery or caesarean section) of prophylactic manual rotation in case of persistent occipital posterior presentation during the second…
- Trial name
- PROPOP (NCT02695238)
- Testing
- Prophylactic Manual Rotation of persistent occipital posterior presentation
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Delivery, Obstetric, Labor, Obstetric
Effects of a Lateral Position With Hip Flexion and Femoral Internal Rotation During the Second Stage of Labor in Nulliparous Women Receiving Epidural Analgesia
This randomized clinical study evaluated the effects of a lateral position with hip flexion and femoral internal rotation during the second stage of labor in nulliparous women receiving epidural labor analgesia.
- Trial name
- NCT07745192
- Testing
- Lateral Position With Hip Flexion and Femoral Internal Rotation, Conventional Lateral Position
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Instrumental Delivery, NEC, Affecting Fetus or Newborn
PROPENSITY-ID: Sonographic and Clinical Assessment of Head Position Prior to Instrumental Delivery and Labour Outcomes
Instrumental delivery is performed in 3-15% of all births (1). Successful instrumental delivery avoids need for cesarean section with associated maternal surgical morbidity, risk from neonatal disimpaction and future pregnancy…
- Conditions
- Instrumental Delivery, NEC, Affecting Fetus or Newborn, Second Stage Cesarean Delivery, Occiput Position
- Trial name
- PROPENSITYID (NCT05557097)
- Testing
- Intrapartum sonography
- Where
- Italy
- Volunteers
- 2,282 people, healthy volunteers welcome
- Sponsor
- University of Parma
Labor Pain, Pregnancy
The Association Between Decreasing Labor Analgesia Epidural Infusion and Forceps Delivery
The objective of this study will be to compare epidural infusion management, specifically looking at infusion rate changes, in patients who receive forceps deliveries versus normal spontaneous vaginal deliveries.
- Trial name
- NCT00443560
- Testing
- Case controlled analysis of epidural labor analgesia patterns
- Where
- United States
- Volunteers
- 2,162 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Prolonged Second Stage of Labor
Trial of IV NTG for CD After Second Stage Arrest for the Prevention of Uterine Extension
Randomized controlled clinical trial of IV nitroglycerin at cesarean delivery for second stage arrest of descent to prevent or uterine extension at the hysterectomy site.
- Trial name
- NITRO (NCT02265965)
- Testing
- intravenous nitroglycerin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Macular Edema Secondary to Retinal Vein Occlusion
A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)
Researchers are looking for a better way to treat people who have macular edema secondary to retinal vein occlusion (RVO). In people with RVO, a blood vessel that carries blood away from the retina (vein) becomes blocked.
- Trial name
- QUASAR (NCT05850520)
- Testing
- Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_higher dose, Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_2 mg, Fluorescein
- Where
- 273 sites in United States, Australia and 25 more
- Volunteers
- 892 people
- Sponsor
- Bayer
Pregnancy
Use of an Occlusal Support Device During the Second Stage of Labor
The primary objectives of this study are to determine if the use of an Occlusal Support Device (OSD)(Mouthguard) can reduce the duration and intensity of the second stage of labor, reduce the incidence of labor complications…
- Trial name
- NCT02807493
- Testing
- Occlusal Support Device, Control
- Where
- United States
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Rupture of Membranes Prior to Onset of Labor, Induction of Labor
Intravenous Dexamethasone for Inducing Labor in Women With Term Pregnancy and Pre-Labour Rupture of Membranes
This clinical trial aims to determine whether giving intravenous dexamethasone can shorten the time it takes for women to deliver after labor induction in term pregnancies with pre-labour rupture of membranes (PROM).
- Conditions
- Rupture of Membranes Prior to Onset of Labor, Induction of Labor, Dexamethasone
- Trial name
- NCT07503184
- Testing
- Dexamethasone, Prostaglandin E1, Normal Saline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Pregnancies, Obstetric Labor
Head-perineum Distance and Delivery Mode
In a prospective cohort of patients in the second phase of labor, the investigators measured the head-perineum distance and correlate it to the mode of delivery (spontaneous delivery - instrumental delivery - ceasarean section).
- Trial name
- EchoPé (NCT04771091)
- Testing
- Mesure of head-perineum distance by transperineal ultrasound
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Rennes University Hospital
Labor, Induced
Use of Papaverine to Shorten the Second Stage/Duration of Labor in Pregnant Women After Cervical Ripening by Double-balloon Catheter
This prospective, randomized, double-blind controlled trial aims to evaluate whether intravenous papaverine, administered immediately after the removal of a double-balloon catheter used for cervical ripening, can shorten the…
- Trial name
- NCT07237880
- Testing
- Papaverine 80 mg IV
- Where
- Israel
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Sphincter (Anal); Perineal Rupture, Obstetric, Perineal Tear
One Plus One Equals Two, Will That do?
A new clinical practice to reduce perineal trauma has been adopted by many maternity wards in Sweden. This practice involves collegial midwifery assistance during the second stage of labor and the birth of the baby.
- Conditions
- Sphincter (Anal); Perineal Rupture, Obstetric, Perineal Tear, Pelvic Floor Disorders, Experience, Life
- Trial name
- Oneplus (NCT03770962)
- Testing
- Two midwives
- Where
- 4 sites in Sweden
- Volunteers
- 3,058 people
- Sponsor
- Region Skane
Labor, Second Stage, Vaginal Delivery
USE OF PERINEAL MIRROR DURING THE SECOND STAGE OF LABOR
Objective: This study was designed to evaluate the effect of perineal mirror use during the second stage of labor on the duration of the second stage, postpartum recovery, and perceived pain, support, and control levels during…
- Conditions
- Labor, Second Stage, Vaginal Delivery, Primiparity, Perineal Mirror Use
- Trial name
- NCT07659249
- Testing
- Perineal Mirror
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Pregnancy
Optimizing Management of the 2nd Stage of Labor: Multicenter Randomized Trial
The investigators propose a large, multicenter, randomized clinical trial of immediate versus delayed pushing for nulliparous women in labor at term reaching complete cervical dilation.
- Trial name
- OMSS (NCT02137200)
- Testing
- Immediate pushing, Delayed pushing
- Where
- 6 sites in United States
- Volunteers
- 2,414 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Labor Onset and Length Abnormalities
Goal-directed Labor Epidural Analgesia Maintenance
The GLEAM trial is a multicenter, pragmatic, cluster-randomized trial to assess the effects of programmed intermittent epidural bolus versus continuous epidural infusion on the rate of spontaneous vaginal delivery and several…
- Trial name
- GLEAM (NCT05255263)
- Testing
- PIEB, CEI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Labor Complication, Avulsion
The Association Between Kristeller Maneuver and Pelvic Floor Trauma After Vaginal Delivery
We want to investigate the association between fundal pressure in the second stage and the risk of levator ani muscle (LAM) injury.
- Trial name
- NCT03752879
- Testing
- Fundal Pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Prevention, Newborn Complication
The Effects Of Pushing Techniques During Second Stage Of Labour On Maternal and Newborn Health
Purpose :To determine the impact of directed Valsalva's's versus spontaneous pushing techniques during second stage of labour on postpartum maternal fatigue. .
- Trial name
- NCT04207658
- Testing
- Valsalva's Style Pushing
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pelvic Pain
Impact of Thermotherapy During Childbirth on Postpartum Perineal Pain (PERISAFE)
Perineal pain is common after vaginal birth. Thermotherapy might be effective to limit postpartum perineal pain, thanks to the effects of local heating or cooling application.
- Trial name
- PERISAFE (NCT04778631)
- Testing
- Heat therapy, Cryotherapy
- Where
- 2 sites in France
- Volunteers
- 115 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oxygen Inhalation Therapy, Second Stage of Labour
Maternal Oxygen Administration for Fetal Distress
Supplementary oxygen is routinely administered to patients, even those with adequate oxygen saturations, in the belief that it increases oxygen delivery.
- Conditions
- Oxygen Inhalation Therapy, Second Stage of Labour, Fetal Distress
- Trial name
- NCT02221440
- Testing
- Low flow nasal oxygen, Low flow room air
- Where
- 3 sites in China
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Navy General Hospital, Beijing
Labor
The Effect of Hyoscine Butylbromide on Shortening of First and Second Stages of Labor
The management of normal labor is both an art and a science. For decades, health providers have worked to manage labor actively and safely, with the goal of shortening the duration of painful labor.
- Trial name
- NCT02839213
- Testing
- Hyoscine Butyl bromide, Saline
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Woman's Health University Hospital, Egypt
Cold Compress
Effect of Perineal Massage Combined With Cold Compress in the Second Stage on the Delivery Outcome of Primipara
Objective: The aim of this study was to investigate the effect of perineal massage and cold compress in second stage on the delivery outcome of primipara.
- Trial name
- NCT05350670
- Testing
- Perineal massage and cold compress
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University