Clinical trials: Labor Induction, open to volunteers
Endotoxemia, Inflammation
Short-Chain Fatty Acids in Lypopolysaccharide-Induced Inflammation and Executive Function
Short-chain fatty acids (SCFAs) are substances produced by gut bacteria when they ferment dietary fiber. They can act as signals between the gut and the brain and may help regulate the body's immune and stress responses.
- Conditions
- Endotoxemia, Inflammation, Executive Function (Cognition)
- Trial name
- NCT07713641
- Testing
- Short-Chain Fatty Acid Colon-Delivery Capsules, Lipopolysaccharide (LPS)
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Labor Induction
Pain Control for Cervical Ripening Balloon
No standard of care exists for pain management during cervical ripening balloon placement. The purpose of this study is to evaluate if vaginal topical lidocaine reduces pain related to cervical ripening balloon placement during…
- Trial name
- NCT07268118
- Testing
- topical vaginal application lidocaine gel
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Beth Israel Deaconess Medical Center
Bronchopulmonary Dysplasia (BPD), Premature Births
PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia
The purpose of the study is to learn how safe montelukast may be in premature infants at significant risk for Bronchopulmonary Dysplasia (BPD) and to determine how much and how quickly montelukast moves from the stomach into the…
- Conditions
- Bronchopulmonary Dysplasia (BPD), Premature Births, Critical Illness
- Trial name
- PRISM (NCT07101640)
- Testing
- montelukast 4 mg granule
- Where
- 5 sites in United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Behavior, Health
Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT06242704
- Testing
- Working Memory Training, Working Memory
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Infections
Azithromycin Before Induction
This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and…
- Trial name
- NCT06543290
- Testing
- Azithromycin Pill
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Arrowhead Regional Medical Center
Multiple Myeloma
A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant
This study is researching an experimental drug called linvoseltamab. The study is focused on participants with newly diagnosed multiple myeloma (NDMM) who are ineligible for autologous stem cell transplantation…
- Trial name
- NCT06932562
- Testing
- Linvoseltamab, Daratumumab, Lenalidomide
- Where
- 59 sites in Australia, Austria and 16 more
- Volunteers
- 1,000 people
- Sponsor
- European Myeloma Network B.V.
Preeclampsia, Preterm Birth
Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications
The Biobank includes data and biological specimens of women from three original studies: 1) First-trimester Prediction of Preeclampsia (PREDICTION Study, NCT02189148), 2) Pre-Eclampsia And growth Retardation, an evaluative…
- Conditions
- Preeclampsia, Preterm Birth, Pregnancy Complications, Fetal Anomalies
- Trial name
- NCT02744365
- Testing
- Observational
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Induction of Labor Affected Fetus / Newborn
Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)
A multicenter pragmatic randomized trial of nulliparous women undergoing a term (≥37 weeks) induction of labor wherein the provider intends to use a Foley catheter for cervical ripening.
- Trial name
- COMFORT (NCT05759988)
- Testing
- Outpatient Foley catheter
- Where
- 6 sites in United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Preterm PROM (Pregnancy)
Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM
Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1).
- Trial name
- NCT07119398
- Testing
- Oxytocin plus Foley Catheter, Oxytocin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Eastern Virginia Medical School
Anxiety
Pre-Examination Reflexology for Anxiety and Pain During Pelvic Examination
The purpose of this study is to evaluate whether a brief standardized reflexology session administered before the first pelvic examination reduces maternal state anxiety among term pregnant women admitted for induction of labor.
- Trial name
- NCT07910136
- Testing
- Pre-Examination Reflexology
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Goni Sintov
Fetal Growth Restriction
Prostaglandins Versus Trans-cervical Balloon for Induction of Labor in Fetal Growth Restriction (PROBIN)
The goal of this randomized trial is to compare two methods of induction in a fetal growth restriction population. The main question it aims to answer is: Is trans-cervical balloon superior to prostaglandins in reducing the…
- Trial name
- PROBIN (NCT05674487)
- Testing
- Trans-cervical balloon, Misoprostol
- Where
- France
- Volunteers
- 774 people
- Sponsor
- University Hospital, Bordeaux
Labor, Induced
Topical Anesthesia During Catheter Insertion for Cervical Ripening (TOLERANCE)
The goal of this RCT is to learn if application of topical anesthetic cream to the perineum and posterior wall of vagina prior to balloon catheter insertion as part of labor induction will reduce pain levels experienced by…
- Trial name
- TOLERANCE (NCT07288021)
- Testing
- Topical Analgesia with Lidocaine-Prilocaine cream
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Bnai Zion Medical Center
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Substance Use Disorders, Simulation Training
Interprofessional Simulation Program for Clinical Resilience and Empathy: Project INSPIRE
The goal of this clinical trial is to develop and evaluate INSPIRE, an intervention for healthcare teams to improve care for individuals with substance use disorder (SUD) during their peri-delivery care.
- Conditions
- Substance Use Disorders, Simulation Training, Pregnancy Related, Patient-centered Care
- Trial name
- INSPIRE (NCT07707115)
- Testing
- INSPIRE
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Utah
Propranolol, Labour Induction
Effects of Oral Propranolol on Induction-Delivery Interval During Induction of Labour With Oxytocin
Prolonged pregnancy could lead to perinatal and maternal complications. Oxytocin has been wildly used for induction of labour, but prolonged labour continued to occur with its attendant sequelae.
- Trial name
- NCT06960850
- Testing
- Propranolol
- Where
- Nigeria
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Federal Teaching Hospital Abakaliki
Induction of Labor, Cervical Ripening
Combined Nipple Stimulation and Foley Balloon for Cervical Ripening
Labor induction rates have increased substantially worldwide, and successful cervical ripening remains a key determinant of induction outcomes.
- Trial name
- NCT07317674
- Testing
- Foley balloon catheter with nipple stimulation, Mechanical cervical ripening with Foley catheter
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Ulcerative Colitis
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).
- Trial name
- MIGHTY (NCT07071519)
- Testing
- Risankizumab
- Where
- 73 sites in United States, Belgium and 14 more
- Volunteers
- 120 people
- Sponsor
- AbbVie
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Bronchopulmonary Dysplasia
Preliminary Study on Microplastics Deposition in Ventilator Circuit and the Risk of Bronchopulmonary Dysplasia in Premature Infants
In this study, the premature infants with gestational age less than 30 weeks were taken as the object, and the deposition characteristics of microplastics in ventilator circuit and its correlation with the risk of…
- Trial name
- Microplastics (NCT07848646)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Huiyi Li
Alcohol Use Disorder, Substance Use Disorders
Modification of Inhibitory Control and Craving Through Transcranial Direct Current Stimulation (tDCS) as an Add-On Treatment for Substance Use Disorder
The aim of this project is to investigate the potential of transcranial direct current stimulation (tDCS) to reduce cognitive deficits and substance craving in individuals with substance use disorders (SUD), with a focus on…
- Trial name
- NCT06959342
- Testing
- Transcranial direct current stimulation (tDCS), Inhibition Training
- Where
- 2 sites in Germany
- Volunteers
- 162 people
- Sponsor
- Central Institute of Mental Health, Mannheim