Clinical trials: Labor Induction
Pregnancy Related
Artificial Induction of Labour in Full-term Singleton Pregnancy : Comparative Randomized Trial of Two Strategies
Labour induction is an obstetrical procedure, which artificially starts the process of cervix dilation, in order to induce labour.
- Trial name
- BESTWAY (NCT04452747)
- Testing
- Vaginal Dinoprostone system (Propess®), Dilatation balloon
- Where
- 2 sites in France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Montpellier
Second Trimester Labor Induction
Second Trimester Labor Induction
A superior second trimester medical abortion regimen has not been identified. Studies suggest that a regimen of mifepristone and misoprostol given 36 to 48 hours apart has the shortest median induction-to-abortion interval…
- Trial name
- NCT00592215
- Testing
- Experimental (mifepristone and misoprostol)
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Prelabor Rupture of Membranes, Premature Rupture of Membrane
Labor Induction With Misoprostol Versus Oxytocin in Women With Premature Rupture of Membranes
This study compares the rate of vaginal delivery after induction of labor with misoprostol versus oxytocin in women with prelabor rupture of membranes.
- Trial name
- NCT04143685
- Testing
- Misoprostol, Oxytocin
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- sammour.rami
Binge Drinking
Brief Alcohol Intervention for School-to-Work Transitions
This is a 2-year research project to test the efficacy of brief motivational intervention for reducing heavy alcohol use in young adults transitioning out of high school.
- Trial name
- NCT01546025
- Testing
- Brief Motivational Counseling, Relaxation training
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Brown University
Nicotine Dependence
Effects of Chantix on Relapse Prevention for Smoking Cessation
The goal of the proposed study is to validate an experimental paradigm to assess medication effects on smoking relapse following a brief (3-day) monitored period of smoking abstinence and a programmed cigarette lapse.
- Trial name
- NCT00948649
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD)
The Correlation Between Red Cell Transfusion and Complications of Prematurity
The aim of this clinical trial is to learn if there is a correlation between the erythrocyte transfusion in the early neonatal period in premature infants and early and late complications of prematurity.
- Conditions
- Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD), Enterocolitis, Necrotizing, Intraventricular Hemorrhage Neonatal
- Trial name
- NCT07123948
- Testing
- Wechsler Intelligence Test, performed by educated psychologists
- Where
- Croatia
- Volunteers
- 128 people
- Sponsor
- Clinical Hospital Center Rijeka
Homelessness, Opioid Education and Naloxone Distribution (OEND)
Homeless Overdose Prevention- Expansion
Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in…
- Conditions
- Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder
- Trial name
- HOPE (NCT07716202)
- Testing
- Homeless Overdose Prevention- Expansion (HOPE) - Low Intensity, Homeless Overdose Prevention- Expansion (HOPE) - High Intensity
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- VA Office of Research and Development
Postpartum Hemorrhage
In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol
The rates of cesarean deliveries (CD) and postpartum hemorrhage (PPH) are on the rise, with failed induction and augmentation of labor as major contributing factors.
- Trial name
- NCT03434444
- Testing
- Oxytocin, Propranolol
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Induction of Labor Affected Fetus / Newborn
Vaginal Misoprostol and Foley Catheter for Induction of Labor
to compare between sequential and concurrent use of vaginal misopristol plus foleys catheter for induction of labor
- Trial name
- NCT02952807
- Testing
- Misoprostol, Foley Catheter
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Bronchopulmonary Dysplasia
Inhaled Budesonide for Non-ventilated Infants at High Risk of Bronchopulmonary Dysplasia: the i-BUD Pilot Study
Bronchopulmonary dysplasia (BPD) is one of the most important morbidities of preterm infants with a high incidence and significant impact on resource utilization and long-term outcome.
- Trial name
- NCT01895075
- Testing
- Inhaled budesonide, Normal saline
- Where
- Canada
- Sponsor
- Dr. Michael Dunn
Induction of Labor
Dilapan-S Versus Double Balloon Catheter (CRB) for Preinduction of Labor at Term
Induction of labor (IOL) is a frequently performed procedure in obstetrics, aimed to achieve vaginal delivery when continuing the pregnancy is no longer advisable.
- Trial name
- NCT07010653
- Testing
- Higroscopic Cervical ripening, Cervical ripening via CRB
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Labor Pain, Induction of Labor
Induction of Labor by Cervical Ripening and Transcutaneous Electrical Nerve Stimulation (TENS)
This study aims to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) for pain management during labor induction by cervical ripening.
- Trial name
- DETENS (NCT07494539)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS), Standard analgesic care
- Volunteers
- 132 people
- Sponsor
- HOT Noémie
Infant, Newborn, Infant, Low Birth Weight
Dexamethasone Therapy in VLBW Infants at Risk of CLD
Infants who are on breathing support are often treated with steroids (dexamethasone); however, the best timing of therapy is not known.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Dexamethasone (NCT00011362)
- Testing
- Dexamethasone Early, Dexamethasone Late
- Where
- 13 sites in United States
- Volunteers
- 371 people
- Sponsor
- NICHD Neonatal Research Network
Preeclampsia, Labor, Premature
Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia
A randomized controlled trial (RCT) of nitric-oxide donor (NOD) isosorbide mononitrate (IMN) versus placebo as an adjuvant to misoprostol/ intra-cervical Foley bulb for induction of labor to decrease rate of cesarean deliveries…
- Trial name
- NOPE (NCT03171480)
- Testing
- Monoket Pill
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Ohio State University
Bronchopulmonary Dysplasia
Safety and Efficacy Evaluation of PNEUMOSTEM® Treatment in Premature Infants With Bronchopulmonary Dysplasia
PNEUMOSTEM® is human umbilical cord blood derived mesenchymal stem cells and it is intended to treat premature infants with bronchopulmonary dysplasia. This study is to assess the safety and the efficacy of this study drug.
- Trial name
- NCT01297205
- Testing
- Human Umbilical Cord Blood Derived-Mesenchymal Stem Cells
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Medipost Co Ltd.
Pregnancy, Labor, Induced
Labor Induction With Oral Versus Vaginal Misoprostol
This study will compare vaginal and oral misoprostol, to determine whether a vaginal misoprostol regimen achieves a higher vaginal delivery rate in a real-world, high-volume setting, and whether this regimen reduces time and…
- Trial name
- NCT04755218
- Where
- United States
- Volunteers
- 2,546 people
- Sponsor
- University of Texas Southwestern Medical Center
Labor, Induced, Cervical Ripening
24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction
The aim of induction of labour is to initiate labour when maternal and fetal conditions necessitate delivery before the onset of spontaneous contractions.
- Trial name
- NCT00843362
- Testing
- Dinoprostone vaginal pessary, Dinoprostone vaginal gel
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- Università degli Studi di Brescia
Prematurity, Apnea
Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Most premature infants require mechanical ventilation for prolonged periods of time and a significant proportion of them develop Bronchopulmonary Dysplasia (BPD).
- Conditions
- Prematurity, Apnea, Respiratory Failure
- Trial name
- NCT01751724
- Testing
- Caffeine citrate, Normal saline
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Miami
Preeclampsia
Pravastatin for Prevention of Preeclampsia
The primary purpose of this pilot study is to determine the pharmacokinetic (PK) parameters and collect preliminary safety data for pravastatin when used as a prophylactic daily treatment in pregnant women at high risk of…
- Trial name
- Statin (NCT01717586)
- Testing
- Pravastatin
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetes, Gestational
Outpatient Cervical Ripening With Orally Administered Misoprostol in Diabetics
A. Null Hypothesis: In term pregnancies complicated by diabetes, there is no difference in the time interval from start of induction to delivery when outpatient cervical ripening and labor induction is initiated with orally…
- Trial name
- NCT00514618
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System