Clinical trials: Labor, Induced
Induced Labor, Cervical Ripening
Safety and Feasibility of the INGA Sensor System for Fetal and Uterine Monitoring During Cervical Ripening
The goal of this clinical trial is to learn about the safety and performance of the INGA Sensor System when used with the INGA balloon catheter during cervical ripening for labor induction in pregnant individuals at term.
- Conditions
- Induced Labor, Cervical Ripening, Cervical Ripening and Induction of Labor, Balloon Catheter for Labor Induction
- Trial name
- INGA-SENPe (NCT07846111)
- Testing
- Cervical ripening, labor Induction, uterus and fetal monitoring
- Where
- Estonia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aalto University
Labor Pain, Induced; Birth
Intracervical Balloon Placement With Nitrous Oxide Administration
This randomized controlled trial aims to compare the effectiveness of nitrous oxide versus oxygen in facilitating the successful placement of a Foley balloon catheter for cervical ripening and induction of labor.
- Trial name
- NCT06498908
- Testing
- Nitrous oxide, Oxygen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jefferson Drapkin
Labor, Pelvic Floor Disorder
Pelvic Floor Ultrasound Before Induction of Labour and Labour Outcome
Pregnancy and vaginal birth are the main causes of pelvic floor disorders such as urinary incontinence and pelvic organ prolapse.
- Conditions
- Labor, Pelvic Floor Disorder, Labor Stage, Second, Induced Labor
- Trial name
- LEVATOR-IOL (NCT07797387)
- Testing
- Three-dimensional transperineal pelvic floor ultrasound
- Where
- Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Labor, Induced, Cervical Ripening
Membrane Stripping for Cervical Ripening
The goal of this interventional study is to evaluate the effectiveness of membrane stripping in cervical ripening compared to double balloon catheter induction. The study population consists of women undergoing labor induction.
- Conditions
- Labor, Induced, Cervical Ripening, Balloon Induction, Membrane Stripping
- Trial name
- Stripping (NCT06591247)
- Testing
- Double Baloon Catheter, Membrane Stripping, PGE2
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Labor, Induced
Use of Papaverine to Shorten the Second Stage/Duration of Labor in Pregnant Women After Cervical Ripening by Double-balloon Catheter
This prospective, randomized, double-blind controlled trial aims to evaluate whether intravenous papaverine, administered immediately after the removal of a double-balloon catheter used for cervical ripening, can shorten the…
- Trial name
- NCT07237880
- Testing
- Papaverine 80 mg IV
- Where
- Israel
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Labor, Induced, Patient Preference
Should I Have an Elective Induction?
The goal of the proposed study is to perform a pilot test of a patient-centered decision support tool to help pregnant people and providers work together in making informed, shared decisions regarding whether or not to opt for…
- Trial name
- SELECTION (NCT05838313)
- Testing
- Elective Induction of Labor Decision Support Tool
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Gestational Diabetes, Hypertension in Pregnancy
Sleep Improvement Therapy Affects Pregnancy Outcomes in Chinese Singletons and Twins by Improving Sleep Quality
During pregnancy, the physical and psychological changes of pregnant women, hyperemesis gravidarum, uterine compression, frequent urination, hip or pelvic pain, back pain, leg cramps, gastroesophageal reflux, changes in mental…
- Conditions
- Gestational Diabetes, Hypertension in Pregnancy, Preterm Labor, NICU Infants
- Trial name
- NCT06687044
- Testing
- Sleep restriction, Stimulation control, Cognitive therapy
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Jun Wei
Induced; Birth, Labor Onset and Length Abnormalities
Papaverine and Oxytocin vs Oxytocin Alone in Labor Induction
This study aims to evaluate the efficacy and safety of combining papaverine with oxytocin for labor induction compared to oxytocin alone
- Trial name
- NCT06547437
- Testing
- Papaverine, normal saline
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Western Galilee Hospital-Nahariya
Labor Onset and Length Abnormalities, Induced; Birth
Comparison of Misoprostol Ripening Efficacy With Dilapan
The purpose of this study is to find out if Dilapan works as well as Misoprostol for preparing the mouth of the uterus (cervix) for inducing labor in women who need to undergo this procedure.
- Trial name
- COMRED (NCT03670836)
- Testing
- Dilapan, Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Columbia University
Labor; Forced or Induced, Affecting Fetus or Newborn, Labor Onset and Length Abnormalities
Clinical Evaluation of Cervical Ripening in the Outpatient Setting
A randomized controlled trial of mifepristone 200mg vs balloon catheter for cervical ripening.
- Trial name
- NCT04271722
- Testing
- Cervical ripening
- Where
- Portugal
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Lisboa Norte
Labor Complication, Induced; Birth
SAINT: Safe Induction of Labor Trial
Over the past years, the rates of labor induction have increased steadily, and at present more than one in four births occurs after induced labor in Norway.
- Conditions
- Labor Complication, Induced; Birth, Pregnancy Related
- Trial name
- SAINT (NCT05719467)
- Testing
- Buscopan 20 MG/ML Injectable Solution, Sodium bicarbonate, Nacl 0.9%
- Where
- 5 sites in Norway
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Induced; Birth
The REDUCED-I Pilot Trial: REDucing the Utilization of CEsarean Sections With Induction
This pilot project is a randomized controlled trial where induced patients receive an intervention of oxytocin discontinuation once in the active stage of labor (≥6 cm dilation).
- Trial name
- (REDUCED-I) (NCT05037617)
- Testing
- Continuation or discontinuation of oxytocin during the active first stage of labor (≥6 cm dilation).
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Labor, Induced, Induced; Birth
Effect of Acidic Vaginal pH on the Efficacy of Dinoprostone for Labor Induction
Acidification of vaginal pH has been proposed as a potential factor that could help increase the efficacy of vaginal prostaglandins in labor induction.
- Trial name
- NCT05100264
- Testing
- Vaginal washing with 5% acetic acid, Vaginal washing with 0.9% NS
- Where
- Greece
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Alexandra Hospital, Athens, Greece
Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension
No-worry Baby Project
The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension, Thyroid Disease Pregnancy, Obesity
- Trial name
- NCT03922087
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,216 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Labor, Induced, Obesity
Misoprostol for Induction of Labor in Obese Women: Comparison Between 25 and 50 mcg Oral Administration
In recent decades, obesity has become a prevalent issue in Portugal, with 38.6% and 13.8% of the population being overweight or obese, respectively.
- Conditions
- Labor, Induced, Obesity, Pregnancy, Cesarean Section
- Trial name
- NCT05857059
- Testing
- Misoprostol 25 mcg, Misoprostol 50 mcg
- Where
- Portugal
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Labor Induction, Induced Delivery
Foley Catheter Versus PGE2 for Labor Induction at Term: a Pilot Study
Induction of labor is one of the most common interventions in obstetrics. In the past decade, the rates of labor induction at term have doubled from approximately 9% to 23% in the United States and from 10% to 20.4% in China.
- Trial name
- NCT04780269
- Testing
- Induction of labor with Foley catheter, Induction of labor with PGE2
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Labor, Induced, Cervix Uteri-Diseases
Comparing Outpatient to Inpatient Cervical Ripening Using Dilapan-S®
The target population for our study is women who present for induction of labor. If there is a decision by the obstetrical team to place a mechanical dilator for cervical ripening, the obstetrical team will notify the research…
- Trial name
- HOMECARE (NCT03665688)
- Testing
- Outpatient Dilapan-S, Inpatient Dilapan-S
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Labor, Induced
'Extended Balloon Catheter' Labour Induction; a Single Arm Pilot Trial'
The overall aim of the single arm pilot study was to assess the effectiveness, safety and acceptance of the 'extended balloon catheter' as a method of induction of labour in women receiving care at Princess Marina Hospital(PMH)…
- Trial name
- NCT05885087
- Testing
- Foley or balloon catheter
- Where
- Botswana
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Botswana
Labor, Induced, Labor, Obstetric
Prediction of Spontaneous Onset of Labor at Term
The study intends to develop a predictive model of spontaneous onset of labor between 39 and 41 weeks of pregnancy in women carrying singletons and without indication of delivery before this date.
- Conditions
- Labor, Induced, Labor, Obstetric, Labor Onset, Predictive Model
- Trial name
- PREDICT (NCT05109247)
- Where
- 3 sites in Switzerland
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Labor, Induced, Cervical Ripening
Labor Induction With a Combined Method (Pharmacologic and Mechanical): Randomized Controlled Trial
Labor induction is a common pregnancy procedure worldwide. Both mechanical and pharmacologic agents are used for induction of labor. These agents reduce the incidence of cesarean delivery in women undergoing induction.
- Trial name
- NCT03928600
- Testing
- Cervical Foley combined with Misoprostol, Dinoprostone 10mg insert OR, Misoprostol
- Where
- Portugal
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar De São João, E.P.E.