Clinical trials: LET
COVID19
Let It Out (LIO) and COVID19: Testing an Online Emotional Disclosure-based Intervention During the COVID19 Pandemic
A randomised controlled trial designed to test whether an online expressive writing intervention (LIO-C) can reduce distress for English-speaking adults during the global COVID19 pandemic.
- Trial name
- LIO-C (NCT04386668)
- Testing
- Let It Out (LIO)-C, Neutral writing control
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University College, London
Lupus Erythematosus, Cutaneous
Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus
To evaluate the therapeutic effect of oral alitretinoin (Toctino®) in the treatment of CLE with respect to proportion of responders based on the Revised Cutaneous Lupus Disease Area and Severity Index (RCLASI) activity score for…
- Trial name
- AliCLE (NCT01407679)
- Testing
- Alitretinoin
- Where
- 3 sites in Germany
- Volunteers
- 7 people
- Sponsor
- University Hospital Muenster
ACL, LET
Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using a Single-bundle Technique and External Tenodesis With Achilles Tendon Allograft.
Several techniques for revision of anterior cruciate ligament (ACL) reconstruction and different types of grafts have been used over the years.
- Trial name
- ACL_REVISION (NCT06868147)
- Where
- Italy
- Volunteers
- 59 people
- Sponsor
- Stefano Zaffagnini
ACL, LET
Outcomes and Complication Rates of Anterior Cruciate Ligament Reconstruction Using the "Over-the-top" Technique Combined With Lateral Extra-articular Tenodesis in Patients Over 50 Years Old, Compared With a Control Group of Patients Under 30
The anterior cruciate ligament (ACL) is one of the main stabilizers of the knee, and its injury is among the most common soft tissue injuries of the knee.
- Conditions
- ACL, LET, Hamstring Muscles
- Trial name
- ACL_50_YO (NCT07041242)
- Testing
- ligament reconstruction using the single-bundle "over-the-top" technique
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- Stefano Zaffagnini
Stress, Sleep Disturbance
Let´s Talk About Sleep in College Student
The concern about the quality of sleep of university students, future professionals of the world, must be crucial for the scientific community, as well as for university professors and professors.
- Trial name
- USLEEP (NCT05265494)
- Testing
- Non invasive neuromodulation NESA (XSIGNAL device)
- Where
- 2 sites in Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Las Palmas de Gran Canaria
Parent Training, Parent Child Relationship
Hold me Tight/Let me Go: Effectiveness of a Course to Enhance Parent-adolescent Relationship
HmT/LmG is a group course for 4-6 parental dyads and consists of 4 group sessions with psycho-education and skills training and 3 individual sessions per family (i.e., 1 session with the adolescent, 1 session with the parents…
- Conditions
- Parent Training, Parent Child Relationship, Parent-child Problem
- Trial name
- NCT06966323
- Testing
- Hold me Tight / Let me Go
- Where
- 5 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- University of Amsterdam
ACL Reconstruction, Tenodesis
Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET)
The anterior cruciate ligament (ACL) is one of the main stabilizers of the knee joint, and its injury is among the most common soft tissue injuries of the knee.
- Conditions
- ACL Reconstruction, Tenodesis, ACL Injuries
- Trial name
- LETOTT (NCT07049484)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Stefano Zaffagnini
Heart Diseases
Creation of an ECG Database in 3T MRI With Healthy Heart and Several Kind of Cardiac Disease.
The aim is to create a database including recordings of ECG data recorded in an MRI acquisition
- Trial name
- DB-ECG-3T (NCT02562534)
- Testing
- MRI compatible ElectroCardioGraph
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Children's Wellbeing, Child Overall Health Related Quality of Life
Let´s Talk About Children Intervention in a School Context
The aim of this study is to examine the fidelity, the perceived benefits, and the effectiveness of the Let's Talk about Children (LTC) -intervention in a school context.
- Conditions
- Children's Wellbeing, Child Overall Health Related Quality of Life, Burnout
- Trial name
- NCT05038280
- Testing
- Let's Talk about Children intervention
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Anterior Cruciate Ligament Injuries
ALL Reconstruction Versus Modified Lemaire's LET in Combination With ACL Reconstruction With a Minimum Follow up of 2 Years
Anterior cruciate ligament (ACL) tears are associated with concomitant lesions of the anterolateral ligament (ALL), which increase rotatory instability of the knee.
- Trial name
- ARAVET (NCT06147427)
- Testing
- ACL reconstruction with hamstrings combined with ALL plasty, ACL reconstruction with hamstrings combined with modified Lemaire's LET
- Where
- France
- Volunteers
- 248 people
- Sponsor
- Hospices Civils de Lyon
Appendicitis
Laparoscopic Versus Open Appendectomy? Let the Patient Decide
This protocol examines choice where it pertains to choosing between two standard methods for appendectomy, laparoscopic or open procedures, and the affect that "cost" of the appendectomy has upon choice.
- Trial name
- NCT01738750
- Testing
- Cost Information Included
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Fibromyalgia
LET for Fibromyalgia
The study is a double blinded, randomized, sham-controlled, parallel group trial conducted at UT Southwestern (UTSW) Medical Center.
- Trial name
- NCT07201818
- Testing
- Lymphatic Enhancement Technology (LET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Anal Canal Squamous Cell Carcinoma, Stage I Anal Cancer AJCC v8
Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial
This phase II trial studies the side effects of LET-IMPT and standard chemotherapy, and how well they work in treating patients with newly diagnosed stage I-III anal canal squamous cell cancer.
- Conditions
- Anal Canal Squamous Cell Carcinoma, Stage I Anal Cancer AJCC v8, Stage II Anal Cancer AJCC v8, Stage IIA Anal Cancer AJCC v8
- Trial name
- NCT03690921
- Testing
- Cisplatin, Fluorouracil, Linear Energy Transfer-Optimized Intensity Modulated Proton Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Lactation Disorders
The Relationship Between Oxytocin Massage in Mothers With Insufficient Milk Production in the Early Postpartum Period and Breastfeeding Self-Efficacy and Milk Let-down Reflex: A Randomized Controlled Study
This randomized controlled trial aims to evaluate the effects of oxytocin massage on breastfeeding self-efficacy and the milk ejection reflex among mothers experiencing insufficient milk supply in the early postpartum period.
- Trial name
- NCT07609693
- Testing
- Oxytocin Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Anterior Cruciate Ligament Reconstruction (ACLR)
The Effect of Lateral Extra-Articular Tenodesis on Lower-Extremity Lean Mass Recovery Following Anterior Cruciate Ligament Reconstruction
The purpose of this study is to determine whether the addition of Lateral Extra-Articular Tenodesis (LET) influences postoperative lower-extremity LM recovery following bone-patellar tendon-bone (BTB) Anterior Cruciate Ligament…
- Trial name
- NCT07777458
- Testing
- Bone-patellar Tendon-bone (BTB), Bone-patellar Tendon-bone (BTB) and Lateral Extra-Articular Tenodesis (LET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Dementia, Mild, Mild Cognitive Impairment (MCI)
The "Let's Talk Tech" Tool to Support Decision Making About Technology Use
The goal of this research is to educate people about different technologies to support care at home when someone is experiencing memory difficulties.
- Trial name
- NCT06817122
- Testing
- Let's Talk Tech
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- University of Washington
Active tDCS, Sham tDCS
Combination of Neurostimulation and Psychotherapy to Stop Worrying
This study aims to investigate whether the combination of transcranial Direct Current Stimulation (tDCS) and cognitive-behavioral therapy (CBT) is more effective for treating repetitive negative thinking (RNT) in patients with…
- Trial name
- NCT06369532
- Testing
- Active tDCS
- Where
- Belgium
- Volunteers
- 85 people
- Sponsor
- University Hospital, Ghent
LET, ACL Reconstruction
Long-term Follow up of the Stability 1 Trial
From 2014-2017, across 7 Canadian and 2 European sites, we randomized 618 patients at high-risk of re-injury, to anterior cruciate ligament reconstruction (ACLR) with or without a lateral extraarticular tenodesis (LET) and…
- Conditions
- LET, ACL Reconstruction, Osteoarthritis (OA) of the Knee
- Trial name
- STABILITY LTF (NCT06885372)
- Testing
- Lateral Extra-Articular Tenodesis (LET), ACL Reconstruction
- Where
- 8 sites in Canada, United Kingdom
- Volunteers
- 510 people
- Sponsor
- Western University, Canada