Clinical trials: Knee Prosthesis
Amputation
Active Knee Prosthesis Study for Improvement of Locomotion for Above Knee Amputees
The purpose of this study is to develop a robust, low-power, stable, and light weight, active knee prosthetic device that can dramatically increase gait symmetry and walking economy of a transfemoral amputee during walking.
- Trial name
- NCT00771589
- Testing
- Active Knee Prosthesis
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Providence VA Medical Center
Arthroplasty Complications, Amputation
Clinical Trial Comparing Negative Pressure Wound Therapy and Standard Dry Dressings
Negative pressure dressings are currently widely used in wound management. Their use is gradually being extended to surgical scars.
- Conditions
- Arthroplasty Complications, Amputation, Prosthesis-Related Infections
- Trial name
- BERLYTZ (NCT04520841)
- Testing
- Prevena TM, Dry dressing
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Deep Vein Thrombosis
Influence of Tourniquet Use and Surgery Duration on the Incidence of Deep Vein Thrombosis in Total Knee Arthroplasty
This is an observational study to analyze the influence of surgery duration and tourniquet time in the incidence of deep venous thrombosis (DVT) in patients that had undergone total knee arthroplasty (TKA).
- Trial name
- NCT01559532
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- University of Sao Paulo General Hospital
Total Knee Arthroplasty
Effection of Total Knee Arthroplasty on Knee Joint
The aim of this study is to evaluate the joint position sense of individuals diagnosed with knee osteoarthritis and who have undergone unilateral total knee arthroplasty surgery, and to examine the effect of joint position sense…
- Trial name
- NCT05965765
- Testing
- Total knee arthroplasty, osteoarthritis without surgery, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KTO Karatay University
Osteoarthritis, Arthritis, Rheumatoid
Primary TKA Cruciate Retaining vs Cruciate Substituting With Rotating Platform Knee Prostheses
The purpose of the study is to evaluate the clinical performance of the cruciate ligament retaining or cruciate ligament substituting implants by obtaining a series of primary TKAs.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Avascular Necrosis of Bone, Post-traumatic Arthritis
- Trial name
- NCT00289081
- Testing
- Total Knee Replacement
- Where
- 4 sites in United States
- Volunteers
- 399 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis of Knee
Stability of the Medial Pivot Total Knee Prosthesis
The purpose of this study is to compare objective and subjective measures of knee stability following total knee arthroplasty with a medial pivot design vs. a posterior stabilized design.
- Trial name
- NCT02577978
- Testing
- Medacta GMK posterior stabilized prosthesis, Medacta GMK Sphere prosthesis
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Northwestern University
Amputation of Hip and Thigh, Level Unspecified
Assessment of Disability Compensation With the C-LEG COMPACT 2 Knee (Ref. 3C60 et 3C60=ST)
Moderately active amputees may have lost their limb due to diabetes, vascular conditions, trauma, tumour or congenital causes. These amputees currently cannot benefit from having a computerised knee because of the performance…
- Trial name
- NCT02382991
- Testing
- 3C60-NMPK, NMPK-3C60
- Where
- 15 sites in Austria, France and 1 more
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Otto Bock France SNC
Prosthetic Joint Infection, Prosthetic Infection
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the…
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Hip Prosthesis Infection, Knee Prosthesis Infection
- Trial name
- NCT04488458
- Testing
- MIC or MBEC+MIC based treatment algorithm
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Arthritis of the Knee
Unity Total Knee Replacement Using Two Different Surgical Techniques
This study will compare two different surgical methods used in total knee replacement with the Unity Total Knee Replacement System.
- Trial name
- NCT02145455
- Testing
- Unity Total Knee Replacement System
- Where
- United Kingdom
- Volunteers
- 111 people
- Sponsor
- Corin
Lower Limb Amputation Above Knee (Injury)
Assessment of the Prosthetic System Impact on Mental Workload in Above-knee Lower Limb Amputees.
New generation of lower limb prosthesis provide improved functionalities. They are usually studied in the scope of biomechanics, sometimes PROMs like quality of life.
- Trial name
- INCREMENT (NCT06635655)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Proteor Group
Amputations, Traumatic
Gait Evaluation of Experienced Below Knee Amputees
Post traumatic amputees with an experience of over 3 months of prosthesis use at home, without any known difficulty using the prosthesis and without stump pathology, using no assistive devices, will be examined in a 3 D…
- Trial name
- NCT00353626
- Where
- Israel
- Volunteers
- 9 people
- Sponsor
- Sheba Medical Center
Total Knee Arthroplasty, Osteoarthritis
A Study to Compare the NexGen LPS and LPS-Flex Knee Implants
The purpose of this study is to test for significant differences in functional outcomes obtained by using a NexGen LPS versus a NexGen LPS-Flex knee implant.
- Trial name
- NCT00763386
- Testing
- NexGen LPS-Flex Fixed Bearing Knee, NexGen Legacy Posterior Stabilized Knee
- Where
- 15 sites in United States, Canada
- Volunteers
- 331 people
- Sponsor
- Zimmer Biomet
Implant Infection, Skeletal Sarcoma
Implant-Related Infections in Patients With Skeletal Sarcomas
The aim of this observational study is to gain knowledge on the microbial and immunological factors behind implant-related infections in patients with skeletal sarcoma.
- Conditions
- Implant Infection, Skeletal Sarcoma, Hip Arthritis, Prosthesis-Related Infections
- Trial name
- IRISSAR (NCT07264296)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Mutars, Modular Universal Tumor And Revision System
Metal-ions in Patients With the PEEK HD Coupling Mechanism of the Knee
The goal of this observational study is to evaluate the changes of serum metal ion (Cobalt and Chrome) levels at 0, 3-6, 12, and 24 months postoperative in patients receiving a MUTARS mega-prostheses of the knee with a PEEK HD…
- Conditions
- Mutars, Modular Universal Tumor And Revision System, Metal-ions, Tumor Prosthesis
- Trial name
- MIONS (NCT05893602)
- Testing
- Blood sample analysis
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Lower Limb Amputation Above Knee (Injury)
Comparative Effectiveness Between Microprocessor Knees and Non-Microprocessor Knees
This study will assess if the functional performance and musculoskeletal outcome of transfemoral amputees are improved after receiving a Microprocessor Knee (MPK) compared to a Non-Microprocessor Knees (NMPK).
- Trial name
- MPK-AOPA (NCT02240186)
- Testing
- Microprocessor Knee (MPK), Non-Microprocessor Knee (NMPK)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Gonarthrosis; Primary, Degenerative Joint Disease of Knee
The Effect of Three Prosthesis Designs in Total Knee Arthroplasty
The purpose of this study is to compare three prosthesis designs to compare three prosthesis designs for total knee arthroplasty and determine the best option for patients in need of a knee replacement.
- Trial name
- NCT03059927
- Testing
- Knee arthroplasty, Cruciate retaining, Knee arthroplasty, Anterior stabilized, Knee arthroplasty, Posterior stabilized
- Where
- 2 sites in Norway
- Volunteers
- 216 people
- Sponsor
- Lovisenberg Diakonale Hospital
Knee Osteoarthritis
Prosthesis and Surgery Guide System for Personalized Total Knee Arthroplasty
The subject is planned to carry out the clinical trails of femoral condyle prosthesis, tibial tray prosthesis and meniscus prosthesis; At the same time, in order to achieve personalized precision bone resection, the clinical…
- Trial name
- NCT04963491
- Testing
- Personalized TKA prosthesis, Zimmer NexGen prostheses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital