Clinical trials: Knee Prosthesis
Osteoarthritis
The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty
The purpose of this study is to evaluate the long-term clinical and functional performance of the P.F.C. Sigma Rotating Platform TC3 knee system in revision knee surgery and to determine whether the implant design results in a…
- Trial name
- TC3 (NCT00733681)
- Testing
- PFC Sigma RP TC3 Revision knee system
- Where
- 9 sites in France, Germany and 2 more
- Volunteers
- 181 people
- Sponsor
- DePuy International
Knee Arthritis, Knee Osteoarthritis
In-vivo Wear Behaviour of AS Coated Versus Uncoated Columbus® Total Knee Prosthesis
This clinical study is a Post-Market Clinical Follow-Up (PMCF) measure and is aiming to compare the in-vivo wear behaviour of the Columbus® total knee prosthesis between the standard Cobalt Chromium (CoCr) and the multilayer…
- Conditions
- Knee Arthritis, Knee Osteoarthritis, Primary Osteoarthritis of Knee Nos, Secondary Osteoarthritis of Knee Nos
- Trial name
- COLRAS (NCT05509972)
- Testing
- total knee prosthesis implantation
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Aesculap AG
Complications; Arthroplasty
In Vivo Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant
A better understanding of knee joint kinematics is important to explain the premature polyethylene wear failures within total knee arthroplasties (TKAs) and to help design a prosthesis that most closely approximates the normal…
- Trial name
- NCT01882751
- Testing
- Conformis CR Total Knee Replacement, Off the Shelf
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Restor3D
Prosthesis User, Lower Limb Amputation Below Knee (Injury)
Caesar Foot Take-Home Validation Testing
The rationale for this study is to conduct a take-home clinical trial to evaluate the impact of the bimodal Caesar foot in a real-world environment.
- Trial name
- NCT07075198
- Testing
- Caesar Foot
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Liberating Technologies, Inc.
Osteoarthritis, Knee, Osteoarthrosis of Knee
Univation XM France
The study is set up due to regulatory purposes and to collect routine clinical data of the mobile-bearing implant univation XM. The study is designed as a prospective follow-up study with a historic patient cohort who have been…
- Conditions
- Osteoarthritis, Knee, Osteoarthrosis of Knee, Arthritis Knee, Unicompartmental Knee Arthroplasty
- Trial name
- NCT04199481
- Where
- France
- Sponsor
- Aesculap AG
Osteoarthritis, Knee
Investigational Testing of Bodycad Unicompartmental Knee Prosthesis (UKS)
This study is designed to observe clinical outcomes of patient-specific knee arthroplasty in patients with osteoarthritis of the medial condyle.
- Trial name
- NCT03432481
- Testing
- Unicompartmental Knee Arthroplasty Surgery, Bodycad Unicompartmental Knee System (BUKS)
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Laboratoires Bodycad Inc.
Hip Prosthesis Infection, Knee Prosthesis Infection
Proof of Concept Study to Assess Safety and Efficacy of Phage Therapy in Hip or Knee Prosthetic Joint Infections Due to Staphylococcus Aureus Treated by DAIR.
Total joint replacements are effective for chronic pain but can lead to Prosthetic Joint Infections (PJI), primarily caused by Staphylococcus aureus and resistant to antibiotics.
- Trial name
- GLORIA (NCT06605651)
- Testing
- Anti-Staphylococcus aureus Bacteriophages (PP1493 and PP1815) intra-articular injection with 0.9% NaCl solution, 0.9% NaCl solution
- Volunteers
- 100 people
- Sponsor
- Phagenix
Osteoarthritis
A Randomized Control Trial to Assess Early Clinical and Functional Outcome of the ROCC and LCS Total Knee Implant Designs
This is a prospective Randomised Control Trial to compare the Early Clinical and Functional Outcome of the ROCC and LCS total knee arthroplasty implant designs.
- Trial name
- NCT00755144
- Testing
- LCS Knee, ROCC Knee
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Evaluation of the Latella™ Knee Implant System for Medial Osteoarthritis Pain Reduction
The objective of the Latella-US study is to demonstrate the safety and efficacy of the Latella Knee Implant System for the reduction of medial osteoarthritis pain.
- Trial name
- Latella-US (NCT02608957)
- Testing
- Latella Knee Implant System
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Cotera, Inc.
Osteoarthritis
A Post-Market Retrospective Study on Revision Total Knee Arthroplasty Using Medacta GMK® Revision Prosthesis
This is a retrospective, single-site observational study, designed to assess the clinical outcomes and collect safety data of GMK Revision knee system used for primary or revision total knee arthroplasty at minimum two years…
- Trial name
- NCT02912351
- Testing
- Patient record review, Radiographs, and questionaires.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Prosthesis User, Amputation
Clinical Investigation (Beta) of Power Knee Mainstream - Dynamic
Prospective two group cross over investigation, comparing the investigational device (Power Knee, a powered microprocessor controlled prosthetic knee) and subjects prescribed microprocessor prosthetic knee (MPK).
- Trial name
- NCT04787627
- Testing
- Power Knee
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Össur Iceland ehf
Knee Arthropathy
Post-market Clinical Follow-up on the balanSys UNI Knee Prosthesis Implanted With a Spacer Block Surgical Technique
The purpose of the study is the evaluation of the clinical and radiological long-term performance of the balanSys UNI fix in a multicenter routine clinical setting.
- Trial name
- NCT04598568
- Testing
- balanSys UNI
- Volunteers
- 116 people
- Sponsor
- Mathys Ltd Bettlach
Knee Arthroplasty
VEGA System® Study in the Total Knee Arthroplasty
This post-market clinical follow-up study intends to investigate long-term functionality of the VEGA System®. The design of the VEGA System® is meant to provide the patient with more knee mobility compared to their pre-operative…
- Trial name
- NCT02944409
- Testing
- total knee prothesis VEGA System
- Where
- 2 sites in France
- Volunteers
- 125 people
- Sponsor
- BBraun Medical SAS
Surgical Wound, Revision Total Knee Arthroplasty
Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty
This study evaluates surgical site complications in subjects undergoing revision of a total knee arthroplasty when closed incision negative pressure therapy is used to manage the closed incision, as compared to a standard of care…
- Conditions
- Surgical Wound, Revision Total Knee Arthroplasty, Wounds and Injuries, Joint Disease
- Trial name
- PROMISES (NCT03274466)
- Testing
- Closed Incision Negative Pressure Therapy (ciNPT), Standard of Care Dressing
- Where
- 17 sites in United States
- Volunteers
- 294 people
- Sponsor
- KCI USA, Inc
Peripheral Arterial Disease, Peripheral Vascular Disease
Evaluation of the Safety and Efficacy of a Vascular Prosthesis as an Above-Knee Bypass Graft in Patients With PAD
The purpose of this study is to assess the safety and efficacy of a novel, tissue-engineered vascular prosthesis, the Human Acellular Vessel (HAV).
- Trial name
- NCT01872208
- Testing
- HAV implantation
- Where
- 3 sites in Poland
- Volunteers
- 20 people
- Sponsor
- Humacyte, Inc.
Post-Meniscectomy Pain Syndrome, Osteoarthritis, Knee
The SUN Clinical Trial (Safety Utilizing NUsurface Meniscus Implant)
The NUsurface® Meniscus Implant SUN Clinical Trial is a multi-center, single-arm, prospective, open label, non-randomized, observational clinical trial to gather safety and probable clinical benefit data on the NUsurface®…
- Trial name
- SUN (NCT02483988)
- Testing
- NUsurface® Meniscus Implant
- Where
- 13 sites in United States
- Volunteers
- 115 people
- Sponsor
- Phoenix Kinetics
Knee Osteoarthritis
A Prospective Study to Evaluate the iTotal Knee and iPoly XE Tibial Inserts
This study is designed to evaluate the clinical outcomes of subjects who have recently undergone surgery with the iTotal® Cruciate Retaining (CR) Total Knee Replacement System (KRS) who have also had iPoly XE Tibial Inserts…
- Trial name
- NCT03289754
- Testing
- iPoly XE tibial insert with ConforMIS iTotal KRS
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Restor3D
Osteoarthritis
Evaluation of the Latella Knee Implant System for Medial Osteoarthritis Pain Reduction (Latella-2 Study)
The objective of the Latella-2 study is to demonstrate the safety and efficacy of the Latella Knee Implant System for the reduction of medial osteoarthritis knee pain.
- Trial name
- NCT02343705
- Testing
- Latella Knee Implant System
- Where
- 12 sites in Netherlands, Spain and 1 more
- Volunteers
- 67 people
- Sponsor
- Cotera, Inc.
Total Knee Replacement
ORIGIN® PS Modular & Associated Instruments
The study objective is to evaluate safety and performance of the ORIGIN® PS (postero-stabilized) Modular devices and associated instruments, more precisely to evaluate safety by the proportion of patients requiring a revision…
- Trial name
- NCT06628050
- Testing
- ORIGIN® PS Modular devices
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Symbios Orthopedie SA
Amputation, Prosthesis User
Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators
The goal of this study is to find out if using microprocessor-controlled prosthetic knees (MPKs), prosthetic knees with a built-in computer, improves health outcomes related to falls in adults who use above-knee prostheses.
- Conditions
- Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower
- Trial name
- NCT06937242
- Testing
- Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hanger Institute for Clinical Research and Education, LLC