Clinical trials: Knee Arthroplasty
Knee Replacement Surgery
The Effect of a Prolonged Peripheral Nerve Block on the Level of Pain After a Knee Replacement
The aim of this study is to examine the effect of a prolonged peripheral nerve block (utilizing continuous adductor canal block) on the level of pain after a knee replacement surgery
- Trial name
- NCT06382285
- Testing
- Continues peripheral block
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Total Knee Replacement
Effectiveness of Acupuncture as an Adjunct to Rehabilitation After Knee Arthroplasty
No randomized trials have tested the effectiveness of acupuncture as a supplement to rehabilitation after total knee replacement.
- Trial name
- NCT00935155
- Testing
- Acupuncture, exercises
- Where
- Denmark
- Volunteers
- 170 people
- Sponsor
- Back and Rehabilitation Center, Copenhagen
Osteo Arthritis Knee and Hip, Lower Limb Arthroplasty
Lower Limb Arthroplasty: Effects of a Tele Prehabilitation Program With Indirect Electrostimulation.
Preoperative fitness is known to predict postoperative outcomes following lower limb arthroplasty, but many patients, especially the most fragile, arrive at surgery with reduced mobility and functional capacity.
- Trial name
- NCT06363643
- Testing
- ELECTROSTIMULATION (ES), EXERCISE (C)
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- University of Pavia
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Impact of Integrated Care Pathways for Prevention of Post-operative Urinary Retention (POUR)
A prospective randomized control trial will be conducted at Good Samaritan Hospital and TriHealth Evendale Hospital. Subjects will receive total hip or knee surgery and follow-up via standard care at the discretion of the…
- Conditions
- Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Urinary Retention
- Trial name
- POUR (NCT03863743)
- Testing
- integrated care pathway, physician's standard of care
- Where
- 2 sites in United States
- Volunteers
- 164 people
- Sponsor
- TriHealth Inc.
Knee Osteoarthritis, Hip Osteoarthritis
Telemedicine in Total Hip Arthroplasty and Total Knee Arthroplasty
The objective of this study is to evaluate patient perspective on telemedicine used in 3 week post operative visits for knee and hip arthroplasty.
- Trial name
- NCT03961711
- Testing
- Telemedicine, In-Person Clinic Visit
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- The Hawkins Foundation
Knee Osteoarthritis
Comparison of the in Vivo Stability of 2 Cementless TKA Designs
The goal of this randomized controlled trial is to analyze the stability of a cementless Total Knee Arthroplasty (TKA) over time and compare it to a well-documented implant in patients with knee osteoarthritis.
- Trial name
- ClessTKA (NCT05651009)
- Testing
- TKA
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Helse Møre og Romsdal HF
Knee Arthroplasty
First Mobilization Protocol for Total Knee Arthroplasty Patients
This single blinded randomized controlled study evaluates the effect of developed First Mobilization Protocol applied to knee arthroplasty patients on state anxiety, kinesiophobia, initial mobilization related symptoms.
- Trial name
- NCT06268899
- Testing
- First mobilization protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Gazi University
Nausea and Vomiting, Postoperative
10% Carbohydrate Drink for Preventing Post-operative Nausea and Vomiting (PONV) After Spinal Morphine
PONV after intrathecal morphine, occurs up to 30-40 percent. The patients having TKR normally are female, obese and non-smoker which are risk factors for PONV.
- Trial name
- NCT01301404
- Testing
- 10% carbohydrate drink
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Mahidol University
Osteoarthritis, Osteoarthritis, Knee
Oxford Signature vs. Conventional Global Study
This study will compare alignment criteria in the Oxford Partial Knee using conventional instrumentation and Signature Custom Guides in order to determine if the use of the Signature Custom Guides results in a higher percentage…
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Osteonecrosis
- Trial name
- NCT01763684
- Testing
- Signature Custom Guides, Conventional Instrumentation
- Where
- 7 sites in United States
- Volunteers
- 266 people
- Sponsor
- Zimmer Biomet
Inflammation, Surgery
The Effects of Lipinova on Inflammatory and Proresolving Lipid Mediator Profiles After Orthopedic Surgery
The aim of this pilot study is to investigate whether pre-operative supplementation with an over the counter dietary supplement containing a fractionated marine lipid concentrate derived from anchovy and sardine oil, Lipinova®…
- Trial name
- NCT03434236
- Testing
- low dose Lipinova (30 mL daily), high dose Lipinova (60mL)
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Total Knee Anthroplasty, Osteoarthritis(Primary)
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA.
- Conditions
- Total Knee Anthroplasty, Osteoarthritis(Primary), Osteoarthritis (OA) of the Knee, Bilateral Knee Osteoarthritis
- Trial name
- COSTI (NCT06809998)
- Testing
- Corticosteroid Injection - 80mg methylprednisolone (total volume 2ml) with 6 mL of 1% Bupivacaine without epinephrine (Total Volume 8 mL)., Band-Aid
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Knee Arthroplasty, Total
Functional Impact at 12 Months Post-op of Posterior Cruciate Ligament Conservation During Robotic-assisted Surgery (MAKO) for Total Knee Replacement.
Studies have been made on the best way to do knee surgery and whether to conserve the posterior cruciate ligament or not during total knee prosthesis insertion is still under debate.
- Trial name
- LCPTG (NCT07489963)
- Testing
- Total knee arthroplasty
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Frail Elderly, Arthroplasties Hip Replacement
Frailty in Hip or Knee Arthroplasty Patients.
The study aims to understand the existing differences between frail and non-frail subjects who underwent a rehabilitation path after receiving hip or knee arthroplasty surgery.
- Conditions
- Frail Elderly, Arthroplasties Hip Replacement, Arthroplasty Knee
- Trial name
- FRAKH (NCT07086716)
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- Joel Pollet
Postoperative Pain Management in Total Knee Arthroplasty
Phase Ⅱ Study of Adductor Canal Block With HR18034 for Postsurgical Pain Management in TKA
Phase Ⅱ, randomized, double-blind, comparator-controlled study to evaluate the efficacy, safety and pharmacokinetics of single injection adductor canal block with HR18034 for postoperative pain management in total knee…
- Trial name
- NCT06509958
- Testing
- HR18034, Ropivacaine Hydrochloride Injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Knee Arthropathy, Knee Arthritis
Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement
The purpose of this study was to investigate the effect of bupivacaine liposomes on postoperative pain in TKA ( total knee replacement ) patients.The main questions answered are: 1.
- Trial name
- NCT06653621
- Testing
- Bupivacaine liposome, Nerve block mode : adductor block, Bupivacaine
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Huazhong University of Science and Technology
Post-op Pain
PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement
The purpose of the study is to evaluate post-op pain requirements in patients undergoing hip or knee replacement surgery who perioperatively receive either Oral acetaminophen or IV acetaminophen
- Trial name
- KHEA (NCT02244619)
- Testing
- Oral acetaminophen, IV acetaminophen
- Where
- United States
- Volunteers
- 515 people
- Sponsor
- Kettering Health Network
Arthritis Knee, Bariatric Surgery Candidate
Risk of Revision Following Knee Arthroplasty in Bariatric Surgery Patients
Previous studies have investigated the outcomes of Knee Arthroplasty (KA) following Bariatric Surgery (BAS), but with substantial limitations as not stratifying for Body Mass Index (BMI) at time of KA or not addressing the type…
- Conditions
- Arthritis Knee, Bariatric Surgery Candidate, Prosthesis Failure, Prosthesis Survival
- Trial name
- NCT06433700
- Testing
- BAS, Non-BAS
- Where
- Denmark
- Volunteers
- 99,965 people
- Sponsor
- Bispebjerg Hospital
Knee Osteoarthritis
Early Postoperative Compex Rehab NMES Use for Total Knee Arthroplasty Patients
This study will examine the effects, if any, of using muscle stimulation on the quadriceps following a total knee replacement. Secondary objectives will be to evaluate and compare pain levels, qualitative outcomes, and the impact…
- Trial name
- NCT01844193
- Testing
- Compex Rehab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Orthopaedic Research Foundation
Arthroplasty, Replacement, Knee
Randomised Total Knee Arthroplasty With Attune S+ or NexGen CR
The primary purpose of this study is to evaluate the clinical performance of the Attune S+ knee primarily based on evaluation with use of Oxford Knee Score. The NexGen TKR will be used as reference standard.
- Trial name
- NexGe (NCT05464641)
- Testing
- Oxford knee score
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Göteborg University
Arthroplasties, Knee Replacement
Swelling Management After Knee Replacement
To determine if inelastic adjustable compression garment results in improved surgical limb swelling control (bioimpedance assessment - primary outcome) after TKA compared to control (TED hose).
- Trial name
- NCT06095401
- Testing
- Inelastic adjustable compression garment (INCOM), Elastic compression garment (CONTROL)
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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