Clinical trials: Knee
Osteoarthritis
Health and Risk Factors in Patients With Hip and Knee Osteoarthritis
Hip and knee osteoarthritis is one of the leading causes of global disability. There is no cure for the disease, but research and guidelines recommends that patients with osteoarthritis, early after the diagnosis, receive…
- Trial name
- NCT03438630
- Where
- Sweden
- Volunteers
- 288,276 people
- Sponsor
- Vastra Gotaland Region
Chronic Pain, Knee Pain Chronic
HFIT Versus TENS Study for Chronic Low Back and Knee Pain
A high-frequency impulse therapy (HFIT) device (Enso, San Francisco, CA) is a portable device for the treatment of musculoskeletal pain.
- Conditions
- Chronic Pain, Knee Pain Chronic, Back Pain, Low
- Trial name
- NCT05821530
- Testing
- HFIT, TENS, Control
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- Hinge Health, Inc
Medial Compartment Osteoarthritis, Genu Varum
TO Plate Fixation vs. External Fixator Comparison (HTO Plate vs. ExFix Study)
This study aims to compare the efficacy, accuracy, and functional outcomes of two different surgical stabilization techniques for medial opening wedge high tibial osteotomy (HTO) in patients with varus deformity and medial…
- Conditions
- Medial Compartment Osteoarthritis, Genu Varum, Varus Deformity, High Tibial Osteotomy
- Trial name
- NCT07220434
- Testing
- Medial HTO Locking Plate, Self-Adjusting HTO External Fixator
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Muhammed Cagatay Engin
Healthy
Reference Values for the One Repetition Maximum Test of Knee Extensors for Brazilians.
Muscle strength is important for health and can affect how well people live, even increasing the risk of death in adults and older people.
- Trial name
- NCT06648421
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Patellofemoral Disorder, Anterior Knee Pain
Quadriceps Strengthening With Patellar Taping in Patellofemoral Pain Syndrome Among Young Adult Male Athletes
This study aims to investigate the effects of electromyography biofeedback (EMG-BF) guided isometric quadriceps strengthening with patellar taping and isometric exercise alone in young adult male athletes with patellofemoral pain…
- Trial name
- PFPS (NCT04753333)
- Testing
- Electromyography biofeedback (EMG-BF)
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Majmaah University
Post Operative Pain
Comparative Study Between Dexmedetomidine and Fentanyl as Adjuvants to Bupivacaine
Combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post…
- Trial name
- NCT06864416
- Testing
- dexmedetomidine as adjuvant to bupivacaine, Fentanyl as adjuvant to bupivacaine
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Osteoarthritis of Knee
Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency
This study investigates the effectiveness of two treatments-genicular nerve radiofrequency ablation and pulsed radiofrequency-in reducing pain and improving function in osteoarthritis patients.
- Trial name
- GRFT-PRF (NCT06894147)
- Testing
- Genicular nerve pulse radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
ACL Reconstruction
A Multi-centre, Double-blind RCT to Investigate the Effect of Alendronate on Knee Function Following ACLR
Anterior cruciate ligament (ACL) is the key ligament connecting the femur to tibia that helps stabilising the knee joint. ACL tear is common.
- Trial name
- NCT05527548
- Testing
- Alendronate (ALN)
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis, Knee
Probiotic Supplements in Osteoarthritis
The current study aims to evaluate the effectiveness of adding probiotics to the standard of care in improving OA patient-related outcomes such as pain, stiffness, and physical activity.
- Trial name
- NCT07364578
- Testing
- Probiotic Formula, Control
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- Beni-Suef University
Anterior Cruciate Ligament Rupture
Hamstring Muscle Strength After ACL Hamstring Reconstruction
Anterior Cruciate Ligament (ACL) reconstructions using hamstring grafts can be performed using one or two hamstring grafts, the semitendinosus (ST) tendon only, or both the semitendinosus and gracilis (ST/G) tendon.
- Trial name
- HAMSTRING (NCT05464485)
- Testing
- ACL hamstring reconstructions using semitendinosus (ST) tendon only, ACL hamstring reconstructions using semitendinosus and gracilis (ST/G) tendon
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Isala
Anesthesia, Anesthesia, Local
Hypobaric L5-S1 Study
Patients going through total hip or knee replacement (arthroplasty) have to be put under spinal anesthesia to prevent them from feeling any pain during surgery.
- Trial name
- NCT06526156
- Testing
- Bupivacaine injection
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University Health Network, Toronto
KOA
A Study of [89Zr]-Oxine-NCR100 Injection for the Cellular Distribution
This clinical study is to evaluate the biodistribution of [89Zr]-Oxine-NCR100 injection in subjects with knee osteoarthritis after local injection and the kinetic behavior characteristics of zirconium-labeled cells at the…
- Trial name
- Distribution (NCT07139431)
- Testing
- NCR100
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Osteoarthritis
Functional Outcome in Two Types of Total Knee Replacement Surgery for People With Osteoarthritis
When performing total knee replacement surgery, the surgeon has a choice as to which type of surgical technique to use. The standard technique at the Royal Infirmary in Edinburgh is the so-called 'medial parapatellar' exposure.
- Trial name
- NCT01576445
- Testing
- Mid-vastus approach, medial parapatellar approach
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Margaret University
Knee Osteoarthritis, Total Knee Arthroplasty
Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance
The investigators hypothesized that intraoperative opioid consumption would be different between remimazolam and propofol if the ANI-guided remifentanil continuous infusion rate was adjusted when the depth of anesthesia was…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Remimazolam
- Trial name
- NCT05322902
- Testing
- remimazolam group, propofol group
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Gangnam Severance Hospital
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
Recurrent Patellar Dislocation, Patellar Instability
Evaluation of Adductor Magnus Tenodesis in Patients With Recurrent Patellar Dislocation.
Between 2010 and 2012, 33 children and adolescents (39 knees) with recurrent patellar dislocation were treated with MPFL reconstruction using the adductor magnus tendon.The aim of the study is to assess the effectiveness of this…
- Conditions
- Recurrent Patellar Dislocation, Patellar Instability, Patellofemoral Osteoarthritis
- Trial name
- NCT05184439
- Testing
- Adductor magnus tenodesis for recurrent patellar dislocation
- Where
- Poland
- Volunteers
- 22 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis
Balneotherapy With Acquabios Thermal Water in Knee Osteoarthritis
The aim of the study is the evaluation of the effect of balneotherapy with Acquabios bicarbonate-alkaline-sodium thermal water in ameliorating some signs and symptoms of knee osteoarthritis in human subjects suffering from this…
- Trial name
- NCT05352477
- Testing
- Balneotherapy with thermal water, Balneotherapy with tap water
- Volunteers
- 88 people
- Sponsor
- University of Roma La Sapienza
Meniscus Lesion
Femoral Blockade and Low-dose Spinal Anesthesia in Outpatient Knee Arthroscopy
The investigators of the current study aimed to evaluate the effect of spinal anesthesia with low dose bupivacaine combined with femoral blockade on duration of anesthesia and time of first analgesic requirement during…
- Trial name
- NCT02322372
- Testing
- Femoral blockade, Intrathecal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara University
Patellofemoral Pain, PFP
Whole-Body Vibration in Patients With Patellofemoral Pain Syndrome
Patellofemoral Pain Syndrome (PFPS), or anterior knee pain, is one of the most common disorders affecting the lower extremities. Currently, there is no established "gold standard" treatment for PFPS.
- Trial name
- NCT07382037
- Testing
- Whole body vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Pamukkale University