Clinical trials: Kinetics
Healthy
A Study in Healthy Men to Test Whether Bosentan Influences the Amount of BI 425809 in the Blood
The main objective of this trial is to investigate the relative bioavailability of BI 425809 given alone (Reference) compared to a combined administration with the moderate CYP3A4 inducer bosentan (Test) following repeated oral…
- Trial name
- NCT05723874
- Testing
- BI 425809, Bosentan
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Methods of Exercise in Children
Gas Exchange Kinetics and Work Load During Exercise
The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs.Participants will exercise in different protocols on a bicycle ergometer or…
- Trial name
- NCT03770507
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Non-alcoholic Fatty Liver Disease (NAFLD)
How Does Dietary Carbohydrate Influence the Formation of an Atherogenic Lipoprotein Phenotype (ALP)?
The hypothesis of this study is that a diet high in sugars will increase abnormalities in blood lipids which are associated with increased cardiovascular disease risk, relative to a diet which is low in sugar.
- Trial name
- CHOT (NCT01790984)
- Testing
- High sugar low starch diet, Low sugar high starch diet
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bruce A. Griffin
Healthy
Micropore Closure Kinetics at Various Body Sites
The study to be performed will define the rate of skin barrier recovery following micropatch application to the skin on the upper arm, volar forearm, and abdomen in healthy subjects.
- Trial name
- NCT03657277
- Testing
- Micropatch
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Diabetes Mellitus, Type 2, Healthy
Effect of Empagliflozin Kinetics on Renal Glucose Reabsorption in Patients With Type II Diabetes and Healthy Controls
Single center, 14-day, open-label trial to examine the effect of 25 mg q.d. empagliflozin on kinetics of renal glucose reabsorption in patients diagnosed with type 2 diabetes mellitus and healthy controls
- Trial name
- NCT01867307
- Testing
- Empagliflozin, BI 10773
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Amyloid-beta
Sleep Quality and Amyloid-Beta Kinetics
The purpose of this study is to change the concentration of amyloid-beta in human cerebrospinal fluid (CSF) by modification of sleep efficiency.
- Trial name
- NCT03077620
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Muscle Protein Synthesis, Whole-body Protein Balance
Essential Amino Acids and Protein Kinetics During Caloric Deprivation
The amount of essential amino acids (EAA) necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined.
- Trial name
- NCT03372928
- Testing
- Standard EAA, High EAA
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Influenza
Pilot Study in Young Adults to Examine the Kinetics of Changes in the B-cell Repertoire Following TIV Immunization
The purpose is to investigate B-cell response to the trivalent Influenza Vaccine (TIV) in healthy young adults by vaccinating participants and obtaining blood samples at designated time points before and after vaccination.
- Trial name
- SLVP023 (NCT02987374)
- Testing
- 2011-2012 Fluzone IIV3 (IM)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Influenza, Vaccine Virus Shedding
Nasal and Systemic Immune Responses to Nasal Influenza Vaccine
Intranasal live attenuated influenza vaccine (LAIV; trade name FluMist/Fluenz-Tetra, manufactured by AstraZeneca/Medimmune) is the standard influenza vaccine given to children aged 2-17 years of age in the UK.
- Trial name
- Flu-M3 (NCT04110366)
- Testing
- Live attenuated influenza vaccine, Vehicle control
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Rheumatoid Arthritis
Effects Of CP-690,550 (Tasocitinib) On Cholesterol Metabolism In Patients With Active Rheumatoid Arthritis
The purpose of study is to explore the effect of CP-690,550 (tasocitinib) on cholesterol metabolism in patients with active rheumatoid arthritis (RA).
- Trial name
- NCT01262118
- Testing
- CP-690,550 (tasocitinib)
- Where
- 11 sites in United States, Hungary
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tuberculosis
Study in Healthy Adults to Evaluate Gene Activation After Vaccination With GlaxoSmithKline (GSK) Biologicals' Candidate Tuberculosis (TB) Vaccine GSK 692342
The purpose of this study is to assess the safety and immunogenicity of two doses of the TB vaccine administered according to a 0, 1 month schedule.
- Trial name
- NCT01669096
- Testing
- GSK Biologicals' investigational TB vaccine GSK 692342
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Biomechanical Phenomena
Effect of Dynamic Taping on Landing Biomechanics in Athletes With Symptoms of Patellar Tendinopathy
Patellar tendinopathy (PT) is an overuse injury associated with loading activities, and popular among basketball and volleyball players.
- Trial name
- NCT05454449
- Where
- Taiwan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Sarcopenia
Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics
A randomized study to demonstrate how animal-based protein-rich food sources can be used by older adults to increase protein intake within pre-existing dietary patterns.
- Trial name
- NCT04830514
- Testing
- Recommended Dietary Allowance of Protein, Habitual protein intake, Optimal Protein Intake
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Healthy Volunteer
A Pharmacodynamic Study to Evaluate Neutrophil Distribution Kinetics and Function Following Single-Dose RoActemra/Actemra (Tocilizumab) in Healthy Volunteers
This Phase IV, single-blind , randomized, two-arm study will explore the pharmacodynamics effects of RoActemra/Actemra (tocilizumab) on neutrophil redistribution, function and survival in healthy subjects.
- Trial name
- NCT01991990
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Neuromuscular Function, Muscle Activation
Mechanistic Drivers of Acute PAPE Responsiveness: Muscle Architecture, Contractile Kinetics, and Excitability in a Randomized Controlled Trial
The goal of this study is to find out if one short set of heavy half-squats can help football players jump higher right away-and to understand what happens inside their muscles and nerves to make that boost happen.
- Conditions
- Neuromuscular Function, Muscle Activation, Postactivation Potentiation, Ultrasonography
- Trial name
- NCT06982937
- Testing
- High-Intensity Half-Squat, Treadmill running
- Where
- Poland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Transtibial Amputation
Metabolic Cost Savings for Transtibial Amputees Wearing the Controlled Energy Storage and Return (CESR) Foot
To determine if below-knee amputees will walk with better efficiency wearing a CESR foot which stores energy at heel strike and releases energy releases energy during push-off.
- Trial name
- NCT00494143
- Testing
- CESR Prosthetic Foot, typical prosthetic foot, standardized prosthetic foot
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Athletic Injuries
Running Retraining to Minimize Braking Forces
The proposed research study aims to investigate whether a gait modification training program to decrease peak braking forces during the stance phase of running will result in a reduction in impact loading and the incidence of…
- Trial name
- NCT03302975
- Testing
- Real-time visual biofeedback during treadmill running
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Influenza
Kinetics of B-Cell Responses to Live, Attenuated Influenza Vaccine (LAIV) in Young Children Two Years of Age
This pilot study will investigate B-cell responses following vaccination with live, attenuated influenza vaccine (LAIV) in healthy children 2 years of age from blood samples taken at designated time points before and after…
- Trial name
- SLVP016 (NCT03020472)
- Testing
- 2008-2009 FluMist LAIV (Intranasal)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Stanford University
Multiple Sclerosis (MS)
A Study to Evaluate the Safety, Tolerability, Kinetics, Biodistribution and Repeatability of 11C-BMS-986196 After Intravenous (IV) Administration in Healthy Participants and After Repeat IV Administration in Participants With Multiple Sclerosis
The purpose of this study is to evaluate the safety, tolerability, kinetics, biodistribution and central nervous system signal of 11C-BMS-986196 after intravenous (IV) administration in healthy participants and after repeat IV…
- Trial name
- NCT05064436
- Testing
- 11C-BMS-986196
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Blood Volume, Blood Coagulation
Volume Kinetics for Starch Solution and Acetated Ringers
Volume kinetics is a method mostly used, so far, to study the distribution and elimination of crystalloid solutions. Voluven (in Sweden the most commonly used colloid for replacement of bleeding during surgery) is poorly studied…
- Trial name
- NCT01195025
- Testing
- acetated Ringers, colloid, colloid+acetated Ringer
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping