Clinical trials: Ketones
Placebo - Control, Ketone Monoester
The Effects of Exogenous Ketones on Cognitive Function
The purpose of this study is to evaluate the acute effects of exogenous ketone monoester (KME) supplementation on cognitive function in three groups of adults aged 19-55 years: (1) obese, sedentary individuals; (2) lean…
- Trial name
- NCT07051655
- Testing
- Ketone Monoester (KE)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Diabetic Ketoacidosis
Use of Blood Ketone Meters to Improve Ambulance Hyperglycaemia Care
In this KARMA2 feasibility study the investigators are testing whether ambulance staff can reliably and safely identify patients at high risk of diabetic ketoacidosis using blood ketone meters and start fluid (saline) therapy…
- Trial name
- KARMA2 (NCT04940897)
- Testing
- Use of CareSens ketone meter
- Where
- United Kingdom
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- East of England Ambulance Service NHS Trust
Hypoxia
Ketone Esters for Optimization of Operator Performance in Hypoxia
The primary purpose of the study was to investigate effects of an orally administered ketone ester drink on endurance exercise performance during acute extreme hypoxia.
- Trial name
- HVMN7 (NCT07065864)
- Testing
- Ketone ester
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Cognition
Targeted Assessment of Cognition and Tactical-performance With Ingested Ketones
The goal of this study is to determine whether consuming a commercially available exogenous ketone supplement (KetoneIQ®) affects cognition, specifically marksmanship, under physical stress (i.e., exhaustive exercise).
- Trial name
- TACTIK (NCT07771790)
- Testing
- KetoneIQ®
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida State University
Alzheimer's Disease
Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease
Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.
- Trial name
- MCT-MA (NCT02709356)
- Testing
- 1-month of 60-40 MCT oil, 1-month of C8 MCT oil
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Hypoxia, Exogenous Ketosis
The Effects of Ketone Ester Supplementation During a 5 Week Live High, Train Low Altitude Training Camp
This study aims to investigate the effects of post-exercise and pre-sleep exogenous ketosis via oral ketone ester supplementation during a 5 week simulated altitude training camp.
- Trial name
- NCT06596083
- Testing
- Ketone ester supplement
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy
Effect of MCT Emulsification on Ketogenesis in Human Adults
Lower brain glucose uptake is present before the onset of cognitive deterioration and may increase the risk of cognitive decline in Alzheimer's disease. Ketones are the brain's main alternative energy substrates.
- Trial name
- NCT02409927
- Testing
- MCT oil 10g, MCT homogenate 10g, Control
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketoses, Metabolic, Ketogenic Dieting
Effect of Nutritional Ketosis on Alcohol Metabolism
The research study is being conducted in health controls to better understand the effects of ketosis on brain functioning after 3 different, randomly assigned, 3-day dietary interventions and the acute effects of alcohol after…
- Conditions
- Ketoses, Metabolic, Ketogenic Dieting, Alcohol Intoxication, Magnetic Resonance Imaging
- Trial name
- KAM (NCT06065657)
- Testing
- Ketone Supplement, Control Diet, Ketogenic diet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alzheimer Disease
Pharmacokinetics of Tricaprilin Including Food Effect on Ketone Body Production
This is a Phase I, single center, open label, fixed-order, crossover, food-effect, pharmacokinetic (PK) study recruiting healthy, adult, male subjects.
- Trial name
- NCT03551769
- Testing
- tricaprilin, standard meal, high-fat meal
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cerecin
Healthy Young Adults
Effects of Exogenous Ketones in Healthy Young Adults
Exogenous ketone supplements in the form of beta-hydroxybutyrate can be utilized as an alternate energy source (in place of glucose) for all cells except red blood cells.
- Trial name
- NCT03452761
- Testing
- Ketone Salts
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Augusta University
Aging
Do Ketone Drinks Improve Immune, Metabolic and Cognitive Health in Older Adults
The goal of this randomised, double-blinded, placebo-controlled trial is to investigate the immune, metabolic and cognitive effects of four weeks of daily ketone supplementation in adults aged 60 to 80 with stable health.
- Trial name
- NCT06068803
- Testing
- Ketone drink
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Deficient Alveolar Bone
Assessment of Efficacy of Prebent Titanium Mesh Versus Customized Poly-ether Ether Ketone Mesh for Three Dimensional Augmentation in Deficient Maxillary Ridge. a Randomized Controlled Clinical Trial.
In conclusion, the choice between titanium and PEEK meshes should consider patient-specific factors, clinical requirements, and surgeon expertise.
- Trial name
- NCT07040124
- Testing
- ti mesh, 3d peek mesh
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Basma Alsheikh
Placebo - Control, Exogenous Ketone Salt
Accuracy of Current Techniques in Quantifying Ketone Levels
The purpose of this study is to determine the accuracy of current measuring techniques used to detect physiological ketone levels.
- Trial name
- NCT06909331
- Testing
- Exogenous ketone salt
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Augusta University
Cerebrovascular Function, Cognition
Ketone Dose and Cerebral Blood Flow Study
Ketone bodies are produced by the liver during periods of food scarcity or severe carbohydrate restriction. Blood ketones are an alternative fuel source used by the brain, heart, and skeletal muscle during periods of fasting.
- Trial name
- kCBF (NCT06032156)
- Testing
- Low Dose β-OHB, High Dose β-OHB
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Exercise, Ultra-endurance Running
Effect of Exogenous Ketosis During Ultra-endurance Exercise
The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump…
- Conditions
- Exercise, Ultra-endurance Running, Ketosis, Skeletal Muscle
- Trial name
- NCT05407753
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Overweight and Obesity, Cognitive Change
Acute Effects of Exercise Combined With Ketone Ester Supplement
To examine the acute changes in cardiometabolic and neurocognitive outcomes in response to exercise combined with ketone ester supplement in overweight/obese adults.
- Conditions
- Overweight and Obesity, Cognitive Change, Ketoses, Metabolic
- Trial name
- NCT06365957
- Testing
- Ketone monoester supplementation, High-intensity interval exercise, Moderate-intensity continuous exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Macau
Intermittent Fasting, Healthy
Monitoring Intermittent Fasting for Human Optimization Using Wearable Technology: An N-of-1 Study
There is a growing interest in personalized health strategies, including diet, exercise, and fasting regimens, to enhance metabolic fitness.
- Conditions
- Intermittent Fasting, Healthy, Digital Health
- Trial name
- NCT06630637
- Testing
- Glucose-Ketone Index (GKI) monitoring, Continuous Glucose Monitoring (CGM), Digital dynamometer
- Where
- Singapore
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Institute for Digital Medicine (WisDM)
Exogenous Ketosis
The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold
The goal of this clinical trial is to determine whether a ketone supplement with carbohydrates extends time to fatigue during cycling compared with a carbohydrate-only supplement in healthy, trained cyclists aged 18-55.
- Trial name
- NCT07224282
- Testing
- Ketone supplementation, Carbohydrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
COVID-19 Acute Respiratory Distress Syndrome
T-Cell Mitochondrial Respiration Response to Ketone Monoester Supplement in Healthy Volunteers and COVID-19
T-Cell Mitochondrial Respiration Response to Ketone monoester (Ketoneaid) in Healthy Volunteers and COVID-19
- Trial name
- NCT05798260
- Testing
- Agilent Seahorse XF Cell Mito Stress Test
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Cerebrovascular Function, Cerebral Blood Flow
Mechanistic Effect of Ketones on Cerebral Blood Flow
Oral supplements containing exogenous ketones have recently become available and represent a novel tool for increasing plasma ketone bodies without the need for dietary restriction.
- Trial name
- MEKC (NCT06217159)
- Testing
- Poikilocapnia, Normocapnia
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- McMaster University