Clinical trials: Keratoconus
Keratoconus
Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus
it is a randomized clinical trial to compare deep lamellar keratoplasty (DLK) Using big bubble technique and Penetrating Keratoplasty (PK) in patients with keratoconus
- Trial name
- NCT00371202
- Testing
- keratoplasty
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Keratoconus
Standard Corneal Collagen Crosslinking Versus Transepithelial Corneal Crosslinking by Iontophoresis of Riboflavin
The standard CXL technique involves removal of the epithelium to enable riboflavin to penetrate into stromal tissue, to avoid epithelial debridement and increasing the patient's comfort and safety transepithelial corneal…
- Trial name
- NCT02456961
- Testing
- iontophoresis of riboflavin, epithelium-off, Corneal collagen crosslinking
- Volunteers
- 126 people
- Sponsor
- Ufa Eye Research Institute
Keratoconus
Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring
The purpose of this study is to postpone the corneal transplantation in keratoconus and promote the stiffness of the cornea across the riboflavin-UVA corneal collagen crosslinking , and after, corneal ring surgery.
- Trial name
- NCT00832897
- Testing
- Corneal collagen crosslinking
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Orthokeratology, Keratoconus
Orthokeratology for Keratoconus
To investigate a possible benefit of Orthokeratology contact lenses to improve uncorrected visual acuity of keratoconus patients
- Trial name
- NCT00816569
- Testing
- Orthokeratology contact lenses
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Keratoconus
Assessing Patient Engagement in Keratoconus Clinical Research
This study aims to investigate the influences behind patient choices regarding involvement, discontinuation, or re-engagement in keratoconus clinical trials.
- Trial name
- NCT06288737
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Keratoconus, Cornea Ectasia
Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions
To evaluate the safety and effectiveness of the PXL Platinum 330 device for performing Corneal Crosslinking in patients with corneal thinning conditions.
- Trial name
- NCT04240457
- Testing
- Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Arbor Center for Eye Care
Keratoconus, Collagen
Effect of Epi-Off Technique Corneal CXL On Endothelial Count by Specular Microscopy in Keratoconus Patients
Determine safety of EPi-off CXL on corneal endothelium by using specular specular microscopy to assess endothelial count.
- Trial name
- NCT05717673
- Testing
- Specular microscopy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Heba Allah Nashaat Mohamed
Keratoconus, Irregular Astigmatism
Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism
Aberrations are the spreading of light from a point focus. Aberrations of the eyes can be objectively evaluated with a wavefront aberrometer.
- Conditions
- Keratoconus, Irregular Astigmatism, Corneal Ectasia, Aberration, Corneal Wavefront
- Trial name
- WFG Sclerals (NCT04698590)
- Testing
- Wavefront Guided Scleral Lenses, Traditional Scleral Lenses
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Corneal Diseases
Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions
The purpose of this study is to determine the ability of a proprietary software screening tool to discriminate normal corneas (front surface of the eye) from previously diagnosed corneal conditions…
- Trial name
- NCT00396188
- Where
- 4 sites in United States
- Volunteers
- 769 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Eye Diseases
Development of an IT Tool Able to Identify Ocular Conditions
The aim of the study is to use machine learning to develop an IT tool able to differentiate between eye conditions analysing corneal biomechanical data.
- Trial name
- NCT05973617
- Testing
- Measurement of corneal biomechanical properties
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aston University
Hydrops in Keratoconus
Intracameral Gas SF6 (Sulfur Hexafluoride) Injection for Acute Hydrops in Keratoconus
Intracameral Gas SF6 (Sulfur Hexafluoride) Injection for Acute Hydrops in Keratoconus
- Trial name
- NCT00593190
- Testing
- Gas SF6 (Sulfur Hexafluoride)
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- HaEmek Medical Center, Israel
Keratoconus, Forme Fruste Keratoconus
Corneal Biomechanical Properties and Anterior Segment Parameters, in Forme Fruste Keratoconus
The present study attempts to evaluate the diagnostic capacity of a) anterior segment parameters b) biomechanical metrics and c) a combination model, in differentiating Forme Fruste Keratoconus (FFK) from healthy corneas.
- Trial name
- NCT01448408
- Where
- Greece
- Sponsor
- Democritus University of Thrace
Corneal Diseases, Keratoconus
Keratoconus, Corneal Diseases and Transplant Registry
The cornea is the clear layer in front of the iris and pupil. It protects the iris and lens and helps focus light on the retina.
- Conditions
- Corneal Diseases, Keratoconus, Corneal Ulcer, Corneal Trauma
- Trial name
- KCDTR (NCT04164407)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier
Keratoconus
Pocket Versus Tunnel ICRS for Treatment of Keratoconus
Keratoconus is a corneal degenerative disease associated with loss of best-corrected visual acuity. The use of intrastromal corneal ring segment implants is indicated to regularize the cornea and to reduce aberrations.
- Trial name
- NCT05748847
- Testing
- Intrastromal corneal ring segment implantation (Pocket), Intrastromal corneal ring segment implantation (Tunnel)
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Assiut University
Keratoconus, Corneal Opacity
Femtosecond Laser-assisted Anterior Lamellar Keratoplasty
The purpose of the study is evaluating safety and clinical efficiency of full femtosecond laser-assisted anterior lamellar keratoplasty (FS-ALK) for curing patients with keratoconus and corneal opacities
- Trial name
- NCT02301598
- Testing
- FS-ALK (Femtolaser-assisted anterior lamellar keratoplasty)
- Volunteers
- 13 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Keratoconus
Intrastromal Corneal Ring Segments and Toric Phakic Posterior Intra-ocular Lenses Implantation in Keratoconus
To compare visual and refractive measurements of intrastromal corneal ring segments versus toric phakic posterior intra-ocular lenses implantation in keratoconus
- Trial name
- NCT05055349
- Testing
- corneal ring segments
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Keratoconus
Refractive Corneal Cross-linking for Progressive Keratoconus
Young patients with keratoconus face two problems: disease progression and corneal shape irregularity. Both underlie the 20% rate of corneal transplantation in keratoconics required to maintain useful vision.
- Trial name
- NCT03531047
- Testing
- Customised CXL
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Keratoconus
CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Trial name
- NCT01956474
- Testing
- Theralight crosslinking and Riboflavin
- Where
- 6 sites in United States
- Volunteers
- 1,324 people
- Sponsor
- Cxlusa
Keratoconus
Corneal De-epithelization Associated With a Therapeutic Photokeratectomy in Patients With Evolutive Keratoconus
Keratoconus is a symmetrical, bilateral, non-inflammatory, idiopathic corneal pathology, characterized by a progressive corneal thinning.
- Trial name
- KERADES (NCT02857881)
- Testing
- De-epithelization and therapeutic photokeratectomy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Keratoconus, Corneal Cross-Linking
Surface Ablation With Corneal Cross Linking in Mild Keratoconus
Interventional and comparative prospective study: Sixty-nine eyes (38 patients) suffering from keratoconus (stages 1-2 Amsler-Krumeich classification) will be divided into four groups.
- Trial name
- NCT05176171
- Testing
- Photorefractive Keratectomy with Corneal Cross-Linking
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University