Clinical trials: Kaposi's Sarcoma
Kaposi's Sarcoma, HIV Infections
Anti-Retrovirals for Kaposi's Sarcoma
The primary purpose of this study is to determine whether a protease inhibitor-based antiretroviral regimen is more efficacious than a non-nucleoside reverse transcriptase inhibitor-based antiretroviral regimen in promoting the…
- Trial name
- ARKS (NCT00444379)
- Testing
- Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
- Where
- Uganda
- Volunteers
- 224 people
- Sponsor
- University of California, San Francisco
HIV, Kaposi's Sarcoma
Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer
BACKGROUND: A number of important scientific advances can be made through the study of blood, bone marrow, tumor, or other tissue samples from patients with HIV infection, infection with Kaposi s sarcoma associated herpesvirus…
- Conditions
- HIV, Kaposi's Sarcoma, Lymphomas, Multicentric Castleman's Disease
- Trial name
- NCT00006518
- Where
- United States
- Volunteers
- 1,029 people
- Sponsor
- National Cancer Institute (NCI)
Sarcoma, Kaposi, HIV Infections
A Study of Targretin Capsules in Patients With AIDS-Related Kaposi's Sarcoma
The purpose of this study is to see if it is safe and effective to give Targretin capsules to patients with AIDS-related Kaposi's sarcoma (KS).
- Trial name
- NCT00002212
- Testing
- Bexarotene
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Ligand Pharmaceuticals
Sarcoma, Kaposi, HIV Infections
A Phase I Study of the Combination of Recombinant GM-CSF, AZT, and Chemotherapy (ABV) (Adriamycin, Bleomycin, Vincristine) in AIDS and Kaposi's Sarcoma
To determine the safety as well as the most effective dose of sargramostim (GM-CSF; granulocyte-macrophage colony stimulating factor) that will prevent the side effects caused by the combined use of zidovudine (AZT) and various…
- Trial name
- NCT00000681
- Testing
- Bleomycin sulfate, Vincristine sulfate, Doxorubicin hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AIDS-related Kaposi Sarcoma, Classic Kaposi Sarcoma
Sunitinib Malate in Treating East African Patients With Kaposi Sarcoma
Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00521092
- Testing
- sunitinib malate, laboratory biomarker analysis, pharmacological study
- Sponsor
- National Cancer Institute (NCI)
Sarcoma, Kaposi, HIV Infections
A Pilot Study of OPC-8212 (Vesnarinone) in Persons With AIDS-Related Kaposi's Sarcoma
To examine the safety and efficacy of two doses of vesnarinone in patients with AIDS-related Kaposi's sarcoma.
- Trial name
- NCT00002131
- Testing
- Vesnarinone
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Otsuka America Pharmaceutical
Sarcoma, Kaposi, HIV Infections
Photodynamic Therapy Clinical Trial For Cutaneous AIDS-Related Kaposi's Sarcoma Study Summary.
To determine the objective tumor response and remission rate of AIDS-related Kaposi's sarcomas (KS) following a single dose of tin ethyl etiopurpurin (SnET2) followed by photodynamic therapy (PDT).
- Trial name
- NCT00002167
- Testing
- Tin ethyl etiopurpurin
- Where
- 6 sites in United States
- Volunteers
- 78 people
- Sponsor
- Clinical Solutions
Non-Hodgkin Lymphoma, Hodgkin Lymphoma
Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors
The goals of this study is to determine if nelfinavir can target Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) in patients with certain cancers.
- Conditions
- Non-Hodgkin Lymphoma, Hodgkin Lymphoma, Kaposi Sarcoma, Gastric Cancer
- Trial name
- NCT02080416
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Acquired Immunodeficiency Syndrome, Kaposi's Sarcoma
Clinical, Laboratory and Epidemiologic Pilot Studies of Individuals at High Risk for Viral-Associated Cancers
This protocol presents the rationale, 25-year historical review, and methods for multidisciplinary, low-risk studies of individuals referred to the NCI Viral Epidemiology Branch (VEB).
- Conditions
- Acquired Immunodeficiency Syndrome, Kaposi's Sarcoma, Leukemia, Lymphoma
- Trial name
- NCT00001560
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Burkitt Lymphoma, KSHV-associated Multicentric Castleman Disease
Rituximab Hyaluronidase in Combination With Chemotherapy in Treating Aggressive B-cell Lymphoma in Uganda
This phase I trial studies how well rituximab hyaluronidase and combination chemotherapy work in treating patients in Uganda with Burkitt lymphoma, diffuse large B-cell lymphoma, or Kaposi sarcoma herpesvirus associated…
- Conditions
- Burkitt Lymphoma, KSHV-associated Multicentric Castleman Disease, Diffuse Large B-Cell Lymphoma
- Trial name
- NCT03864419
- Testing
- Rituximab and Hyaluronidase Human, Cyclophosphamide, Vincristine
- Where
- Uganda
- Volunteers
- 18 people
- Sponsor
- Fred Hutchinson Cancer Center
Lymphoma, Sarcoma
Altretamine and Etoposide in Treating Patients With HIV-Related Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002936
- Testing
- altretamine, etoposide
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Kaposi Sarcoma, Skin
Trial of Ixazomib for Kaposi Sarcoma
This phase II trial studies how well ixazomib works in treating patients with Kaposi sarcoma. Ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT04305691
- Testing
- Ixazomib Citrate, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 10 sites in United States
- Volunteers
- 41 people
- Sponsor
- AIDS Malignancy Consortium
Kaposi Sarcoma
PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma
Background: Kaposi sarcoma (KS) tumors grow on the skin, lymph nodes, lungs, bone, and gastrointestinal tract. KS often affects people with immune deficiencies, such as among people living with HIV or those with prior history of…
- Trial name
- NCT04303117
- Testing
- PDS01ADC, M7824
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Adrenal Cortical Cancer, Brain Cancer
Spectroscopy With Surface Coils and Decoupling
The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI)…
- Conditions
- Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00581815
- Testing
- Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
AIDS-related Kaposi Sarcoma, HIV Infection
A Phase II Trial of COL-3 in Patients With HIV Related Kaposi's Sarcoma
COL-3 may stop the growth of cancer by stopping blood flow to the tumor. Randomized phase II trial to compare the effectiveness of two different regimens of COL-3 in treating patients who have HIV-related Kaposi's sarcoma.
- Trial name
- NCT00020683
- Testing
- incyclinide, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
Sarcoma, Kaposi, HIV Infections
Topical Use of 4,4'-Dihydroxybenzophenone-2,4-Dinitrophenylhydrazone (A-007) in the Treatment of Advanced Malignancies Including Kaposi's Sarcoma and Lymphoproliferative Disorders
To evaluate topical A-007 in patients with advanced malignancies including Kaposi's sarcoma and lymphoproliferative disorders.
- Conditions
- Sarcoma, Kaposi, HIV Infections, Lymphoproliferative Disorders
- Trial name
- NCT00002153
- Testing
- A-007
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- DEKK-TEC, Inc.
Kaposi Sarcoma
Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma
Background: Kaposi Sarcoma (KS) is common in people with human immunodeficiency virus (HIV) but can also occur in people who do not have HIV.
- Trial name
- NCT04941274
- Testing
- Abemaciclib
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- National Cancer Institute (NCI)
Sarcoma, Kaposi, HIV Infections
The Safety and Effectiveness of Ritonavir in the Treatment of HIV-Related Kaposi's Sarcoma
To evaluate the safety and anti-Kaposi's sarcoma activity of ritonavir.
- Trial name
- NCT00002366
- Testing
- Ritonavir
- Where
- 2 sites in Australia
- Sponsor
- Abbott
Kaposi Sarcoma, Sarcoma, Kaposi
Pomalidomide for Kaposi Sarcoma in People With or Without HIV
Background: Pomalidomide is a drug that can treat cancer through several mechanisms. It is taken by mouth (orally). Pomalidomide can help treat cancer by blocking certain factors that promote tumor growth or by stimulating the…
- Trial name
- NCT01495598
- Testing
- Pomalidomide
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Cancer Institute (NCI)
Skin Kaposi Sarcoma
Pomalidomide Treatment in Patients With Kaposi Sarcoma
This phase II trial studies the effect of pomalidomide in treating patients with Kaposi sarcoma. Pomalidomide is a cancer fighting drug that stops the growth of blood vessels, stimulates the immune system, and may kill cancer…
- Trial name
- NCT04577755
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- 15 sites in United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)