Clinical trials: Jaundice, Obstructive
Surgery, Biliary Disease
Bile Duct Injury Digestif
Data accumulated from medical record collected from January 2008 until December 2018
- Conditions
- Surgery, Biliary Disease, Bile Duct Injury, Sepsis
- Trial name
- NCT04582240
- Testing
- no intervention
- Volunteers
- 24 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Systemic Inflammatory Response Syndrome, Jaundice, Obstructive
Cholinergic Anti-inflammatory Pathway in Prevention & Treatment of the SIRS in Patients With Jaundice After Operation.
RATIONALE:Anticholinesterase drugs and cholinergic M receptor antagonist are applied to patients who have obstructive jaundice after operation.
- Trial name
- NCT02279147
- Testing
- neostigmine methylsulfate，raceanisodamine hydrochloride
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wanqing Gu
Cholestasis, Icterus
FGF19 in Obstructive Cholestasis: "Unveil the Signal"
Rationale: Bile salts are potent signalling molecules influencing various metabolic and functional processes. Bile salts exert these functions by activating nuclear (e.g. FXR ) and plasma cell membrane-bound receptors (e.g.
- Conditions
- Cholestasis, Icterus, Cholangiocarcinoma, Pancreatic Neoplasms
- Trial name
- FOCUS (NCT05718349)
- Testing
- Biospecimen sampling
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Nicole Hildebrand
Hepatobiliary Disorders
Evaluation of Efficacy, Safety and Molecular Mechanism of Pentoxifylline Supplementation in Patients With Hepatic and Obstructive Jaundice
Investigating the efficacy, safety, and molecular mechanism of Pentoxifylline supplementation in improving elevated direct bilirubin level and liver function tests in patients with hepatic and post-hepatic jaundice
- Trial name
- NCT06944704
- Testing
- Pentoxifylline
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Tanta University
Cholangiocarcinoma
Comparison of Biliary Stenting Alone vs. Stenting With Photodynamic Therapy (PDT) During ERCP
This study entails retrospective and prospective review of data from a database protocol. Data gathered will be then analyzed for a set amount of patients. In this study, the investigators will compare biliary stenting vs.
- Trial name
- PDT (NCT01439685)
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Biliary Tract Neoplasms, Biliary Drainage
Suprapapillary Versus Transpapillary Plastic Stents for Unresectable Malignant Hilar Biliary Obstruction
Bile duct blockage caused by cancer near the liver hilum (where the bile ducts join) leads to jaundice and infection. The standard treatment is to place a plastic stent (a small tube) through an endoscope to drain the bile.
- Conditions
- Biliary Tract Neoplasms, Biliary Drainage, Malignant Biliary Obstruction, Obstructive Jaundice
- Trial name
- NCT07811791
- Testing
- Suprapapillary plastic stent placement, Transpapillary plastic stent placement
- Where
- 8 sites in Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Jaundice, Obstructive, Jaundice; Malignant
Microbiological Assessment of Bile in Patients Undergone to Endoscopic Retrograde Cholangiography (ERCP): the "Microbile Registry"
The study is a prospective evaluation of the microbial assessment in patients undergoing to ERC with naive papilla; the population includes all the indication to biliary drainage.
- Conditions
- Jaundice, Obstructive, Jaundice; Malignant, Choledocholithiasis, Biliary Stricture
- Trial name
- Microbile (NCT06115564)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Unità Sanitaria Locale della Romagna
Obstructive Jaundice, Surgical Procedure, Unspecified
Application of n-3 Fatty to Patient of Jaundice
The safety and efficacy of ω-3 fatty acid in patients with obstructive jaundice is not known. This study provided evidences that ω-3 fatty acid-based parenteral nutrition improved postoperative recovery for patients with…
- Trial name
- NCT03376945
- Testing
- trail cohort, control cohort
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Huazhong University of Science and Technology
Cholangitis, Secondary Biliary, Cholangiocarcinoma
Advanced Endoscopy During COVID-19
In this study, investigators aim to explore the status of advanced endoscopy in different endoscopy units all over the world.
- Conditions
- Cholangitis, Secondary Biliary, Cholangiocarcinoma, Obstructive Jaundice, Pancreas Cancer
- Trial name
- NCT04385147
- Testing
- Endoscopic management according to standard of care
- Where
- 5 sites in United States, Egypt and 3 more
- Volunteers
- 670 people
- Sponsor
- Al-Azhar University
Jaundice, Obstructive, Klatskin Tumor
Process Optimization of Preoperative Biliary Drainage in Patients With Malignant Obstructive Jaundice
The purpose of this study is to evaluate the safety and effectiveness of different methods of preoperative biliary drainage in patients with extrahepatic bile duct neoplasms with obstructive jaundice (hilar cholangiocarcinoma…
- Trial name
- NCT03527875
- Testing
- PTBD group, ENBD group, EBS group
- Volunteers
- 564 people
- Sponsor
- Shanghai Zhongshan Hospital
Pancreatic Cancer, Cholangiocarcinoma of the Extrahepatic Bile Duct
EUS Evaluation of CBD Diameter in Malignant Obstructive Jaundice
The main objective of the study is to evaluate the size of the common bile duct (CBD) in a large cohort of patients with jaundice secondary to pancreatic head or distal bile duct malignancy undergoing diagnostic EUS for tissue…
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma of the Extrahepatic Bile Duct, Ampulla of Vater Cancer, Jaundice, Obstructive
- Trial name
- ECCO (NCT03494023)
- Testing
- Endoscopic ultrasound
- Where
- Romania
- Volunteers
- 539 people
- Sponsor
- Clinical Hospital Colentina
Choledocholithiasis, Jaundice, Obstructive
Immediate vs. Elective Endoscopic Removal of Large CBD Stones in High-Risk Elderly Patients
The goal of this clinical trial is to compare two different approaches for removing large or multiple stones from the common bile duct in older adults with chronic diseases.
- Trial name
- NCT06948279
- Testing
- The endoscopic retrograde cholangiopancreatography (ERCP) with insertion of a plastic stent., The endoscopic retrograde cholangiopancreatography (ERCP) with immediate stone extraction attempts.
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- National Liver Institute, Egypt
Biliary Tract Neoplasms, Jaundice, Obstructive
Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents
Endoscopic retrograde biliary drainage (ERBD) is now widely accepted as the standard intervention for the relief of obstructive jaundice in patients with unresectable malignant biliary obstruction.
- Trial name
- NCT01315522
- Testing
- ComVi stent, Uncovered SEMS
- Where
- 3 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Cholestasis, Jaundice, Obstructive
SMOFlipid to Lessen the Severity of Neonatal Cholestasis
Parenteral nutrition (PN) provides intravenous nutritional supplementation for infants unable to absorb adequate enteral nutrients secondary to insufficient intestinal length or function.
- Trial name
- NCT02721277
- Testing
- SMOFlipid
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Florida
Matrix Metalloproteinase
Enzyme Activity of Matrix Metalloproteinases in the Serum of Patients With Malignant Obstructive Hyperbilirubinemia Before and After PTBD
The purpose of this study is to detect differences in the enzymatic activity of matrix metalloproteinases in patients with malignant obstructive hyperbilirubinemia before and after percutaneous biliary drainage.
- Trial name
- NCT04801914
- Testing
- Percutaneous biliary drainage
- Where
- Serbia
- Volunteers
- 30 people
- Sponsor
- Institut za Rehabilitaciju Sokobanjska Beograd
Biliary Stricture, Jaundice, Obstructive
Multicenter RCT for BIliary Brushing: RX Cytology, BOSTON vs. Infinity®, US Endoscopy
The aim of this prospective national multicenter randomized study is to compare, during an ERCP for VBP stenosis, the sensitivity of two biliary brushes: the INFINITY® vs the RX Cytology Brush® The main objective is the…
- Trial name
- BIB (NCT04251013)
- Testing
- Biliary brushing with the RX Cytology brush, Boston Scientific, Biliary brushing with the Infinity® brush, US Endoscopy
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Société Française d'Endoscopie Digestive
Jaundice Extrahepatic Obstructive, Disorder of Bile Duct Stent
Role of Endoscopic RFA in Prolonging the Patency of Metal Stents in Patients With Malignant Obstructive Jaundice
Patients with malignant obstructive jaundice (cancer of head of pancreas and cholangiocarcinoma) generally have a very poor prognosis with less than 20% patients having resectable disease at presentation.
- Trial name
- NCT01275768
- Testing
- Endoscopic radio-frequency ablation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Asian Institute of Gastroenterology, India
Pancreatitis, Cholangitis
preGallstep - A Clinical Pilot Trial
In Denmark, more than 7500 cholecystectomies are performed every year. Common bile duct gallstones (CBDS) are found in 3.4% to 18% of patients undergoing cholecystectomy.
- Conditions
- Pancreatitis, Cholangitis, Cholecystitis; Gallstone, Jaundice, Obstructive
- Trial name
- NCT04801238
- Testing
- LCBDE + LC, ERC + LC
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Lars Tue Sorensen
Perihilar Cholangiocarcinoma, Jaundice, Obstructive
Endoscopic Versus Radiologic Biliary Drainage for Perihilar Malignant Obstruction
This retrospective monocentric study aims at comparing multimodality endoscopic biliary drainage versus percutaneous radiologic biliary drainage in case of perihilar malignant obstruction.
- Trial name
- NCT05078801
- Testing
- Endoscopic drainage, Percutaneous transhepatic biliary drainage
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Obstructive Jaundice, Periampullary Tumour
Metal or Plastic Stents to Relieve Obstruction of Obstructive Jaundice Prior to Resection of Periampullary Tumors.
Patients with obstructive jaundice due to periampullary tumor can temporarily be relieved of their jaundice with transpapillary stenting at endoscopic retrograde cholangio-pancreatography (ERCP) prior to operation.
- Trial name
- SEMS (NCT02166840)
- Testing
- Plastic stent (7-10Fr), Self Expanding Metal Stent
- Where
- Sweden
- Volunteers
- 92 people
- Sponsor
- Karolinska University Hospital