Clinical trials: Ischemic Stroke, completed
Acute Ischaemic Stroke
Magnetic Resonance Post-contrast Vascular Hyperintensities at 3 T: a Sensitive Sign of Vascular Occlusion in Acute Ischaemic Stroke
Magnetic resonance imaging (MRI) is the diagnostic cornerstone for precisely identifying acute ischaemic strokes and locating vascular occlusions.
- Trial name
- NCT03971526
- Testing
- MRI images review
- Volunteers
- 130 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Stroke, Endovascular Treatment
Endovascular treatmenT for Acute Ischemic Stroke in China
This is a retrospective real world registry study, aiming to explore the effectiveness and safety of endovascular treatment of acute ischemic stroke in a Chinese population.
- Trial name
- DETECT-China (NCT04752735)
- Testing
- endovascular treatment
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- General Hospital of Shenyang Military Region
Cardiovascular Diseases, Coronary Disease
Cardiovascular Health Study (CHS) Events Follow-up Study
To support follow-up for the Cardiovascular Health Study (CHS) of coronary heart disease and stroke risk factors in adults 65 years or older.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Diabetes Mellitus
- Trial name
- NCT00149435
- Volunteers
- 5,888 people
- Sponsor
- University of Washington
Ischemic Stroke
Cough and Swallow Rehab Following Stroke
Stroke is the leading case of neurologic swallow dysfunction, or dysphagia. Post stroke dysphagia is associated with approximately 50% increase in the rate of pneumonia diagnoses; aspiration pneumonia is the most common…
- Trial name
- NCT01907321
- Testing
- Expiratory muscle strength training, Measures performed on all subjects, Pulmonary function test
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Cerebral Infarction, Brain Ischemia
Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke
Rationale The only proven therapy for acute stroke is tPA within 4.5 hours of symptom onset. This is the standard of care for patients presenting to our hospital within that time frame.
- Conditions
- Cerebral Infarction, Brain Ischemia, Stroke
- Trial name
- TIAS (NCT02101606)
- Testing
- Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Stroke, Acute, Stroke
Evaluation of Small Vessel Disease by 3D-rotational Angiography
This study is aimed to elucidate the factors affecting the remodeling process of arteriolosclerosis under current practice recommendations.
- Conditions
- Stroke, Acute, Stroke, Small Vessel Cerebrovascular Disease, Ischemic Stroke
- Trial name
- NCT04611906
- Where
- Hong Kong
- Volunteers
- 24 people
- Sponsor
- Chinese University of Hong Kong
Disorder of Consciousness, Traumatic Brain Injury
Sub-study of the NEURODOC Project : Neurophysiological Evaluation of a Routine Care Open Label tDCS Session
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Traumatic Brain Injury, Anoxic Brain Injury, Stroke
- Trial name
- Neurodoc (NCT04035655)
- Testing
- Coma Recovery Scale - revised, Electrophysiological recordings
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Ischemic Stroke, Hemorrhagic Stroke
Effects of Transcranial Electrical Stimulation in Stroke Individuals
The present study will use transcranial electrical stimulation (tES) with conventional physical therapy in sub-acute (at least 2 weeks after stroke onset) to chronic stroke within 2 years to investigate the effect on cortical…
- Conditions
- Ischemic Stroke, Hemorrhagic Stroke, Chronic Stroke, Subacute Stroke
- Trial name
- NCT06134921
- Testing
- transcranial direct current stimulation (Active), transcranial alternating current stimulation (active), Conventional physical therapy program
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Brain Ischemia,Stoke
Dyslipidemia Management in Chinese Post Stroke Patients
The purpose of this study is to provide current and reliable data of dyslipidimia management together with control situation of blood pressure and glucose for post-stroke patients within 6-12 months from attack, and also the…
- Trial name
- NCT01897883
- Where
- 26 sites in China
- Volunteers
- 5,000 people
- Sponsor
- AstraZeneca
Ischemic Stroke
Clinical Study on Huatuo Zaizao Pills for Post-stroke Treatment
The purpose of this study was to evaluate the improvement of limb motor function and nerve function of patients with HTZZ during stroke rehabilitation.
- Trial name
- NCT04910256
- Testing
- Huatuo Zaizao Pills, Basic treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Acute Ischemic Stroke
PREVAIL: PREvention of VTE After Acute Ischemic Stroke With LMWH Enoxaparin ( - VTE: Venous Thromboembolism - LMWH: Low Molecular Weight Heparin)
Primary objective: To demonstrate superiority of enoxaparin 40 mg sc qd in the prevention of VTE compared to UFH (unfractionated heparin) 5000 U sc q12 hours given for 10 ± 4 days following acute ischemic stroke.
- Trial name
- NCT00077805
- Testing
- Enoxaparin sodium
- Where
- 15 sites in United States, Australia and 13 more
- Sponsor
- Sanofi
Carotid Artery Disease, Stroke
Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy
The objective of the CANOPY trial is to assess the continued safety and effectiveness of the RX Acculink Carotid Stent System under commercial use in subjects at standard risk for adverse events from Carotid Endarterectomy (CEA)…
- Conditions
- Carotid Artery Disease, Stroke, Amaurosis Fugax, Transient Ischemic Attack (TIA)
- Trial name
- CANOPY (NCT01445613)
- Testing
- RX Acculink Carotid Stent System (RX Acculink)
- Where
- United States
- Volunteers
- 1,203 people
- Sponsor
- Abbott Medical Devices
Acute Ischemic Stroke
HRS-7450 Injection Phase II Clinical Trial for Acute Ischemic Stroke.
This study plans to enroll a total of 208 patients with Acute Ischemic Stroke (AIS) who present within 4.5 to 24 hours of symptom onset and meet the specified imaging criteria.
- Trial name
- NCT07233070
- Testing
- HRS-7450 Injection
- Where
- 2 sites in China
- Volunteers
- 210 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Atrial Fibrillation, Ischemic Stroke
Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs DOACs)
The purpose of this study is to assess safety and effectiveness of direct oral anticoagulants (DOACs) for stroke prevention in patients with non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Systemic Embolization, Major Bleed
- Trial name
- NCT03568916
- Testing
- Apixaban (ATC B01AF02), Dabigatran (ATC B01AE07), Rivaroxaban (ATC B01AF01)
- Where
- Canada
- Volunteers
- 227,579 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Acute Ischemic Stroke
Combined Use of Contact Aspiration and the Stent Retriever Technique Versus Stent Retriever Alone for Recanalisation in Acute Cerebral Infarction
Mechanical thrombectomy (MT) with a stent retriever (SR) device is now the standard intervention in ischemic stroke with large vessel occlusion. Favorable outcome is strongly associated with the successful reperfusion status.
- Trial name
- ASTER2 (NCT03290885)
- Testing
- Combined contact aspiration/Stent Retriever Technique, Stent retriever technique
- Where
- 11 sites in France
- Volunteers
- 408 people
- Sponsor
- Hopital Foch
Stroke, Ischemic
Safety of RNS60 in Large Vessel Occlusion Stroke Patients Undergoing Endovascular Thrombectomy
A Phase II, randomized, blinded, placebo-controlled, parallel group study with patients experiencing a large vessel occlusion acute ischemic stroke who are selected for endovascular revascularization.
- Trial name
- RESCUE (NCT04693715)
- Testing
- RNS60
- Where
- 7 sites in United States
- Volunteers
- 83 people
- Sponsor
- Revalesio Corporation
Sub-arachnoid Haemorrhage
Levosimendan as Treatment of Aneurysmal SubArachnoid Haemorrhage
Sub-arachnoid haemorrhage (SAH) are often due to ruptured intracerebral aneurysms and are associated with an importante morbi-mortality.
- Trial name
- LEVOSAH (NCT05664191)
- Testing
- Levosimendan
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke, Arterial Occlusion
Multimodal Neuroimaging in the Selection of Acute Ischemic Stroke (AIS) Patients to Endovascular Treatment (EVT)
To study the feasibility and usefulness of multimodal MR compared to multimodal CT to select patients with acute ischemic stroke and favorable clinical outcome after mechanical thrombectomy.
- Conditions
- Ischemic Stroke, Arterial Occlusion, CTS, Magnetic Resonance Imaging
- Trial name
- IMAGECAT (NCT03745391)
- Testing
- MULTIMODAL MAGNETIC RESONANCE (Multimodal MR), MULTIMODAL COMPUTERIZED TOMOGRAPHY (Multimodal CT)
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Germans Trias i Pujol Hospital
Brain Ischemia
Magnetic Resonance Imaging to Investigate Silent Strokes During Neck and Skull Angioplasty
This study will use magnetic resonance imaging (MRI) to determine if silent strokes occur during angioplasty of the blood vessels in the neck or skull.
- Trial name
- NCT00015717
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Transient Ischemic Attack
Determinants of Adherence to Post-stroke/Transient Ischemic Attack Secondary Prevention Treatment: Cohort Study in the Rhône
The effectiveness of emergency management of acute ischemic stroke has improved considerably in recent years with thrombolysis and more recently thrombectomy.
- Trial name
- OBSTACLE (NCT03153020)
- Testing
- Patients with stroke or transient ischemic attack
- Where
- France
- Volunteers
- 633 people
- Sponsor
- Hospices Civils de Lyon
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