Clinical trials: Ischemia-reperfusion
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation.
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury, Post-Cardiac Arrest Syndrome
- Trial name
- NCT07895771
- Testing
- Minimal sedation, Standard continuous sedation
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Arthropathy of Knee, Spinal Anesthesia
Dexmedetomidine on Tourniquet Induced -Systemic Effects
Eighty patients were randomly assigned to either control (CON) or dexmedetomidine (DEX) group. DEX group received a loading dose of 0.5 µg/ kg of intravenous dexmedetomidine over 10 minutes, followed by a continuous infusion of…
- Conditions
- Arthropathy of Knee, Spinal Anesthesia, Tourniquet, Ischemia-reperfusion Injury
- Trial name
- NCT04307290
- Testing
- Dexmedetomidine Hydrochloride, or Saline
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Wonkwang University Hospital
Ischemic Stroke, Neuroprotection
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With No Reperfusion Therapy (INSIST-NRT)
To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who missed recanalization operation.
- Trial name
- NCT04664946
- Testing
- Intra-arterial administration of neuroprotective agents
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hui-Sheng Chen
Acute Coronary Syndromes
Clopidogrel as Adjunctive Reperfusion Therapy - Thrombolysis in Myocardial Infarction
The purpose of this study is to determine if the combination of aspirin plus clopidogrel is more effective than aspirin alone in preventing another heart attack, chest pain, stroke or death in people who have already had a heart…
- Trial name
- CLARITY-TIMI28 (NCT00714961)
- Testing
- Clopidogrel (SR25990)
- Where
- 24 sites in United States, Argentina and 22 more
- Volunteers
- 3,491 people
- Sponsor
- Sanofi
ST Elevation Acute Myocardial Infarction
Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients
Infarct size is a major determinant of prognosis after Acute Myocardial Infarction (AMI). The investigators recently reported that cyclosporine A, when administered immediately prior to percutaneous coronary intervention (PCI)…
- Trial name
- CIRCUS (NCT01502774)
- Testing
- Injection of Cyclosporin, Echocardiography
- Where
- 45 sites in Belgium, France and 1 more
- Volunteers
- 970 people
- Sponsor
- Hospices Civils de Lyon
Acute Ischemic Stroke
Ali Pay Intelligent Navigation Applet-aided Pre-hospital Triage for Non-emergency Medical Service Patients With Acute Ischemic Stroke
According to the Bigdata Observatory platform for Stroke of China (BOSC), the proportion of patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis or endovascular treatment in China is 5.64% and 1.45%…
- Trial name
- i-Path (NCT06613074)
- Testing
- Ali Pay intelligent navigation applet
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Stroke
Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic Stroke (REVISE-1)
Currently, early reperfusion is considered as the most effective therapy for the treatment of acute ischemic stroke (AIS). Over the past 20 years, intravenous tissue plasminogen activator (IV tPA) has been demonstrated to be the…
- Trial name
- NCT03210051
- Testing
- Remote ischemic conditioning, Endovascular treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Ischemia-reperfusion Injury
The Effect of EPLerenone on Ischemia Reperfusion Injury in Human myoCARDium
In the laboratory, the researchers will investigate whether the drug eplerenone improves contractile function after ischemia and reperfusion in heart tissue.
- Trial name
- EPLICARD (NCT02118753)
- Testing
- Eplerenone
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Radboud University Medical Center
Ischemic Heart Disease
Hyperbaric Oxygen Therapy in Patients With Chronic Stable Ischemic Heart Disease: An Option for Therapeutic Angiogenesis?
Hyperbaric oxygen therapy (HBOT) is proposed as a possible in vivo angiogenic stimulator for improving microvascular myocardial perfusion and anginal symptoms as assessed by myocardial perfusion imaging and angina questionnaire…
- Trial name
- NCT02760394
- Testing
- HBOT
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Assaf Harofeh MC
End Stage Chronic Renal Failure, Chronic Kidney Disease (Stages 4 and 5)
Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage
The goal of this clinical trial is to test how storage temperature of deceased donor kidneys affects kidney function after transplant in adult patients receiving a kidney transplant.
- Conditions
- End Stage Chronic Renal Failure, Chronic Kidney Disease (Stages 4 and 5), Kidney Transplantation Recipients
- Trial name
- NCT07385651
- Testing
- 10˚C deceased donor kidney storage using Traferox XPort
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Acute Ischemic Stroke
SUMMIT RISE Study of Acute Ischemic Stroke Patients
SUMMIT RISE Study of Acute Ischemic Stroke Patients
- Trial name
- NCT07436156
- Testing
- Route 92 Medical Reperfusion Systems
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Route 92 Medical, Inc.
Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
Optimal Post Tpa-Iv Monitoring in Ischemic Stroke
OPTIMISTmain is an investigator-initiated and conducted, international, multicentre, stepped wedge cluster randomized controlled trial comparing the effects of different intensities of nursing care monitoring for patients with…
- Trial name
- NCT03734640
- Testing
- Low-intensity monitoring strategy, Guideline recommended standard monitoring
- Where
- 54 sites in United States, Australia and 5 more
- Volunteers
- 4,922 people
- Sponsor
- Craig Anderson
Acute Myocardial Infarction
Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury
The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion injury in AMI patients.
- Trial name
- tSGM-AMI (NCT06947135)
- Testing
- Morphine
- Where
- 3 sites in China
- Volunteers
- 166 people
- Sponsor
- The Second Hospital of Anhui Medical University
Acute Ischemic Stroke
COOLing of the Ischemic PENumbra in Patients With Acute Ischemic Stroke.
This study will develop and validate a novel, active/conductive combined head and neck cooling system to selectively cool the ischemic penumbra during the acute phase of stroke, reducing neuronal damage and improving stroke…
- Trial name
- PEN-Cool (NCT07844096)
- Testing
- PEN-Cool Conductive Head-and-Neck Cooling System, Standard Reperfusion Therapy / Routine Care
- Where
- 5 sites in India
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Stroke
Reperfusion Therapy in Acute Ischemic Stroke With Unclear Onset
This study will test the hypothesis whether patients with unclear-onset stroke (UnCLOS) treated with thrombolysis could achieve a prespecified rate of good clinical outcome.
- Trial name
- RESTORE (NCT01138059)
- Volunteers
- 83 people
- Sponsor
- Asan Medical Center
Angina Pectoris, Myocardial Infarction
GLP-1 Loading During Elective Percutaneous Coronary Intervention
Angina is caused by narrowings or blockages within coronary arteries. Coronary angioplasty and stenting is performed for people with angina to improve the blood supply to the heart by placing metal tubes within the artery using…
- Conditions
- Angina Pectoris, Myocardial Infarction, Reperfusion Injury, Coronary Heart Disease
- Trial name
- GOLD-PCI (NCT02127996)
- Testing
- GLP-1
- Where
- United Kingdom
- Volunteers
- 193 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Stroke, Ischemic Stroke
EndoVascular Treatment With Stent-retriever and/or Thromboaspiration vs. Best Medical Therapy in Acute Ischemic Stroke
Prospective, multi-center, randomized, controlled, open, blinded-endpoint trial with a sequential design. The randomization employs a 1:1 ratio of mechanical thrombectomy with stentriever and/or Thromboaspiration versus medical…
- Trial name
- RESILIENT (NCT02216643)
- Testing
- Thrombectomy, Stentriever Solitaire FR® or Penumbra System®
- Where
- 15 sites in Brazil
- Volunteers
- 221 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Ischemic Stroke, Ischemic Stroke
Impact of Presenting Symptoms on Treatment Time and Outcomes in Acute Ischemic Stroke
This observational study aims to understand how the specific symptoms a person experiences at the start of an acute ischemic stroke affect how quickly they receive treatment and how well they recover.
- Conditions
- Acute Ischemic Stroke, Ischemic Stroke, Stroke
- Trial name
- NCT07750847
- Volunteers
- 120 people
- Sponsor
- Assiut University
Oxidative Stress, Ischemia-reperfusion Injury
Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery
Ischemia and reperfusion injury during free flap reconstructive surgery creates a state of increased oxidative stress that can adversely affect the flap outcomes.
- Trial name
- NCT05327348
- Testing
- Intravenous Ascorbate, Normal Saline 10 mL Injection
- Where
- 3 sites in Malaysia
- Volunteers
- 34 people
- Sponsor
- University of Malaya
Ischemic Stroke, Hypothermia
Reperfusion With Cooling in Cerebral Acute Ischemia II
The purpose of this study is to determine whether reducing a patients body temperature (mild hypothermia of 33 degrees Centigrade) will significantly reduce the risk of brain injury (notably reperfusion injury and hemorrhagic…
- Trial name
- ReCCLAIM II (NCT01728649)
- Testing
- Mild Hypothermia
- Where
- United States
- Sponsor
- WellStar Health System