Clinical trials: Iron Deficiencies
Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
The goal of this clinical trial is to learn which iron treatment works better for adults with congestive heart failure and low iron levels: intravenous (IV) iron given through a vein or oral (PO) iron taken by mouth.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Iron Deficiency
- Trial name
- IRONICA (NCT07053475)
- Testing
- Ferric Carboxymaltose, Ferrous Sulfate
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Syed Hamza Mufarrih
Iron Deficiency Anemia
Efficacy and Safety of Intravenous Ferric Carboxymaltose (FCM) in Patients With Iron Deficiency Anemia (IDA)
The main objective of this study is to demonstrate the efficacy and safety of an investigational intravenous (IV) iron, ferric carboxymaltose (FCM), compared to oral iron in subjects who have iron deficiency anemia (IDA) and have…
- Trial name
- NCT00982007
- Testing
- Ferric Carboxymaltose (FCM), Ferrous Sulfate Tablets, IV Iron (standard of care)
- Where
- United States
- Volunteers
- 997 people
- Sponsor
- American Regent, Inc.
Iron Deficiency Anemia
Safety Assessment of Iron Sucrose (Venofer) in Patients With Chronic Kidney Disease Who Cannot Tolerate Ferumoxytol (Feraheme) or Iron Dextran (INFed or Dexferrum)
The objective of this study is to assess the safety and tolerability of Venofer in patients with chronic kidney disease who cannot tolerate Ferumoxytol (Feraheme) or intravenous iron containing a dextran (INFed or Dexferrum).
- Trial name
- ASSURED (NCT01151592)
- Testing
- Iron Sucrose
- Where
- United States
- Sponsor
- American Regent, Inc.
Iron-deficiency, Iron Deficiency Anemia
Iron Metabolism Disorders in Patients With Sepsis or Septic Shock.
Anemia is a common health problem. Depending on a geographical region, anemia affects even 50% of population. Among patients admitted to the intensive care unit (ICU) anemia may affect as much as 66% of patients.
- Conditions
- Iron-deficiency, Iron Deficiency Anemia, Anemia of Chronic Disease, Sepsis
- Trial name
- NCT05217836
- Testing
- ferritin; iron; transferrin; transferrin saturation; hemoglobin in reticulocyte; hepcidin
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Medical University of Silesia
Iron Deficiency Anemia, Iron Deficiency, Anaemia in Children
Comparison Of Efficacy Of Iron Polymaltose Complex And Ferrous Sulphate In Iron Deficiency Anemia In Pediatric Patients
This study aims to compare the efficacy of two iron preparation for the management of children presented with iron deficiency anemia. Ferrous sulphate and lron polymaltose (ferric form) are most commonly used preparations.
- Trial name
- NCT06742528
- Testing
- Ferrous sulfate, Iron Polymaltose Complex
- Where
- Pakistan
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Arooj Khan
Anemia, Iron Deficiency
Iron and Prebiotics Fortification in Kenyan Infants
Iron deficiency and anemia are health issues affecting mainly infants and women in developing countries. Iron deficiency in infancy can have long-lasting impact on cognitive and motor development of the child.
- Conditions
- Anemia, Iron Deficiency, Diarrhea, Malaria
- Trial name
- Iro'n'Pre (NCT02118402)
- Testing
- Fortified maize porridge
- Where
- Kenya
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron-deficiency
Measuring Dietary Iron Absorption From Edible Insects and Assessing the Effect of Chitin Content on Iron Bioavailability (Study 1)
Due to the growing world population, there is a need to develop viable ecological and nutritional alternatives to animal food products.
- Trial name
- Sustironable1 (NCT04510831)
- Testing
- Refined maize with extrinsic addition of labelled FeSO4, T.molitor native chitin, T molitor reduced chitin
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Iron Deficiency, Anaemia in Children
A Novel Nano-iron Supplement to Safely Combat Iron Deficiency and Anaemia in Young Children: a Doubleblind Randomised Controlled Trial
This study aims to determine whether IHAT is non-inferior to ferrous sulphate at correcting iron deficiency and anaemia, and if IHAT does not increase diarrhoea risk in young children living in rural and resource-poor areas of…
- Trial name
- IHAT-Gut (NCT02941081)
- Testing
- IHAT, Ferrous Sulphate
- Where
- The Gambia
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Iron-deficiency
Study of the Prevalence of Iron Deficiency in Elderly Patient in Hospital Environment
Iron deficiency is defined by insufficient tissue iron stores and anemia is the ultimate stage of iron deficiency. Anemia should never be neglected in an elderly subject because it is associated with an increase in mortality, but…
- Trial name
- CARENFERPA (NCT05514951)
- Testing
- Blood sampling
- Where
- 16 sites in France
- Volunteers
- 888 people
- Sponsor
- Vifor Pharma
Iron Deficiency, Heart Failure
Study to Compare Ferric Carboxymaltose With Placebo in Patients With Acute Heart Failure and Iron Deficiency
Study to Compare Ferric Carboxymaltose With Placebo in Patients With Acute Heart Failure and Iron Deficiency (Affirm-AHF)
- Trial name
- Affirm-AHF (NCT02937454)
- Testing
- ferric carboxymaltose, Normal saline 0.9%
- Where
- 16 sites in Argentina, Brazil and 13 more
- Volunteers
- 1,132 people
- Sponsor
- Vifor (International) Inc.
Iron Deficiency
Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age
research study of Ferric carboxymaltose to treat fatigue/exhaustion symptoms, believed to be due to iron deficiency.
- Trial name
- Prefer (NCT01110356)
- Testing
- Ferinject, Saline
- Where
- Austria
- Volunteers
- 294 people
- Sponsor
- Vifor Pharma
Iron Deficiency Anemia, Iron Deficiency Anemia of Pregnancy
Neuroimaging Ancillary Study
As a follow-up to the RAPIDIRON Trial (NCT05358509), and in combination with the RAPIDIRON-KIDS Study (NCT05504863), this study will involve infants of RAPIDIRON Trial participants recruited at one site in Karnataka and is…
- Conditions
- Iron Deficiency Anemia, Iron Deficiency Anemia of Pregnancy, Neurodevelopmental Disorder of Foetus, Iron Deficiency Anemia Treatment
- Trial name
- NCT05545527
- Testing
- Ferric carboxymaltose, Iron isomaltoside, Ferric Sulfate
- Where
- India
- Volunteers
- 184 people
- Sponsor
- Thomas Jefferson University
Aortic Stenosis, Iron-deficiency
Iron Supplementation in TAVI and SAVR Patients With Iron Deficiency
The INERTIA trial is a multicenter double-blinded randomized trial of intravenous iron supplementation in patients with severe aortic stenosis and iron deficiency undergoing TAVI or SAVR.
- Trial name
- INERTIA (NCT04786769)
- Testing
- Ferric carboxymaltose
- Volunteers
- 2,500 people
- Sponsor
- Hospital de Santa Cruz, Portugal
Advanced Gastric Carcinoma
Efficacy and Safety oF FErric CarboxymalTose in Patients With Advanced Gastric Cancer(EFFECT-AGC)
The main objective of this study is to evaluate the efficacy and safety of IV FCM(ferric carboxymaltose) in patients with AGC receiving palliative chemotherapy.
- Trial name
- NCT05226169
- Testing
- Ferinject, Conservative management
- Where
- South Korea
- Volunteers
- 330 people
- Sponsor
- Asan Medical Center
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese Adults
Na-GST-1 and Na-APR-1 are proteins expressed during the adult stage of the Necator americanus hookworm life cycle that are thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02126462
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Na-GST-1/Alhydrogel®, Hepatitis B vaccine
- Where
- Gabon
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Iron Deficiency
Healthy Infant Development Project - Sucrose Component
Iron deficiency affects the opioid and dopamine systems in rodent models, with a higher pain threshold. The opioid system is involved in sucrose's ability to reduce pain and distress during neonatal procedures.
- Trial name
- NCT02728141
- Testing
- Water, Sucrose
- Where
- China
- Volunteers
- 424 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Iron Status
The Relationship Between Iron Status, Cognitive Performance, Subjective Mood and Fatigue in Women of Reproductive Age.
Iron deficiency is the most prevalent nutritional deficiency worldwide with one in four estimated to be affected by iron deficiency anaemia.
- Trial name
- NCT04257669
- Where
- United Kingdom
- Volunteers
- 379 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Iron Deficiency (Without Anemia), B12 Deficiency Vitamin
Hydroponic Fortification and Dietary App Effect on Nutrients Level (Harvest)
Veganism and vegetarianism have clear benefits where they have a lower risk of many health issues. However, they also have a higher risk of nutrients and vitamin deficiency such as iron and vitamin B12.
- Trial name
- NCT05740462
- Testing
- Recipes consumption, Hydroponic unit
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Varus-Derotation Osteotomy Surgery, Iron-deficiency Anemia
Pediatric Outcomes and Recovery With Peri-Operative Iron Supplement Evaluation
Varus-derotation osteotomy (VDRO) is a surgery to prevent or address hip displacement in children. Many children having this surgery have cerebral palsy or other neuromotor disorders, who have a higher rate of malnutrition…
- Conditions
- Varus-Derotation Osteotomy Surgery, Iron-deficiency Anemia, Pelvic Osteotomy Surgery, Cerebral Palsy
- Trial name
- PORPOISE (NCT07095244)
- Testing
- Iron Supplement, Comprehensive Nutrition Management
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of British Columbia
Anemia
A Functional Food for the Prevention of Iron-deficiency Anemia
It has been estimated that 1 in 2 women expecting a baby will be diagnosed with iron deficiency. In turn iron deficiency can affect the health and wellbeing or both mother and child.
- Trial name
- NCT01055431
- Testing
- Control bread, Teff Bread
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University