Clinical trials: Invasive Ventilation
Chronic Respiratory Failure
Ambulatory Adaptation to Non-Invasive Mechanical Ventilation
A randomised study to assess the effectiveness of ambulatory adaptation to non-invasive mechanical ventilation in patient with hypercapnic respiratory failure secondary to neuromuscular diseases or alterations in thoracic cage in…
- Trial name
- NCT00698958
- Testing
- Ambulatory adaptation to non- invasive mechanical ventilation for 7 days, Hospital based adaptation to non- invasive mechanical ventilation for 7 days
- Volunteers
- 52 people
- Sponsor
- Hospital Clinic of Barcelona
Hypercapnic Respiratory Failure
Use of TpCO2 (Transcutaneous CO2 Measurement) as PaCO2 Predictor During NIV in Case of Acute Hypercapnic Respiratory Failure
In patients suffering from hypercapnic respiratory failure and treated by non invasive ventilation (NIV), the interest of using transcutaneous CO2 measurement to evaluate PaCO2 and PaCO2 variation over time is unknown and will be…
- Trial name
- TpCO2-NIV (NCT01857635)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Lausanne Hospitals
Chronic Obstructive Pulmonary Disease
Impact of a Telemonitoring Program on the Rate of Hospitalizations for Worsening of Cardio-respiratory Symptoms in COPD Patients Treated at Home by Long-term Non-invasive Ventilation (NIV)
COPD is characterized by non-reversible chronic airway obstruction. Its evolution is punctuated by successive exacerbations precipitating the progression of the disease and its co-morbidities.
- Trial name
- EXA-VNI2 (NCT02756533)
- Testing
- Telemonitoring of daily parameters recorded by NIV
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Cystic Fibrosis
HFN Versus NIV in Cystic Fibrosis. The HIFEN Study
Many patients with cystic fibrosis (CF) require hospitalization and/or Intensive Care Unit (ICU) admission because of acute exacerbation of chronic respiratory failure or for any acute deterioration of clinical status.
- Trial name
- NCT02262871
- Testing
- High flow nasal oxygen cannula, Noninvasive ventilation
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Airway Extubation
Analysis of the Magnetic Tape Bandage on Respiratory Functional Effects.
Invasive mechanical ventilation (IMV) is the mainstay of supportive care in acute respiratory failure. However, maintaining ventilatory support beyond what is necessary may increase the risk of nosocomial infections, favour…
- Trial name
- NCT05356299
- Testing
- Magnetictape bandage application
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Hospital Universitario Doctor Peset
The Critically Ill Patient is Requiring Intubation, Septic Shock
Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation
The study is a prospective randomized controlled trial comparing the efficacy and safety of propofol-ketamine ("Ketofol") versus propofol monotherapy in geriatric ICU patients.
- Conditions
- The Critically Ill Patient is Requiring Intubation, Septic Shock, Pneumonia
- Trial name
- NCT07530146
- Testing
- Ketofol, propofol (drug)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Helwan University
Respiratory Distress Syndrome, Adult, Acute Lung Injury
Perfluorocarbon (PFC) Inhalation Treatment of Acute Lung Injury/Acute Respiratory Distress Syndrome
PFCs (perfluorocarbons, PFC), an ideal liquid respiratory media, has special chemical and biological properties, including high solubility of gas, swiftness of carrying and release, low surface tension, high proportion, almost…
- Trial name
- NCT01391481
- Testing
- Perfluorocarbon, Sterile Water for Injection
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Prematurity, Respiratory Distress Syndrome
Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome
The purpose of this study is to evaluate the hypothesis that nasal intermittent positive pressure(NIPP), used as a primary mode of ventilation in preterm infants with RDS, will decrease the need for conventional endotracheal…
- Trial name
- NCT00821119
- Testing
- nasal intermittent positive pressure ventilation
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Severe Sepsis, Septic Shock
A Non-invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients.
To evaluate the use of sonographic inferior caval vein assessment in mechanically ventilated septic patients. Volume assessment in mechanically ventilated patients with inflammation is of major importance to guide fluid therapy.
- Trial name
- NCT00398736
- Testing
- sonographic measurement of inferior caval vein diameter
- Sponsor
- Charite University, Berlin, Germany
Neuromuscular Diseases, Obesity Hypoventilation Syndrome
Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis Platform
The main objective will be to determine the effectiveness of home non-invasive ventilation by flow-time and time-pressure curves analysis in a cohort of patients with this treatment by digital diagnosis platform.
- Conditions
- Neuromuscular Diseases, Obesity Hypoventilation Syndrome, Lung Disease, Restrictive
- Trial name
- PRE-HVNI (NCT03085537)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Corporacion Parc Tauli
Pulmonary Embolism
High-Flow Nasal Cannula Versus Non-Invasive Ventilation for Acute Respiratory Failure in Pulmonary Embolism.
Acute pulmonary embolism (PE) often causes hypoxemic respiratory failure through ventilation-perfusion mismatch and right-ventricular (RV) strain; supportive oxygenation plus prompt anticoagulation are crucial to care .
- Trial name
- NCT07381712
- Testing
- High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Respiratory Failure, Exacerbation of COPD
Multicenter National Randomized Controlled Open Label Study Assessing Interest of Non Invasive Ventilation in out-of Hospital Setting During Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients. VeNIS BPCO
Goal of the study: To show that prehospital NPPV use for COPD decompensation, as compared to only standard medical treatment, might enable a decrease in intubation rate.
- Conditions
- Acute Respiratory Failure, Exacerbation of COPD, Non Invasive Positive Pressure Ventilation, Out of Hospital Setting
- Trial name
- VeNIS BPCO (NCT01626937)
- Testing
- Non invasive ventilation, conventional medical treatment
- Volunteers
- 398 people
- Sponsor
- Centre Hospitalier d'Agen
Amyotrophic Lateral Sclerosis, Chronic Respiratory Failure
Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis
Non-invasive mechanical ventilation (NIV) has been increasingly used as a treatment of chronic hypercapnic respiratory failure. Its use in patients affected by chronic obstructive pulmonary disorders is still controversial, while…
- Trial name
- NCT00560287
- Testing
- Non invasive ventilation delivered with one of the ventilator specifically designed for NIV and given to the patient by the home care providers, Non invasive ventilation
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Salvatore Maugeri
Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E/E') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure.
- Conditions
- Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema, Weaning Failure of Mechanical Ventilation, Spontaneous Breathing Test
- Trial name
- ATARI (NCT06923267)
- Testing
- No Pressure Support No Positive End Expiratory Pressure Spontaneous Breathing Trial, Pressure Support Spontaneous Breathing trial, Humidified High Flow Spontaneous Breathing Trial
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Asthma Acute
Analysis of Non-invasive Ventilatory Support Modes: High Flow Nasal Cannula and Non-invasive Ventilation
This study compares two types of noninvasive treatments for asthma attacks with the objective of analyzing the efficacy of each therapy during the period of exacerbations in infants and asthmatics hospitalized.
- Trial name
- NCT04033666
- Testing
- High Flow Nasal cannula, NIV Noninvasive Ventilation
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
Respiratory Distress Syndrome in Premature Infant, Surfactant Deficiency Syndrome Neonatal
Feasibility Study - Neofact
For therapy of respiratory distress syndrome (RDS) in premature babies, there are several established options. An important therapeutic aspect is the tracheal administration of exogenous surfactant into the child's lung.
- Trial name
- NCT04086095
- Testing
- Neofact application aid
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
COPD, Non-invasive Ventilation
Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving Carbon Dioxide Clearance in AECOPD Patients
High-frequency oscillatory ventilation (HFOV), as an ideal lung-protecting ventilation method, has been gradually used in neonatal critical care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05435183
- Testing
- Non-invasive high-frequency oscillatory ventilation, Noninvasive Bilevel Positive Pressure Ventilation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Tricuspid Regurgitation, Mechanical Ventilation Pressure High
Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV)…
- Conditions
- Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
- Trial name
- NCT06229886
- Testing
- Application of positive-end-expiratory pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Chronic Obstructive Pulmonary Disease
Initiation of Long-term Non-invasive Ventilation in COPD
Rationale: Application of long-term non-invasive ventilation (NIV) in stable chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure (CHRF) has recently been shown to improve survival…
- Trial name
- RECONSIDER (NCT02652559)
- Testing
- Transcutaneous measurements of PCO2, Telemonitoring, EMG
- Where
- Netherlands
- Volunteers
- 67 people
- Sponsor
- University Medical Center Groningen
Bronchiolitis
Interest of High Flow Nasal Cannula (HFNC) Versus Non Invasive Ventilation During the Initial Management of Severe Bronchiolitis in Infants
1. The purpose of the study is to evaluate prospectively the clinical benefits of High flow nasal canula (HFNC: 2l/kg/min) versus nasal CPAP( continuous positive airway pressure) (n-CPAP: 7 cmH2O) in the initial management of…
- Trial name
- TRAMONTANE (NCT02457013)
- Testing
- HFNC, nCPAP
- Where
- France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Montpellier