Clinical trials: Intrusive Memories
Intrusive Memories
Cortisol and the Formation of Intrusive Memories
Intrusive memories of traumatic events are core features of posttraumatic stress disorder (PTSD) but little is known about the neurobiological formation of intrusions.
- Trial name
- NCT02552654
- Testing
- Stress Film, Hydrocortisone
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Working Memory, Consolidation/Recconsolidation Memory
Theories of Working Memory and Consolidation/RECOnsolidation in the Process of Resorption of Post-traumatic Symptoms.
EMDR is a psychotherapeutic approach recommended by the World Health Organization (WHO) for the treatment of disorders such as post-traumatic stress disorder, anxiety, depression and, more generally, psychological distress.
- Conditions
- Working Memory, Consolidation/Recconsolidation Memory, Eye Movement Desensitization and Reprocessing, Alterning Bilateral Stimulation
- Trial name
- NCT06469333
- Testing
- Eye movements (EM), Auditory stimulations, Tactile stimulations
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University of Lorraine
Memory
Intrusive Reexperiencing: The Role of Working Memory Capacity and Thought Suppression
This study aims at identifying risk factors for the development of intrusive reexperiencing symptoms. In particular, the investigators examine the influence of working memory capacity and thought suppression on the occurrence of…
- Trial name
- NCT01007682
- Testing
- Show distressing movie and tell half of the two study groups to suppress memories of the movie
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Intrusive Memories
The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories
The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.
- Trial name
- NCT03031405
- Testing
- Oxytocin nasal spray
- Where
- Germany
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
PTSD
Exposure by Assessment: Effects of Daily AMQ-Based EMA of an Intrusive Trauma Memory in PTSD
Intrusive re-experiencing is a hallmark of PTSD. The study applies ecological momentary assessment (EMA) of participants' trauma memories (active group) vs.
- Trial name
- NCT07658157
- Testing
- AMQ-based ecological momentary assessment of an intrusive memory, AMQ-based ecological momentary assessment of an emotionally neutral memory
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel Aviv University
Non-clinical Participants, Intrusive Memories
Understanding Reactions to Emotional Material in the Media During COVID-19 - Study 2
This second feasibility study aims to adapt a protocol usually run in the laboratory in the Psychology Department for healthy participants (including the trauma film paradigm (James et al., 2016) and a simple cognitive task…
- Trial name
- NCT05063825
- Testing
- Simple cognitive task intervention
- Where
- Sweden
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Intrusive Memories
Behavioral Modulation of Intrusive Memories
The purpose of the study is to examine whether sleep affects the development of intrusive memories.
- Trial name
- NCT03227081
- Testing
- Sleep Deprivation
- Where
- Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Sleep, Intrusive Memories
Sleep and Wellbeing Study
Most people will experience a psychologically traumatic event, such as a life-threatening accident, at some point in their life.
- Conditions
- Sleep, Intrusive Memories, Posttraumatic Stress Disorder
- Trial name
- NCT03012685
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Oxford
Post Traumatic Stress Disorder, Stress Disorders, Post-Traumatic
Reducing Intrusive Memories in Refugees and Asylum Seekers With PTSD
This research study is designed to investigate the use of a simple cognitive task for decreasing the number of intrusive memories of traumatic events experienced by refugees and asylum seekers with a diagnosis of Post-traumatic…
- Conditions
- Post Traumatic Stress Disorder, Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Trauma, Psychological
- Trial name
- NCT04394156
- Testing
- Brief cognitive intervention
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Surrey
Posttraumatic Stress Disorder, Intrusive Traumatic Memories
Tackling Intrusive Traumatic Memories After Childbirth
This single-blind waitlist randomized controlled trial aims to investigate the efficacy of a single-session behavioral intervention composed of a brief evocation of the childbirth memory followed by a visuospatial task (the…
- Trial name
- ASTRAL (NCT05381155)
- Testing
- A single-session behavioral intervention composed of a brief evocation of the childbirth memory followed by a Tetris gameplay
- Where
- 2 sites in Switzerland
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic
Reducing Intrusive Memories in Refugees and Asylum Seekers With PTSD: A Pilot Study
This research study was designed to investigate the use of a simple cognitive task for decreasing the number of intrusive memories of traumatic events experienced by refugees and asylum seekers with a diagnosis of Post-traumatic…
- Conditions
- Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Mental Disorder, Trauma and Stressor Related Disorders
- Trial name
- NCT04394832
- Testing
- Brief cognitive intervention
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Surrey
Post-traumatic Stress Disorders
Simple Cognitive Task After Trauma
This research study is designed to investigate the effects of a simple cognitive task (a memory cue following by playing the computer game "Tetris") on intrusive memories ("flashbacks") and other symptoms after a traumatic event.
- Trial name
- NCT03509792
- Testing
- Simple cognitive task
- Where
- Sweden
- Volunteers
- 42 people
- Sponsor
- Karolinska Institutet
Generalized Anxiety, Fear of Failure
Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence
The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs).
- Conditions
- Generalized Anxiety, Fear of Failure, Rumination
- Trial name
- ImRs_LLM_DeanG (NCT07565714)
- Testing
- Imagery Rescripting Intervention
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Intrusion Symptom
Remote Delivery of a Visuospatial Intervention to Reduce Traumatic Intrusive Memories After Paediatric Intensive Care
This study aims to examine the feasibility and acceptability of a brief intervention, involving a imagery-competing task, remotely delivered to parents who are currently experiencing persistent intrusive traumatic memories at…
- Trial name
- NCT05500105
- Testing
- Simple cognitive task intervention
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Post Traumatic Stress Disorder
Computer Assisted Lessening of Intrusive Memories in the Emergency Department
During the COVID-19 pandemic, clinical staff working in frontline NHS hospital and pre-hospital departments (e.g. emergency department, intensive care unit, ambulance service) are being faced with difficult and stressful…
- Trial name
- CALM-ED (NCT04769999)
- Testing
- Simple cognitive task
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Oxford
Intrusive Memories of Traumatic Event(s), Post Traumatic Stress Disorder
Simple Cognitive Task Intervention After Trauma During COVID-19 In Hospital Staff EKUT-P RCT
This research study is designed to investigate the effects of a remotely delivered simple cognitive task (a memory cue followed by playing the computer game "Tetris" with mental rotation instructions) on intrusive memories…
- Trial name
- NCT04460014
- Testing
- Simple cognitive task intervention
- Where
- Sweden
- Volunteers
- 164 people
- Sponsor
- Karolinska Institutet
Post-traumatic Stress Disorder, Cocaine Use Disorder
Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories
An investigation of the effect of matrix-metalloproteinase-(MMP)-9 inhibition with minocycline on the reconsolidation of trauma- or cocaine-related memories
- Trial name
- Memocycline (NCT05902819)
- Testing
- Imagery, Minocycline
- Where
- Switzerland
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Intrusive Memories of Traumatic Event(s)
A Brief GAmeplay Intervention for NHS ICU Staff Affected by COVID-19 Trauma (GAINS Study)
Intensive care unit (ICU) staff are frequently exposed to traumatic events at work (e.g., witnessing patients die), amplified by the COVID-19 pandemic.
- Trial name
- GAINS (NCT04992390)
- Testing
- Brief digital imagery-competing task intervention
- Where
- United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- P1vital Products Limited
Intrusive Memories
The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories
The aim of the current project is to investigate the impact of an activation of the cannabinoid system with an exogenous cannabinoid dronabinol (delta-9-tetrahydrocannabinol) on the formation of intrusive memories after analog…
- Trial name
- NCT04871269
- Testing
- Dronabinol
- Where
- Germany
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intrusive Memories, PTSD
The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories
The purpose of the study is to examine whether oxytocin and certain polygenic risk scores affect the development of intrusive memories, a cardinal symptom of PTSD.
- Trial name
- NCT03875391
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany