Clinical trials: Intraoperative Hypotension, open to volunteers
Biliary and Pancreatic Diseases, Endoscopic Retrograde Cholangiopancreatography (ERCP)
A 2×2 Factorial Randomized Controlled Trial for ERCP
To investigate the effects of propofol vs. cyclopropofol and sufentanil vs. esketamine on intraoperative hypoxemia and hypotension in elderly patients undergoing ERCP, as well as the interaction between these two factors.
- Trial name
- NCT07584902
- Testing
- Anesthesia induction using propofol+sufentanil, Anesthesia induction using propofol+esketamine, Anesthesia induction using ciprofol+sufentanil
- Volunteers
- 236 people
- Sponsor
- Gang Chen
Serum Lactate Post-pancreatic Duodenectomy
Intra-operative Hypotension and Post-operative Lactate Level After Pancreatic-duodenectomy
Intraoperative hypotension is a frequent occurrence during pancreaticoduodenectomy (PD) and has been associated with impaired tissue perfusion and organ dysfunction.
- Trial name
- HYPOL (NCT07346274)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Clinico Humanitas
Hypotension During Surgery
The Noninvasive Blood Pressure Measurement Effect on the Hypotension
Around 300 million surgical operations are performed globally, and of these, 40 to 50 million are performed in the USA. The perioperative period is characterized by hemodynamic instability and, most importantly, hypotension.
- Trial name
- NCT05993481
- Testing
- Blood Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs)
PRO STRESS Trial: Proactive Low-Dose Norepinephrine to Reduce Intraoperative Fluid Administration in Patients at High-Risk for Postoperative Pulmonary Complications Undergoing Laparoscopic Abdominal Surgery
Intraoperative hypotension is commonly treated with fluid administration; however, excessive fluid therapy may contribute to postoperative pulmonary complications.
- Conditions
- Intraoperative Hypotension, Postoperative Pulmonary Complications (PPCs), Fluid Over-load
- Trial name
- PRO STRESS (NCT07627360)
- Testing
- Norepinephrine
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Suez Canal University
Intraoperative Hypotension
Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia.
- Trial name
- NCT07301307
- Testing
- Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software, Conventional Intraoperative Hemodynamic management
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Intraoperative Hypotension, Ciprofol
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors.
- Conditions
- Intraoperative Hypotension, Ciprofol, Renin-angiotensin System Inhibitors
- Trial name
- NCT06952608
- Testing
- Ciprofol group, Propofol group
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal
Effect of Remimazolam Versus Propofol Total Intravenous Anesthesia on Intraoperative Hemodynamic Stability in Patients Undergoing Thoracic or Abdominal Endovascular Aortic Repair
The purpose of this study is to compare two intravenous anesthetics, remimazolam and propofol, for their effects on intraoperative hemodynamic stability in patients undergoing thoracic or abdominal endovascular aortic repair.
- Conditions
- Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal, Intraoperative Hypotension, Hemodynamic Instability During Anesthesia
- Trial name
- NCT07806006
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Intraoperative Hypotension, Hepatectomy
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
The goal of this clinical trial is to learn whether remimazolam helps prevent low blood pressure better than propofol during major liver surgery in adults.
- Trial name
- NCT07789275
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
the Severity and Duration of Intraoperative Hypotension
Remimazolam in High Risk ERCP Patients
We conducted a randomized trial to investigate whether the administration of Remimazolam in patients undergoing high-risk endoscopic retrograde cholangiopancreatography (ERCP) could significantly reduce the occurrence of…
- Trial name
- NCT06258356
- Testing
- Remimazolam
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Intraoperative Hypotension
Feasibility Study of E-Fusion Vasopressor Titration-Assist During Multi-Level Spine Surgery
This is a single-arm feasibility study of E-Fusion Vasopressor Titration-Assist, a clinical decision support software, in 10 adults undergoing multi-level spine surgery.
- Trial name
- NCT07840937
- Testing
- E-Fusion Vasopressor Titration-Assist
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Autonomous Healthcare, Inc.
the Severity and Duration of Intraoperative Hypotension
Applying HPI in Oral Cancer Surgery
Investigating HPI effect in oral cancer surgery
- Trial name
- NCT07405892
- Testing
- HPI, HPI silence
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Spine Surgery, Intraoperative Hypotension
Superiority of Phenylephrine Versus Norepinephrine in Complex Spine Surgery (SPiNeS)
The purpose of this research is to compare two commonly used medications, phenylephrine and norepinephrine, that are used to treat low blood pressure during complex spine surgery.
- Conditions
- Spine Surgery, Intraoperative Hypotension, Tissue Perfusion
- Trial name
- NCT07796282
- Testing
- Phenylephrine hydrochloride infusion, Norepinephrine bitartrate infusion
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Hemodynamic MAP Stability
Delta Variation to Guide Hemodynamic Optimization
intraoperative hemodynamic optimization will be based on the percentage of variation of the parameters
- Trial name
- DELTA (NCT06932484)
- Testing
- parameters
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Delirium (POD), Intraoperative Hypotension
Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery
In older patients having surgery, postoperative delirium (an acute disturbance in awareness, attention, or cognition) is common and associated with short-term and long-term morbidity and mortality.
- Trial name
- ASPIRE-85 (NCT07713121)
- Testing
- MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group)
- Where
- Germany
- Volunteers
- 3,432 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Intraoperative Hypotension
Internal Jugular Vein Collapsibility Index as a Predictor of Hypotension
The internal jugular vein (IJV) collapsibility index has been proposed as a practical alternative of of the inferior vena cava collapsibility index (IVC-CI), as it is easily accessible using bedside ultrasonography.
- Trial name
- NCT07692425
- Testing
- Internal Jugular Vein Collapsibility Index
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Hypotension During Surgery
External Validation of Prediction Algorithm Using Non-invasive Monitoring Device for Intraoperative Hypotension
The goal of this prospective observational study is to externally validate the prediction algorithm using non-invasive monitoring device for intraoperative hypotension.
- Trial name
- NCT06897514
- Testing
- Prediction algorithm for intraoperative hypotension
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Intraoperative Hypotension
Oscillometric Versus Intraarterial Blood Pressure Monitoring During Robot-Assisted Prostatectomy
The PROST-BP trial is a prospective, single-center, randomized, patient-blinded, non-inferiority trial investigating whether intermittent oscillometric blood pressure monitoring is non-inferior to continuous intraarterial blood…
- Trial name
- PROST-BP (NCT07349186)
- Testing
- Oscillometric blood pressure monitoring, Intraarterial blood pressure monitoring
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- University of Hamburg-Eppendorf
General Anesthesia, Aged
Remimazolam Versus Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery
This prospective observational cohort study evaluates the effectiveness and safety of two benzodiazepine sedatives-remimazolam and midazolam-used for general anesthesia induction in elderly patients (≥65 years) undergoing…
- Conditions
- General Anesthesia, Aged, Intraoperative Hypotension, Anxiety
- Trial name
- NCT07746505
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi