Clinical trials: Intraoperative Hypotension
Blood Pressure, Complication,Postoperative
HIgh Versus STAndard Blood Pressure Target in Hypertensive High-risk Patients Undergoing Major Abdominal Surgery
This study is a multicenter randomized controlled trial comparing two strategies of mean arterial blood pressure management (MAP ≥ 80mmHg vs MAP ≥ 65 mmHg) in high-risk surgical patients undergoing elective…
- Conditions
- Blood Pressure, Complication,Postoperative, Intraoperative Hypotension
- Trial name
- HISTAP (NCT05637606)
- Testing
- Ephedrine, Norepinephrine, Etilefrine Hydrochloride bolus
- Where
- 18 sites in Italy
- Volunteers
- 636 people
- Sponsor
- Humanitas Clinical and Research Center
Hypotension During Surgery, Perioperative Complication
Hypotension Predictive Index Effect on Intraoperative Hypotension During Pancreatic Surgery.
Intraoperative hypotension (IOH) is a sudden clinical phenomenon that occurs frequently during general anesthesia. Prevention of IOH has been linked to reduced postoperative organ damage and decreased incidence of perioperative…
- Trial name
- EHPI-Pan (NCT06097052)
- Testing
- Hypotension Predictive Index
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituto Clinico Humanitas
Intraoperative Hypotension, Hemodynamic Instability
AI-Assisted Blood Pressure Control During Anesthesia
This proof-of-concept randomized controlled trial evaluates a reinforcement learning (RL)-based clinical decision support system for intraoperative hemodynamic management during non-cardiac surgery.
- Trial name
- RL-PRAIS PoC (NCT07123675)
- Testing
- Device: AI Clinical Decision Support System, Procedure: Standard of Care Anesthesia
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Biliary and Pancreatic Diseases, Endoscopic Retrograde Cholangiopancreatography (ERCP)
A 2×2 Factorial Randomized Controlled Trial for ERCP
To investigate the effects of propofol vs. cyclopropofol and sufentanil vs. esketamine on intraoperative hypoxemia and hypotension in elderly patients undergoing ERCP, as well as the interaction between these two factors.
- Trial name
- NCT07584902
- Testing
- Anesthesia induction using propofol+sufentanil, Anesthesia induction using propofol+esketamine, Anesthesia induction using ciprofol+sufentanil
- Volunteers
- 236 people
- Sponsor
- Gang Chen
Intra-operative Hypotension
Preoperative Point of Care Ultrasound Guided Fluid Optimization and Intravenous Ondansetron to Prevent General Anesthesia-Induced Hypotension
Hypotension is a common side-effect of general anesthesia induction and is related to adverse outcomes including significantly increasing risk of one-year mortality.
- Trial name
- NCT05784350
- Testing
- fluid boluses guided by IVC diameter via US/administration of pre-operative IV Odansetrone
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Meir Medical Center
the Severity and Duration of Intraoperative Hypotension
HPI in Older Patients Undergoing Major Gastrointestinal Surgery
The incidence of intraoperative hypotension was 91%. The increasing incidence of intraoperative hypotension would increase the risk of postoperative complications, such as postoperative arrythmia, stroke or acute kidney injury.
- Trial name
- NCT05297318
- Testing
- hypotension prediction index guided, without hypotesion prediction index guided
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Myocardial Infarction Postoperative, Myocardial Injury
Myocardial Infarction in the Perioperative Setting
Acute myocardial infarction (AMI) is a significant complication following non-cardiac surgery. The investigators sought to evaluate incidence of perioperative AMI, its preoperative and intraoperative risk factors and the outcomes…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Intraoperative Complications, Intraoperative Hypotension
- Trial name
- MIPS (NCT03837535)
- Testing
- Surgery
- Where
- Sweden
- Volunteers
- 400,742 people
- Sponsor
- Karolinska University Hospital
Intraoperative Hypotension
Continuous Versus Bolus Administration of Norepinephrine to Treat Hypotension During Anesthetic Induction
Intraoperative hypotension is common in patients having non-cardiac surgery with general anesthesia and is associated with organ injury and death.
- Trial name
- INDUCT (NCT05940649)
- Testing
- Continuous norepinephrine administration
- Where
- Germany
- Volunteers
- 262 people
- Sponsor
- Kristen Thomsen
Intraoperative Hypotension
HPI Algorithm for the Prevention of IOH During Spinal Surgery [HPIFPIOH]
The aim of this study is to investigate the hypothesis that the use of the Hypotension Prediction Index algorithm (HPI) can reduce intraoperative hypotension (IOH) in adult patients undergoing spinal surgery in the prone position…
- Trial name
- HPIFPIOH (NCT05341167)
- Testing
- HPI algorithm using Edwards device https://www.edwards.com/gb/devices/decision-software/hpi, Vasoactive Agent
- Where
- 2 sites in Greece
- Volunteers
- 85 people
- Sponsor
- Attikon Hospital
Hypotension During Surgery
The Noninvasive Blood Pressure Measurement Effect on the Hypotension
Around 300 million surgical operations are performed globally, and of these, 40 to 50 million are performed in the USA. The perioperative period is characterized by hemodynamic instability and, most importantly, hypotension.
- Trial name
- NCT05993481
- Testing
- Blood Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Shock, Surgical, Shock
Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients
The current standard of catecholamine vasopressor management of perioperative hypotension in kidney transplant patients carries significant risks and falls short in many ways.
- Conditions
- Shock, Surgical, Shock, Hypotension and Shock, Kidney Transplant; Complications
- Trial name
- NCT04529005
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois at Chicago
Intraoperative Hypotension
PPI Guided Strategies for Prevention and Treatment of Intraoperative Hypotension
Intraoperative hypotension is closely related to the poor prognosis of surgery. The study is focused on the effectiveness of maintaining normal peripheral perfusion index (PPI) on time-weighted average of hypotension during…
- Trial name
- NCT05792696
- Testing
- PPI guided strategies, Empirical strategies
- Where
- China
- Volunteers
- 54 people
- Sponsor
- zhiqiang zhou
Hypotension, Acute Kidney Injury
A Clinical Decision Support Trial to Reduce Intraoperative Hypotension
The purpose of this study is to provide messages to providers if their patient is at high risk of developing intraoperative hypotension based on past medical history and co-morbidities preoperatively and minutes of hypotension…
- Trial name
- NCT04062994
- Testing
- Nudge to reduce intraoperative hypotension
- Where
- 4 sites in United States
- Volunteers
- 30,000 people
- Sponsor
- University of California, Los Angeles
Anesthesia, General
Continuous Versus 1-min Oscillometric Arterial BP Monitoring
Hypotension is common during surgery and about one-third of hypotension occur during the period from anesthesia induction to skin incision. Therefore, monitoring blood pressure during this period is crucial.
- Trial name
- NCT05792436
- Testing
- 1-min interval oscillometric method, arterial catheterization method
- Where
- 2 sites in South Korea
- Volunteers
- 258 people
- Sponsor
- Seoul National University Hospital
Intraoperative Hypotension
Effects of Remimazolam on the Intraoperative Hemodynamics in Bypass Surgery
This study is a randomized, controlled trial. A total of 72 patients will be randomized to receive remimazolam anesthesia or balanced anesthesia (propofol + desflurane) during extracranial-intracranial bypass surgery.
- Trial name
- NCT05557253
- Testing
- Remimazolam, Balanced Anesthesia
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Hypotension on Induction
Efficacy of Oral Diltiazem on the Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
The primary endpoint is the effect of the addition of oral Diltiazem and Tranexamic Acid to general anesthesia aided reduction in blood loss during functional endoscopic sinus surgery (FESS).
- Trial name
- NCT03580590
- Testing
- oral Diltiazem, IV Tranexamic Acid
- Volunteers
- 40 people
- Sponsor
- Assiut University
Intraoperative Hypotension
Hypotension Prediction Index for Blood Pressure Management
Design: Single-center randomized comparison of invasive arterial pressure monitoring vs. arterial pressure monitoring combined with Acumen Hypotension Prediction Index (HPI) software guidance on intraoperative hypotension…
- Trial name
- HPI (NCT03610165)
- Testing
- Acumen HPI-enabled EV1000 screen, Control
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- The Cleveland Clinic
Intraoperative Hypotension
Bispectral Index Guided Sevoflurane Titration
Electroencephalographic-based monitoring systems such as the bispectral index (BIS) may reduce anaesthetic overdose rates. The investigators hypothesised that goal-directed sevoflurane administration (guided by BIS monitoring)…
- Trial name
- NCT02515019
- Testing
- Bispectral index Monitoring
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Intraoperative Hypotension and Acute Kidney Injury After Off-pump Coronary Artery Bypass Grafting Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Hypotension is an important risk factor for the development of AKI after noncardiac surgery.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- NCT03889730
- Where
- China
- Volunteers
- 821 people
- Sponsor
- Peking University First Hospital
Radiography, Interventional
Early Detection of Intra Operative Hypotension (IOH) During the Induction of General Anaesthesia
During general anaesthesia, intraoperative hypotension (IOH), defined as a mean arterial pressure (MAP) drop of more than 20%, is frequent with potential deleterious effects for patients.
- Trial name
- NCT03756935
- Testing
- All monitoring
- Volunteers
- 62 people
- Sponsor
- Hopital Lariboisière