Clinical trials: Intraoperative Fluid Management
Ischemic Heart Disease, Aortic Aneurysm
Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose
Intranasal insulin is reported to improves memory performance in patients suffering from cognitive impairment. The investigators have previously shown that intraoperative insulin administration preserves both short and long-term…
- Trial name
- NCT02729064
- Testing
- Humulin R, Normal Saline
- Where
- Canada
- Volunteers
- 141 people
- Sponsor
- Hiroaki Sato, MD., PhD.
Fluid Management
Hemodynamic Optimization Based on a Dynamic Elastance Protocol
In this study investigators explore the effects of a dynamic elastance guided protocol compared to a stroke volume variation fluid therapy on lactate levels during major abdominal surgery.
- Trial name
- NCT05187273
- Testing
- Elastance Group
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fluid Overload
Body Composition Monitoring(BCM) for Determination of the Fluid Status in Patients Undergoing General Anesthesia
The purpose of this study is to evaluate a recently developed device, which measures body composition (i.e. the water content of the body) in the perioperative setting.
- Trial name
- BCM (NCT01945541)
- Testing
- Body Composition Monitoring
- Where
- Austria
- Volunteers
- 73 people
- Sponsor
- Medical University of Vienna
Crohn's Disease, Ulcerative Colitis
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
The purpose of this study is to find out if guided fluid administration with the esophageal monitor is superior to standard fluid administration and whether use of the hetastarch or lactated ringers offers different benefits with…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Rectal Cancer, Colon Cancer
- Trial name
- NCT00467922
- Testing
- Hextend, Lactated Ringers
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Corewell Health West
Surgical Blood Loss, Hemorrhage
The Cryopreserved vs. Liquid Platelets Trial
This trial is a phase III multicentre blinded randomised controlled clinical non-inferiority trial of cryopreserved platelets vs. conventional liquid-stored platelets for the management of surgical bleeding.
- Trial name
- CLIP II (NCT03991481)
- Testing
- Cryopreserved platelets, Liquid-stored platelets
- Where
- 6 sites in Australia
- Volunteers
- 388 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Esophageal Neoplasm
Volume Restriction in Esophageal Carcinoma Surgery: Randomized Clinical Trial
An exploratory single-centre randomized clinical trial was performed in order to investigate whether the fluid volume administered during esophageal carcinoma surgery affects pulmonary gas exchange and tissue perfusion.
- Trial name
- NCT02033213
- Testing
- Restrictive group, Liberal group
- Where
- Croatia
- Volunteers
- 16 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Craniosynostosis
Pleth Variability Index Monitoring in Pediatric Craniosynostosis Surgery
This prospective observational study aims to evaluate the role of pleth variability index (PVI) and perfusion index (PI) monitoring in intraoperative hemodynamic control among pediatric patients undergoing craniosynostosis…
- Trial name
- PVI-CRANIO (NCT07657598)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Muzaffer GENCER
Intra Operative Fluid Management
Renal Function During Laparoscopic Surgery
Aim of this study was to investigate the cardiac and renal responses to the administration of different amount of crystalloids, with and without dopamine, during gynaecological laparoscopic surgery.
- Trial name
- NCT01722630
- Testing
- Dopamine
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Catholic University of the Sacred Heart
Acute Normovolemic Hemodilution, Cardiac Surgery
Impact of Pleth Variability Index-Guided Acute Normovolemic Hemodilution on Intraoperative Fluid Management and Postoperative Complications in Cardiac Surgery
Acute normovolemic hemodilution (ANH) is a widely used blood conservation strategy in cardiac surgery aimed at reducing intraoperative blood loss and the need for allogeneic blood transfusion.
- Conditions
- Acute Normovolemic Hemodilution, Cardiac Surgery, Postoperative Complication, Pleth Variability Index
- Trial name
- NCT07466082
- Testing
- acute normovolemic hemodilution, PVI dependant acute normovolemic hemodilution
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Obesity
Obesity and Goal-directed Intraoperative Fluid Therapy
The purpose of the study is to compare non-obese patients (BMI≤ 30 kg/m2)versus obese patients (BMI> 30 kg/m2) in regard of their respective needs for intraoperative fluid therapy during laparoscopic surgery.
- Trial name
- NCT01052519
- Testing
- Goal directed fluid therapy
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Intraoperative Fluid Management
Intraoperative Different Fluid Therapy Protocols
We aimed to evaluate the relationship between different intraoperative fluid therapy protocols and postoperative renal damage and mortality.
- Trial name
- NCT06188299
- Testing
- Restricted Fluid Administration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara City Hospital Bilkent
Brain Tumor, Craniotomy
Intraoperative Goal Directed Fluid Management in Supratentorial Brain Tumor Craniotomy
Pulse pressure variation (PPV) to standard fluid management (4ml/Kg/hr) in patients undergoing supratentorial mass excision. The investigators hypothesize that in these procedures, goal-directed fluid therapy (GDT) might improve…
- Trial name
- NCT03033706
- Testing
- Pulse pressure variation guided fluid therapy, Traditional fluid therapy, Brain tumor excision
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Cairo University
Intraoperative Fluid Volume, Hemodynamics
Pulse Pressure Variation Based Intraoperative Fluid Management Versus Traditional Fluid Management for Colonic Cancer Patients Undergoing Mass Resection and Anastomosis
pulse pressure variation based intraoperative fluid therapy versus traditional fluid therapy for colonic cancer patients undergoing mass resection and anastomosis for maintaining adequate hydration without complications.
- Conditions
- Intraoperative Fluid Volume, Hemodynamics, Serum Lactate, Intestinal Edema
- Trial name
- NCT05502835
- Testing
- pulse pressure variation, conventional fluid management
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Intracranial Aneurysm, Brain Edema
Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
This is a prospective, randomized controlled trial to determine if using FloTrac/EV1000 system in neurosurgical patients undergoing craniotomies for aneurysm repair or tumor resection complicated by cerebral edema, or complex…
- Conditions
- Intracranial Aneurysm, Brain Edema, Scoliosis, Surgery
- Trial name
- NCT02701582
- Testing
- Phenylephrine, Epinephrine, Albumin
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- NYU Langone Health
Anesthesia, General, Fluid Therapy
Management of Intraoperative Fluids in Ambulatory Surgery
This is a single-center prospective randomized control trial (RCT) to determine whether the continuous monitoring of the plethysmographic variability index (PVI) during low-risk surgeries, can be used to optimize the…
- Conditions
- Anesthesia, General, Fluid Therapy, Ambulatory Surgical Procedures
- Trial name
- MIFAS (NCT03193320)
- Testing
- Fluid therapy protocol
- Where
- Venezuela
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Policlinica Metropolitana
Liver Transplantation (LT), End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL)
The goal of the REFIL-2 study is to evaluate the effectiveness of a low splanchnic blood volume restrictive fluid management strategy (a strategy that involves limiting fluid administration and prioritizing the use of medications…
- Trial name
- REFIL-2 (NCT07695363)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Phlebotomy, Optimized cardiac output liberal fluid management strategy
- Where
- 4 sites in Canada
- Volunteers
- 866 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Femoral Neck Fractures
the Effects of Perioperative Goal Directed and Conventional Fluid Management on the IVC Collapsibility Index
The investigators aimed to compare the effects of targeted fluid management and traditional fluid management on the inferior vena cava collapsibility index in participants who will undergo proximal femoral surgery.
- Trial name
- NCT05154435
- Testing
- mostcare hemodynamic monitor
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hemodynamic
Three Different GHDT ( Goal Hemodynamic Directed Therapy) Strategies for Intraoperative Fluid Management Optimization During Major Abdominal Surgery: A Randomized Controlled Trial
Major oncological surgery is among the most complex procedures, involving patients with a combination of high-risk factors that can significantly influence immediate postoperative outcomes and quality of life.
- Trial name
- SMART FLUID (NCT06871150)
- Testing
- Flotrac sensor, HPI, HPI-AFM
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- ASST Sette Laghi
Epidural Anesthesia
Effect of Intraoperative Fluid Management on Morbidity
The purpose of this study is to determine whether intraoperative fluid and sodium restriction decreases postoperative morbidity
- Trial name
- NCT00156338
- Testing
- fluid management
- Where
- 3 sites in Germany
- Volunteers
- 108 people
- Sponsor
- University Hospital Muenster
Other Complications of Esophagostomy
Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response…
- Trial name
- PPV (NCT01933451)
- Testing
- Intraoperative fluid therapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital