Clinical trials: Intracytoplasmic Sperm Injection
Infertility
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin D ( ICSI-CD)
Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc.
- Trial name
- NCT03677492
- Testing
- Medium Supplemented with Cytochalasin D
- Where
- 2 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- Ibn Sina Hospital
Male Infertility
Effect of Sorting of Apoptotic Spermatozoa on the Outcome of Assisted Reproduction
In assisted reproductive technology (ART) semen needs to be processed. Commonly used methods rely on physical properties of the spermatozoa, such as the swim-up methods and density gradient centrifugation.
- Trial name
- Spermsorting (NCT02166567)
- Testing
- Staining of spermatozoa with the YoPro dye and sorting of the stained spermatozoa with FACS, Swim-up
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Endometrioma
Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients
Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm \&with or without GnRh agonists for all endometrioma patients
- Trial name
- GnRh (NCT02737800)
- Testing
- endometrioma aspiration, GnRh agonist ( Decapeptyl ), standard long stimulation protocol
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kasr El Aini Hospital
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.
This prospective, non-randomised, open-label, clinical trial is conducting on polycystic ovary syndrome (PCOS) subjects to compare the effects of two pituitary suppression regimens; GnRH Agonist-Long Protocol and GnRH…
- Conditions
- In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility, Polycystic Ovary Syndrome
- Trial name
- NCT04727671
- Testing
- Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Intracytoplasmic Sperm Injection, GnRH Agonist
Effect of GnRH Agonist Treatment Protocols on Ovarian Reserve
This study aimed to compare the gonadotropin-releasing hormone agonist (ultra-short) protocol versus (short and long) protocols on ovarian reserve in women undergoing intracytoplasmic sperm injection
- Conditions
- Intracytoplasmic Sperm Injection, GnRH Agonist, Infertility, Ovarian Reserve
- Trial name
- NCT05567731
- Testing
- ultrashort GnRHa, short GnRHa, long GnRHa
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Intracytoplasmic Sperm Injection
ICSI Outcome of Ejaculated Versus Extracted Testicular Spermatozoa
The study is retrospective to compare ICSI outcome of patients with cryptozoospermia or severe oligozoospermia after use of ejaculated versus extracted testicular sperms in different cycles for the same patient.
- Trial name
- NCT03033563
- Testing
- Intracytoplasmic sperm injection
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Adam International Hospital
Infertility
Interest of Estrogen Scheduling Before Ovarian Stimulation With Corifollitropin Alfa
E2 given in late luteal phase can be extended beyond the onset of menses for a period of at least eight days before the start of the stimulation, allowing scheduling of stimulation in order to limit oocytes retrievals during…
- Trial name
- PRESCORI (NCT02884245)
- Testing
- Estrogens
- Where
- 3 sites in France
- Volunteers
- 334 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Infertility
A Study to Evaluate the Ease of Use, Local Tolerance, Safety and Effectiveness of Gonal-f® (Filled-by-mass in a Prefilled Pen)
This is a prospective, open-label, non-comparative, multicentric Phase 4 study to evaluate the ease of use, local tolerance, safety and effectiveness of Gonal-f® (filled-by-mass in a prefilled pen) in subjects undergoing ovarian…
- Trial name
- NCT01115725
- Testing
- Gonal-f® (follitropin alfa)
- Where
- Greece
- Volunteers
- 76 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Effect of Cabergoline on Endometrial Vascularity During IntraCytoplasmic Sperm Injection
The purpose of this study is to determine the effect of giving cabergoline to patients at risk of OHSS (ovarian hyperstimulation syndrome) after ovum pick up, on endometrial vascularity and it's effect on pregnancy outcome
- Trial name
- NCT02306564
- Testing
- Cabergoline
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Infertility
Timing of Estrogen Support During the Luteal Phase of in Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) Cycle
To test the hypothesis that adding estradiol (E2) to progesterone supplementation later in the luteal phase of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles, rather than earlier in the luteal phase…
- Trial name
- NCT01367912
- Testing
- estradiol tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 301 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Infertility
A Comparative Study of Sibling Oocytes: ICSI vs. the PICSI Sperm Selection Method
The aim of this research is to compare sibling oocytes using two sperm selection methods for choosing the best quality spermatozoa before they are injected into oocytes and the influence of each of these methods on embryo quality…
- Trial name
- NCT03240302
- Testing
- ICSI petri dish, PICSI petri dish
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Infertility, Recurrent Implantation Failure
Effect of Reproductive Tract Microbiota on Pregnancy Outcome in IVF/ICSI
A single center，observational cohort study to explore the relationship between reproductive tract microbiota and pregnancy outcome in the patients accepted IVF/ICSI.
- Conditions
- Infertility, Recurrent Implantation Failure, Recurrent Miscarriage
- Trial name
- NCT04293068
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Ovarian Diseases
Antral Follicle Priming Prior to ICSI (Intracytoplasmic Sperm Injection) in Previously Diagnosed Low Responders
The aim of this study is to compare the effectiveness of testosterone,estradiol and a combined treatment with estrogens/progestagens prior to IVF-ICSI in previously diagnosed low responder patients.
- Trial name
- FOLLPRIM (NCT01310647)
- Testing
- Testosterone, Estradiol, CombEq
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Female Infertility
Caesarean Section and Intracytoplasmic Sperm Injection (ICSI) Outcome
Although Caesarean section (CS) is often a necessary surgical intervention, it may also be associated with an increased risk of short- and long-term sequelae.
- Trial name
- NCT05528835
- Testing
- Frozen embryo transfer
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Alexandria University
Multifollicular Stimulation
An Observational Study of Gonal-F Filled by Mass Pens in Multifollicular Stimulation Prior to In-vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI)
This is a prospective, observational study in women using Gonal-F filled-by-mass (FbM) in ovarian hyperstimulation as part of their in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment at infertility…
- Trial name
- NCT01075854
- Testing
- Gonal-F (Follitropin alfa)
- Where
- South Korea
- Volunteers
- 1,539 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Pregnancy Outcome
Assessment of Follicular Fluid Level of Coenzyme Q10 in Women Undergoing ICSI
The aim of this study to assess the follicular fluid level of coenzyme Q10 in women undergoing intracytoplasmic sperm injection (ICSI) and its impact on pregnancy outcome.
- Trial name
- NCT04515134
- Testing
- assessment of follicular level of coenzyme Q10 in the ovaries in females undergoing ICSI
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- South Valley University
Infertility
Trigger Protocol on the Rate of Pregnancy After Intracytoplasmic Sperm Injection
Infertility is a condition affecting both female and male, characterized by the inability to conceive after 12 months or more of regular, unprotected sexual activity.
- Trial name
- NCT06966219
- Testing
- Intracytoplasmic sperm injection
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Suez University
Intracytoplasmatic Sperm Injection
Metformin in Intracytoplasmic Sperm Injection Cycles
The relationship between serum progesterone level on the day of human chorionic gonadotropin administration and outcome of in vitro fertilization /intracytoplasmic sperm injection and embryo transfer has been controversial for…
- Trial name
- NCT03088631
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Assiut University
Infertility, Female
Time-lapse Monitoring of Early Embryo Development After Ovarian Stimulation During Infertility Treatment
The number of children conceived by assisted reproductive technology is increasing in Nordic countries as well as worldwide. An important factor of success in treatment of infertility is a short "time to pregnancy" with impact on…
- Trial name
- NCT01882166
- Testing
- fostimon, puregon
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
Infertility
Prospective, Randomized Trial Comparing ICSI to Insemination for Non-Male Factor Patients Undergoing PGT-A
Intracytoplasmic sperm injection (ICSI) is a procedure performed during in vitro fertilization (IVF) in which a single sperm is injected directly into an oocyte.
- Trial name
- NCT05548101
- Testing
- ICSI
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Texas Fertility Center