Clinical trials: Intracytoplasmic Sperm Injection
Infertility
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin B ( ICSI-LB)
Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc.
- Trial name
- NCT03678597
- Testing
- Medium Supplemented with Latrunculin B
- Where
- 3 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- Ibn Sina Hospital
Unexplained Infertility
ICSI Versus Conventional IVF in Couples With Unexplained Infertility
This multicenter, open-label, parallel-group, randomized controlled trial aims to compare the live birth rate, fertilization outcomes, other pregnancy outcomes and safety between ICSI and conventional IVF among couples with…
- Trial name
- ICSI/IVF-UI (NCT07294027)
- Testing
- ICSI, IVF
- Where
- 7 sites in China
- Volunteers
- 848 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Endometriosis
Use of Antioxidant in Endometriotic Women to Improve Intracytoplasmic Sperm Injection (ICSI)
ROS plays an essential role in the pathogenesis of many reproductive processes. High follicular fluid ROS levels are associated with negative IVF outcomes.
- Trial name
- ROS (NCT02058212)
- Testing
- ascorbate 1000mg, vitamin E 400, zinc and selenium
- Where
- 3 sites in Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infertility
HCG Levels After Ovulation Triggering as Predictors of ICSI Outcome
This study aimed to assess the correlation between HCG levels after ovulation triggering and ICSI outcomes, affected by HCG formulation and dose
- Trial name
- NCT05969834
- Testing
- uHCG, rHCG, uHCG and GnRHa
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Preterm Birth, Gestational Diabetes Mellitus (GDM)
Evaluation of Maternal and Neonatal Outcomes in Women Are Conceived Through Assisted Reproductive Technology Compared to Other Fertility Treatments and Naturally Conceived Women: It is a Retrospective Cohort Study Conducted Over a 5-year Period at a Fertility Center in a Lebanese Hospital
Background: The number of couples experiencing difficulties conceiving and seeking treatment for infertility has increased dramatically over time.
- Conditions
- Preterm Birth, Gestational Diabetes Mellitus (GDM), Gestational Hypertension
- Trial name
- non (NCT06836843)
- Testing
- Since this is an observational study rather than an interventional study, the exposure type refers to all potential factors influencing pregnancy both before and during pregnancy
- Where
- Lebanon
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lebanese University
Infertility
HbA1c in Intracytoplasmic Sperm Injection
ICSI has increased nowadays for treating cases of longstanding infertility . HbA1c has an important value in evaluating glucose level in blood
- Trial name
- NCT03731858
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Unexplained Infertility
The Effects of Using Fertile Chip in Sperm Selection for Intracytoplasmic Sperm Injection in Unexplained Infertility
The aim of the current study is to evaluate to effectiveness of sperm selection by using fertile chip in unexplained infertile couples on intracytoplasmic sperm injection (ICSI) cycles.
- Trial name
- NCT02488434
- Testing
- fertile chip
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Baskent University
Intracytoplasmic Sperm Injection, Sperm
Sperm Selection by Rheotaxis and Thermotaxis in In-Situ Handmade Microfluidics of Fluidic Walls in the Same ICSI Plate
Microfluidics technologies are proving their capability to select suitable sperm for ICSI, especially those that take advantage of the rheotaxic properties of sperm migration.
- Conditions
- Intracytoplasmic Sperm Injection, Sperm, Microfluidics
- Trial name
- IS-MFluidics (NCT06243926)
- Testing
- Sperm selection for ICSI
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CREA Medicina de la Reproducción SL
Infertility
Predictive Value of Endometrial Cytokines in Endometrial Implantation in Cases of Intracytoplasmic Sperm Injection
For all women immediately after ovum retrieval from 80 women undergoing IVF, intra uterine salin flushing will be analyzed using a multiplex immunoassay for soluble regulators of implantation, namely Interleukin (IL)-1b, Tumor…
- Trial name
- NCT02854514
- Testing
- Aspiration of endometrial secretion
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Benha University
Embryo/Fetus Death, Blastocyst Disintegration
Assessment of Implantation Potential of Embryos by Time-lapse Technology
1. Culture conditions of developing embryos are highly controlled in the Embryoscope and are monitored by Time-lapse videography to produce 3D images at different stages.This cannot be done under conventional culture conditions.
- Conditions
- Embryo/Fetus Death, Blastocyst Disintegration, Aneuploidy, Complication of Implant
- Trial name
- Embryoscope (NCT01760278)
- Testing
- recombinant Follicle Stimulating Hormone (rFSH)
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bloom IVF and Fertility Centre
Infertility
Intralipid Therapy for Women 35-40 Years With Positive Natural Killer Cells Undergoing Intracytoplasmic Sperm Injection (ICSI)
Intralipid can suppress natural killer cells that are known to be involve in repeated implantation failure and recurrent miscarriages.Intralipid is made of purified soybean oil, egg phospholipids, glycerol and water.
- Trial name
- NCT01916798
- Testing
- Intralipid infusion
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Culture, ICSI, IVF
Comparison of Two Embryo Culture Media for IVF and ICSI
In this research, the two media used are Global medium and SSM medium with serum), which are routinely used in the reproduction biology unit. This study simply consists in setting up a methodology to compare these to media.
- Trial name
- NCT02586324
- Testing
- global medium, SSM
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Infertility, Female
Antimullerian Hormone as an Indicator for Ovarian Response
Anti Mullerian hormone (AMH) is gaining place as ovarian marker, chiefly in infertility assistance. Investigators explored its correlation with oocytes retrieval after long GnRH agonist protocol for stimulation, in younger and…
- Trial name
- NCT03291860
- Testing
- Ovum retrievum
- Volunteers
- 66 people
- Sponsor
- Ain Shams Maternity Hospital
Polycystic Ovarian Syndrome (PCOS)
Enhancing PCOS Management for Better Outcomes of Intracytoplasmic Sperm Injection
The goal of this clinical trial is to evaluate and compare the effectiveness of combined Myoinositol and Metformin therapy versus a combination of Pioglitazone and Metformin, and Metformin alone in infertile women with Polycystic…
- Trial name
- NCT07604779
- Testing
- Metformin monotherapy, Myoinositol and metformin, pioglitazone and metformin
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Beni-Suef University
IVF
Uterine Lesions and Their Association to Invitro Fertilization(IVF) or Intracytoplasmic Sperm Injection(ICSI) Outcome
1. To study the effect of uterine wall , intracavitary , cervical as well as cervical canal lesion on the outcome of IVF/ICSI cycle. 2. To establish a score for prediction of IVF/ICSI cycle success .
- Trial name
- NCT04939376
- Testing
- IVF
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infertility
Zona Pellucida Bound Sperm vs. Embryologist Selected Sperm for Intracytoplasmic Sperm Injection
This study aims to assess the clinical significance of the intracytoplasmic sperm injection (ICSI) with zona-pellucida (ZP) bound sperm compared to ICSI with embryologist selected sperm for patients undergoing in vitro…
- Trial name
- NCT05859152
- Testing
- Zona Pellucida-Bound Sperm Selection for ICSI, Routine Embryologist Selected Sperm
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- IVI America
Infertile High-risk Patients With Polycystic Ovaries
GnRH Agonist (GnRHa) Withdrawal at Late Stage of Long Protocol and the Incidence of Ovarian Hyper-stimulation
To test whether GnRHa withheld 2-3 days before ovulation trigger reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic ovaries (PCOs) who have been treated with…
- Trial name
- NCT01634724
- Testing
- a drug withdrawal during the long protocol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Nanjing University
Infertility
An Observational Study to Evaluate Efficacy, Safety and Clinical Outcomes of Currently Used Pharmaceutical Therapies for Controlled Ovarian Stimulation in Assisted Reproductive Techniques
Human gonadotrophins have been successfully used for the treatment of infertility for more than 30 years. This observational study is being conducted to evaluate the efficacy and safety of the gonadotropins used for controlled…
- Trial name
- ESCORT (NCT01149070)
- Where
- Hungary
- Volunteers
- 10,103 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Female Infertility Due to Diminished Ovarian Reserve
Antagonist Protocol in Poor Responders
The effect of use of the growth hormone with antagonist protocol on the outcome of the IVF/ICSI cycles in poor responders.
- Trial name
- NCT02195947
- Testing
- Growth Hormone
- Where
- Egypt
- Volunteers
- 141 people
- Sponsor
- Cairo University
Infertility, Female, Infertility
Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Female inability to conceive a child. The purpose of this prospective randomized, double-blinded, double dummy, two-arm cross-over study is to investigate the difference on histological, transcriptional and immunological level in…
- Conditions
- Infertility, Female, Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- NCT03677336
- Testing
- Dydrogesterone Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel