Clinical trials: Intractable Pain
Bone Neoplasm,Malignant Vertebral Column Thoracic Secondary
Dorsal Root Ganglion Thermal Radiofrequency Versus Pulsed Radiofrequency for Metastatic Pain in Thoracic Vertebral Body
AIM OF THE WORK To evaluate the effectiveness and safety of Pulsed and Thermal Radiofrequency lesion of the dorsal root ganglion (RF-DRG) on a consecutive group of patients presenting with chronic thoracic pain due to vertebral…
- Trial name
- NCT03204942
- Testing
- PRF on DRG, TRF on DRG, Corticosteroid injection
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- National Cancer Institute, Egypt
Intractable Pain
Behavioral Treatments for Chronic Pain
The purpose of the study is to test a brief, group-administered psychosocial intervention to reduce interference of pain with daily life, emotional distress, and pain intensity, and improve quality of life and physical activity…
- Trial name
- NCT00371865
- Testing
- Cognitive-behavioral therapy, Acceptance-based therapy
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- US Department of Veterans Affairs
Myocardial Ischemia
ACT34-CMI -- Adult Autologous CD34+ Cells
The purpose of this study is to evaluate the efficacy and safety of intramyocardial injections of CLBS14 in patients with refractory chronic myocardial ischemia.
- Trial name
- NCT00300053
- Testing
- CLBS14 (low-dose), CLBS14 (high-dose)
- Where
- 26 sites in United States
- Volunteers
- 321 people
- Sponsor
- Lisata Therapeutics, Inc.
Pain, Intractable, Breakthrough Pain
Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain
The purpose of this study is to determine whether the local anesthetic bupivacaine delivered intrathecally in small doses via PTM self-administered boluses significantly improves the breakthrough pain and functional status of…
- Conditions
- Pain, Intractable, Breakthrough Pain, Chronic Pain
- Trial name
- NCT02886286
- Testing
- Bupivacaine, Opioid
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University Hospitals Cleveland Medical Center
Chronic Pain, Intractable Pain
Study to Evaluate Automated Intensity Management in Patients Undergoing a BSC SCS Temporary Trial
The purpose of the study is to assess the feasibility of using information extracted from physiologic signals to automatically adjust stimulation in patients undergoing Spinal Cord Stimulation (SCS).
- Conditions
- Chronic Pain, Intractable Pain, Low Back Pain, Pain, Neuropathic
- Trial name
- AIM (NCT04909593)
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Boston Scientific Corporation
Advanced Cancer, Pain
Lenalidomide (Revlimid) for the Treatment of Refractory Cancer Pain
The goal of this clinical research study is to learn if lenalidomide can help to treat uncontrolled pain caused by advanced cancer. Primary Objectives: 1.
- Trial name
- NCT00684242
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Phantom Limb Pain, Neuroma Amputation
C-RFA of Residual Limb Neuroma
To assess changes in pain, physical function, and health-related quality of life in patients with post-amputation neuroma-associated residual limb pain after cooled radiofrequency ablation.
- Trial name
- NCT04538417
- Testing
- Cooled Radiofrequency Ablation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Utah
Pain, Amputation
Sciatic Block in Contralateral Limb Phantom and Residual Limb Pain
Participants with chronic, refractory phantom limb pain (PLP) or residual limb pain (RLP) for more than 6 months will be enrolled in this clinical trial.
- Trial name
- NCT05046639
- Testing
- 10 mL 2% lidocaine, 10 mL preservative free saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Northwestern University
Complex Regional Pain Syndrome
Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome
The purpose of this study is to determine whether epidural and ketamine infusions are effective in the treatment of Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT02094352
- Testing
- Ketamine Infusion + Epidural Infusion, Control Group + Epidural infusion, Ketamine Booster Infusion
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Overactive Bladder
Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?
The purpose of this research study is to help determine if 10 injections of Botox ® 100 units is less painful than 20 injections of Botox ® 100 units based on effectiveness in reducing urge incontinence episodes.
- Trial name
- NCT04124939
- Testing
- OnabotulinumtoxinA 100 Units
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Pain, Pain, Acute
Pawsitive Impacts of Therapy Dog Visits
The goal of this unique 18 month study is to better understand the experiences of pain patients in the Royal University Hospital (RUH) Emergency Department (ED), to create excellence in health care.
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Intractable
- Trial name
- NCT04727749
- Testing
- Therapy Dog Team Visit
- Where
- Canada
- Volunteers
- 211 people
- Sponsor
- University of Saskatchewan
Chronic Myocardial Ischemia, Refractory Angina Pectoris
Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina
The purpose of the study is to assess the safety and efficacy of targeted intramyocardial delivery of Auto-CD34+ cells for increasing exercise time and amelioration of anginal symptoms in subjects with refractory angina and…
- Conditions
- Chronic Myocardial Ischemia, Refractory Angina Pectoris, Advanced Coronary Heart Disease
- Trial name
- RENEW (NCT01508910)
- Testing
- Auto-CD34+ cells, Standard of care
- Where
- 41 sites in United States
- Volunteers
- 291 people
- Sponsor
- Lisata Therapeutics, Inc.
Intractable Pain
Prometra's Utilization in Mitigating Pain (PUMP)
Clinical evaluation of the safety and efficacy of the Prometra Programmable Infusion Pump to accurately supply drug to the intrathecal space for the treatment of chronic pain.
- Trial name
- PUMP (NCT00817596)
- Testing
- Infusion Pump (Prometra)
- Where
- 3 sites in United States
- Volunteers
- 110 people
- Sponsor
- Flowonix Medical
Pain, Intractable
OPTIONS Spinal Cord Stimulation Programming Parameters
The purpose of this study is to evaluate programming options in spinal cord stimulation for the management of chronic, intractable pain of the trunk and limbs.
- Trial name
- NCT02503787
- Testing
- Spinal Cord Stimulation (SCS)
- Where
- 11 sites in United States
- Volunteers
- 64 people
- Sponsor
- MedtronicNeuro
Chronic Pain, Pain, Intractable
An Implantable Spinal Cord Stimulation Pain Management System
There are many treatment options available for the management of chronic pain . Some include, but are not limited to, over-the-counter medications, Non-Steroidal Anti-Inflammatory Drugs, Physical Therapy, Transcutaneous…
- Conditions
- Chronic Pain, Pain, Intractable, Pain, Back Pain
- Trial name
- NCT00205855
- Testing
- Precision SCS
- Where
- 9 sites in United States
- Volunteers
- 65 people
- Sponsor
- Boston Scientific Corporation
Migraine, Headache
Ticagrelor Therapy for RefrACTORy Migraine Study
This is a prospective, open-label, single-arm pilot study treating 40 subjects to assess the hypothesis that P2Y, G protein-coupled 12 (P2Y12) inhibition with Brilinta/ticagrelor (90 mg by mouth (PO) twice a day) reduces episodic…
- Conditions
- Migraine, Headache, Migraine Headache
- Trial name
- TRACTOR (NCT02518464)
- Testing
- Ticagrelor 90 mg twice per day
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Columbia University
Intractable Neuropathic Pain, Pain
Spinal Cord Stimulation (SCS) for Neuropathic Pain of Back or Lower Extremity
The primary objective of this study is to compare the efficacy and patient preference for spinal cord stimulation (SCS) using the Precision device with the electrode array placed at T7 versus placement at T8.
- Conditions
- Intractable Neuropathic Pain, Pain, Back Pain, Lower Extremity Pain
- Trial name
- NCT00399841
- Testing
- Precision for Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Boston Scientific Corporation
Chronic Low-Back Pain, Refractory Pain
Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)
The objective of this study is to evaluate the efficacy of BurstDR dorsal column stimulation, compared with conventional medical management, in improving pain and back-related physical function in subjects suffering with chronic…
- Conditions
- Chronic Low-Back Pain, Refractory Pain, Neuropathic Pain
- Trial name
- NCT04479787
- Testing
- Spinal Cord Stimulation, Conventional Medical Management
- Where
- 30 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Devices
Chronic Non-malignant Pain, Chronic Pain
Embrace TDD: Post-Market Study to Evaluate Intrathecal Morphine as an Alternative to Systemic Opioids for Chronic Pain
This is a prospective, multi-center, post market study to evaluate Intrathecal (IT) preservative-free morphine sulfate (PFMS) using the SynchroMed™ II infusion system as an alternative to systemic opioids for the treatment of…
- Conditions
- Chronic Non-malignant Pain, Chronic Pain, Pain, Back, Pain, Leg
- Trial name
- NCT03761277
- Testing
- Medtronic SynchroMed™ II infusion system, Preservative-free morphine sulfate (PFMS)
- Where
- 16 sites in United States
- Volunteers
- 93 people
- Sponsor
- MedtronicNeuro
Chronic Refractory Neuropathic Pain
An Open-label Continuation Trial to Assess the Continued Efficacy and Safety of Ascending Doses of Lacosamide in Subjects With Chronic Refractory Neuropathic Pain
This trial is the follow-on trial to a preceeding open-label trial which included patients with chronic refractory neuropathic pain. It is conducted at one site in the United Kingdom and the patient enrollment is completed.
- Trial name
- NCT00237458
- Testing
- Lacosamide
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- UCB Pharma