Clinical trials: Intracranial Neoplasm
Gastrointestinal Stromal Tumors, Sdh
Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)
Funding Source - FDA OOPD FDA-approved products for patients with unresectable or metastatic GIST include therapies such as imatinib and sunitinib.
- Conditions
- Gastrointestinal Stromal Tumors, Sdh, GIST, Cancer
- Trial name
- NCT03556384
- Testing
- Temozolomide
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Adam Burgoyne, MD, PhD
Grade 2 Meningioma, Intracranial Meningioma
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery.
- Trial name
- NCT03180268
- Testing
- Biospecimen Collection, Clinical Observation, Intensity-Modulated Radiation Therapy
- Where
- 215 sites in United States, Canada and 3 more
- Volunteers
- 162 people
- Sponsor
- NRG Oncology
Lung Cancer
Intracranial Activity of AZD9291 (TAGRISSO) in Advanced EGFRm NSCLC Patients With Asymptomatic Brain Metastases
Patients will receive AZD9291 at a dose of 80 mg once daily. Intracranial response will be assessed with brain MRI scan, systemic evaluation will be done by PET-CT (Positron Emission Tomography-Computed Tomography) scan.
- Trial name
- NCT02736513
- Testing
- AZD9291
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Soroka University Medical Center
Breast Cancer Metastatic, Brain Metastases
Hippocampal-sparing Whole Brain Radiotherapy for Brain Metastases From Breast Cancer
Based on evidence that radiation-induced damage to the hippocampus plays a considerable role in neurocognitive decline after cranial irradiation, hippocampal-sparing whole brain radiation therapy (HS-WBRT) has been proposed.
- Trial name
- NCT03002532
- Testing
- whole brain radiotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Meningioma
Monthly SOM230C for Recurrent or Progressive Meningioma
The purpose of this research study is to evaluate the effectiveness and safety of SOM230C in treating recurrent meningiomas. SOM230C is a newly discovered drug that may stop meningioma cells from growing abnormally.
- Trial name
- NCT00859040
- Testing
- SOM230C
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Patrick Y. Wen, MD
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Intracerebral Hemorrhage, Subarachnoid Hemorrhage
Al Prediction of Sarcopenia Risk in Neurocritical ICU Patients
This prospective observational study aims to evaluate sarcopenia in intensive care patients with intracranial pathologies using ultrasound and to compare the predictive performance of different artificial intelligence models.
- Conditions
- Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, Epidural Hematoma
- Trial name
- NCT07712198
- Testing
- Prospective Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Intracranial Tumors, Glioblastoma
A Pilot Study to Evaluate PBR PET in Brain Tumor Patients Treated With Chemoradiation or Immunotherapy
This research study is studying the changes in primary and metastatic brain tumor inflammation using positron emission tomography (PET) imaging using a radioactive substance called [11C] PBR28a, which is also known as peripheral…
- Conditions
- Intracranial Tumors, Glioblastoma, Melanoma
- Trial name
- NCT02431572
- Testing
- PBR PET, Cancer Immunotherapy, Radiation and chemotherapy
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Adult Intracranial Neoplasm, Vascular: Intracranial
Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions
The purpose of this study is to evaluate the effectiveness of using Fluorescein Sodium and the Yellow 560 microscope to aid in treatment of intracranial tumors and vascular lesions.
- Trial name
- Fluorescein (NCT02028325)
- Testing
- Fluorescein Sodium
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Indiana University
CNS Germ Cell Tumor
Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx)
This study will look to see how well patients with relapsed or recurrent intracranial germ cell tumors respond to the new combination of chemotherapy (in induction)of Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) followed by…
- Trial name
- NCT01270724
- Testing
- Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx).
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Nationwide Children's Hospital
Brain Tumor Adult, Brain Tumor Benign
Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors
Cerebrospinal fluid is a clear fluid that surrounds and protects the brain. During surgery for brain tumors, neurosurgeons often need to open the covering of the brain (the dura) to reach the tumor.
- Conditions
- Brain Tumor Adult, Brain Tumor Benign, CerebroSpinal Fluid (CSF) Leak, Craniotomy
- Trial name
- CSF-IMR (NCT07411690)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Brain Injuries, Traumatic, Spinal Cord Trauma
Characterization of Human Autoantibody Titers After Central Nervous System Insult
The aim of the study is to quantitate Central Nervous System (CNS) autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
- Conditions
- Brain Injuries, Traumatic, Spinal Cord Trauma, Intracranial Neoplasm
- Trial name
- CHAT CNS (NCT03089749)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Utah
Posterior Fossa Hemorrhage, Lung Cancer
Pilot Study of Model Based Iterative Reconstruction Using 64-Slice
This study is being performed to confirm that the new technique, Model-Based Iterative Reconstruction (MBIR) with reduced radiation dose can deliver equivalent image quality for CT scans compared to current techniques (Filtered…
- Conditions
- Posterior Fossa Hemorrhage, Lung Cancer, Flank Pain, Urolithiasis
- Trial name
- MBIR (NCT01431378)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Metastatic Malignant Neoplasm in the Brain, Stage IV Non-Small Cell Lung Cancer AJCC v7
Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer
This phase I/II trial studies the side effects and best dose of nivolumab when giving together with stereotactic radiosurgery or whole brain radiotherapy with or without ipilimumab and to see how well they work in treating…
- Trial name
- NCT02696993
- Testing
- Cognitive Assessment, Ipilimumab, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Intracranial Tumor
Comparison of Fluorescein-INtra-VItal Microscopy Versus Conventional Frozen Section Diagnosis for intraOperative Histopathological Evaluation
With the appliance of the in-vivo microscopy after Fluorescein staining, the investigators hypothesize that the preliminary in-vivo histopathological diagnostic accuracy is not inferior to conventional frozen section analysis…
- Trial name
- INVIVO (NCT04597801)
- Testing
- Alcon
- Where
- 3 sites in Germany
- Volunteers
- 210 people
- Sponsor
- Technical University of Munich
Optic Nerve Sheath Neoplasm, Intracranial Pressure Increase
Optic Nerve Sheath Diameter in Pediatric Patients
Endotracheal intubation and laryngeal mask are generally applied to secure the airway during general anesthesia. There is a widespread opinion among anesthesiologists that endotracheal intubation increases intracranial pressure.
- Conditions
- Optic Nerve Sheath Neoplasm, Intracranial Pressure Increase, Intubation Complication, Airway Complication of Anesthesia
- Trial name
- NCT05445271
- Testing
- Optic nerve sheath diameter measurement with linear ultrasound
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Neoplasms, Nervous System Disease
Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients
Background: Neurofibromatosis type II (NF2) is associated with tumors of the nerves, brain, and spinal cord. Most people with NF2 develop vestibular schwannomas, or tumors on the hearing and balance nerves.
- Conditions
- Neoplasms, Nervous System Disease, Vestibular Disease
- Trial name
- NCT01222728
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Intracranial Pressure Increase
Posterior Fossa Intracranial Pressure (ICP) Measurement: Clinical Study
In modern medicine, doctors attempt to monitor all physiological variables to assess their evolution and to decide, based on their changes, the therapeutic attitudes to adopt.
- Trial name
- Postfossa ICP (NCT04675216)
- Testing
- Posterior fossa intracranial pressure measurement
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- University of Valencia
Non-Small Cell Lung Cancer, Brain Metastases From Non-small Cell Lung Cancer (NSCLC)
Sacituzumab Tirumotecan（Sac-TMT） and Brain Radotherapy for EGFR+ NSCLC With Brain Mets
his study is a Phase II, multicenter clinical trial evaluating the combination of an antibody-drug conjugate (ADC) called Sacituzumab Tirumotecan (SKB264) and brain radiotherapy for patients with advanced non-small cell lung…
- Conditions
- Non-Small Cell Lung Cancer, Brain Metastases From Non-small Cell Lung Cancer (NSCLC), EGFR Mutation Positive Advanced Non-Small Cell Lung Cancer
- Trial name
- NCT07789444
- Testing
- brain radiotherapy, Sacituzumab Tirumotecan (Sac-TMT)
- Volunteers
- 53 people
- Sponsor
- Xiaorong Dong
Skull Fractures, Stroke
Simulation Training in Emergency Department Imaging 2
Background and study aims: Computerised Tomography (CT) head scans are frequently requested by Emergency Department (ED) clinicians as one of the investigations for their patients.
- Conditions
- Skull Fractures, Stroke, Intracranial Bleed, Brain Tumor
- Trial name
- STEDI2 (NCT05427838)
- Testing
- Online training
- Where
- 6 sites in United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust